3QPM
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![BU of 3qpm by Molmil](/molmil-images/mine/3qpm) | Crystal structure of peroxiredoxin Prx4 from Pseudosciaena crocea | Descriptor: | GLYCEROL, Peroxiredoxin | Authors: | Lian, F.M, Teng, Y.B, Jiang, Y.L, He, Y.X, Chen, Y, Zhou, C.Z. | Deposit date: | 2011-02-14 | Release date: | 2012-02-22 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | The N-terminal beta-sheet of peroxiredoxin Prx4 in the large yellow croaker Pseudosciaena crocea is critical for its peroxidase and anti-bacterial activities To be Published
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8X73
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![BU of 8x73 by Molmil](/molmil-images/mine/8x73) | Crystal structure of Peroxiredoxin I in complex with compound 19-069 | Descriptor: | Peroxiredoxin-1, methyl (2~{S})-2-[[(2~{R},4~{a}~{S},6~{a}~{R},6~{a}~{S},14~{a}~{S},14~{b}~{R})-2,4~{a},6~{a},6~{a},9,14~{a}-hexamethyl-10-oxidanyl-11-oxidanylidene-1,3,4,5,6,13,14,14~{b}-octahydropicen-2-yl]carbamoylamino]-3-oxidanyl-propanoate | Authors: | Zhang, H, Luo, C. | Deposit date: | 2023-11-22 | Release date: | 2024-06-19 | Method: | X-RAY DIFFRACTION (1.61 Å) | Cite: | Discovery of a Novel Orally Bioavailable FLT3-PROTAC Degrader for Efficient Treatment of Acute Myeloid Leukemia and Overcoming Resistance of FLT3 Inhibitors. J.Med.Chem., 67, 2024
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8X71
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![BU of 8x71 by Molmil](/molmil-images/mine/8x71) | Crystal structure of Peroxiredoxin I in complex with compound 19-064 | Descriptor: | Peroxiredoxin-1, methyl 3-[[(2~{R},4~{a}~{S},6~{a}~{R},6~{a}~{S},14~{a}~{S},14~{b}~{R})-2,4~{a},6~{a},6~{a},9,14~{a}-hexamethyl-10-oxidanyl-11-oxidanylidene-1,3,4,5,6,13,14,14~{b}-octahydropicen-2-yl]carbamoylamino]oxetane-3-carboxylate | Authors: | Zhang, H, Luo, C. | Deposit date: | 2023-11-22 | Release date: | 2024-06-19 | Method: | X-RAY DIFFRACTION (1.58 Å) | Cite: | Discovery of a Novel Orally Bioavailable FLT3-PROTAC Degrader for Efficient Treatment of Acute Myeloid Leukemia and Overcoming Resistance of FLT3 Inhibitors. J.Med.Chem., 67, 2024
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6E0G
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![BU of 6e0g by Molmil](/molmil-images/mine/6e0g) | Mitochondrial peroxiredoxin from Leishmania infantum after heat stress without unfolding client protein | Descriptor: | mitochondrial 2-cys-peroxiredoxin | Authors: | Teixeira, F, Tse, E, Makepeace, K.A.T, Borchers, C.H, Castro, H, Tomas, A.M, Poole, L.B, Southworth, D.R, Jakob, U. | Deposit date: | 2018-07-06 | Release date: | 2019-02-20 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Chaperone activation and client binding of a 2-cysteine peroxiredoxin. Nat Commun, 10, 2019
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6E0F
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![BU of 6e0f by Molmil](/molmil-images/mine/6e0f) | Mitochondrial peroxiredoxin from Leishmania infantum in complex with unfolding client protein after heat stress | Descriptor: | mitochondrial 2-cys-peroxiredoxin | Authors: | Teixeira, F, Tse, E, Makepeace, K.A.T, Borchers, C.H, Castro, H, Tomas, A.M, Poole, L.B, Southworth, D.R, Jakob, U. | Deposit date: | 2018-07-06 | Release date: | 2019-02-20 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Chaperone activation and client binding of a 2-cysteine peroxiredoxin. Nat Commun, 10, 2019
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6P0W
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![BU of 6p0w by Molmil](/molmil-images/mine/6p0w) | |
8HLA
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![BU of 8hla by Molmil](/molmil-images/mine/8hla) | |
8HH0
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![BU of 8hh0 by Molmil](/molmil-images/mine/8hh0) | |
6Q5V
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![BU of 6q5v by Molmil](/molmil-images/mine/6q5v) | 1-Cys SiPrx, a Prx6-family 1-Cys peroxiredoxin of the thermoacidophilic archaeon Sulfolobus islandicus | Descriptor: | Peroxiredoxin | Authors: | Stroobants, S, Maes, D, Peeters, E, van Molle, I. | Deposit date: | 2018-12-09 | Release date: | 2019-05-29 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.747 Å) | Cite: | Structure of the Prx6-subfamily 1-Cys peroxiredoxin from Sulfolobus islandicus. Acta Crystallogr.,Sect.F, 75, 2019
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8EKW
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![BU of 8ekw by Molmil](/molmil-images/mine/8ekw) | Cryo-EM structure of human PRDX4 | Descriptor: | Peroxiredoxin-4 | Authors: | Su, C.C. | Deposit date: | 2022-09-22 | Release date: | 2023-05-03 | Last modified: | 2023-11-15 | Method: | ELECTRON MICROSCOPY (2.83 Å) | Cite: | High-resolution structural-omics of human liver enzymes. Cell Rep, 42, 2023
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7WEU
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![BU of 7weu by Molmil](/molmil-images/mine/7weu) | |
7WET
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![BU of 7wet by Molmil](/molmil-images/mine/7wet) | Crystal structure of Peroxiredoxin I in complex with the inhibitor Cela | Descriptor: | (2R,4aS,6aS,12bR,14aS,14bR)-10-hydroxy-2,4a,6a,9,12b,14a-hexamethyl-11-oxo-1,2,3,4,4a,5,6,6a,11,12b,13,14,14a,14b-tetradecahydropicene-2-carboxylic acid, Peroxiredoxin-1 | Authors: | Zhang, H, Luo, C. | Deposit date: | 2021-12-24 | Release date: | 2022-12-28 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.76 Å) | Cite: | Celastrol suppresses colorectal cancer via covalent targeting peroxiredoxin 1. Signal Transduct Target Ther, 8, 2023
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5UCX
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![BU of 5ucx by Molmil](/molmil-images/mine/5ucx) | |
5EPT
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![BU of 5ept by Molmil](/molmil-images/mine/5ept) | |
5UKA
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![BU of 5uka by Molmil](/molmil-images/mine/5uka) | Salmonella typhimurium AhpC E49Q mutant | Descriptor: | Alkyl hydroperoxide reductase subunit C, CHLORIDE ION, POTASSIUM ION, ... | Authors: | Perkins, A, Nelson, K, Parsonage, D, Poole, L, Karplus, P.A. | Deposit date: | 2017-01-20 | Release date: | 2018-01-24 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Experimentally Dissecting the Origins of Peroxiredoxin Catalysis. Antioxid.Redox Signal., 28, 2018
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4EO3
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![BU of 4eo3 by Molmil](/molmil-images/mine/4eo3) | Peroxiredoxin Nitroreductase Fusion Enzyme | Descriptor: | (4R)-2-METHYLPENTANE-2,4-DIOL, Bacterioferritin comigratory protein/NADH dehydrogenase, FLAVIN MONONUCLEOTIDE, ... | Authors: | Prosper, P, Haouz, A, Navaza, A, Jacquot, J.-P, Rouhier, N. | Deposit date: | 2012-04-13 | Release date: | 2012-10-17 | Last modified: | 2017-11-15 | Method: | X-RAY DIFFRACTION (1.649 Å) | Cite: | In the absence of thioredoxins, what are the reductants for peroxiredoxins in Thermotoga maritima? Antioxid Redox Signal, 18, 2013
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2PN8
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![BU of 2pn8 by Molmil](/molmil-images/mine/2pn8) | Crystal structure of human peroxiredoxin 4 (thioredoxin peroxidase) | Descriptor: | Peroxiredoxin-4 | Authors: | Pilka, E.S, Kavanagh, K.L, Cooper, C, von Delft, F, Sundstrom, M, Arrowsmith, C.A, Weigelt, J, Edwards, A, Oppermann, U, Structural Genomics Consortium (SGC) | Deposit date: | 2007-04-24 | Release date: | 2007-05-22 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystal structure of human peroxiredoxin 4 (thioredoxin peroxidase). To be Published
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4FH8
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![BU of 4fh8 by Molmil](/molmil-images/mine/4fh8) | |
2NVL
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![BU of 2nvl by Molmil](/molmil-images/mine/2nvl) | Crystal structure of archaeal peroxiredoxin, thioredoxin peroxidase from Aeropyrum pernix K1 (sulfonic acid form) | Descriptor: | Probable peroxiredoxin | Authors: | Nakamura, T, Yamamoto, T, Abe, M, Matsumura, H, Hagihara, Y, Goto, T, Yamaguchi, T, Inoue, T. | Deposit date: | 2006-11-13 | Release date: | 2007-11-20 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.36 Å) | Cite: | Oxidation of archaeal peroxiredoxin involves a hypervalent sulfur intermediate Proc.Natl.Acad.Sci.Usa, 105, 2008
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2V41
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1N8J
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![BU of 1n8j by Molmil](/molmil-images/mine/1n8j) | |
1PRX
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![BU of 1prx by Molmil](/molmil-images/mine/1prx) | HORF6 A NOVEL HUMAN PEROXIDASE ENZYME | Descriptor: | HORF6 | Authors: | Choi, H.-J, Kang, S.W, Yang, C.-H, Rhee, S.G, Ryu, S.-E. | Deposit date: | 1998-04-03 | Release date: | 1998-06-17 | Last modified: | 2021-11-03 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal structure of a novel human peroxidase enzyme at 2.0 A resolution. Nat.Struct.Biol., 5, 1998
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2V2G
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1QQ2
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![BU of 1qq2 by Molmil](/molmil-images/mine/1qq2) | CRYSTAL STRUCTURE OF A MAMMALIAN 2-CYS PEROXIREDOXIN, HBP23. | Descriptor: | CHLORIDE ION, THIOREDOXIN PEROXIDASE 2 | Authors: | Hirotsu, S, Abe, Y, Okada, K, Nagahara, N, Hori, H, Nishino, T, Hakoshima, T. | Deposit date: | 1999-06-10 | Release date: | 1999-10-29 | Last modified: | 2021-11-03 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Crystal structure of a multifunctional 2-Cys peroxiredoxin heme-binding protein 23 kDa/proliferation-associated gene product. Proc.Natl.Acad.Sci.USA, 96, 1999
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3HY2
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![BU of 3hy2 by Molmil](/molmil-images/mine/3hy2) | Crystal Structure of Sulfiredoxin in Complex with Peroxiredoxin I and ATP:Mg2+ | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Peroxiredoxin-1, ... | Authors: | Jonsson, T.J, Johnson, L.C, Lowther, W.T. | Deposit date: | 2009-06-22 | Release date: | 2009-10-06 | Last modified: | 2021-10-13 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Protein Engineering of the Quaternary Sulfiredoxin-Peroxiredoxin Enzyme-Substrate Complex Reveals the Molecular Basis for Cysteine Sulfinic Acid Phosphorylation J.Biol.Chem., 284, 2009
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