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8Y9B
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TcdB1 in complex with mini-binder
分子名称: De novo design mini-binder, Toxin B, ZINC ION
著者Lv, X.C, Lu, P.L.
登録日2024-02-06
公開日2024-08-28
最終更新日2024-10-16
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献De novo design of mini-protein binders broadly neutralizing Clostridioides difficile toxin B variants.
Nat Commun, 15, 2024
8X2I
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BU of 8x2i by Molmil
Cryo-EM structure of the TcsL at pH 5.0 in its open conformation
分子名称: Cytotoxin-L, ZINC ION
著者Zhan, X, Tao, L.
登録日2023-11-09
公開日2023-12-13
実験手法ELECTRON MICROSCOPY (2.5 Å)
主引用文献Structural dynamics of CROPs control stability and toxicity of Paeniclostridium sordellii lethal toxin
Nat Commun, 2023
8X2H
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BU of 8x2h by Molmil
Cryo-EM structure of the TcsL at pH 5.0 in its closed conformation
分子名称: Cytotoxin-L, ZINC ION
著者Zhan, X, Tao, L.
登録日2023-11-09
公開日2023-12-13
実験手法ELECTRON MICROSCOPY (2.9 Å)
主引用文献Structural dynamics of CROPs control stability and toxicity of Paeniclostridium sordellii lethal toxin
Nat Commun, 2023
8QEO
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BU of 8qeo by Molmil
cryo-EM structure complex of Frizzled-7 and Clostridioides difficile toxin B
分子名称: Frizzled-7, Toxin B, ZINC ION
著者Kinsolving, J, Bous, J.
登録日2023-09-01
公開日2024-03-20
実験手法ELECTRON MICROSCOPY (3.26 Å)
主引用文献Structural and functional insight into the interaction of Clostridioides difficile toxin B and FZD 7.
Cell Rep, 43, 2024
8QEN
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BU of 8qen by Molmil
cryo-EM structure of apo Clostridioides difficile toxin B
分子名称: Toxin B, ZINC ION
著者Kinsolving, J, Bous, J, Structural Genomics Consortium (SGC)
登録日2023-09-01
公開日2024-03-20
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献Structural and functional insight into the interaction of Clostridioides difficile toxin B and FZD 7.
Cell Rep, 43, 2024
8JHZ
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BU of 8jhz by Molmil
Cryo-EM structure of the TcsH-TMPRSS2 complex
分子名称: Hemorrhagic toxin, Transmembrane protease serine 2, ZINC ION
著者Zhou, R, Liang, T, Zhan, X.
登録日2023-05-25
公開日2024-03-20
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献Molecular basis of TMPRSS2 recognition by Paeniclostridium sordellii hemorrhagic toxin.
Nat Commun, 15, 2024
8P52
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Photorhabdus luminescens Makes caterpillars floppy (Mcf) toxin
分子名称: Toxin protein
著者Belyy, A, Heilen, P, Hofnagel, O, Raunser, S.
登録日2023-05-23
公開日2023-11-01
最終更新日2023-12-27
実験手法ELECTRON MICROSCOPY (3.6 Å)
主引用文献Structure and activation mechanism of the Makes caterpillars floppy 1 toxin.
Nat Commun, 14, 2023
8P50
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Photorhabdus luminescens Makes caterpillars floppy (Mcf) toxin with the C-terminal deletion in complex with Arf3
分子名称: ADP-ribosylation factor 3, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
著者Belyy, A, Heilen, P, Hofnagel, O, Raunser, S.
登録日2023-05-23
公開日2023-11-01
最終更新日2023-12-27
実験手法ELECTRON MICROSCOPY (4.04 Å)
主引用文献Structure and activation mechanism of the Makes caterpillars floppy 1 toxin.
Nat Commun, 14, 2023
8P51
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Photorhabdus luminescens Makes caterpillars floppy (Mcf) toxin with the C-terminal deletion
分子名称: Toxin protein
著者Belyy, A, Heilen, P, Hofnagel, O, Raunser, S.
登録日2023-05-23
公開日2023-11-01
最終更新日2023-12-27
実験手法ELECTRON MICROSCOPY (3.55 Å)
主引用文献Structure and activation mechanism of the Makes caterpillars floppy 1 toxin.
Nat Commun, 14, 2023
8JB5
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BU of 8jb5 by Molmil
The cryo-EM structure of Paeniclostridium sordellii lethal toxin (TcsL)
分子名称: Cytotoxin-L, ZINC ION
著者Zhan, X, Tao, L.
登録日2023-05-08
公開日2023-12-13
最終更新日2023-12-20
実験手法ELECTRON MICROSCOPY (2.9 Å)
主引用文献Structural dynamics of CROPs control stability and toxicity of Paeniclostridium sordellii lethal toxin
Nat Commun, 2023
7UBX
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BU of 7ubx by Molmil
Structure of a pore forming fragment of Clostridium difficile toxin A in complex with VHH AA6
分子名称: Nanobody VHH AA6, Toxin A
著者Chen, B, Rongsheng, J, Kay, P.
登録日2022-03-15
公開日2022-11-16
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.81 Å)
主引用文献Neutralizing epitopes on Clostridioides difficile toxin A revealed by the structures of two camelid VHH antibodies.
Front Immunol, 13, 2022
7U1Z
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BU of 7u1z by Molmil
Crystal structure of the DRBD and CROPs of TcdA
分子名称: SULFATE ION, Toxin A
著者Baohua, C, Peng, C, Kay, P, Rongsheng, J.
登録日2022-02-22
公開日2022-03-09
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (3.18 Å)
主引用文献Structure and conformational dynamics of Clostridioides difficile toxin A.
Life Sci Alliance, 5, 2022
7POG
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BU of 7pog by Molmil
High-resolution structure of native toxin A from Clostridioides difficile
分子名称: Toxin A, ZINC ION
著者Boesen, T, Joergensen, R, Aminzadeh, A, Engelbrecht Larsen, C.
登録日2021-09-08
公開日2021-12-08
最終更新日2024-07-17
実験手法ELECTRON MICROSCOPY (2.83 Å)
主引用文献High-resolution structure of native toxin A from Clostridioides difficile.
Embo Rep., 23, 2022
7V1N
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BU of 7v1n by Molmil
Structure of the Clade 2 C. difficile TcdB in complex with its receptor TFPI
分子名称: Isoform Beta of Tissue factor pathway inhibitor, Toxin B
著者Luo, J, Yang, Q, Zhang, X, Zhang, Y, Wan, L, Li, Y, Tao, L.
登録日2021-08-05
公開日2022-02-23
最終更新日2022-03-30
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献TFPI is a colonic crypt receptor for TcdB from hypervirulent clade 2 C. difficile.
Cell, 185, 2022
7N9Q
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BU of 7n9q by Molmil
State 3 of TcdB and FZD2 at pH5
分子名称: Toxin B
著者Jiang, M, Zhang, J.
登録日2021-06-18
公開日2022-03-02
最終更新日2024-06-05
実験手法ELECTRON MICROSCOPY (4.6 Å)
主引用文献Structural Basis for Receptor Recognition of Clostridium difficile Toxin B and its Dissociation upon Acidification
To Be Published
7N9Y
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BU of 7n9y by Molmil
Full-length TcdB and CSPG4 (401-560) complex
分子名称: Chondroitin sulfate proteoglycan 4, Toxin B
著者Jiang, M, Zhang, J.
登録日2021-06-18
公開日2022-03-02
最終更新日2024-06-05
実験手法ELECTRON MICROSCOPY (4.8 Å)
主引用文献Structural Basis for Receptor Recognition of Clostridium difficile Toxin B and its Dissociation upon Acidification
To Be Published
7N9R
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BU of 7n9r by Molmil
state 4 of TcdB and FZD2 at pH5
分子名称: Toxin B
著者Jiang, M, Zhang, J.
登録日2021-06-18
公開日2022-03-02
最終更新日2024-06-05
実験手法ELECTRON MICROSCOPY (5.9 Å)
主引用文献Structural Basis for Receptor Recognition of Clostridium difficile Toxin B and its Dissociation upon Acidification
To Be Published
7N9S
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BU of 7n9s by Molmil
TcdB and frizzled-2 CRD complex
分子名称: Frizzled-2, Toxin B
著者Jiang, M, Zhang, J.
登録日2021-06-18
公開日2022-03-02
最終更新日2024-06-05
実験手法ELECTRON MICROSCOPY (5.1 Å)
主引用文献Structural Basis for Receptor Recognition of Clostridium difficile Toxin B and its Dissociation upon Acidification
To Be Published
7N97
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BU of 7n97 by Molmil
State 2 of TcdB and FZD2 at pH5
分子名称: Frizzled-2, Toxin B
著者Jiang, M, Zhang, J.
登録日2021-06-17
公開日2022-03-02
最終更新日2024-06-05
実験手法ELECTRON MICROSCOPY (5.1 Å)
主引用文献Structural Basis for Receptor Recognition of the Clostridium difficile Toxin B and its Dissociation upon Acidification
To Be Published
7N8X
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BU of 7n8x by Molmil
Partial C. difficile TcdB and CSPG4 fragment
分子名称: Chondroitin sulfate proteoglycan 4, Toxin B
著者Jiang, M, Zhang, J.
登録日2021-06-16
公開日2022-03-02
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献Structural Basis for Receptor Recognition of Clostridium difficile Toxin B and its Dissociation upon Acidification
To Be Published
7N95
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BU of 7n95 by Molmil
state 1 of TcdB and FZD2 at pH5
分子名称: Frizzled-2, Toxin B
著者Jiang, M, Zhang, J.
登録日2021-06-16
公開日2022-03-02
最終更新日2024-06-05
実験手法ELECTRON MICROSCOPY (4.1 Å)
主引用文献Structural Basis for Receptor Recognition of Clostridium difficile Toxin B and its Dissociation upon Acidification
To Be Published
7ML7
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BU of 7ml7 by Molmil
Structural basis for CSPG4 as a receptor for TcdB and a therapeutic target in Clostridioides difficile infection
分子名称: Chondroitin sulfate proteoglycan 4, Toxin B, ZINC ION
著者Chen, P, Jin, R.
登録日2021-04-27
公開日2021-06-09
最終更新日2021-06-30
実験手法ELECTRON MICROSCOPY (3.17 Å)
主引用文献Structural basis for CSPG4 as a receptor for TcdB and a therapeutic target in Clostridioides difficile infection.
Nat Commun, 12, 2021
6OQ5
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BU of 6oq5 by Molmil
Structure of the full-length Clostridium difficile toxin B in complex with 3 VHHs
分子名称: 5D, 7F, E3, ...
著者Chen, P, Lam, K, Jin, R.
登録日2019-04-25
公開日2019-07-10
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (3.87 Å)
主引用文献Structure of the full-length Clostridium difficile toxin B.
Nat.Struct.Mol.Biol., 26, 2019
6OQ6
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BU of 6oq6 by Molmil
Structure of the pore forming fragment of Clostridium difficile toxin B in complex with VHH 5D
分子名称: 5D, Toxin B
著者Chen, P, Lam, K, Jin, R.
登録日2019-04-25
公開日2019-07-10
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.97 Å)
主引用文献Structure of the full-length Clostridium difficile toxin B.
Nat.Struct.Mol.Biol., 26, 2019
6C0B
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BU of 6c0b by Molmil
Structural basis for recognition of frizzled proteins by Clostridium difficile toxin B
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Frizzled-2, MALONATE ION, ...
著者Chen, P, Lam, K, Jin, R.
登録日2017-12-28
公開日2018-05-16
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structural basis for recognition of frizzled proteins byClostridium difficiletoxin B.
Science, 360, 2018

 

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