PDB: 47038 件ウェブページステータス検索Chemie searchBIRD

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1VQJ	GENE V PROTEIN MUTANT WITH VAL 35 REPLACED BY ILE 35 (V35I) 分子名称: GENE V PROTEIN 著者 Zhang, H, Skinner, M.M, Sandberg, W.S, Wang, A.H.-J, Terwilliger, T.C. 登録日 1996-08-14 公開日 1997-02-12 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Context dependence of mutational effects in a protein: the crystal structures of the V35I, I47V and V35I/I47V gene V protein core mutants. J.Mol.Biol., 259, 1996
5O8U	Covalent Inhibitor 4b bound to the Lipid Pocket of p38alpha Mutant S252C 分子名称: 4-[3-[7-azanyl-4-(2-phenylethylamino)quinazolin-2-yl]phenyl]butan-2-one, Mitogen-activated protein kinase 14 著者 Buehrmann, M, Rauh, D. 登録日 2017-06-14 公開日 2017-09-06 最終更新日 2024-11-13 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Covalent Lipid Pocket Ligands Targeting p38 alpha MAPK Mutants. Angew. Chem. Int. Ed. Engl., 56, 2017
2CLX	4-Arylazo-3,5-diamino-1H-pyrazole CDK Inhibitors: SAR Study, Crystal Structure in Complex with CDK2, Selectivity, and Cellular Effects 分子名称: 4-[(E)-(3,5-DIAMINO-1H-PYRAZOL-4-YL)DIAZENYL]PHENOL, CELL DIVISION PROTEIN KINASE 2 著者 Krystof, V, Cankar, P, Frysova, I, Slouka, J, Kontopidis, G, Dzubak, P, Hajduch, M, Deazevedo, W.F, Paprskarova, M, Orsag, M, Rolcik, J, Latr, A, Fischer, P.M, Strnad, M. 登録日 2006-05-02 公開日 2006-11-01 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 4-Arylazo-3,5-Diamino-1H-Pyrazole Cdk Inhibitors: Sar Study, Crystal Structure in Complex with Cdk2, Selectivity, and Cellular Effects J.Med.Chem., 49, 2006
2C6M	Crystal structure of the human CDK2 complexed with the triazolopyrimidine inhibitor 分子名称: 4-{[5-(CYCLOHEXYLOXY)[1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-7-YL]AMINO}BENZENESULFONAMIDE, CELL DIVISION PROTEIN KINASE 2 著者 Richardson, C.M, Dokurno, P, Murray, J.B, Surgenor, A.E. 登録日 2005-11-10 公開日 2005-12-07 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Triazolo[1,5-A]Pyrimidines as Novel Cdk2 Inhibitors: Protein Structure-Guided Design and Sar. Bioorg.Med.Chem.Lett., 16, 2006
5O8V	Covalent Inhibitor 4a bound to the Lipid Pocket of p38alpha Mutant S251C 分子名称: Mitogen-activated protein kinase 14, ~{N}-[3-[7-azanyl-4-(2-phenylethylamino)quinazolin-2-yl]phenyl]propanamide 著者 Buehrmann, M, Rauh, D. 登録日 2017-06-14 公開日 2017-09-06 最終更新日 2024-10-23 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Covalent Lipid Pocket Ligands Targeting p38 alpha MAPK Mutants. Angew. Chem. Int. Ed. Engl., 56, 2017
5O90	Crystal structure of a P38alpha T185G mutant in complex with TAB1 peptide. 分子名称: 4-(4-FLUOROPHENYL)-1-(4-PIPERIDINYL)-5-(2-AMINO-4-PYRIMIDINYL)-IMIDAZOLE, Mitogen-activated protein kinase 14, TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 著者 Nichols, C.E, De Nicola, G.F, Thapa, D. 登録日 2017-06-15 公開日 2018-01-31 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.49 Å) 主引用文献 TAB1-Induced Autoactivation of p38 alpha Mitogen-Activated Protein Kinase Is Crucially Dependent on Threonine 185. Mol. Cell. Biol., 38, 2018
5OMG	p38alpha in complex with pyrazolobenzothiazine inhibitor COXP4M12 分子名称: 3-(4-fluorophenyl)-4-methyl-1~{H}-pyrazolo[4,3-c][1,2]benzothiazine 5,5-dioxide, Mitogen-activated protein kinase 14, octyl beta-D-glucopyranoside 著者 Buehrmann, M, Rauh, D. 登録日 2017-07-31 公開日 2019-03-13 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Co-crystal structure determination and cellular evaluation of 1,4-dihydropyrazolo[4,3-c] [1,2] benzothiazine 5,5-dioxide p38 alpha MAPK inhibitors. Biochem.Biophys.Res.Commun., 511, 2019
5FTK	Cryo-EM structure of human p97 bound to ADP 分子名称: ADENOSINE-5'-DIPHOSPHATE, TRANSITIONAL ENDOPLASMIC RETICULUM ATPASE 著者 Banerjee, S, Bartesaghi, A, Merk, A, Rao, P, Bulfer, S.L, Yan, Y, Green, N, Mroczkowski, B, Neitz, R.J, Wipf, P, Falconieri, V, Deshaies, R.J, Milne, J.L.S, Huryn, D, Arkin, M, Subramaniam, S. 登録日 2016-01-14 公開日 2016-01-27 最終更新日 2024-05-08 実験手法 ELECTRON MICROSCOPY (2.4 Å) 主引用文献 2.3 A Resolution Cryo-Em Structure of Human P97 and Mechanism of Allosteric Inhibition Science, 351, 2016
9AX8	70S initiation complex (tRNA-fMet M1, initiation factor 2 + CUG start codon) 分子名称: 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... 著者 Mattingly, J.M, Nguyen, H.A, Dunham, C.M. 登録日 2024-03-06 公開日 2024-09-18 最終更新日 2024-10-23 実験手法 ELECTRON MICROSCOPY (2.6 Å) 主引用文献 Structural analysis of noncanonical translation initiation complexes. J.Biol.Chem., 300, 2024
2EXU	Crystal Structure of Saccharomyces cerevisiae transcription elongation factors Spt4-Spt5NGN domain 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, ETHANOL, Transcription initiation protein SPT4/SPT5, ... 著者 Xu, F, Guo, M, Fang, P, Teng, M, Niu, L. 登録日 2005-11-08 公開日 2006-11-08 最終更新日 2024-10-30 実験手法 X-RAY DIFFRACTION (2.23 Å) 主引用文献 Crystal Structure of Saccharomyces cerevisiae transcription elongation factors Spt4-Spt5NGN domain To be published
1VQG	GENE V PROTEIN MUTANT WITH ILE 47 REPLACED BY LEU 47 (I47L) 分子名称: GENE V PROTEIN 著者 Skinner, M.M, Terwilliger, T.C. 登録日 1996-08-14 公開日 1997-02-12 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (1.82 Å) 主引用文献 Potential use of additivity of mutational effects in simplifying protein engineering. Proc.Natl.Acad.Sci.USA, 93, 1996
1VQI	GENE V PROTEIN MUTANT WITH ILE 47 REPLACED BY VAL 47 (I47V) 分子名称: GENE V PROTEIN 著者 Zhang, H, Skinner, M.M, Sandberg, W.S, Wang, A.H.-J, Terwilliger, T.C. 登録日 1996-08-14 公開日 1997-02-12 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Context dependence of mutational effects in a protein: the crystal structures of the V35I, I47V and V35I/I47V gene V protein core mutants. J.Mol.Biol., 259, 1996
1VQD	GENE V PROTEIN MUTANT WITH VAL 35 REPLACED BY ILE 35 AND ILE 47 REPLACED BY LEU 47 (V35I, I47L) 分子名称: GENE V PROTEIN 著者 Skinner, M.M, Terwilliger, T.C. 登録日 1996-08-14 公開日 1997-02-12 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (1.82 Å) 主引用文献 Potential use of additivity of mutational effects in simplifying protein engineering. Proc.Natl.Acad.Sci.USA, 93, 1996
1VQF	GENE V PROTEIN MUTANT WITH VAL 35 REPLACED BY ILE 35 AND ILE 47 REPLACED BY VAL 47 (V35I, I47V) 分子名称: GENE V PROTEIN 著者 Zhang, H, Skinner, M.M, Sandberg, W.S, Wang, A.H.-J, Terwilliger, T.C. 登録日 1996-08-14 公開日 1997-02-12 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Context dependence of mutational effects in a protein: the crystal structures of the V35I, I47V and V35I/I47V gene V protein core mutants. J.Mol.Biol., 259, 1996
1VQE	GENE V PROTEIN MUTANT WITH VAL 35 REPLACED BY ILE 35 AND ILE 47 REPLACED BY MET 47 (V35I, I47M) 分子名称: GENE V PROTEIN 著者 Skinner, M.M, Terwilliger, T.C. 登録日 1996-08-14 公開日 1997-02-12 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Potential use of additivity of mutational effects in simplifying protein engineering. Proc.Natl.Acad.Sci.USA, 93, 1996
1VQC	GENE V PROTEIN MUTANT WITH VAL 35 REPLACED BY ILE 35 AND ILE 47 REPLACED BY PHE 47 (V35I, I47F) 分子名称: GENE V PROTEIN 著者 Skinner, M.M, Terwilliger, T.C. 登録日 1996-08-14 公開日 1997-02-12 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Potential use of additivity of mutational effects in simplifying protein engineering. Proc.Natl.Acad.Sci.USA, 93, 1996
5KF6	Structure of proline utilization A from Sinorhizobium meliloti complexed with L-tetrahydrofuroic acid and NAD+ in space group P21 分子名称: Bifunctional protein PutA, FLAVIN-ADENINE DINUCLEOTIDE, MAGNESIUM ION, ... 著者 Tanner, J.J. 登録日 2016-06-12 公開日 2016-10-05 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Structures of Proline Utilization A (PutA) Reveal the Fold and Functions of the Aldehyde Dehydrogenase Superfamily Domain of Unknown Function. J.Biol.Chem., 291, 2016
4O0M	Crystal structure of T. Elongatus BP-1 Clock Protein KaiC 分子名称: ADENOSINE-5'-TRIPHOSPHATE, Circadian clock protein kinase KaiC, MAGNESIUM ION 著者 Pattanayek, R, Egli, M. 登録日 2013-12-13 公開日 2014-05-14 最終更新日 2024-10-30 実験手法 X-RAY DIFFRACTION (2.84 Å) 主引用文献 An arginine tetrad as mediator of input-dependent and input-independent ATPases in the clock protein KaiC Acta Crystallogr.,Sect.D, D70, 2014
2FVD	Cyclin Dependent Kinase 2 (CDK2) with diaminopyrimidine inhibitor 分子名称: (4-AMINO-2-{[1-(METHYLSULFONYL)PIPERIDIN-4-YL]AMINO}PYRIMIDIN-5-YL)(2,3-DIFLUORO-6-METHOXYPHENYL)METHANONE, Cell division protein kinase 2 著者 Crowther, R.L, Lukacs, C.M, Kammlott, R.U. 登録日 2006-01-30 公開日 2006-10-10 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Discovery of [4-Amino-2-(1-methanesulfonylpiperidin-4-ylamino)pyrimidin-5-yl](2,3-difluoro-6- methoxyphenyl)methanone (R547), a potent and selective cyclin-dependent kinase inhibitor with significant in vivo antitumor activity. J.Med.Chem., 49, 2006
5R8V	PanDDA analysis group deposition Form1 MAP kinase p38-alpha -- Fragment N09139b in complex with MAP kinase p38-alpha 分子名称: CHLORIDE ION, DIMETHYL SULFOXIDE, MAGNESIUM ION, ... 著者 De Nicola, G.F, Nichols, C.E. 登録日 2020-03-04 公開日 2020-07-22 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (1.479 Å) 主引用文献 Mining the PDB for Tractable Cases Where X-ray Crystallography Combined with Fragment Screens Can Be Used to Systematically Design Protein-Protein Inhibitors: Two Test Cases Illustrated by IL1 beta-IL1R and p38 alpha-TAB1 Complexes. J.Med.Chem., 63, 2020
5R9A	PanDDA analysis group deposition Form1 MAP kinase p38-alpha -- Fragment N13838a in complex with MAP kinase p38-alpha 分子名称: 4-benzamido-2-methyl-pyrazole-3-carboxamide, CHLORIDE ION, GLYCEROL, ... 著者 De Nicola, G.F, Nichols, C.E. 登録日 2020-03-04 公開日 2020-07-22 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (1.53 Å) 主引用文献 Mining the PDB for Tractable Cases Where X-ray Crystallography Combined with Fragment Screens Can Be Used to Systematically Design Protein-Protein Inhibitors: Two Test Cases Illustrated by IL1 beta-IL1R and p38 alpha-TAB1 Complexes. J.Med.Chem., 63, 2020
5R9Q	PanDDA analysis group deposition Form1 MAP kinase p38-alpha -- Fragment N07422b in complex with MAP kinase p38-alpha 分子名称: 1-phenylmethoxyurea, CHLORIDE ION, Mitogen-activated protein kinase 14, ... 著者 De Nicola, G.F, Nichols, C.E. 登録日 2020-03-04 公開日 2020-07-22 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (1.645 Å) 主引用文献 Mining the PDB for Tractable Cases Where X-ray Crystallography Combined with Fragment Screens Can Be Used to Systematically Design Protein-Protein Inhibitors: Two Test Cases Illustrated by IL1 beta-IL1R and p38 alpha-TAB1 Complexes. J.Med.Chem., 63, 2020
5RA5	PanDDA analysis group deposition Form1 MAP kinase p38-alpha -- Fragment N11302a in complex with MAP kinase p38-alpha 分子名称: (1~{S},5~{R})-8-methyl-8-azabicyclo[3.2.1]octan-3-amine, CHLORIDE ION, DIMETHYL SULFOXIDE, ... 著者 De Nicola, G.F, Nichols, C.E. 登録日 2020-03-04 公開日 2020-07-22 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (1.54 Å) 主引用文献 Mining the PDB for Tractable Cases Where X-ray Crystallography Combined with Fragment Screens Can Be Used to Systematically Design Protein-Protein Inhibitors: Two Test Cases Illustrated by IL1 beta-IL1R and p38 alpha-TAB1 Complexes. J.Med.Chem., 63, 2020
5R93	PanDDA analysis group deposition Form1 MAP kinase p38-alpha -- Fragment KCL077 in complex with MAP kinase p38-alpha 分子名称: CHLORIDE ION, DIMETHYL SULFOXIDE, MAGNESIUM ION, ... 著者 De Nicola, G.F, Nichols, C.E. 登録日 2020-03-04 公開日 2020-07-22 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (1.489 Å) 主引用文献 Mining the PDB for Tractable Cases Where X-ray Crystallography Combined with Fragment Screens Can Be Used to Systematically Design Protein-Protein Inhibitors: Two Test Cases Illustrated by IL1 beta-IL1R and p38 alpha-TAB1 Complexes. J.Med.Chem., 63, 2020
5R9K	PanDDA analysis group deposition Form1 MAP kinase p38-alpha -- Fragment N14246a in complex with MAP kinase p38-alpha 分子名称: 2,3-dihydro-1-benzoxepine-5-carboxylic acid, CHLORIDE ION, DIMETHYL SULFOXIDE, ... 著者 De Nicola, G.F, Nichols, C.E. 登録日 2020-03-04 公開日 2020-07-22 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (1.498 Å) 主引用文献 Mining the PDB for Tractable Cases Where X-ray Crystallography Combined with Fragment Screens Can Be Used to Systematically Design Protein-Protein Inhibitors: Two Test Cases Illustrated by IL1 beta-IL1R and p38 alpha-TAB1 Complexes. J.Med.Chem., 63, 2020

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