5OMG
p38alpha in complex with pyrazolobenzothiazine inhibitor COXP4M12
Summary for 5OMG
Entry DOI | 10.2210/pdb5omg/pdb |
Descriptor | Mitogen-activated protein kinase 14, octyl beta-D-glucopyranoside, 3-(4-fluorophenyl)-4-methyl-1~{H}-pyrazolo[4,3-c][1,2]benzothiazine 5,5-dioxide, ... (4 entities in total) |
Functional Keywords | p38, kinase, inhibitor, pyrazolobenzothiazine, complex, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 41964.91 |
Authors | Buehrmann, M.,Rauh, D. (deposition date: 2017-07-31, release date: 2019-03-13, Last modification date: 2024-05-08) |
Primary citation | Bartolini, D.,Buhrmann, M.,Barreca, M.L.,Manfroni, G.,Cecchetti, V.,Rauh, D.,Galli, F. Co-crystal structure determination and cellular evaluation of 1,4-dihydropyrazolo[4,3-c] [1,2] benzothiazine 5,5-dioxide p38 alpha MAPK inhibitors. Biochem.Biophys.Res.Commun., 511:579-586, 2019 Cited by PubMed: 30824186DOI: 10.1016/j.bbrc.2019.02.063 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
Download full validation report