PDB: 278 件ウェブページステータス検索Chemie searchBIRD

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8OO0	Chaetomium thermophilum Methionine Aminopeptidase 2 autoproteolysis product at the 80S ribosome 分子名称: 18S rRNA, 28S rRNA, 40S ribosomal protein S0, ... 著者 Klein, M.A, Wild, K, Kisonaite, M, Sinning, I. 登録日 2023-04-04 公開日 2024-02-21 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Methionine aminopeptidase 2 and its autoproteolysis product have different binding sites on the ribosome. Nat Commun, 15, 2024
8GLV	96-nm repeat unit of doublet microtubules from Chlamydomonas reinhardtii flagella 分子名称: 28 kDa inner dynein arm light chain, axonemal, AAA+ ATPase domain-containing protein, ... 著者 Walton, T, Brown, A. 登録日 2023-03-23 公開日 2023-05-31 最終更新日 2023-06-28 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Axonemal structures reveal mechanoregulatory and disease mechanisms. Nature, 618, 2023
8GB3	Structure of the Mycobacterium tuberculosis Hsp70 protein DnaK bound to the nucleotide exchange factor GrpE 分子名称: Chaperone protein DnaK, Protein GrpE 著者 Xiao, X, Li, H. 登録日 2023-02-24 公開日 2024-01-31 最終更新日 2024-05-01 実験手法 ELECTRON MICROSCOPY (3.7 Å) 主引用文献 Structure of the M. tuberculosis DnaK-GrpE complex reveals how key DnaK roles are controlled. Nat Commun, 15, 2024
8D24	Crystal structure of Plasmodium falciparum GRP78-NBD in complex with VER155008 分子名称: 4-[[(2R,3S,4R,5R)-5-[6-amino-8-[(3,4-dichlorophenyl)methylamino]purin-9-yl]-3,4-dihydroxy-oxolan-2-yl]methoxymethyl]benzonitrile, Chaperone DnaK, SULFATE ION 著者 Mrozek, A, Park, H.W. 登録日 2022-05-27 公開日 2023-05-31 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 A non-traditional crystal-based compound screening method targeting the ATP binding site of Plasmodium falciparum GRP78 for identification of novel nucleoside analogues. Front Mol Biosci, 9, 2022
8D22	Crystal structure of Plasmodium falciparum GRP78-NBD in complex with Piclidenoson 分子名称: Chaperone DnaK, Piclidenoson, SULFATE ION 著者 Mrozek, A, Park, H.W. 登録日 2022-05-27 公開日 2023-05-31 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 A non-traditional crystal-based compound screening method targeting the ATP binding site of Plasmodium falciparum GRP78 for identification of novel nucleoside analogues. Front Mol Biosci, 9, 2022
8D20	Crystal structure of Plasmodium falciparum GRP78 in complex with 5'-Methylthioadenosine 分子名称: 5'-DEOXY-5'-METHYLTHIOADENOSINE, Chaperone DnaK, SULFATE ION 著者 Mrozek, A, Park, H.W. 登録日 2022-05-27 公開日 2023-05-31 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 A non-traditional crystal-based compound screening method targeting the ATP binding site of Plasmodium falciparum GRP78 for identification of novel nucleoside analogues. Front Mol Biosci, 9, 2022
8D1Y	Crystal structure of Plasmodium falciparum GRP78 in complex with Trans-Zeatin Riboside 分子名称: Chaperone DnaK, N-[(2E)-4-hydroxy-3-methylbut-2-en-1-yl]adenosine, SULFATE ION 著者 Mrozek, A, Park, H.W. 登録日 2022-05-27 公開日 2023-05-31 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 A non-traditional crystal-based compound screening method targeting the ATP binding site of Plasmodium falciparum GRP78 for identification of novel nucleoside analogues. Front Mol Biosci, 9, 2022
8D1W	Crystal structure of Plasmodium falciparum GRP78 in complex with (2R,3R,4S,5R)-2-(6-amino-8-((2-chlorobenzyl)amino)-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol 分子名称: 8-{[(2-chlorophenyl)methyl]amino}adenosine, Chaperone DnaK, SULFATE ION 著者 Mrozek, A, Chen, Y, Antoshchenko, T, Park, H.W, Smil, D, Zepeda, C.A.V. 登録日 2022-05-27 公開日 2023-05-31 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Targeting Plasmodium falciparum GRP78: nucleoside analogues as agents against the malaria chaperone Frontiers in Molecular Bioscience, 2022
8D1S	Crystal structure of Plasmodium falciparum GRP78 in complex with Toyocamycin 分子名称: 4-amino-7-(beta-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile, Chaperone DnaK, SULFATE ION 著者 Mrozek, A, Chen, Y, Antoshchenko, T, Park, H.W. 登録日 2022-05-27 公開日 2023-05-31 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 A non-traditional crystal-based compound screening method targeting the ATP binding site of Plasmodium falciparum GRP78 for identification of novel nucleoside analogues. Front Mol Biosci, 9, 2022
8D1Q	Crystal structure of Plasmodium falciparum GRP78-NBD in complex with 8-Aminoadenosine 分子名称: (2R,3R,4S,5R)-2-(6,8-diaminopurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol, Chaperone DnaK, SULFATE ION 著者 Mrozek, A, Chen, Y, Antoshchenko, T, Park, H.W. 登録日 2022-05-27 公開日 2023-05-31 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 A non-traditional crystal-based compound screening method targeting the ATP binding site of Plasmodium falciparum GRP78 for identification of novel nucleoside analogues. Front Mol Biosci, 9, 2022
8D1P	Crystal structure of Plasmodium falciparum GRP78-NBD in complex with 7-Deaza-2'-C-methyladenosine 分子名称: 7-(2-C-methyl-beta-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine, Chaperone DnaK, SULFATE ION 著者 Mrozek, A, Chen, Y, Antoshchenko, T, Park, H.W. 登録日 2022-05-27 公開日 2023-05-31 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (1.88 Å) 主引用文献 A non-traditional crystal-based compound screening method targeting the ATP binding site of Plasmodium falciparum GRP78 for identification of novel nucleoside analogues. Front Mol Biosci, 9, 2022
7Z3O	Cryo-EM structure of the ribosome-associated RAC complex on the 80S ribosome - RAC-2 conformation 分子名称: 18S rRNA, 26S rRNA, 40S ribosomal protein S0, ... 著者 Kisonaite, M, Wild, K, Sinning, I. 登録日 2022-03-02 公開日 2023-04-12 最終更新日 2023-05-31 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 Structural inventory of cotranslational protein folding by the eukaryotic RAC complex. Nat.Struct.Mol.Biol., 30, 2023
7Z3N	Cryo-EM structure of the ribosome-associated RAC complex on the 80S ribosome - RAC-1 conformation 分子名称: 18S rRNA, 26S rRNA, 40S ribosomal protein S0, ... 著者 Kisonaite, M, Wild, K, Sinning, I. 登録日 2022-03-02 公開日 2023-04-12 最終更新日 2023-05-31 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Structural inventory of cotranslational protein folding by the eukaryotic RAC complex. Nat.Struct.Mol.Biol., 30, 2023
7X3K	Cryo-EM structure of RAC in the State C2 RNC-RAC complex 分子名称: Ribosome-associated complex subunit SSZ1, Zuotin 著者 Chen, Y, Gao, N. 登録日 2022-03-01 公開日 2022-06-29 実験手法 ELECTRON MICROSCOPY (6 Å) 主引用文献 Structural remodeling of ribosome associated Hsp40-Hsp70 chaperones during co-translational folding. Nat Commun, 13, 2022
7SQC	Ciliary C1 central pair apparatus isolated from Chlamydomonas reinhardtii 分子名称: ADENOSINE-5'-DIPHOSPHATE, CPC1, Calmodulin, ... 著者 Gui, M, Wang, X, Dutcher, S.K, Brown, A, Zhang, R. 登録日 2021-11-05 公開日 2022-04-13 最終更新日 2024-06-05 実験手法 ELECTRON MICROSCOPY (3.8 Å) 主引用文献 Ciliary central apparatus structure reveals mechanisms of microtubule patterning. Nat.Struct.Mol.Biol., 29, 2022
7RAX	ATP-binding state of the nucleotide-binding domain of Hsp70 DnaK mutant T199A 分子名称: ADENOSINE-5'-TRIPHOSPHATE, Chaperone protein DnaK, GLYCEROL, ... 著者 Wang, W, Hendrickson, W.A. 登録日 2021-07-04 公開日 2023-07-05 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.41 Å) 主引用文献 Visualization of Hsp70-catalyzed ATP Hydrolysis To Be Published
7Q4R	Crystal structure of human HSP72-NBD in complex with fragment 1 分子名称: 4-(4-phenyl-1,3-thiazol-2-yl)piperazine-1-carboxamide, Heat shock 70 kDa protein 1A, MAGNESIUM ION, ... 著者 Le Bihan, Y.V, Westwood, I.M, van Montfort, R.L.M. 登録日 2021-11-02 公開日 2022-02-02 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.79 Å) 主引用文献 Discovery and Characterization of a Cryptic Secondary Binding Site in the Molecular Chaperone HSP70. Molecules, 27, 2022
7PLK	Crystal structure bovine Hsc70(aa1-554)E213A/D214A in complex with nicotinic-acid-derivative 分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, 5-pyrrol-1-ylpyridine-3-carboxylic acid, GLYCEROL, ... 著者 Zehe, M, Grimm, C, Sotriffer, C. 登録日 2021-08-31 公開日 2022-09-07 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.48781371 Å) 主引用文献 Combined In-Solution Fragment Screening and Crystallographic Binding-Mode Analysis with a Two-Domain Hsp70 Construct. Acs Chem.Biol., 2024
7P31	Plasmodium falciparum Hsp70-x chaperone nucleotide binding domain in complex with NCL-00023818 分子名称: 4-IODOPYRAZOLE, AMP PHOSPHORAMIDATE, CHLORIDE ION, ... 著者 Mohamad, N, O'Donoghue, A, Kantsadi, A.L, Vakonakis, I. 登録日 2021-07-06 公開日 2021-07-14 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.36 Å) 主引用文献 Plasmodium falciparum Hsp70-x chaperone nucleotide binding domain in complex with small molecule ligands To Be Published
7OOH	Plasmodium falciparum Hsp70-x chaperone nucleotide binding domain in complex with NCL-00023818 分子名称: 4-IODOPYRAZOLE, AMP PHOSPHORAMIDATE, CHLORIDE ION, ... 著者 Mohamad, N, O'Donoghue, A, Kantsadi, A.L, Vakonakis, I. 登録日 2021-05-27 公開日 2021-06-09 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.36 Å) 主引用文献 Plasmodium falciparum Hsp70-x chaperone nucleotide binding domain in complex with NCL-00023818 To Be Published
7OOG	Plasmodium falciparum Hsp70-x chaperone nucleotide binding domain in complex with NCL-00023823 分子名称: 4-bromanylpyridin-2-amine, AMP PHOSPHORAMIDATE, CHLORIDE ION, ... 著者 Mohamad, N, O'Donoghue, A, Kantsadi, A.L, Vakonakis, I. 登録日 2021-05-27 公開日 2021-06-02 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.42 Å) 主引用文献 Plasmodium falciparum Hsp70-x chaperone nucleotide binding domain in complex with NCL-00023823 To Be Published
7OOE	Plasmodium falciparum Hsp70-x chaperone nucleotide binding domain in complex with Z321318226 分子名称: AMP PHOSPHORAMIDATE, CHLORIDE ION, GLYCEROL, ... 著者 Mohamad, N, O'Donoghue, A, Kantsadi, A.L, Vakonakis, I. 登録日 2021-05-27 公開日 2021-06-02 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.369 Å) 主引用文献 Structures of P. falciparum Hsp70-x nucleotide binding domain with small molecule ligands To Be Published
7OLC	Thermophilic eukaryotic 80S ribosome at idle POST state 分子名称: 18S rRNA, 26S rRNA, 40S ribosomal protein S0, ... 著者 Kisonaite, M, Wild, K, Sinning, I. 登録日 2021-05-19 公開日 2022-01-26 最終更新日 2022-04-06 実験手法 ELECTRON MICROSCOPY (2.9 Å) 主引用文献 High-resolution structures of a thermophilic eukaryotic 80S ribosome reveal atomistic details of translocation. Nat Commun, 13, 2022
7ODI	Crystal structure of bovine Hsc70(aa1-554)E213A/D214A in complex with methanesulfonamide 分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, GLYCEROL, Heat shock cognate 71 kDa protein, ... 著者 Zehe, M, Grimm, C, Sotriffer, C. 登録日 2021-04-29 公開日 2022-06-01 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (1.83 Å) 主引用文献 Combined In-Solution Fragment Screening and Crystallographic Binding-Mode Analysis with a Two-Domain Hsp70 Construct. Acs Chem.Biol., 2024
7ODD	Crystal structure of bovine Hsc70(aa1-554)E213A/D214A in complex with tricine 分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, GLYCEROL, Heat shock cognate 71 kDa protein, ... 著者 Zehe, M, Grimm, C, Sotriffer, C. 登録日 2021-04-29 公開日 2022-06-01 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (1.984 Å) 主引用文献 Combined In-Solution Fragment Screening and Crystallographic Binding-Mode Analysis with a Two-Domain Hsp70 Construct. Acs Chem.Biol., 2024

 

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