7SLZ
 
 | | CRYSTAL STRUCTURE OF GID4 IN COMPLEX WITH BPF023596 | | 分子名称: | Glucose-induced degradation protein 4 homolog, N-[(1s,4s)-4-(1H-benzimidazol-2-yl)cyclohexyl]-N~2~-[(1H-indol-2-yl)methyl]glycinamide | | 著者 | Song, X, Dong, A, Calabrese, M, Wang, F, Owen, D, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) | | 登録日 | 2021-10-25 | | 公開日 | 2022-01-19 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.97 Å) | | 主引用文献 | CRYSTAL STRUCTURE OF GID4 IN COMPLEX WITH BPF023596
To Be Published
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7DBO
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7DG7
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7DG9
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5EPP
 | | Structural Insights into the Interaction of p97 N-terminus Domain and VBM Motif in Rhomboid Protease, RHBDL4 | | 分子名称: | Rhomboid-related protein 4, Transitional endoplasmic reticulum ATPase | | 著者 | Lim, J.J, Lee, Y, Ly, T.T, Kang, J.Y, Lee, J.-G, An, J.Y, Youn, H.-S, Park, K.R, Kim, T.G, Yang, J.K, Jun, Y, Eom, S.H. | | 登録日 | 2015-11-12 | | 公開日 | 2016-09-14 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.88 Å) | | 主引用文献 | Structural insights into the interaction of p97 N-terminus domain and VBM in rhomboid protease, RHBDL4.
Biochem.J., 473, 2016
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2PJH
 | | Strctural Model of the p97 N domain- npl4 UBD complex | | 分子名称: | Nuclear protein localization protein 4 homolog, Transitional endoplasmic reticulum ATPase | | 著者 | Isaacson, R, Pye, V.E, Simpson, S, Meyer, H.H, Zhang, X, Freemont, P. | | 登録日 | 2007-04-16 | | 公開日 | 2007-05-08 | | 最終更新日 | 2024-05-22 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Detailed structural insights into the p97-Npl4-Ufd1 interface.
J.Biol.Chem., 282, 2007
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4RV0
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3TIW
 | | Crystal structure of p97N in complex with the C-terminus of gp78 | | 分子名称: | CHLORIDE ION, E3 ubiquitin-protein ligase AMFR, Transitional endoplasmic reticulum ATPase | | 著者 | Haenzelmann, P, Schindelin, H. | | 登録日 | 2011-08-22 | | 公開日 | 2011-09-14 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (1.802 Å) | | 主引用文献 | The Structural and Functional Basis of the p97/Valosin-containing Protein (VCP)-interacting Motif (VIM): MUTUALLY EXCLUSIVE BINDING OF COFACTORS TO THE N-TERMINAL DOMAIN OF p97.
J.Biol.Chem., 286, 2011
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1CZ4
 | | NMR STRUCTURE OF VAT-N: THE N-TERMINAL DOMAIN OF VAT (VCP-LIKE ATPASE OF THERMOPLASMA) | | 分子名称: | VCP-LIKE ATPASE | | 著者 | Coles, M, Diercks, T, Liermann, J, Groeger, A, Rockel, B, Baumeister, W, Koretke, K, Lupas, A, Peters, J, Kessler, H. | | 登録日 | 1999-09-01 | | 公開日 | 1999-10-12 | | 最終更新日 | 2024-05-22 | | 実験手法 | SOLUTION NMR | | 主引用文献 | The solution structure of VAT-N reveals a 'missing link' in the evolution of complex enzymes from a simple betaalphabetabeta element.
Curr.Biol., 9, 1999
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1CZ5
 | | NMR STRUCTURE OF VAT-N: THE N-TERMINAL DOMAIN OF VAT (VCP-LIKE ATPASE OF THERMOPLASMA) | | 分子名称: | VCP-LIKE ATPASE | | 著者 | Coles, M, Diercks, T, Liermann, J, Groeger, A, Rockel, B, Baumeister, W, Koretke, K, Lupas, A, Peters, J, Kessler, H. | | 登録日 | 1999-09-01 | | 公開日 | 1999-10-12 | | 最終更新日 | 2024-05-22 | | 実験手法 | SOLUTION NMR | | 主引用文献 | The solution structure of VAT-N reveals a 'missing link' in the evolution of complex enzymes from a simple betaalphabetabeta element.
Curr.Biol., 9, 1999
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1QCS
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1QDN
 | | AMINO TERMINAL DOMAIN OF THE N-ETHYLMALEIMIDE SENSITIVE FUSION PROTEIN (NSF) | | 分子名称: | BETA-MERCAPTOETHANOL, PROTEIN (N-ETHYLMALEIMIDE SENSITIVE FUSION PROTEIN (NSF)), SULFATE ION | | 著者 | May, A.P, Misura, K.M.S, Whiteheart, S.W, Weis, W.I. | | 登録日 | 1999-05-21 | | 公開日 | 1999-06-21 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Crystal structure of the amino-terminal domain of N-ethylmaleimide-sensitive fusion protein.
Nat.Cell Biol., 1, 1999
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3QQ7
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4KDL
 | | Crystal structure of p97/VCP N in complex with OTU1 UBXL | | 分子名称: | Transitional endoplasmic reticulum ATPase, Ubiquitin thioesterase OTU1 | | 著者 | Kim, S.J, Kim, E.E. | | 登録日 | 2013-04-25 | | 公開日 | 2014-03-19 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.81 Å) | | 主引用文献 | Structural Basis for Ovarian Tumor Domain-containing Protein 1 (OTU1) Binding to p97/Valosin-containing Protein (VCP).
J.Biol.Chem., 289, 2014
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4KDI
 | | Crystal structure of p97/VCP N in complex with OTU1 UBXL | | 分子名称: | Transitional endoplasmic reticulum ATPase, Ubiquitin thioesterase OTU1 | | 著者 | Kim, S.J, Kim, E.E. | | 登録日 | 2013-04-25 | | 公開日 | 2014-03-19 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (1.86 Å) | | 主引用文献 | Structural Basis for Ovarian Tumor Domain-containing Protein 1 (OTU1) Binding to p97/Valosin-containing Protein (VCP).
J.Biol.Chem., 289, 2014
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5B6C
 | | Structural Details of Ufd1 binding to p97 | | 分子名称: | Peptide from Ubiquitin fusion degradation protein 1 homolog, Transitional endoplasmic reticulum ATPase | | 著者 | Le, L.T.M, Yang, J.K. | | 登録日 | 2016-05-26 | | 公開日 | 2017-01-04 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | | 主引用文献 | Structural Details of Ufd1 Binding to p97 and Their Functional Implications in ER-Associated Degradation
PLoS ONE, 11, 2016
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5GLF
 | | Structural insights into the interaction of p97 N-terminal domain and SHP motif in Derlin-1 rhomboid pseudoprotease | | 分子名称: | Derlin-1, Transitional endoplasmic reticulum ATPase | | 著者 | Lim, J.J, Lee, Y, Yoon, S.Y, Ly, T.T, Kang, J.Y, Youn, H.-S, An, J.Y, Lee, J.-G, Park, K.R, Kim, T.G, Yang, J.K, Jun, Y, Eom, S.H. | | 登録日 | 2016-07-11 | | 公開日 | 2016-11-09 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | | 主引用文献 | Structural insights into the interaction of human p97 N-terminal domain and SHP motif in Derlin-1 rhomboid pseudoprotease.
FEBS Lett., 590, 2016
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9BOQ
 | | Human p97/VCP structure with a triazole inhibitor (NSC799462/dodecamer) | | 分子名称: | 3-(2,6-difluoro-4-{[(4P)-5-{[(2S)-hexan-2-yl]sulfanyl}-4-(pyridin-3-yl)-4H-1,2,4-triazol-3-yl]methoxy}phenyl)prop-2-yn-1-yl (1-methylpiperidin-4-yl)carbamate, ADENOSINE-5'-DIPHOSPHATE, Transitional endoplasmic reticulum ATPase | | 著者 | Nandi, P, DeVore, K, Chiu, P.-L. | | 登録日 | 2024-05-05 | | 公開日 | 2024-08-21 | | 実験手法 | ELECTRON MICROSCOPY (3.33 Å) | | 主引用文献 | Mechanism of allosteric inhibition of human p97/VCP ATPase and its disease mutant by triazole inhibitors.
Commun Chem, 7, 2024
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7OAT
 | | Structural basis for targeted p97 remodelling by ASPL as prerequisite for p97 trimethylation by METTL21D | | 分子名称: | 1,2-ETHANEDIOL, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | | 著者 | Petrovic, S, Heinemann, U, Roske, Y. | | 登録日 | 2021-04-20 | | 公開日 | 2022-08-03 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.995 Å) | | 主引用文献 | Structural remodeling of AAA+ ATPase p97 by adaptor protein ASPL facilitates posttranslational methylation by METTL21D.
Proc.Natl.Acad.Sci.USA, 120, 2023
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6CHS
 | | Cdc48-Npl4 complex in the presence of ATP-gamma-S | | 分子名称: | MAGNESIUM ION, Npl4, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ... | | 著者 | Kim, K.H, Bodnar, N.O, Walz, T, Rapoport, T.A. | | 登録日 | 2018-02-22 | | 公開日 | 2018-07-04 | | 最終更新日 | 2024-03-13 | | 実験手法 | ELECTRON MICROSCOPY (4.3 Å) | | 主引用文献 | Structure of the Cdc48 ATPase with its ubiquitin-binding cofactor Ufd1-Npl4.
Nat. Struct. Mol. Biol., 25, 2018
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5X4L
 | | Crystal structure of the UBX domain of human UBXD7 in complex with p97 N domain | | 分子名称: | Transitional endoplasmic reticulum ATPase, UBX domain-containing protein 7 | | 著者 | Jiang, T, Li, Z, Wang, Y, Xu, M. | | 登録日 | 2017-02-13 | | 公開日 | 2017-03-22 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.402 Å) | | 主引用文献 | Crystal structures of the UBX domain of human UBXD7 and its complex with p97 ATPase
Biochem. Biophys. Res. Commun., 486, 2017
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8B5R
 | | p97-p37-SPI substrate complex | | 分子名称: | I3 sequence being threaded through the p97 channel, Protein phosphatase 1 regulatory subunit 7, Serine/threonine-protein phosphatase PP1-gamma catalytic subunit, ... | | 著者 | van den Boom, J, Marini, G, Meyer, H, Saibil, H. | | 登録日 | 2022-09-24 | | 公開日 | 2023-06-07 | | 最終更新日 | 2024-07-24 | | 実験手法 | ELECTRON MICROSCOPY (6.1 Å) | | 主引用文献 | Structural basis of ubiquitin-independent PP1 complex disassembly by p97.
Embo J., 42, 2023
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8KG2
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8OOI
 | | Full composite cryo-EM map of p97/VCP in ADP.Pi state | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | | 著者 | Cheng, T.C, Sakata, E, Schuetz, A.K. | | 登録日 | 2023-04-05 | | 公開日 | 2024-01-31 | | 最終更新日 | 2024-03-13 | | 実験手法 | ELECTRON MICROSCOPY (2.61 Å) | | 主引用文献 | Characterizing ATP processing by the AAA+ protein p97 at the atomic level.
Nat.Chem., 16, 2024
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5IFS
 | | Quantitative interaction mapping reveals an extended ubiquitin regulatory domain in ASPL that disrupts functional p97 hexamers and induces cell death | | 分子名称: | 1,2-ETHANEDIOL, ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, ... | | 著者 | Roske, Y, Arumughan, A, Heinemann, U, Wanker, E. | | 登録日 | 2016-02-26 | | 公開日 | 2016-10-26 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.46 Å) | | 主引用文献 | Quantitative interaction mapping reveals an extended UBX domain in ASPL that disrupts functional p97 hexamers.
Nat Commun, 7, 2016
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