8IK5
 
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8IKE
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8IKH
 | | Cryo-EM structure of human receptor with G proteins | | 分子名称: | 3-[(1R)-1-(2-methoxyphenyl)-2-nitro-ethyl]-2-phenyl-1H-indole, Cannabinoid receptor 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | 著者 | Shen, S.Y, Shao, Z.H. | | 登録日 | 2023-02-28 | | 公開日 | 2024-06-05 | | 最終更新日 | 2024-07-17 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Structure-based identification of a G protein-biased allosteric modulator of cannabinoid receptor CB1.
Proc.Natl.Acad.Sci.USA, 121, 2024
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8IKG
 | | Cryo-EM structure of human receptor with G proteins | | 分子名称: | 3-[(1S)-1-(furan-2-yl)-2-nitro-ethyl]-2-phenyl-1H-indole, Cannabinoid receptor 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | 著者 | Shen, S.Y, Shao, Z.H. | | 登録日 | 2023-02-28 | | 公開日 | 2024-06-05 | | 最終更新日 | 2024-07-17 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Structure-based identification of a G protein-biased allosteric modulator of cannabinoid receptor CB1.
Proc.Natl.Acad.Sci.USA, 121, 2024
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8IJD
 | | Cryo-EM structure of human HCAR2-Gi complex with MK-6892 | | 分子名称: | 2-[[2,2-dimethyl-3-[3-(5-oxidanylpyridin-2-yl)-1,2,4-oxadiazol-5-yl]propanoyl]amino]cyclohexene-1-carboxylic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Pan, X, Fang, Y. | | 登録日 | 2023-02-27 | | 公開日 | 2024-01-03 | | 実験手法 | ELECTRON MICROSCOPY (3.25 Å) | | 主引用文献 | Structural insights into ligand recognition and selectivity of the human hydroxycarboxylic acid receptor HCAR2.
Cell Discov, 9, 2023
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8IJB
 | | Cryo-EM structure of human HCAR2-Gi complex with acipimox | | 分子名称: | 5-methyl-4-oxidanyl-pyrazin-4-ium-2-carboxylic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Pan, X, Fang, Y. | | 登録日 | 2023-02-27 | | 公開日 | 2024-01-03 | | 実験手法 | ELECTRON MICROSCOPY (3.23 Å) | | 主引用文献 | Structural insights into ligand recognition and selectivity of the human hydroxycarboxylic acid receptor HCAR2.
Cell Discov, 9, 2023
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8IJA
 | | Cryo-EM structure of human HCAR2-Gi complex with niacin | | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | | 著者 | Pan, X, Fang, Y. | | 登録日 | 2023-02-26 | | 公開日 | 2024-01-03 | | 実験手法 | ELECTRON MICROSCOPY (2.69 Å) | | 主引用文献 | Structural insights into ligand recognition and selectivity of the human hydroxycarboxylic acid receptor HCAR2.
Cell Discov, 9, 2023
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8IJ9
 | | Crystal structure of the ELKS1/Rab6B complex | | 分子名称: | ELKS/Rab6-interacting/CAST family member 1, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | | 著者 | Jin, G, Wei, Z. | | 登録日 | 2023-02-26 | | 公開日 | 2023-06-14 | | 最終更新日 | 2024-05-29 | | 実験手法 | X-RAY DIFFRACTION (2.04 Å) | | 主引用文献 | Structural basis of ELKS/Rab6B interaction and its role in vesicle capturing enhanced by liquid-liquid phase separation.
J.Biol.Chem., 299, 2023
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8IJ3
 | | Cryo-EM structure of human HCAR2-Gi complex without ligand (apo state) | | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | | 著者 | Pan, X, Fang, Y. | | 登録日 | 2023-02-24 | | 公開日 | 2024-01-03 | | 実験手法 | ELECTRON MICROSCOPY (3.28 Å) | | 主引用文献 | Structural insights into ligand recognition and selectivity of the human hydroxycarboxylic acid receptor HCAR2.
Cell Discov, 9, 2023
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8GB3
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8IHP
 | | Structure of Semliki Forest virus VLP in complex with the receptor VLDLR-LA3 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Capsid protein, ... | | 著者 | Cao, D, Ma, B, Cao, Z, Zhang, X, Xiang, Y. | | 登録日 | 2023-02-23 | | 公開日 | 2023-04-12 | | 最終更新日 | 2023-05-24 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Structure of Semliki Forest virus in complex with its receptor VLDLR.
Cell, 186, 2023
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8CNN
 | | BeF3 Phospho-HRas GSA complex | | 分子名称: | ACETATE ION, BERYLLIUM TRIFLUORIDE ION, DI(HYDROXYETHYL)ETHER, ... | | 著者 | Baumann, P, Jin, Y. | | 登録日 | 2023-02-23 | | 公開日 | 2023-09-27 | | 最終更新日 | 2024-04-10 | | 実験手法 | X-RAY DIFFRACTION (1.48 Å) | | 主引用文献 | Far-reaching effects of tyrosine64 phosphorylation on Ras revealed with BeF 3 - complexes.
Commun Chem, 7, 2024
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8CNJ
 | | HRas(1-166) in complex with GDP and BeF3- | | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, BERYLLIUM TRIFLUORIDE ION, GTPase HRas, ... | | 著者 | Baumann, P, Jin, Y. | | 登録日 | 2023-02-23 | | 公開日 | 2023-09-27 | | 最終更新日 | 2024-04-10 | | 実験手法 | X-RAY DIFFRACTION (1.35 Å) | | 主引用文献 | Far-reaching effects of tyrosine64 phosphorylation on Ras revealed with BeF 3 - complexes.
Commun Chem, 7, 2024
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8GAP
 | | Structure of LARP7 protein p65-telomerase RNA complex in telomerase | | 分子名称: | Telomerase La-related protein p65, Telomerase RNA, Telomerase associated protein p50, ... | | 著者 | Wang, Y, He, Y, Wang, Y, Yang, Y, Singh, M, Eichhorn, C.D, Zhou, Z.H, Feigon, J. | | 登録日 | 2023-02-23 | | 公開日 | 2023-06-28 | | 最終更新日 | 2024-06-19 | | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | | 主引用文献 | Structure of LARP7 Protein p65-telomerase RNA Complex in Telomerase Revealed by Cryo-EM and NMR.
J.Mol.Biol., 435, 2023
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8GAT
 | | Structure of human NDS.1 Fab and 1G01 Fab in complex with influenza virus neuraminidase from A/Indiana/10/2011 (H3N2v), based on consensus cryo-EM map with only Fab 1G01 resolved | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Fab 1G01, heavy chain, ... | | 著者 | Tsybovsky, Y, Lederhofer, J, Kwong, P.D, Kanekiyo, M. | | 登録日 | 2023-02-23 | | 公開日 | 2024-02-28 | | 最終更新日 | 2024-04-24 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Protective human monoclonal antibodies target conserved sites of vulnerability on the underside of influenza virus neuraminidase.
Immunity, 57, 2024
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8GAU
 | | Structure of human NDS.1 Fab and 1G01 Fab in complex with influenza virus neuraminidase from A/Indiana/10/2011 (H3N2v) | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Fab 1G01, heavy chain, ... | | 著者 | Tsybovsky, Y, Lederhofer, J, Kwong, P.D, Kanekiyo, M. | | 登録日 | 2023-02-23 | | 公開日 | 2024-02-28 | | 最終更新日 | 2024-04-24 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | Protective human monoclonal antibodies target conserved sites of vulnerability on the underside of influenza virus neuraminidase.
Immunity, 57, 2024
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8GAV
 | | Structure of human NDS.3 Fab in complex with influenza virus neuraminidase from A/Darwin/09/2021 (H3N2) | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Fab NDS.3, heavy chain, ... | | 著者 | Tsybovsky, Y, Lederhofer, J, Kwong, P.D, Kanekiyo, M. | | 登録日 | 2023-02-23 | | 公開日 | 2024-02-28 | | 最終更新日 | 2024-04-24 | | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | | 主引用文献 | Protective human monoclonal antibodies target conserved sites of vulnerability on the underside of influenza virus neuraminidase.
Immunity, 57, 2024
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8IHJ
 | | Cryo-EM structure of HCA3-Gi complex with acifran | | 分子名称: | (5~{S})-5-methyl-4-oxidanylidene-5-phenyl-furan-2-carboxylic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Suzuki, S, Nishikawa, K, Suzuki, H, Fujiyoshi, Y. | | 登録日 | 2023-02-22 | | 公開日 | 2023-08-30 | | 最終更新日 | 2023-12-06 | | 実験手法 | ELECTRON MICROSCOPY (3.07 Å) | | 主引用文献 | Structural basis of hydroxycarboxylic acid receptor signaling mechanisms through ligand binding.
Nat Commun, 14, 2023
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8IHB
 | | Cryo-EM structure of HCA2-Gi complex with GSK256073 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 8-chloranyl-3-pentyl-7H-purine-2,6-dione, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | 著者 | Suzuki, S, Nishikawa, K, Suzuki, H, Fujiyoshi, Y. | | 登録日 | 2023-02-22 | | 公開日 | 2023-09-13 | | 最終更新日 | 2023-12-06 | | 実験手法 | ELECTRON MICROSCOPY (2.85 Å) | | 主引用文献 | Structural basis of hydroxycarboxylic acid receptor signaling mechanisms through ligand binding.
Nat Commun, 14, 2023
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8IHI
 | | Cryo-EM structure of HCA2-Gi complex with acifran | | 分子名称: | (5~{S})-5-methyl-4-oxidanylidene-5-phenyl-furan-2-carboxylic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | 著者 | Suzuki, S, Nishikawa, K, Suzuki, H, Fujiyoshi, Y. | | 登録日 | 2023-02-22 | | 公開日 | 2023-08-30 | | 最終更新日 | 2023-12-06 | | 実験手法 | ELECTRON MICROSCOPY (3.11 Å) | | 主引用文献 | Structural basis of hydroxycarboxylic acid receptor signaling mechanisms through ligand binding.
Nat Commun, 14, 2023
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8IHK
 | | Cryo-EM structure of HCA3-Gi complex with acifran (local) | | 分子名称: | (5~{S})-5-methyl-4-oxidanylidene-5-phenyl-furan-2-carboxylic acid, Soluble cytochrome b562,Hydroxycarboxylic acid receptor 3 | | 著者 | Suzuki, S, Nishikawa, K, Suzuki, H, Fujiyoshi, Y. | | 登録日 | 2023-02-22 | | 公開日 | 2023-08-30 | | 最終更新日 | 2023-12-06 | | 実験手法 | ELECTRON MICROSCOPY (3.21 Å) | | 主引用文献 | Structural basis of hydroxycarboxylic acid receptor signaling mechanisms through ligand binding.
Nat Commun, 14, 2023
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8IHH
 | | Cryo-EM structure of HCA2-Gi complex with LUF6283 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 5-butyl-1~{H}-pyrazole-3-carboxylic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | 著者 | Suzuki, S, Nishikawa, K, Suzuki, H, Fujiyoshi, Y. | | 登録日 | 2023-02-22 | | 公開日 | 2023-08-30 | | 最終更新日 | 2023-12-06 | | 実験手法 | ELECTRON MICROSCOPY (3.06 Å) | | 主引用文献 | Structural basis of hydroxycarboxylic acid receptor signaling mechanisms through ligand binding.
Nat Commun, 14, 2023
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8IHF
 | | Cryo-EM structure of HCA2-Gi complex with MK6892 | | 分子名称: | 2-[[2,2-dimethyl-3-[3-(5-oxidanylpyridin-2-yl)-1,2,4-oxadiazol-5-yl]propanoyl]amino]cyclohexene-1-carboxylic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | 著者 | Suzuki, S, Nishikawa, K, Suzuki, H, Fujiyoshi, Y. | | 登録日 | 2023-02-22 | | 公開日 | 2023-08-30 | | 最終更新日 | 2023-12-06 | | 実験手法 | ELECTRON MICROSCOPY (2.97 Å) | | 主引用文献 | Structural basis of hydroxycarboxylic acid receptor signaling mechanisms through ligand binding.
Nat Commun, 14, 2023
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8GAE
 | | Hsp90 provides platform for CRaf dephosphorylation by PP5 | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Heat shock protein HSP 90-beta, ... | | 著者 | Jaime-Garza, M, Nowotny, C.A, Coutandin, D, Wang, F, Tabios, M, Agard, D.A. | | 登録日 | 2023-02-22 | | 公開日 | 2023-04-26 | | 最終更新日 | 2023-05-03 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Hsp90 provides a platform for kinase dephosphorylation by PP5.
Nat Commun, 14, 2023
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8GAG
 | | Cannabinoid receptor 1-Gi complex with novel ligand | | 分子名称: | Cannabinoid receptor 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Tummino, T.A, Iliopoulos-Tsoutsouvas, C, Braz, J.M, O'Brien, E.S, Krishna Kumar, K, Makriyannis, M, Basbaum, A.I, Shoichet, B.K. | | 登録日 | 2023-02-22 | | 公開日 | 2024-02-28 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Cannabinoid receptor 1-Gi complex with novel ligand
To Be Published
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