9EQK
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9EQH
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8SG2
| BIVALENT INTERACTIONS OF PIN1 WITH THE C-TERMINAL TAIL OF PKC | 分子名称: | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, Protein kinase C beta type | 著者 | Dixit, K, Yang, Y, Chen, X.R, Igumenova, T.I. | 登録日 | 2023-04-11 | 公開日 | 2024-05-08 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | A novel bivalent interaction mode underlies a non-catalytic mechanism for Pin1-mediated protein kinase C regulation. Elife, 13, 2024
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8QO9
| Cryo-EM structure of a human spliceosomal B complex protomer | 分子名称: | 116 kDa U5 small nuclear ribonucleoprotein component, MINX pre-mRNA, Microfibrillar-associated protein 1, ... | 著者 | Zhang, Z, Kumar, V, Dybkov, O, Will, C.L, Urlaub, H, Stark, H, Luehrmann, R. | 登録日 | 2023-09-28 | 公開日 | 2024-01-24 | 実験手法 | ELECTRON MICROSCOPY (5.29 Å) | 主引用文献 | New insights into the functions of B complex proteins revealed by cryo-EM of dimerized
spliceosomes To Be Published
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8Q7N
| cryo-EM structure of the human spliceosomal B complex protomer (tri-snRNP core region) | 分子名称: | 116 kDa U5 small nuclear ribonucleoprotein component, MINX pre-mRNA, Microfibrillar-associated protein 1, ... | 著者 | Zhang, Z, Kumar, V, Dybkov, O, Will, C.L, Urlaub, H, Stark, H, Luehrmann, R. | 登録日 | 2023-08-16 | 公開日 | 2024-01-24 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | New insights into the functions of B complex proteins revealed by cryo-EM of dimerized spliceosomes To Be Published
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8PXX
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8PXW
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8H6L
| Cryo-EM structure of human exon-defined spliceosome in the early B state. | 分子名称: | 116 kDa U5 small nuclear ribonucleoprotein component, GUANOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, ... | 著者 | Zhang, W, Zhan, X, Zhang, X, Bai, R, Lei, J, Yan, C, Shi, Y. | 登録日 | 2022-10-18 | 公開日 | 2024-05-01 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | 主引用文献 | Structural insights into human exon-defined spliceosome prior to activation. Cell Res., 2024
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8H6K
| Cryo-EM structure of human exon-defined spliceosome in the mature B state. | 分子名称: | 116 kDa U5 small nuclear ribonucleoprotein component, GUANOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, ... | 著者 | Zhang, W, Zhan, X, Zhang, X, Bai, R, Lei, J, Yan, C, Shi, Y. | 登録日 | 2022-10-18 | 公開日 | 2024-05-01 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | 主引用文献 | Structural insights into human exon-defined spliceosome prior to activation. Cell Res., 2024
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7SUR
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7SUQ
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7SA5
| Two-state solution NMR structure of Apo Pin1 | 分子名称: | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | 著者 | Born, A, Vogeli, B. | 登録日 | 2021-09-22 | 公開日 | 2021-10-20 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Reconstruction of Coupled Intra- and Interdomain Protein Motion from Nuclear and Electron Magnetic Resonance. J.Am.Chem.Soc., 143, 2021
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7OQE
| Saccharomyces cerevisiae spliceosomal pre-A complex (delta BS-A ACT1) | 分子名称: | 56 kDa U1 small nuclear ribonucleoprotein component, ACT1 pre-mRNA (delta BS-A), Cold sensitive U2 snRNA suppressor 1, ... | 著者 | Zhang, Z, Rigo, N, Dybkov, O, Fourmann, J, Will, C.L, Kumar, V, Urlaub, H, Stark, H, Luehrmann, R. | 登録日 | 2021-06-03 | 公開日 | 2021-08-11 | 最終更新日 | 2021-09-29 | 実験手法 | ELECTRON MICROSCOPY (5.9 Å) | 主引用文献 | Structural insights into how Prp5 proofreads the pre-mRNA branch site. Nature, 596, 2021
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7NMZ
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7LP5
| Structure of Nedd4L WW3 domain | 分子名称: | Angiomotin,E3 ubiquitin-protein ligase NEDD4-like | 著者 | Alam, S.L, Alian, A, Thompson, T, Rheinemann, L, Volkman, B.F, Peterson, F.C, Sundquist, W.I. | 登録日 | 2021-02-11 | 公開日 | 2021-07-28 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Interactions between AMOT PPxY motifs and NEDD4L WW domains function in HIV-1 release. J.Biol.Chem., 297, 2021
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7LP4
| Structure of Nedd4L WW3 domain | 分子名称: | E3 ubiquitin-protein ligase NEDD4-like | 著者 | Alam, S.L, Alian, A, Thompson, T, Rheinemann, L, Volkman, B.F, Peterson, F.C, Sundquist, W.I. | 登録日 | 2021-02-11 | 公開日 | 2021-07-28 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Interactions between AMOT PPxY motifs and NEDD4L WW domains function in HIV-1 release. J.Biol.Chem., 297, 2021
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7LP3
| Structure of Nedd4L WW3 domain | 分子名称: | Angiomotin, E3 ubiquitin-protein ligase NEDD4-like, SULFATE ION | 著者 | Alian, A, Alam, S.L, Thompson, T, Rheinemann, L, Sundquist, W.I. | 登録日 | 2021-02-11 | 公開日 | 2021-07-28 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.61 Å) | 主引用文献 | Interactions between AMOT PPxY motifs and NEDD4L WW domains function in HIV-1 release. J.Biol.Chem., 297, 2021
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7LP2
| Structure of Nedd4L WW3 domain | 分子名称: | Angiomotin, E3 ubiquitin-protein ligase, GLYCEROL, ... | 著者 | Alian, A, Alam, S.L, Thompson, T, Rheinemann, L, Sundquist, W.I. | 登録日 | 2021-02-11 | 公開日 | 2021-07-28 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.88 Å) | 主引用文献 | Interactions between AMOT PPxY motifs and NEDD4L WW domains function in HIV-1 release. J.Biol.Chem., 297, 2021
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7LP1
| Structure of Nedd4L WW3 domain | 分子名称: | E3 ubiquitin-protein ligase NEDD4-like, GLYCEROL, NITRATE ION | 著者 | Alian, A, Alam, S.L, Thompson, T, Rheinemann, L, Sundquist, W.I. | 登録日 | 2021-02-11 | 公開日 | 2021-07-28 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.35 Å) | 主引用文献 | Interactions between AMOT PPxY motifs and NEDD4L WW domains function in HIV-1 release. J.Biol.Chem., 297, 2021
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7KKF
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7F0M
| Crystal Structure of human Pin1 complexed with a potent covalent inhibitor | 分子名称: | 3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL, 8-(2-chloranylethanoyl)-4-[(5-naphthalen-1-ylfuran-2-yl)methyl]-1-thia-4,8-diazaspiro[4.5]decan-3-one, Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | 著者 | Liu, L, Li, J. | 登録日 | 2021-06-05 | 公開日 | 2022-02-16 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Computational and Structure-Based Development of High Potent Cell-Active Covalent Inhibitor Targeting the Peptidyl-Prolyl Isomerase NIMA-Interacting-1 (Pin1). J.Med.Chem., 65, 2022
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7EKV
| Crystal Structure of human Pin1 complexed with a covalent inhibitor | 分子名称: | 3,6,9,12,15,18,21-HEPTAOXATRICOSANE-1,23-DIOL, 8-(2-chloroacetyl)-4-((5-phenylfuran-2-yl)methyl)-1-thia-4,8-diazaspiro[4.5]decan-3-one, Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | 著者 | Liu, L, Li, J. | 登録日 | 2021-04-06 | 公開日 | 2022-02-16 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Computational and Structure-Based Development of High Potent Cell-Active Covalent Inhibitor Targeting the Peptidyl-Prolyl Isomerase NIMA-Interacting-1 (Pin1). J.Med.Chem., 65, 2022
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7EFX
| Crystal Structure of human PIN1 complexed with covalent inhibitor | 分子名称: | 4-((5-bromofuran-2-yl)methyl)-8-(2-chloroacetyl)-1-thia-4,8-diazaspiro[4.5]decan-3-one, Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | 著者 | Liu, L, Li, J, Zhu, R, Pei, Y. | 登録日 | 2021-03-23 | 公開日 | 2022-02-16 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.41 Å) | 主引用文献 | Computational and Structure-Based Development of High Potent Cell-Active Covalent Inhibitor Targeting the Peptidyl-Prolyl Isomerase NIMA-Interacting-1 (Pin1). J.Med.Chem., 65, 2022
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7EFJ
| Crystal Structure Analysis of human PIN1 | 分子名称: | 3,6,9,12,15,18,21-HEPTAOXATRICOSANE-1,23-DIOL, 8-(2-chloroacetyl)-4-(furan-2-ylmethyl)-1-thia-4,8-diazaspiro[4.5]decan-3-one, Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | 著者 | Liu, L, Li, J. | 登録日 | 2021-03-21 | 公開日 | 2022-02-16 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.992 Å) | 主引用文献 | Computational and Structure-Based Development of High Potent Cell-Active Covalent Inhibitor Targeting the Peptidyl-Prolyl Isomerase NIMA-Interacting-1 (Pin1). J.Med.Chem., 65, 2022
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7BQG
| Complex structure of SAV1 and Dendrin | 分子名称: | POTASSIUM ION, Protein salvador homolog 1,Dendrin | 著者 | Lin, Z, Zhang, M. | 登録日 | 2020-03-24 | 公開日 | 2020-09-23 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.55010867 Å) | 主引用文献 | A WW Tandem-Mediated Dimerization Mode of SAV1 Essential for Hippo Signaling. Cell Rep, 32, 2020
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