PDB: 47720 件ウェブページステータス検索Chemie searchBIRD

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8DGN	14-3-3 epsilon bound to phosphorylated PEAK2 (pS826) peptide 分子名称: 14-3-3 protein epsilon, Phosphorylated PEAK2 (pS826) peptide 著者 Roy, M.J, Hardy, J.M, Lucet, I.S. 登録日 2022-06-24 公開日 2023-06-07 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (3.16 Å) 主引用文献 Structural mapping of PEAK pseudokinase interactions identifies 14-3-3 as a molecular switch for PEAK3 signaling. Nat Commun, 14, 2023
8DP5	Structure of the PEAK3/14-3-3 complex 分子名称: 14-3-3 protein beta/alpha, 14-3-3 protein epsilon, Protein PEAK3, ... 著者 Torosyan, H, Paul, M, Jura, N, Verba, K.A. 登録日 2022-07-14 公開日 2023-06-28 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Structural insights into regulation of the PEAK3 pseudokinase scaffold by 14-3-3. Nat Commun, 14, 2023
8DGM	14-3-3 epsilon bound to phosphorylated PEAK1 (pT1165) peptide 分子名称: 1,2-ETHANEDIOL, 14-3-3 protein epsilon, Inactive tyrosine-protein kinase PEAK1 著者 Roy, M.J, Hardy, J.M, Lucet, I.S. 登録日 2022-06-24 公開日 2023-06-07 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Structural mapping of PEAK pseudokinase interactions identifies 14-3-3 as a molecular switch for PEAK3 signaling. Nat Commun, 14, 2023
8DGP	14-3-3 epsilon bound to phosphorylated PEAK3 (pS69) peptide 分子名称: 1,2-ETHANEDIOL, 14-3-3 protein epsilon, Phosphorylated PEAK3 (pS69) peptide, ... 著者 Roy, M.J, Hardy, J.M, Lucet, I.S. 登録日 2022-06-24 公開日 2023-06-07 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Structural mapping of PEAK pseudokinase interactions identifies 14-3-3 as a molecular switch for PEAK3 signaling. Nat Commun, 14, 2023
1A38	14-3-3 PROTEIN ZETA BOUND TO R18 PEPTIDE 分子名称: 14-3-3 PROTEIN ZETA, R18 PEPTIDE (PHCVPRDLSWLDLEANMCLP) 著者 Petosa, C, Masters, S.C, Pohl, J, Wang, B, Fu, H, Liddington, R.C. 登録日 1998-01-28 公開日 1999-03-02 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (3.35 Å) 主引用文献 14-3-3zeta binds a phosphorylated Raf peptide and an unphosphorylated peptide via its conserved amphipathic groove. J.Biol.Chem., 273, 1998
1A37	14-3-3 PROTEIN ZETA BOUND TO PS-RAF259 PEPTIDE 分子名称: 14-3-3 PROTEIN ZETA, PS-RAF259 PEPTIDE LSQRQRST(SEP)TPNVHM 著者 Petosa, C, Masters, S.C, Pohl, J, Wang, B, Fu, H, Liddington, R.C. 登録日 1998-01-28 公開日 1999-03-02 最終更新日 2024-06-05 実験手法 X-RAY DIFFRACTION (3.6 Å) 主引用文献 14-3-3zeta binds a phosphorylated Raf peptide and an unphosphorylated peptide via its conserved amphipathic groove. J.Biol.Chem., 273, 1998
8C2E	Structure of 14-3-3 sigma delta C with electrophilic peptide 4IEA-5 分子名称: 14-3-3 protein sigma, ARG-SER-ALA-SEP-CYS-PRO-SER-LEU, CHLORIDE ION, ... 著者 van den Oetelaar, M.C.M, Ottmann, C. 登録日 2022-12-22 公開日 2023-11-01 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 A simple method for developing lysine targeted covalent protein reagents. Nat Commun, 14, 2023
8C2F	Structure of 14-3-3 sigma delta C with electrophilic peptide 3MHR-5 分子名称: 14-3-3 protein sigma, ARG-ALA-HIS-SEP-CYS-PRO-ALA-SER-LEU-GLN, CHLORIDE ION, ... 著者 van den Oetelaar, M.C.M, Ottmann, C. 登録日 2022-12-22 公開日 2023-11-01 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 A simple method for developing lysine targeted covalent protein reagents. Nat Commun, 14, 2023
5BTV	Crystal structure of human 14-3-3 sigma in complex with a Tau-protein peptide surrounding pS324 分子名称: 14-3-3 protein sigma, CALCIUM ION, CHLORIDE ION, ... 著者 Ottmann, C, Schumacher, B, Bartel, M. 登録日 2015-06-03 公開日 2016-07-20 最終更新日 2019-03-13 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Involvement of 14-3-3 in tubulin instability and impaired axon development is mediated by Tau. Faseb J., 29, 2015
4FL5	Crystal structure of human 14-3-3 sigma in complex with a Tau-protein peptide surrounding pS214 分子名称: 14-3-3 protein sigma, CALCIUM ION, CHLORIDE ION, ... 著者 Schumacher, B, Ottmann, C. 登録日 2012-06-14 公開日 2013-12-11 最終更新日 2017-06-07 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Involvement of 14-3-3 in tubulin instability and impaired axon development is mediated by Tau. FASEB J., 29, 2015
4J6S	14-3-3gamma complexed with the N-terminal sequence of tyrosine hydroxylase (residues 1-43) 分子名称: 14-3-3 protein gamma, N-terminal motif of tyrosine hydroxylase 著者 Mileni, M, Martinez, A, Stevens, R.C. 登録日 2013-02-11 公開日 2013-10-02 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (3.08 Å) 主引用文献 The N-terminal sequence of tyrosine hydroxylase is a conformationally versatile motif that binds 14-3-3 proteins and membranes. J.Mol.Biol., 426, 2014
6GHP	14-3-3sigma in complex with a TASK3 peptide stabilized by semi-synthetic natural product FC-NAc 分子名称: 14-3-3 protein sigma, CHLORIDE ION, Potassium channel subfamily K member 9, ... 著者 Andrei, S.A, de Vink, P.J, Brunsveld, L, Ottmann, C, Higuchi, Y. 登録日 2018-05-08 公開日 2018-08-01 最終更新日 2018-10-17 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Rationally Designed Semisynthetic Natural Product Analogues for Stabilization of 14-3-3 Protein-Protein Interactions. Angew. Chem. Int. Ed. Engl., 57, 2018
4BG6	14-3-3 interaction with Rnd3 prenyl-phosphorylation motif 分子名称: 14-3-3 PROTEIN ZETA/DELTA, 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, FARNESYL, ... 著者 Riou, P, Kjaer, S, Purkiss, A, O'Reilly, N, McDonald, N.Q. 登録日 2013-03-23 公開日 2013-05-29 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 14-3-3 Proteins Interact with a Hybrid Prenyl-Phosphorylation Motif to Inhibit G Proteins. Cell(Cambridge,Mass.), 153, 2013
8EXH	Agrobacterium tumefaciens Tpilus 分子名称: (14S,17R)-20-amino-17-hydroxy-11,17-dioxo-12,16,18-trioxa-17lambda~5~-phosphaicosan-14-yl tetradecanoate, Protein virB2 著者 Beltran, L.C, Egelman, E.H. 登録日 2022-10-25 公開日 2023-03-22 最終更新日 2024-06-19 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 Archaeal DNA-import apparatus is homologous to bacterial conjugation machinery Nat Commun, 14, 2023
6CR2	Crystal structure of sterol 14-alpha demethylase (CYP51B) from Aspergillus fumigatus in complex with the VNI derivative N-(1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethyl)-4-(5-(2-fluoro-4-(2,2,2-trifluoroethoxy)phenyl)-1,3,4-oxadiazol-2-yl)benzamide 分子名称: 14-alpha sterol demethylase Cyp51B, N-[(1R)-1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethyl]-4-{5-[2-fluoro-4-(2,2,2-trifluoroethoxy)phenyl]-1,3,4-oxadiazol-2-yl}benzamide, PROTOPORPHYRIN IX CONTAINING FE 著者 Friggeri, L, Hargrove, T.Y, Wawrzak, Z, Lepesheva, G.I. 登録日 2018-03-16 公開日 2018-06-27 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.38 Å) 主引用文献 Sterol 14 alpha-Demethylase Structure-Based Design of VNI (( R)- N-(1-(2,4-Dichlorophenyl)-2-(1 H-imidazol-1-yl)ethyl)-4-(5-phenyl-1,3,4-oxadiazol-2-yl)benzamide)) Derivatives To Target Fungal Infections: Synthesis, Biological Evaluation, and Crystallographic Analysis. J. Med. Chem., 61, 2018
8C3C	14-3-3 sigma with Pin1 binding site pS72 and bound Fusicoccin A 分子名称: 14-3-3 protein sigma, FUSICOCCIN, MAGNESIUM ION, ... 著者 Verhoef, C.J, Cossar, P. 登録日 2022-12-23 公開日 2023-06-14 最終更新日 2023-07-05 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Tracking the mechanism of covalent molecular glue stabilization using native mass spectrometry. Chem Sci, 14, 2023
8C2G	14-3-3 sigma with Pin1 binding site pS72 and covalently bound CV1040 分子名称: 14-3-3 protein sigma, 2-iodanyl-4-(2-phenylimidazol-1-yl)benzaldehyde, MAGNESIUM ION, ... 著者 Verhoef, C.J, Cossar, P. 登録日 2022-12-22 公開日 2023-06-14 最終更新日 2023-07-05 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Tracking the mechanism of covalent molecular glue stabilization using native mass spectrometry. Chem Sci, 14, 2023
7A6R	Structure of 14-3-3 gamma in complex with DAPK2 peptide containing the 14-3-3 binding motif 分子名称: 14-3-3 protein gamma, DAPK2 C-terminal peptide 著者 Horvath, M, Obsilova, V, Obsil, T. 登録日 2020-08-26 公開日 2021-08-25 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 14-3-3 proteins inactivate DAPK2 by promoting its dimerization and protecting key regulatory phosphosites. Commun Biol, 4, 2021
7A6Y	Structure of 14-3-3 gamma in complex with DAPK2 peptide stabilized by FC-A 分子名称: 14-3-3 protein gamma, DAPK2 C-terminal peptide, FUSICOCCIN 著者 Horvath, M, Obsilova, V, Obsil, T. 登録日 2020-08-27 公開日 2021-08-25 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 14-3-3 proteins inactivate DAPK2 by promoting its dimerization and protecting key regulatory phosphosites. Commun Biol, 4, 2021
6GKF	Structure of 14-3-3 gamma in complex with caspase-2 14-3-3 binding motif Ser139 分子名称: 14-3-3 protein gamma, Caspase-2 著者 Alblova, M, Obsil, T, Obsilova, V. 登録日 2018-05-20 公開日 2018-10-17 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.598 Å) 主引用文献 14-3-3 protein masks the nuclear localization sequence of caspase-2. FEBS J., 285, 2018
6GKG	Structure of 14-3-3 gamma in complex with caspase-2 14-3-3 binding motif Ser164 分子名称: 14-3-3 protein gamma, Caspase-2 著者 Alblova, M, Obsil, T, Obsilova, V. 登録日 2018-05-20 公開日 2018-10-17 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.847 Å) 主引用文献 14-3-3 protein masks the nuclear localization sequence of caspase-2. FEBS J., 285, 2018
8C42	Ternary structure of 14-3-3sigma, PKA-responsive ERa phosphopeptide and Fusicoccin-A 分子名称: 14-3-3 protein sigma, De-acetylated Fusicoccin, Estrogen receptor, ... 著者 Somsen, B.A, Ottmann, C. 登録日 2022-12-30 公開日 2023-12-27 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Molecular basis and dual ligand regulation of tetrameric estrogen receptor alpha /14-3-3 zeta protein complex. J.Biol.Chem., 299, 2023
8C43	Ternary structure of 14-3-3sigma, strep-tagged PKA-responsive ERa phosphopeptide, and Fusicoccin-A. 分子名称: 14-3-3 protein sigma, De-acetylated Fusicoccin, Estrogen Receptor alpha phosphopeptide, ... 著者 Somsen, B.A, Ottmann, C. 登録日 2022-12-30 公開日 2023-12-27 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Molecular basis and dual ligand regulation of tetrameric estrogen receptor alpha /14-3-3 zeta protein complex. J.Biol.Chem., 299, 2023
3AXY	Structure of Florigen Activation Complex Consisting of Rice Florigen Hd3a, 14-3-3 Protein GF14 and Rice FD Homolog OsFD1 分子名称: 14-3-3-like protein GF14-C, Protein HEADING DATE 3A, Rice FD homolog OsFD1 著者 Ohki, I, Furuita, K, Hayashi, K, Taoka, K, Tsuji, H, Nakagawa, A, Shimamoto, K, Kojima, C. 登録日 2011-04-19 公開日 2011-08-03 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 14-3-3 proteins act as intracellular receptors for rice Hd3a florigen Nature, 476, 2011
7NMZ	Structure of 14-3-3 eta in complex with Nedd4-2(335-455) containing two 14-3-3 binding motifs Ser342 and Ser448 分子名称: 14-3-3 protein eta, E3 ubiquitin-protein ligase NEDD4-like 著者 Pohl, P, Obsil, T, Obsilova, V. 登録日 2021-02-23 公開日 2021-07-21 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.303 Å) 主引用文献 14-3-3-protein regulates Nedd4-2 by modulating interactions between HECT and WW domains. Commun Biol, 4, 2021

 

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