7B07
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![BU of 7b07 by Molmil](/molmil-images/mine/7b07) | TgoT_6G12 apo | Descriptor: | CALCIUM ION, DNA polymerase | Authors: | Samson, C, Legrand, P, Tekpinar, M, Rozenski, J, Abramov, M, Holliger, P, Pinheiro, V, Herdewijn, P, Delarue, M. | Deposit date: | 2020-11-18 | Release date: | 2020-12-30 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (3.099 Å) | Cite: | Structural Studies of HNA Substrate Specificity in Mutants of an Archaeal DNA Polymerase Obtained by Directed Evolution. Biomolecules, 10, 2020
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4FLU
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![BU of 4flu by Molmil](/molmil-images/mine/4flu) | |
8WPP
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![BU of 8wpp by Molmil](/molmil-images/mine/8wpp) | Structure of monkeypox virus polymerase complex F8-A22-E4-H5 with endogenous DNA | Descriptor: | A22R DNA polymerase processivity factor, DNA polymerase, E4R Uracil-DNA glycosylase, ... | Authors: | Wang, X, Li, N, Gao, N. | Deposit date: | 2023-10-10 | Release date: | 2023-11-29 | Last modified: | 2023-12-27 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structural insights into the assembly and mechanism of mpox virus DNA polymerase complex F8-A22-E4-H5. Mol.Cell, 83, 2023
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4FYD
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![BU of 4fyd by Molmil](/molmil-images/mine/4fyd) | |
6V93
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![BU of 6v93 by Molmil](/molmil-images/mine/6v93) | Structure of DNA Polymerase Zeta/DNA/dNTP Ternary Complex | Descriptor: | 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, CALCIUM ION, DNA, ... | Authors: | Malik, R, Kopylov, M, Jain, R, Ubarrextena-Belandia, I, Aggarwal, A.K. | Deposit date: | 2019-12-13 | Release date: | 2020-08-19 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structure and mechanism of B-family DNA polymerase zeta specialized for translesion DNA synthesis. Nat.Struct.Mol.Biol., 27, 2020
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8HM0
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![BU of 8hm0 by Molmil](/molmil-images/mine/8hm0) | F8-A22-E4 complex of MPXV in trimeric form | Descriptor: | DNA polymerase, DNA polymerase processivity factor component A20, E4R | Authors: | Li, Y.N, Shen, Y.P, Hu, Z.W, Yan, R.H. | Deposit date: | 2022-12-02 | Release date: | 2023-05-31 | Last modified: | 2023-12-13 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structural basis for the assembly of the DNA polymerase holoenzyme from a monkeypox virus variant. Sci Adv, 9, 2023
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4FM0
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![BU of 4fm0 by Molmil](/molmil-images/mine/4fm0) | |
7B0H
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![BU of 7b0h by Molmil](/molmil-images/mine/7b0h) | TgoT_6G12 Ternary complex | Descriptor: | DNA (5'-D(P*AP*AP*CP*GP*GP*CP*AP*AP*AP*TP*GP*CP*G)-3'), DNA (5'-D(P*CP*GP*CP*AP*TP*T)-3'), DNA polymerase, ... | Authors: | Samson, C, Legrand, P, Tekpinar, M, Rozenski, J, Abramov, M, Holliger, P, Pinheiro, V, Herdewijn, P, Delarue, M. | Deposit date: | 2020-11-19 | Release date: | 2021-01-13 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (3.15 Å) | Cite: | Structural Studies of HNA Substrate Specificity in Mutants of an Archaeal DNA Polymerase Obtained by Directed Evolution. Biomolecules, 10, 2020
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3SUQ
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![BU of 3suq by Molmil](/molmil-images/mine/3suq) | RB69 DNA Polymerase (Y567A) Ternary Complex with dCTP Opposite 2AP (AT rich sequence) | Descriptor: | 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, 5'-D(*AP*AP*TP*TP*AP*AP*TP*TP*AP*AP*TP*TP*(2DA))-3', 5'-D(P*CP*(2PR)P*TP*AP*AP*TP*TP*AP*AP*TP*TP*AP*AP*TP*TP*G)-3', ... | Authors: | Xia, S, Konigsberg, W.H, Wang, J. | Deposit date: | 2011-07-11 | Release date: | 2011-11-09 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (3.15 Å) | Cite: | Structure of the 2-Aminopurine-Cytosine Base Pair Formed in the Polymerase Active Site of the RB69 Y567A-DNA Polymerase. Biochemistry, 50, 2011
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3K5N
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![BU of 3k5n by Molmil](/molmil-images/mine/3k5n) | Crystal structure of E.coli Pol II-abasic DNA binary complex | Descriptor: | DNA (5'-D(*GP*TP*CP*CP*TP*GP*(3DR)*TP*AP*CP*GP*CP*TP*AP*GP*GP*CP*AP*CP*A)-3'), DNA (5'-D(*GP*TP*GP*CP*CP*TP*AP*GP*CP*GP*TP*AP*G)-3'), DNA polymerase II | Authors: | Yang, W, Wang, F. | Deposit date: | 2009-10-07 | Release date: | 2010-02-02 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (3.15 Å) | Cite: | Structural insight into translesion synthesis by DNA Pol II. Cell(Cambridge,Mass.), 139, 2009
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4FLZ
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![BU of 4flz by Molmil](/molmil-images/mine/4flz) | |
6P1H
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![BU of 6p1h by Molmil](/molmil-images/mine/6p1h) | Cryo-EM Structure of DNA Polymerase Delta Holoenzyme | Descriptor: | 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, CALCIUM ION, DNA (30-MER), ... | Authors: | Jain, R, Rice, W, Aggarwal, A.K. | Deposit date: | 2019-05-19 | Release date: | 2019-10-02 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Cryo-EM structure and dynamics of eukaryotic DNA polymerase delta holoenzyme. Nat.Struct.Mol.Biol., 26, 2019
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1WAF
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![BU of 1waf by Molmil](/molmil-images/mine/1waf) | DNA POLYMERASE FROM BACTERIOPHAGE RB69 | Descriptor: | DNA POLYMERASE, GUANOSINE | Authors: | Wang, J, Satter, A.K.M.A, Wang, C.C, Karam, J.D, Konigsberg, W.H, Steitz, T.A. | Deposit date: | 1997-04-13 | Release date: | 1998-01-14 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Crystal structure of a pol alpha family replication DNA polymerase from bacteriophage RB69. Cell(Cambridge,Mass.), 89, 1997
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8G9F
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![BU of 8g9f by Molmil](/molmil-images/mine/8g9f) | Complete auto-inhibitory complex of Xenopus laevis DNA polymerase alpha-primase | Descriptor: | DNA polymerase alpha catalytic subunit, DNA polymerase alpha subunit B, DNA primase, ... | Authors: | Mullins, E.A, Chazin, W.J, Eichman, B.F. | Deposit date: | 2023-02-21 | Release date: | 2023-04-12 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | A mechanistic model of primer synthesis from catalytic structures of DNA polymerase alpha-primase. Nat.Struct.Mol.Biol., 31, 2024
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7PMK
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![BU of 7pmk by Molmil](/molmil-images/mine/7pmk) | S. cerevisiae replisome-SCF(Dia2) complex bound to double-stranded DNA (conformation I) | Descriptor: | Cell division control protein 45,Cell division control protein 45, Chromosome segregation in meiosis protein 3, DNA helicase, ... | Authors: | Jenkyn-Bedford, M, Yeeles, J.T.P, Deegan, T.D. | Deposit date: | 2021-09-02 | Release date: | 2021-11-10 | Last modified: | 2022-02-02 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | A conserved mechanism for regulating replisome disassembly in eukaryotes. Nature, 600, 2021
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7PMN
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![BU of 7pmn by Molmil](/molmil-images/mine/7pmn) | S. cerevisiae replisome-SCF(Dia2) complex bound to double-stranded DNA (conformation II) | Descriptor: | Cell division control protein 45,Cell division control protein 45, Chromosome segregation in meiosis protein 3, DNA polymerase alpha-binding protein, ... | Authors: | Jenkyn-Bedford, M, Yeeles, J.T.P, Deegan, T.D. | Deposit date: | 2021-09-02 | Release date: | 2021-11-10 | Last modified: | 2022-01-26 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | A conserved mechanism for regulating replisome disassembly in eukaryotes. Nature, 600, 2021
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7PFO
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![BU of 7pfo by Molmil](/molmil-images/mine/7pfo) | Core human replisome | Descriptor: | Cell division control protein 45 homolog, Claspin, DNA polymerase epsilon catalytic subunit A, ... | Authors: | Jones, M.J, Yeeles, J.T.P. | Deposit date: | 2021-08-11 | Release date: | 2021-11-10 | Last modified: | 2023-10-18 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Structure of a human replisome shows the organisation and interactions of a DNA replication machine. Embo J., 40, 2021
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5VU8
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![BU of 5vu8 by Molmil](/molmil-images/mine/5vu8) | TNA polymerase, closed ternary complex | Descriptor: | DNA polymerase, DNA template, DNA/TNA hybrid primer, ... | Authors: | Chim, N, Chaput, J.C. | Deposit date: | 2017-05-18 | Release date: | 2017-12-06 | Last modified: | 2017-12-13 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Structural basis for TNA synthesis by an engineered TNA polymerase. Nat Commun, 8, 2017
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7KC0
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![BU of 7kc0 by Molmil](/molmil-images/mine/7kc0) | Structure of the Saccharomyces cerevisiae replicative polymerase delta in complex with a primer/template and the PCNA clamp | Descriptor: | 2',3'-DIDEOXY-THYMIDINE-5'-TRIPHOSPHATE, DNA (25-MER), DNA (5'-D(P*AP*TP*GP*AP*CP*CP*AP*TP*GP*AP*TP*TP*AP*CP*GP*AP*AP*TP*TP*GP*C)-3'), ... | Authors: | Zheng, F, Georgescu, R, Li, H, O'Donnell, M.E. | Deposit date: | 2020-10-04 | Release date: | 2020-12-02 | Last modified: | 2020-12-16 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Structure of eukaryotic DNA polymerase delta bound to the PCNA clamp while encircling DNA. Proc.Natl.Acad.Sci.USA, 117, 2020
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2ATQ
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![BU of 2atq by Molmil](/molmil-images/mine/2atq) | RB69 single-stranded DNA binding protein-DNA polymerase fusion | Descriptor: | DNA polymerase, GUANOSINE-5'-DIPHOSPHATE, ZINC ION, ... | Authors: | Sun, S, Geng, L, Shamoo, Y. | Deposit date: | 2005-08-25 | Release date: | 2006-05-09 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Structure and enzymatic properties of a chimeric bacteriophage RB69 DNA polymerase and single-stranded DNA binding protein with increased processivity. Proteins, 65, 2006
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6ISI
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![BU of 6isi by Molmil](/molmil-images/mine/6isi) | Structure of 9N-I DNA polymerase incorporation with 3'-CL in the active site | Descriptor: | 3-[2-[2-(2-azanylethoxy)ethoxy]ethoxy]propanoic acid, CALCIUM ION, DNA (5'-D(P*AP*CP*GP*GP*GP*TP*AP*AP*GP*CP*AP*GP*TP*CP*CP*GP*CP*G)-3'), ... | Authors: | Linwu, S.W, Maestre-Reyna, M, Tsai, M.D, Tu, Y.H, Chang, W.H. | Deposit date: | 2018-11-16 | Release date: | 2019-08-28 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Thermococcus sp. 9°N DNA polymerase exhibits 3'-esterase activity that can be harnessed for DNA sequencing. Commun Biol, 2, 2019
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8J86
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![BU of 8j86 by Molmil](/molmil-images/mine/8j86) | Monkeypox virus DNA replication holoenzyme F8, A22 and E4 complex in a DNA binding form | Descriptor: | CALCIUM ION, DNA (5'-D(P*AP*GP*CP*TP*GP*CP*TP*AP*TP*GP*TP*GP*AP*GP*AP*TP*TP*AP*AP*GP*TP*TP*AP*T)-3'), DNA (5'-D(P*GP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*GP*AP*TP*AP*AP*CP*TP*TP*AP*AP*TP*CP*TP*CP*AP*CP*AP*TP*AP*GP*CP*AP*GP*CP*TP*)-3'), ... | Authors: | Xu, Y, Wu, Y, Wu, X, Zhang, Y, Yang, Y, Li, D, Yang, B, Gao, K, Zhang, Z, Dong, C. | Deposit date: | 2023-04-30 | Release date: | 2024-05-01 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (3.22 Å) | Cite: | Structural basis of human mpox viral DNA replication inhibition by brincidofovir and cidofovir. Int.J.Biol.Macromol., 270, 2024
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6ISH
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![BU of 6ish by Molmil](/molmil-images/mine/6ish) | Structure of 9N-I DNA polymerase incorporation with 3'-AL in the active site | Descriptor: | CALCIUM ION, DNA (5'-D(*AP*CP*TP*GP*GP*TP*AP*AP*GP*CP*AP*GP*TP*CP*CP*GP*C)-3'), DNA (5'-D(P*GP*CP*GP*GP*AP*CP*TP*GP*CP*TP*TP*AP*CP*CP*(DAL))-3'), ... | Authors: | Linwu, S.W, Maestre-Reyna, M, Tsai, M.D, Tu, Y.H, Chang, W.H. | Deposit date: | 2018-11-16 | Release date: | 2019-08-28 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Thermococcus sp. 9°N DNA polymerase exhibits 3'-esterase activity that can be harnessed for DNA sequencing. Commun Biol, 2, 2019
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8G9L
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![BU of 8g9l by Molmil](/molmil-images/mine/8g9l) | DNA initiation subcomplex of Xenopus laevis DNA polymerase alpha-primase | Descriptor: | 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, DNA polymerase alpha catalytic subunit, DNA primase large subunit, ... | Authors: | Mullins, E.A, Durie, C.L, Ohi, M.D, Chazin, W.J, Eichman, B.F. | Deposit date: | 2023-02-21 | Release date: | 2023-04-12 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | A mechanistic model of primer synthesis from catalytic structures of DNA polymerase alpha-primase. Nat.Struct.Mol.Biol., 31, 2024
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7QHS
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![BU of 7qhs by Molmil](/molmil-images/mine/7qhs) | S. cerevisiae CMGE nucleating origin DNA melting | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Cell division control protein 45, ... | Authors: | Lewis, J.S, Sousa, J.S, Costa, A. | Deposit date: | 2021-12-14 | Release date: | 2022-06-15 | Last modified: | 2022-07-06 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Mechanism of replication origin melting nucleated by CMG helicase assembly. Nature, 606, 2022
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