6PE7
Crystal Structure of ABBV-323 FAB
Summary for 6PE7
| Entry DOI | 10.2210/pdb6pe7/pdb |
| Descriptor | FAB Heavy Chain, FAB Light chain, SULFATE ION, ... (4 entities in total) |
| Functional Keywords | cd40, fab, immune system |
| Biological source | Homo sapiens (Human) More |
| Total number of polymer chains | 2 |
| Total formula weight | 48231.68 |
| Authors | Argiriadi, M.A. (deposition date: 2019-06-20, release date: 2019-08-14, Last modification date: 2024-10-09) |
| Primary citation | Argiriadi, M.A.,Benatuil, L.,Dubrovska, I.,Egan, D.A.,Gao, L.,Greischar, A.,Hardman, J.,Harlan, J.,Iyer, R.B.,Judge, R.A.,Lake, M.,Perron, D.C.,Sadhukhan, R.,Sielaff, B.,Sousa, S.,Wang, R.,McRae, B.L. CD40/anti-CD40 antibody complexes which illustrate agonist and antagonist structural switches. BMC Mol Cell Biol, 20:29-29, 2019 Cited by PubMed Abstract: CD40 is a 48 kDa type I transmembrane protein that is constitutively expressed on hematopoietic cells such as dendritic cells, macrophages, and B cells. Engagement of CD40 by CD40L expressed on T cells results in the production of proinflammatory cytokines, induces T helper cell function, and promotes macrophage activation. The involvement of CD40 in chronic immune activation has resulted in CD40 being proposed as a therapeutic target for a range of chronic inflammatory diseases. CD40 antagonists are currently being explored for the treatment of autoimmune diseases and several anti-CD40 agonist mAbs have entered clinical development for oncological indications. PubMed: 31382872DOI: 10.1186/s12860-019-0213-4 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.74 Å) |
Structure validation
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