5B6C
 
 | | Structural Details of Ufd1 binding to p97 | | 分子名称: | Peptide from Ubiquitin fusion degradation protein 1 homolog, Transitional endoplasmic reticulum ATPase | | 著者 | Le, L.T.M, Yang, J.K. | | 登録日 | 2016-05-26 | | 公開日 | 2017-01-04 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | | 主引用文献 | Structural Details of Ufd1 Binding to p97 and Their Functional Implications in ER-Associated Degradation
PLoS ONE, 11, 2016
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7PUX
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3TIW
 | | Crystal structure of p97N in complex with the C-terminus of gp78 | | 分子名称: | CHLORIDE ION, E3 ubiquitin-protein ligase AMFR, Transitional endoplasmic reticulum ATPase | | 著者 | Haenzelmann, P, Schindelin, H. | | 登録日 | 2011-08-22 | | 公開日 | 2011-09-14 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (1.802 Å) | | 主引用文献 | The Structural and Functional Basis of the p97/Valosin-containing Protein (VCP)-interacting Motif (VIM): MUTUALLY EXCLUSIVE BINDING OF COFACTORS TO THE N-TERMINAL DOMAIN OF p97.
J.Biol.Chem., 286, 2011
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4KDL
 | | Crystal structure of p97/VCP N in complex with OTU1 UBXL | | 分子名称: | Transitional endoplasmic reticulum ATPase, Ubiquitin thioesterase OTU1 | | 著者 | Kim, S.J, Kim, E.E. | | 登録日 | 2013-04-25 | | 公開日 | 2014-03-19 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.81 Å) | | 主引用文献 | Structural Basis for Ovarian Tumor Domain-containing Protein 1 (OTU1) Binding to p97/Valosin-containing Protein (VCP).
J.Biol.Chem., 289, 2014
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4KDI
 | | Crystal structure of p97/VCP N in complex with OTU1 UBXL | | 分子名称: | Transitional endoplasmic reticulum ATPase, Ubiquitin thioesterase OTU1 | | 著者 | Kim, S.J, Kim, E.E. | | 登録日 | 2013-04-25 | | 公開日 | 2014-03-19 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (1.86 Å) | | 主引用文献 | Structural Basis for Ovarian Tumor Domain-containing Protein 1 (OTU1) Binding to p97/Valosin-containing Protein (VCP).
J.Biol.Chem., 289, 2014
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5EPP
 | | Structural Insights into the Interaction of p97 N-terminus Domain and VBM Motif in Rhomboid Protease, RHBDL4 | | 分子名称: | Rhomboid-related protein 4, Transitional endoplasmic reticulum ATPase | | 著者 | Lim, J.J, Lee, Y, Ly, T.T, Kang, J.Y, Lee, J.-G, An, J.Y, Youn, H.-S, Park, K.R, Kim, T.G, Yang, J.K, Jun, Y, Eom, S.H. | | 登録日 | 2015-11-12 | | 公開日 | 2016-09-14 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.88 Å) | | 主引用文献 | Structural insights into the interaction of p97 N-terminus domain and VBM in rhomboid protease, RHBDL4.
Biochem.J., 473, 2016
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1QCS
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4KO8
 | | Structure of p97 N-D1 R155H mutant in complex with ATPgS | | 分子名称: | MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, Transitional endoplasmic reticulum ATPase | | 著者 | Xia, D, Tang, W.K. | | 登録日 | 2013-05-11 | | 公開日 | 2013-11-13 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (1.98 Å) | | 主引用文献 | Altered Intersubunit Communication Is the Molecular Basis for Functional Defects of Pathogenic p97 Mutants.
J.Biol.Chem., 288, 2013
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4RV0
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3QQ8
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3QWZ
 | | Crystal structure of FAF1 UBX-p97N-domain complex | | 分子名称: | FAS-associated factor 1, Transitional endoplasmic reticulum ATPase | | 著者 | Park, J.K, Jeon, H, Lee, J.J, Kim, K.H, Lee, K.J, Kim, E.E. | | 登録日 | 2011-02-28 | | 公開日 | 2012-05-09 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Dissection of the interaction between FAF1 UBX and p97
To be Published
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3QC8
 | | Crystal Structure of FAF1 UBX Domain In Complex with p97/VCP N Domain Reveals The Conserved FcisP Touch-Turn Motif of UBX Domain Suffering Conformational Change | | 分子名称: | FAS-associated factor 1, Transitional endoplasmic reticulum ATPase | | 著者 | Kim, K.H, Kang, W, Suh, S.W, Yang, J.K. | | 登録日 | 2011-01-15 | | 公開日 | 2011-07-20 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Crystal structure of FAF1 UBX domain in complex with p97/VCP N domain reveals a conformational change in the conserved FcisP touch-turn motif of UBX domain
Proteins, 79, 2011
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3HU3
 | | Structure of p97 N-D1 R155H mutant in complex with ATPgS | | 分子名称: | MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, Transitional endoplasmic reticulum ATPase | | 著者 | Tang, W.-K. | | 登録日 | 2009-06-12 | | 公開日 | 2010-06-16 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | A novel ATP-dependent conformation in p97 N-D1 fragment revealed by crystal structures of disease-related mutants.
Embo J., 29, 2010
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5DYG
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5GLF
 | | Structural insights into the interaction of p97 N-terminal domain and SHP motif in Derlin-1 rhomboid pseudoprotease | | 分子名称: | Derlin-1, Transitional endoplasmic reticulum ATPase | | 著者 | Lim, J.J, Lee, Y, Yoon, S.Y, Ly, T.T, Kang, J.Y, Youn, H.-S, An, J.Y, Lee, J.-G, Park, K.R, Kim, T.G, Yang, J.K, Jun, Y, Eom, S.H. | | 登録日 | 2016-07-11 | | 公開日 | 2016-11-09 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | | 主引用文献 | Structural insights into the interaction of human p97 N-terminal domain and SHP motif in Derlin-1 rhomboid pseudoprotease.
FEBS Lett., 590, 2016
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1CR5
 | | N-TERMINAL DOMAIN OF SEC18P | | 分子名称: | 1-ETHYL-PYRROLIDINE-2,5-DIONE, SEC18P (RESIDUES 22 - 210) | | 著者 | Babor, S.M, Fass, D. | | 登録日 | 1999-08-13 | | 公開日 | 1999-12-22 | | 最終更新日 | 2018-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Crystal structure of the Sec18p N-terminal domain.
Proc.Natl.Acad.Sci.USA, 96, 1999
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5FTJ
 | | Cryo-EM structure of human p97 bound to UPCDC30245 inhibitor | | 分子名称: | 1-(3-(5-FLUORO-1H-INDOL-2-YL)PHENYL)PIPERIDIN-4-YL)(2-(4-ISOPROPYL-PIPERAZIN1-YL)ETHYL)-CARBAMATE, ADENOSINE-5'-DIPHOSPHATE, TRANSITIONAL ENDOPLASMIC RETICULUM ATPASE | | 著者 | Banerjee, S, Bartesaghi, A, Merk, A, Rao, P, Bulfer, S.L, Yan, Y, Green, N, Mroczkowski, B, Neitz, R.J, Wipf, P, Falconieri, V, Deshaies, R.J, Milne, J.L.S, Huryn, D, Arkin, M, Subramaniam, S. | | 登録日 | 2016-01-14 | | 公開日 | 2016-01-27 | | 最終更新日 | 2024-05-08 | | 実験手法 | ELECTRON MICROSCOPY (2.3 Å) | | 主引用文献 | 2.3 A Resolution Cryo-Em Structure of Human P97 and Mechanism of Allosteric Inhibition
Science, 351, 2016
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1QDN
 | | AMINO TERMINAL DOMAIN OF THE N-ETHYLMALEIMIDE SENSITIVE FUSION PROTEIN (NSF) | | 分子名称: | BETA-MERCAPTOETHANOL, PROTEIN (N-ETHYLMALEIMIDE SENSITIVE FUSION PROTEIN (NSF)), SULFATE ION | | 著者 | May, A.P, Misura, K.M.S, Whiteheart, S.W, Weis, W.I. | | 登録日 | 1999-05-21 | | 公開日 | 1999-06-21 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Crystal structure of the amino-terminal domain of N-ethylmaleimide-sensitive fusion protein.
Nat.Cell Biol., 1, 1999
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7LMY
 | | Cryo-EM structure of human p97 in complex with NMS-873 in the presence of ATP, Npl4/Ufd1, and Ub6 | | 分子名称: | 3-[3-cyclopentylsulfanyl-5-[[3-methyl-4-(4-methylsulfonylphenyl)phenoxy]methyl]-1,2,4-triazol-4-yl]pyridine, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | | 著者 | Pan, M, Yu, Y, Liu, L, Zhao, M. | | 登録日 | 2021-02-06 | | 公開日 | 2021-09-15 | | 最終更新日 | 2024-05-29 | | 実験手法 | ELECTRON MICROSCOPY (2.4 Å) | | 主引用文献 | Mechanistic insight into substrate processing and allosteric inhibition of human p97.
Nat.Struct.Mol.Biol., 28, 2021
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5FTK
 | | Cryo-EM structure of human p97 bound to ADP | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, TRANSITIONAL ENDOPLASMIC RETICULUM ATPASE | | 著者 | Banerjee, S, Bartesaghi, A, Merk, A, Rao, P, Bulfer, S.L, Yan, Y, Green, N, Mroczkowski, B, Neitz, R.J, Wipf, P, Falconieri, V, Deshaies, R.J, Milne, J.L.S, Huryn, D, Arkin, M, Subramaniam, S. | | 登録日 | 2016-01-14 | | 公開日 | 2016-01-27 | | 最終更新日 | 2024-05-08 | | 実験手法 | ELECTRON MICROSCOPY (2.4 Å) | | 主引用文献 | 2.3 A Resolution Cryo-Em Structure of Human P97 and Mechanism of Allosteric Inhibition
Science, 351, 2016
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5X4L
 | | Crystal structure of the UBX domain of human UBXD7 in complex with p97 N domain | | 分子名称: | Transitional endoplasmic reticulum ATPase, UBX domain-containing protein 7 | | 著者 | Jiang, T, Li, Z, Wang, Y, Xu, M. | | 登録日 | 2017-02-13 | | 公開日 | 2017-03-22 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.402 Å) | | 主引用文献 | Crystal structures of the UBX domain of human UBXD7 and its complex with p97 ATPase
Biochem. Biophys. Res. Commun., 486, 2017
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5IFS
 | | Quantitative interaction mapping reveals an extended ubiquitin regulatory domain in ASPL that disrupts functional p97 hexamers and induces cell death | | 分子名称: | 1,2-ETHANEDIOL, ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, ... | | 著者 | Roske, Y, Arumughan, A, Heinemann, U, Wanker, E. | | 登録日 | 2016-02-26 | | 公開日 | 2016-10-26 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.46 Å) | | 主引用文献 | Quantitative interaction mapping reveals an extended UBX domain in ASPL that disrupts functional p97 hexamers.
Nat Commun, 7, 2016
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8OOI
 | | Full composite cryo-EM map of p97/VCP in ADP.Pi state | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | | 著者 | Cheng, T.C, Sakata, E, Schuetz, A.K. | | 登録日 | 2023-04-05 | | 公開日 | 2024-01-31 | | 最終更新日 | 2024-03-13 | | 実験手法 | ELECTRON MICROSCOPY (2.61 Å) | | 主引用文献 | Characterizing ATP processing by the AAA+ protein p97 at the atomic level.
Nat.Chem., 16, 2024
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4KLN
 | | Structure of p97 N-D1 A232E mutant in complex with ATPgS | | 分子名称: | MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, Transitional endoplasmic reticulum ATPase | | 著者 | Xia, D, Tang, W.K. | | 登録日 | 2013-05-07 | | 公開日 | 2013-11-13 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.62 Å) | | 主引用文献 | Altered Intersubunit Communication Is the Molecular Basis for Functional Defects of Pathogenic p97 Mutants.
J.Biol.Chem., 288, 2013
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3QQ7
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