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2J9I
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Lengsin is a survivor of an ancient family of class I glutamine synthetases in eukaryotes that has undergone evolutionary re- engineering for a tissue-specific role in the vertebrate eye lens.
分子名称: GLUTAMATE-AMMONIA LIGASE DOMAIN-CONTAINING PROTEIN 1
著者Wyatt, K, White, H.E, Wang, L, Bateman, O.A, Slingsby, C, Orlova, E.V, Wistow, G.
登録日2006-11-09
公開日2006-12-13
最終更新日2024-05-08
実験手法ELECTRON MICROSCOPY (17 Å)
主引用文献Lengsin is a Survivor of an Ancient Family of Class I Glutamine Synthetases Re-Engineered by Evolution for a Role in the Vertebrate Lens.
Structure, 14, 2006
5DM3
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Crystal Structure of Glutamine Synthetase from Chromohalobacter salexigens DSM 3043(Csal_0679, TARGET EFI-550015) with bound ADP
分子名称: ADENOSINE-5'-DIPHOSPHATE, L-glutamine synthetase
著者Yadava, U, Vetting, M.W, Al Obaidi, N.F, Toro, R, Morisco, L.L, Benach, J, Koss, J, Wasserman, S.R, Attonito, J.D, Scott Glenn, A, Chamala, S, Chowdhury, S, Lafleur, J, Love, J, Seidel, R.D, Whalen, K.L, Gerlt, J.A, Almo, S.C, Enzyme Function Initiative (EFI)
登録日2015-09-07
公開日2015-09-16
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Crystal Structure of Glutamine Synthetase from Chromohalobacter salexigens DSM 3043(Csal_0679, TARGET EFI-550015) with bound ADP
To be published
8WWU
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1-naphthylamine GS in complex with AMP PNP
分子名称: Glutamine synthetase, MAGNESIUM ION, MANGANESE (II) ION, ...
著者Zhang, S.T, Zhou, N.Y.
登録日2023-10-26
公開日2024-01-03
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Discovery of the 1-naphthylamine biodegradation pathway reveals a glutamine synthetase-like protein that catalyzes 1-naphthylamine glutamylation
To Be Published
8WWV
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1-naphthylamine GS in complex with ADP and MetSox-P
分子名称: ADENOSINE-5'-DIPHOSPHATE, Glutamine synthetase, L-METHIONINE-S-SULFOXIMINE PHOSPHATE, ...
著者Zhang, S.T, Zhou, N.Y.
登録日2023-10-26
公開日2024-01-03
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Discovery of the 1-naphthylamine biodegradation pathway reveals a glutamine synthetase-like protein that catalyzes 1-naphthylamine glutamylation
To Be Published
7V4H
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Cryo-EM Structure of Glycine max glutamine synthetase GmGS Beta2
分子名称: Glutamine synthetase
著者Xu, W, Chen, Y, Xing, Q, Huang, C.
登録日2021-08-13
公開日2022-05-18
最終更新日2024-06-12
実験手法ELECTRON MICROSCOPY (2.9 Å)
主引用文献Assembly status transition offers an avenue for activity modulation of a supramolecular enzyme.
Elife, 10, 2021
7CQU
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GmaS/ADP/MetSox-P complex
分子名称: ADENOSINE-5'-DIPHOSPHATE, L-METHIONINE-S-SULFOXIMINE PHOSPHATE, MAGNESIUM ION, ...
著者Li, C.Y, Zhang, Y.Z.
登録日2020-08-11
公開日2020-11-18
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.06 Å)
主引用文献Crystal structures of gamma-glutamylmethylamide synthetase provide insight into bacterial metabolism of oceanic monomethylamine.
J.Biol.Chem., 296, 2020
7CQX
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GmaS/ADP complex-Conformation 2
分子名称: ADENOSINE-5'-DIPHOSPHATE, Type III glutamate--ammonia ligase
著者Li, C.Y, Zhang, Y.Z.
登録日2020-08-11
公開日2020-11-18
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.301 Å)
主引用文献Crystal structures of gamma-glutamylmethylamide synthetase provide insight into bacterial metabolism of oceanic monomethylamine.
J.Biol.Chem., 296, 2020
7CQW
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GmaS/ADP complex-Conformation 1
分子名称: ADENOSINE-5'-DIPHOSPHATE, Type III glutamate--ammonia ligase
著者Li, C.Y, Zhang, Y.Z.
登録日2020-08-11
公開日2020-11-18
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.297 Å)
主引用文献Crystal structures of gamma-glutamylmethylamide synthetase provide insight into bacterial metabolism of oceanic monomethylamine.
J.Biol.Chem., 296, 2020
7CQQ
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GmaS in complex with AMPPNP and MetSox
分子名称: (2S)-2-AMINO-4-(METHYLSULFONIMIDOYL)BUTANOIC ACID, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
著者Li, C.Y, Zhang, Y.Z.
登録日2020-08-11
公開日2020-11-18
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.295 Å)
主引用文献Crystal structures of gamma-glutamylmethylamide synthetase provide insight into bacterial metabolism of oceanic monomethylamine.
J.Biol.Chem., 296, 2020
7CQL
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Apo GmaS without ligand
分子名称: Type III glutamate--ammonia ligase
著者Li, C.Y, Zhang, Y.Z.
登録日2020-08-11
公開日2020-11-18
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.801 Å)
主引用文献Crystal structures of gamma-glutamylmethylamide synthetase provide insight into bacterial metabolism of oceanic monomethylamine.
J.Biol.Chem., 296, 2020
7CQN
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GmaS in complex with AMPPCP
分子名称: PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, Type III glutamate--ammonia ligase
著者Li, C.Y, Zhang, Y.Z.
登録日2020-08-11
公開日2020-11-18
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.962 Å)
主引用文献Crystal structures of gamma-glutamylmethylamide synthetase provide insight into bacterial metabolism of oceanic monomethylamine.
J.Biol.Chem., 296, 2020
3FKY
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Crystal structure of the glutamine synthetase Gln1deltaN18 from the yeast Saccharomyces cerevisiae
分子名称: CITRATE ANION, Glutamine synthetase
著者He, Y.X, Gui, L, Liu, Y.Z, Du, Y, Zhou, Y.Y, Li, P, Zhou, C.Z.
登録日2008-12-18
公開日2009-10-06
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.95 Å)
主引用文献Crystal structure of Saccharomyces cerevisiae glutamine synthetase Gln1 suggests a nanotube-like supramolecular assembly
Proteins, 76, 2009
5ZLI
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Crystal structure of glutamine synthetase from helicobacter pylori
分子名称: Glutamine synthetase
著者Joo, H.K, Lee, J.Y.
登録日2018-03-28
公開日2018-08-29
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Structural Analysis of Glutamine Synthetase from Helicobacter pylori.
Sci Rep, 8, 2018
3NG0
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Crystal Structure of Glutamine Synthetase from Synechocystis sp. PCC 6803
分子名称: Glutamine synthetase, MANGANESE (II) ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
著者Saelices, L, Cascio, D, Florencio, F.J, Muro-Pastor, M.I.
登録日2010-06-10
公開日2011-06-15
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Crystal Structure of Glutamine Synthetase from Synechocystis sp. PCC 6803
To be Published
1LGR
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INTERACTIONS OF NUCLEOTIDES WITH FULLY UNADENYLYLATED GLUTAMINE SYNTHETASE FROM SALMONELLA TYPHIMURIUM
分子名称: ADENOSINE MONOPHOSPHATE, GLUTAMINE SYNTHETASE, MANGANESE (II) ION
著者Liaw, S.-H, Eisenberg, D.
登録日1994-08-05
公開日1994-11-30
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.79 Å)
主引用文献Interactions of nucleotides with fully unadenylylated glutamine synthetase from Salmonella typhimurium.
Biochemistry, 33, 1994
7W85
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Structural of the filamentous Escherichia coli glutamine synthetase
分子名称: Glutamine synthetase, NICKEL (II) ION
著者Huang, P.-C, Chen, S.-K, Wu, K.-P.
登録日2021-12-07
公開日2022-04-06
最終更新日2024-06-26
実験手法ELECTRON MICROSCOPY (2.94 Å)
主引用文献Structural basis for the helical filament formation of Escherichia coli glutamine synthetase.
Protein Sci., 31, 2022
2WHI
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Crystal structure of Mycobacterium Tuberculosis Glutamine Synthetase in complex with a purine analogue inhibitor and L-methionine-S- sulfoximine phosphate.
分子名称: 1-(3,4-dichlorobenzyl)-3,7-dimethyl-8-morpholin-4-yl-3,7-dihydro-1H-purine-2,6-dione, CHLORIDE ION, GLUTAMINE SYNTHETASE 1, ...
著者Nilsson, M.T, Krajewski, W.W, Jones, T.A, Mowbray, S.L.
登録日2009-05-05
公開日2009-09-01
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structural Basis for the Inhibition of Mycobacterium Tuberculosis Glutamine Synthetase by Novel ATP-Competitive Inhibitors.
J.Mol.Biol., 393, 2009
2WGS
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Crystal structure of Mycobacterium Tuberculosis Glutamine Synthetase in complex with a purine analogue inhibitor.
分子名称: 1-(3,4-dichlorobenzyl)-3,7-dimethyl-8-morpholin-4-yl-3,7-dihydro-1H-purine-2,6-dione, CHLORIDE ION, GLUTAMINE SYNTHETASE 1
著者Nilsson, M.T, Krajewski, W.W, Jones, T.A, Mowbray, S.L.
登録日2009-04-27
公開日2009-09-01
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.55 Å)
主引用文献Structural Basis for the Inhibition of Mycobacterium Tuberculosis Glutamine Synthetase by Novel ATP-Competitive Inhibitors.
J.Mol.Biol., 393, 2009
4XYC
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NANOMOLAR INHIBITORS OF MYCOBACTERIUM TUBERCULOSIS GLUTAMINE SYNTHETASE 1: SYNTHESIS, BIOLOGICAL EVALUATION AND X-RAY CRYSTALLOGRAPHIC STUDIES
分子名称: 9-phenyl-4H-imidazo[1,2-a]indeno[1,2-e]pyrazin-4-one, Glutamine synthetase 1
著者Couturier, C, Silve, S, Morales, R, Ppessegue, B, Llopart, S, Nair, A, Bauer, A, Scheiper, B, poeverlein, c, Ganzhorn, A, Lagrange, S, Bacque, E.
登録日2015-02-02
公開日2015-03-25
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (3.3 Å)
主引用文献Nanomolar inhibitors of Mycobacterium tuberculosis glutamine synthetase 1: Synthesis, biological evaluation and X-ray crystallographic studies.
Bioorg.Med.Chem.Lett., 25, 2015
8FBP
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Glutamine synthetase from Pseudomonas aeruginosa, filament double-unit in compressed conformation
分子名称: Glutamine synthetase
著者Phan, I.Q, Staker, B, Shek, R, Moser, T.H, Evans, J.E, van Voorhis, W.C, Myler, P.J, Seattle Structural Genomics Center for Infectious Disease (SSGCID)
登録日2022-11-29
公開日2024-02-14
実験手法ELECTRON MICROSCOPY (2.8 Å)
主引用文献Glutamine synthetase from Pseudomonas aeruginosa, filament double-unit in compressed conformation
To Be Published
6PEW
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CryoEM Plasmodium falciparum glutamine synthetase
分子名称: Glutamine synthetase
著者Ho, C.M, Lai, M, Zhou, Z.H.
登録日2019-06-21
公開日2019-12-11
最終更新日2024-03-20
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献Bottom-up structural proteomics: cryoEM of protein complexes enriched from the cellular milieu.
Nat.Methods, 17, 2020
8PVG
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Structure of E. coli glutamine synthetase determined by cryoEM at 100 keV
分子名称: Glutamine synthetase
著者McMullan, G, Naydenova, K, Mihaylov, D, Peet, M.J, Wilson, H, Yamashita, K, Dickerson, J.L, Chen, S, Cannone, G, Lee, Y, Hutchings, K.A, Gittins, O, Sobhy, M, Wells, T, El-Gomati, M.M, Dalby, J, Meffert, M, Schulze-Briese, C, Henderson, R, Russo, C.J.
登録日2023-07-17
公開日2023-11-29
最終更新日2023-12-06
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献Structure determination by cryoEM at 100 keV.
Proc.Natl.Acad.Sci.USA, 120, 2023
3O6X
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Crystal Structure of the type III Glutamine Synthetase from Bacteroides fragilis
分子名称: ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, Glutamine synthetase, ...
著者van Rooyen, J.M, Belrhali, H, Abratt, V.R, Sewell, B.T.
登録日2010-07-29
公開日2011-03-09
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (3.5 Å)
主引用文献Crystal Structure of Type III Glutamine Synthetase: Surprising Reversal of the Inter-Ring Interface.
Structure, 19, 2011
2BVC
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Crystal structure of Mycobacterium tuberculosis glutamine synthetase in complex with a transition state mimic
分子名称: ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, GLUTAMINE SYNTHETASE 1, ...
著者Krajewski, W.W, Jones, T.A, Mowbray, S.L.
登録日2005-06-23
公開日2005-07-07
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structure of Mycobacterium Tuberculosis Glutamine Synthetase in Complex with a Transition-State Mimic Provides Functional Insights.
Proc.Natl.Acad.Sci.USA, 102, 2005
5ZLP
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Crystal structure of glutamine synthetase from helicobacter pylori
分子名称: (2S)-2-AMINO-4-[METHYL(PHOSPHONOOXY)PHOSPHORYL]BUTANOIC ACID, ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ...
著者Joo, H.K, Lee, J.Y.
登録日2018-03-29
公開日2018-08-29
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (2.93 Å)
主引用文献Structural Analysis of Glutamine Synthetase from Helicobacter pylori.
Sci Rep, 8, 2018

 

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