7TA5
 
 | |
2CQY
 | |
8FXH
 | |
8FXI
 | | Cryo-EM structure of Stanieria sp. CphA2 in complex with ADPCP and 4x(beta-Asp-Arg) | | 分子名称: | 1-[(4-aminopyrimidin-5-yl)amino]-2,5-anhydro-1-deoxy-6-O-[(S)-hydroxy{[(R)-hydroxy(phosphonomethyl)phosphoryl]oxy}phosphoryl]-D-allitol, 4x(beta-Asp-Arg), MAGNESIUM ION, ... | | 著者 | Markus, L.M, Sharon, I, Strauss, M, Schmeing, T.M. | | 登録日 | 2023-01-24 | | 公開日 | 2023-06-14 | | 最終更新日 | 2023-11-08 | | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | | 主引用文献 | Structure and function of a hexameric cyanophycin synthetase 2.
Protein Sci., 32, 2023
|
|
7YBU
 | | Human propionyl-coenzyme A carboxylase | | 分子名称: | 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, Propionyl-CoA carboxylase alpha chain, mitochondrial, ... | | 著者 | Su, J.Y, Liu, D.S. | | 登録日 | 2022-06-29 | | 公開日 | 2023-07-05 | | 最終更新日 | 2024-07-03 | | 実験手法 | ELECTRON MICROSCOPY (2.2 Å) | | 主引用文献 | Human propionyl-coenzyme A carboxylase
To Be Published
|
|
5CSL
 | |
3VA7
 | |
8RTH
 | | Trypanosoma brucei 3-methylcrotonyl-CoA carboxylase | | 分子名称: | 3-methylcrotonyl-CoA carboxylase, putative, 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, ... | | 著者 | Ruiz, F.M, Plaza-Pegueroles, A, Fernandez-Tornero, C. | | 登録日 | 2024-01-26 | | 公開日 | 2024-04-17 | | 最終更新日 | 2024-04-24 | | 実験手法 | ELECTRON MICROSCOPY (2.37 Å) | | 主引用文献 | The cryo-EM structure of trypanosome 3-methylcrotonyl-CoA carboxylase provides mechanistic and dynamic insights into its enzymatic function.
Structure, 2024
|
|
5KKN
 | | Crystal structure of human ACC2 BC domain in complex with ND-646, the primary amide of ND-630 | | 分子名称: | 2-[1-[(2~{R})-2-(2-methoxyphenyl)-2-(oxan-4-yloxy)ethyl]-5-methyl-6-(1,3-oxazol-2-yl)-2,4-bis(oxidanylidene)thieno[2,3-d]pyrimidin-3-yl]-2-methyl-propanamide, Acetyl-CoA carboxylase 2 | | 著者 | Wang, R, Paul, D, Tong, L. | | 登録日 | 2016-06-22 | | 公開日 | 2016-07-13 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Acetyl-CoA carboxylase inhibition by ND-630 reduces hepatic steatosis, improves insulin sensitivity, and modulates dyslipidemia in rats.
Proc.Natl.Acad.Sci.USA, 113, 2016
|
|
5CSK
 | |
1W96
 | | Crystal Structure of Biotin Carboxylase Domain of Acetyl-coenzyme A Carboxylase from Saccharomyces cerevisiae in Complex with Soraphen A | | 分子名称: | ACETYL-COENZYME A CARBOXYLASE, SORAPHEN A | | 著者 | Shen, Y, Volrath, S.L, Weatherly, S.C, Elich, T.D, Tong, L. | | 登録日 | 2004-10-06 | | 公開日 | 2005-01-04 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | A Mechanism for the Potent Inhibition of Eukaryotic Acetyl-Coenzyme a Carboxylase by Soraphen A, a Macrocyclic Polyketide Natural Product
Mol.Cell, 16, 2004
|
|
1W93
 | | Crystal Structure of Biotin Carboxylase Domain of Acetyl-Coenzyme A Carboxylase from Saccharomyces cerevisiae | | 分子名称: | ACETYL-COENZYME A CARBOXYLASE | | 著者 | Shen, Y, Volrath, S.L, Weatherly, S.C, Elich, T.D, Tong, L. | | 登録日 | 2004-10-05 | | 公開日 | 2005-01-04 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | A Mechanism for the Potent Inhibition of Eukaryotic Acetyl-Coenzyme a Carboxylase by Soraphen A, a Macrocyclic Polyketide Natural Product
Mol.Cell, 16, 2004
|
|
3HBL
 | |
1DV1
 | | STRUCTURE OF BIOTIN CARBOXYLASE (APO) | | 分子名称: | BIOTIN CARBOXYLASE, PHOSPHATE ION | | 著者 | Thoden, J.B, Blanchard, C.Z, Holden, H.M, Waldrop, G.L. | | 登録日 | 2000-01-19 | | 公開日 | 2000-06-09 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Movement of the biotin carboxylase B-domain as a result of ATP binding.
J.Biol.Chem., 275, 2000
|
|
5KS8
 | |
3HB9
 | |
5DOT
 | | Crystal Structure of Human Carbamoyl phosphate synthetase I (CPS1), apo form | | 分子名称: | 1,2-ETHANEDIOL, Carbamoyl-phosphate synthase [ammonia], mitochondrial, ... | | 著者 | Polo, L.M, de Cima, S, Fita, I, Rubio, V. | | 登録日 | 2015-09-11 | | 公開日 | 2015-12-09 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Structure of human carbamoyl phosphate synthetase: deciphering the on/off switch of human ureagenesis.
Sci Rep, 5, 2015
|
|
6UEL
 | | CPS1 bound to allosteric inhibitor H3B-193 | | 分子名称: | Carbamoyl-phosphate synthase [ammonia], mitochondrial, N~1~-[(4-fluorophenyl)methyl]-N~1~-methyl-N~4~-(4-methyl-1,3-thiazol-2-yl)piperidine-1,4-dicarboxamide, ... | | 著者 | Larsen, N.A, Nguyen, T.V. | | 登録日 | 2019-09-21 | | 公開日 | 2020-03-18 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Small Molecule Inhibition of CPS1 Activity through an Allosteric Pocket.
Cell Chem Biol, 27, 2020
|
|
6YBQ
 | | Engineered glycolyl-CoA carboxylase (quintuple mutant) with bound CoA | | 分子名称: | 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, COENZYME A, Propionyl-CoA carboxylase alpha subunit, ... | | 著者 | Schuller, J.M, Schuller, S.K, Zarzycki, J, Scheffen, M, Marchal, D.M, Erb, T.J. | | 登録日 | 2020-03-17 | | 公開日 | 2020-10-28 | | 最終更新日 | 2021-05-12 | | 実験手法 | ELECTRON MICROSCOPY (1.96 Å) | | 主引用文献 | A new-to-nature carboxylation module to improve natural and synthetic CO2 fixation
Nat Catal, 2021
|
|
1T36
 | | Crystal structure of E. coli carbamoyl phosphate synthetase small subunit mutant C248D complexed with uridine 5'-monophosphate | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, Carbamoyl-phosphate synthase large chain, ... | | 著者 | Thoden, J.B, Huang, X, Raushel, F.M, Holden, H.M. | | 登録日 | 2004-04-24 | | 公開日 | 2004-09-21 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Long-range allosteric transitions in carbamoyl phosphate synthetase.
Protein Sci., 13, 2004
|
|
4RCN
 | |
1DV2
 | | The structure of biotin carboxylase, mutant E288K, complexed with ATP | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, BIOTIN CARBOXYLASE | | 著者 | Thoden, J.B, Blanchard, C.Z, Holden, H.M, Waldrop, G.L. | | 登録日 | 2000-01-19 | | 公開日 | 2000-06-09 | | 最終更新日 | 2024-05-22 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Movement of the biotin carboxylase B-domain as a result of ATP binding.
J.Biol.Chem., 275, 2000
|
|
6YBP
 | | Propionyl-CoA carboxylase of Methylorubrum extorquens with bound CoA | | 分子名称: | 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, COENZYME A, Propionyl-CoA carboxylase alpha subunit, ... | | 著者 | Schuller, J.M, Schuller, S.K, Zarzycki, J, Scheffen, M, Marchal, D.M, Erb, T.J. | | 登録日 | 2020-03-17 | | 公開日 | 2020-10-28 | | 最終更新日 | 2021-05-12 | | 実験手法 | ELECTRON MICROSCOPY (3.48 Å) | | 主引用文献 | A new-to-nature carboxylation module to improve natural and synthetic CO2 fixation
Nat Catal, 2021
|
|
2YL2
 | | Crystal structure of human acetyl-CoA carboxylase 1, biotin carboxylase (BC) domain | | 分子名称: | ACETYL-COA CARBOXYLASE 1 | | 著者 | Muniz, J.R.C, Froese, D.S, Krysztofinska, E, Vollmar, M, Beltrami, A, Krojer, T, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Weigelt, J, Bountra, C, Yue, W.W, Oppermann, U. | | 登録日 | 2011-05-31 | | 公開日 | 2011-06-15 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Crystal Structure of Human Acetyl-Coa Carboxylase 1, Biotin Carboxylase (Bc) Domain
To be Published
|
|
3BG5
 | | Crystal Structure of Staphylococcus Aureus Pyruvate Carboxylase | | 分子名称: | 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, ADENOSINE-5'-TRIPHOSPHATE, MANGANESE (II) ION, ... | | 著者 | Xiang, S, Tong, L. | | 登録日 | 2007-11-26 | | 公開日 | 2008-02-26 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Crystal structures of human and Staphylococcus aureus pyruvate carboxylase and molecular insights into the carboxyltransfer reaction.
Nat.Struct.Mol.Biol., 15, 2008
|
|
