8E6H
 
 | | X-ray structure of the Deinococcus radiodurans Nramp/MntH divalent transition metal transporter A47W mutant in an occluded, manganese-bound state | | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... | | 著者 | Ray, S, Gaudet, R. | | 登録日 | 2022-08-22 | | 公開日 | 2023-05-03 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.39 Å) | | 主引用文献 | High-resolution structures with bound Mn 2+ and Cd 2+ map the metal import pathway in an Nramp transporter.
Elife, 12, 2023
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7M2T
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6UM9
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6ZW3
 | | Racemic compound of RNA duplexes. | | 分子名称: | RNA (5'-R(*(0C)P*(0C)P*(0G)P*(0C)P*(0C)P*(0U)P*(0G)P*(0G))-3'), RNA (5'-R(*(0C)P*(0U)P*(0G)P*(0G)P*(0G)P*(0C)P*(0G)P*(0G))-3'), RNA (5'-R(*CP*CP*GP*CP*CP*UP*GP*G)-3'), ... | | 著者 | Rypniewski, W. | | 登録日 | 2020-07-27 | | 公開日 | 2021-05-26 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.522 Å) | | 主引用文献 | Broken symmetry between RNA enantiomers in a crystal lattice.
Nucleic Acids Res., 49, 2021
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7MP6
 | | Neurofibromin homodimer | | 分子名称: | Isoform I of Neurofibromin | | 著者 | Lupton, C.J, Bayly-Jones, C, Ellisdon, A.M. | | 登録日 | 2021-05-04 | | 公開日 | 2021-12-15 | | 最終更新日 | 2024-05-29 | | 実験手法 | ELECTRON MICROSCOPY (6.25 Å) | | 主引用文献 | The cryo-EM structure of the human neurofibromin dimer reveals the molecular basis for neurofibromatosis type 1.
Nat.Struct.Mol.Biol., 28, 2021
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6MG5
 | | Structure of full-length human lambda-6A light chain JTO in complex with coumarin 1 | | 分子名称: | 7-(diethylamino)-4-methyl-2H-1-benzopyran-2-one, Light chain JTO, PHOSPHATE ION | | 著者 | Morgan, G.J, Yan, N.L, Mortenson, D.E, Stanfield, R.L, Wilson, I.A, Kelly, J.W. | | 登録日 | 2018-09-12 | | 公開日 | 2019-04-10 | | 最終更新日 | 2019-12-25 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Stabilization of amyloidogenic immunoglobulin light chains by small molecules.
Proc.Natl.Acad.Sci.USA, 116, 2019
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8E0P
 | | Crystal structure of mouse APCDD1 in fusion with engineered MBP | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 3-[BENZYL(DIMETHYL)AMMONIO]PROPANE-1-SULFONATE, CHLORIDE ION, ... | | 著者 | Hsieh, F.L, Chang, T.H, Gabelli, S.B, Nathans, J. | | 登録日 | 2022-08-09 | | 公開日 | 2023-05-03 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.33 Å) | | 主引用文献 | Structure of WNT inhibitor adenomatosis polyposis coli down-regulated 1 (APCDD1), a cell-surface lipid-binding protein.
Proc.Natl.Acad.Sci.USA, 120, 2023
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6P0F
 | | N-terminal domain of Thermococcus Gammatolerans McrB | | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, AMMONIUM ION, GTPase subunit of restriction endonuclease, ... | | 著者 | Hosford, C.J, Chappie, J.S. | | 登録日 | 2019-05-17 | | 公開日 | 2019-12-18 | | 最終更新日 | 2024-10-23 | | 実験手法 | X-RAY DIFFRACTION (1.683 Å) | | 主引用文献 | The structure of theThermococcus gammatoleransMcrB N-terminal domain reveals a new mode of substrate recognition and specificity among McrB homologs.
J.Biol.Chem., 295, 2020
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6TVJ
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8DXB
 | | HIV-1 reverse transcriptase/rilpivirine with bound fragment 5-fluoroindole-2-carboxylic acid at the NNRTI Adjacent site | | 分子名称: | 1,2-ETHANEDIOL, 4-{[4-({4-[(E)-2-cyanoethenyl]-2,6-dimethylphenyl}amino)pyrimidin-2-yl]amino}benzonitrile, 5-fluoroindole-2-carboxylic acid, ... | | 著者 | Chopra, A, Ruiz, F.X, Bauman, J.D, Arnold, E. | | 登録日 | 2022-08-02 | | 公開日 | 2023-05-31 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Halo Library, a Tool for Rapid Identification of Ligand Binding Sites on Proteins Using Crystallographic Fragment Screening.
J.Med.Chem., 66, 2023
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6P0J
 | | Crystal structure of GDP-bound human RalA | | 分子名称: | CALCIUM ION, GUANOSINE-5'-DIPHOSPHATE, Ras-related protein Ral-A | | 著者 | Bum-Erdene, K, Gonzalez-Gutierrez, G, Liu, D, Meroueh, S.O. | | 登録日 | 2019-05-17 | | 公開日 | 2020-03-04 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.31 Å) | | 主引用文献 | Small-molecule covalent bond formation at tyrosine creates a binding site and inhibits activation of Ral GTPases.
Proc.Natl.Acad.Sci.USA, 117, 2020
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6U79
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6MGA
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7MFI
 | | Bovine sigma-2 receptor bound to cholesterol | | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CHOLESTEROL, ... | | 著者 | Alon, A, Kruse, A.C. | | 登録日 | 2021-04-09 | | 公開日 | 2021-12-15 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.81 Å) | | 主引用文献 | Structures of the sigma 2 receptor enable docking for bioactive ligand discovery.
Nature, 600, 2021
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6ZY8
 | | Cryo-EM structure of the entire Human topoisomerase II alpha in State 2 | | 分子名称: | (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol -5-yl 4,6-O-[(1R)-ethylidene]-beta-D-glucopyranoside, DNA (5'-D(*CP*GP*CP*GP*CP*AP*TP*CP*GP*TP*CP*AP*TP*CP*CP*TP*C)-3'), DNA (5'-D(*GP*AP*GP*GP*AP*TP*GP*AP*CP*GP*AP*TP*G)-3'), ... | | 著者 | Vanden Broeck, A, Lamour, V. | | 登録日 | 2020-07-30 | | 公開日 | 2021-05-26 | | 最終更新日 | 2024-05-01 | | 実験手法 | ELECTRON MICROSCOPY (7.4 Å) | | 主引用文献 | Structural basis for allosteric regulation of Human Topoisomerase II alpha.
Nat Commun, 12, 2021
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6P0M
 | | Crystal structure of GDP-bound human RalA in a covalent complex with aryl sulfonyl fluoride compounds. | | 分子名称: | 4-[(3-chloropyridin-2-yl)sulfamoyl]benzene-1-sulfonic acid, CALCIUM ION, CHLORIDE ION, ... | | 著者 | Bum-Erdene, K, Gonzalez-Gutierrez, G, Liu, D, Ghozayel, M.K, Xu, D, Meroueh, S.O. | | 登録日 | 2019-05-17 | | 公開日 | 2020-03-04 | | 最終更新日 | 2024-10-30 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Small-molecule covalent bond formation at tyrosine creates a binding site and inhibits activation of Ral GTPases.
Proc.Natl.Acad.Sci.USA, 117, 2020
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7A1R
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6M8W
 | | PSEUDOMONAS SERINE-CARBOXYL PROTEINASE (SEDOLISIN) COMPLEXED WITH THE INHIBITOR AIAF | | 分子名称: | AIAF PEPTIDE INHIBITOR, CALCIUM ION, CHLORIDE ION, ... | | 著者 | Wlodawer, A, Li, M, Gustchina, A, Dauter, Z, Uchida, K, Oyama, H, Goldfarb, N.E, Dunn, B.M, Oda, K. | | 登録日 | 2018-08-22 | | 公開日 | 2018-10-24 | | 最終更新日 | 2019-12-04 | | 実験手法 | X-RAY DIFFRACTION (1.1 Å) | | 主引用文献 | Inhibitor complexes of the Pseudomonas serine-carboxyl proteinase
Biochemistry, 40, 2001
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8DXH
 | | HIV-1 reverse transcriptase/rilpivirine with bound fragment 5-fluoroquinazolin-4-ol at W266 site | | 分子名称: | 1,2-ETHANEDIOL, 4-{[4-({4-[(E)-2-cyanoethenyl]-2,6-dimethylphenyl}amino)pyrimidin-2-yl]amino}benzonitrile, 5-fluoranyl-3,4-dihydroquinazolin-4-ol, ... | | 著者 | Chopra, A, Ruiz, F.X, Bauman, J.D, Arnold, E. | | 登録日 | 2022-08-02 | | 公開日 | 2023-05-31 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Halo Library, a Tool for Rapid Identification of Ligand Binding Sites on Proteins Using Crystallographic Fragment Screening.
J.Med.Chem., 66, 2023
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6TWG
 | | Solution structure of antimicrobial peptide, crabrolin Plus in the presence of Lipopolysaccharide | | 分子名称: | Crabrolin Plus, mutant of Crabrolin peptide | | 著者 | Cantini, F, Bouchemal, N, Savarin, P, Sette, M. | | 登録日 | 2020-01-13 | | 公開日 | 2020-07-22 | | 最終更新日 | 2024-06-19 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Effect of positive charges in the structural interaction of crabrolin isoforms with lipopolysaccharide.
J.Pept.Sci., 26, 2020
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7M57
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6MCK
 | | p97 D1D2 with CB5083 bound | | 分子名称: | 1-[4-(benzylamino)-7,8-dihydro-5H-pyrano[4,3-d]pyrimidin-2-yl]-2-methyl-1H-indole-4-carboxamide, Transitional endoplasmic reticulum ATPase | | 著者 | Xia, D, Tang, W.K. | | 登録日 | 2018-08-31 | | 公開日 | 2019-01-23 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (3.77 Å) | | 主引用文献 | Structural Basis of p97 Inhibition by the Site-Selective Anticancer Compound CB-5083.
Mol. Pharmacol., 95, 2019
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6U3S
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6PE7
 | | Crystal Structure of ABBV-323 FAB | | 分子名称: | FAB Heavy Chain, FAB Light chain, SULFATE ION | | 著者 | Argiriadi, M.A. | | 登録日 | 2019-06-20 | | 公開日 | 2019-08-14 | | 最終更新日 | 2024-10-09 | | 実験手法 | X-RAY DIFFRACTION (1.74 Å) | | 主引用文献 | CD40/anti-CD40 antibody complexes which illustrate agonist and antagonist structural switches.
BMC Mol Cell Biol, 20, 2019
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7M1H
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