PDB: 37722 件ウェブページステータス検索Chemie searchBIRD

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8W0F	Cryo-EM structure of a human MCM2-7 double hexamer on dsDNA 分子名称: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, DNA (47-MER), ... 著者 Hunker, O, Yang, R, Bleichert, F. 登録日 2024-02-13 公開日 2024-10-02 実験手法 ELECTRON MICROSCOPY (2.8 Å) 主引用文献 Multiple pathways for licensing human replication origins To Be Published
4LB5	Crystal structure of PKZ Zalpha in complex with ds(CG)6 (hexagonal form) 分子名称: 5'-D(*TP*CP*GP*CP*GP*CP*GP*CP*GP*CP*GP*CP*G)-3', ACETATE ION, Protein kinase containing Z-DNA binding domains 著者 De Rosa, M, Zacarias, S, Athanasiadis, A. 登録日 2013-06-20 公開日 2013-09-18 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural basis for Z-DNA binding and stabilization by the zebrafish Z-DNA dependent protein kinase PKZ. Nucleic Acids Res., 41, 2013
4FWF	Complex structure of LSD2/AOF1/KDM1b with H3K4 mimic 分子名称: FLAVIN-ADENINE DINUCLEOTIDE, Histone H3.1, Lysine-specific histone demethylase 1B, ... 著者 Zhang, Q, Chen, Z. 登録日 2012-07-01 公開日 2013-01-16 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Structure-function analysis reveals a novel mechanism for regulation of histone demethylase LSD2/AOF1/KDM1b Cell Res., 23, 2013
4M6X	Mutant structure of methyltransferase from Streptomyces hygroscopicus complexed with S-adenosyl-L-homocysteine and methylphenylpyruvic acid 分子名称: (2R)-2-hydroxy-3-phenylpropanoic acid, (3R)-2-oxo-3-phenylbutanoic acid, CALCIUM ION, ... 著者 Liu, Y.C, Zou, X.W, Chan, H.C, Huang, C.J, Li, T.L. 登録日 2013-08-12 公開日 2014-06-25 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structure and mechanism of a nonhaem-iron SAM-dependent C-methyltransferase and its engineering to a hydratase and an O-methyltransferase Acta Crystallogr.,Sect.D, 70, 2014
3S73	The origin of the hydrophobic effect in the molecular recognition of arylsulfonamides by carbonic anhydrase 分子名称: 1,3-benzothiazole-2-sulfonamide, Carbonic anhydrase 2, ZINC ION 著者 Snyder, P.W, Heroux, A, Whitesides, G.W. 登録日 2011-05-26 公開日 2011-12-21 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Mechanism of the hydrophobic effect in the biomolecular recognition of arylsulfonamides by carbonic anhydrase. Proc.Natl.Acad.Sci.USA, 108, 2011
5X8B	Crystal structure of ATP-TMP and ADP bound thymidylate kinase from Thermus thermophilus HB8 分子名称: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... 著者 Chaudhary, S.K, Jeyakanthan, J, Sekar, K. 登録日 2017-03-01 公開日 2018-03-14 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.39 Å) 主引用文献 Structural and functional roles of dynamically correlated residues in thymidylate kinase. Acta Crystallogr D Struct Biol, 74, 2018
5X8V	Y92H mutant of thermus thermophilus HB8 thymidylate kinase 分子名称: CHLORIDE ION, SODIUM ION, Thymidylate kinase 著者 Chaudhary, S.K, Jeyakanthan, J, Sekar, K. 登録日 2017-03-03 公開日 2018-03-14 最終更新日 2024-03-27 実験手法 X-RAY DIFFRACTION (1.66 Å) 主引用文献 Structural and functional roles of dynamically correlated residues in thymidylate kinase. Acta Crystallogr D Struct Biol, 74, 2018
5X98	Y162F mutant of thermus thermophilus HB8 thymidylate kinase 分子名称: FORMIC ACID, MAGNESIUM ION, Thymidylate kinase 著者 Chaudhary, S.K, Jeyakanthan, J, Sekar, K. 登録日 2017-03-05 公開日 2018-03-14 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.76 Å) 主引用文献 Structural and functional roles of dynamically correlated residues in thymidylate kinase. Acta Crystallogr D Struct Biol, 74, 2018
4PJJ	MYOSIN VI (MD-INSERT2-CAM, DELTA-INSERT1) post-rigor state - long soaking with PO4 分子名称: ADENOSINE-5'-DIPHOSPHATE, CALCIUM ION, Calmodulin, ... 著者 Isabet, T, Benisty, H, Llinas, P, Sweeney, H.L, Houdusse, A. 登録日 2014-05-12 公開日 2015-04-29 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 How actin initiates the motor activity of Myosin. Dev.Cell, 33, 2015
5ZX2	Mycobacterium tuberculosis RNA polymerase transcription initiation complex with ECF sigma factor sigma H and 7nt RNA 分子名称: DNA (47-MER), DNA (48-MER), DNA-directed RNA polymerase subunit alpha, ... 著者 Li, L, Zhang, Y. 登録日 2018-05-17 公開日 2019-03-20 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Structural basis for transcription initiation by bacterial ECF sigma factors. Nat Commun, 10, 2019
4PLN	Crystal Structure of Chicken Netrin-1 (LN-LE3) complexed with mouse Neogenin (FN4-5) 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Neogenin, ... 著者 Xu, K, Nikolov, D.B. 登録日 2014-05-18 公開日 2014-06-18 最終更新日 2024-10-30 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Neural migration. Structures of netrin-1 bound to two receptors provide insight into its axon guidance mechanism. Science, 344, 2014
4POK	Crystal structures of thioredoxin with mesna at 2.5A resolution 分子名称: 1-THIOETHANESULFONIC ACID, Thioredoxin 著者 Sridhar, V, Chie-Leon, B, Badger, J, Nienaber, V.L, Hausheer, F.H. 登録日 2014-02-25 公開日 2014-10-29 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.52 Å) 主引用文献 BNP7787 Forms Novel Covalent Adducts on Human Thioredoxin and Modulates Thioredoxin Activity J Pharmacol Clin Toxicol, 2, 2014
3S71	The origin of the hydrophobic effect in the molecular recognition of arylsulfonamides by carbonic anhydrase 分子名称: 1-benzofuran-2-sulfonamide, Carbonic anhydrase 2, ZINC ION 著者 Snyder, P.W, Heroux, A, Whitesides, G.W. 登録日 2011-05-26 公開日 2011-10-19 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.25 Å) 主引用文献 Mechanism of the hydrophobic effect in the biomolecular recognition of arylsulfonamides by carbonic anhydrase. Proc.Natl.Acad.Sci.USA, 108, 2011
4ZJK	FIVE MINUTES IRON LOADED HUMAN H FERRITIN 分子名称: CHLORIDE ION, FE (II) ION, Ferritin heavy chain, ... 著者 Pozzi, C, Di Pisa, F, Mangani, S. 登録日 2015-04-29 公開日 2015-09-09 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.56 Å) 主引用文献 Iron binding to human heavy-chain ferritin. Acta Crystallogr.,Sect.D, 71, 2015
4PR4	Human Aldose Reductase complexed with Schl7802 at 1.06 A 分子名称: 3-(3'-nitrobiphenyl-3-yl)propanoic acid, Aldose reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE 著者 Rechlin, C, Heine, A, Klebe, G. 登録日 2014-03-05 公開日 2015-04-08 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.06 Å) 主引用文献 Keys to open the specificity pocket: Biphenylic Inhibitors of the human aldose reductase To be Published
4PSW	Crystal structure of histone acetyltransferase complex 分子名称: COENZYME A, Histone H4 type VIII, Histone acetyltransferase type B catalytic subunit, ... 著者 Yang, M, Li, Y. 登録日 2014-03-08 公開日 2014-07-09 実験手法 X-RAY DIFFRACTION (2.101 Å) 主引用文献 Hat2p recognizes the histone H3 tail to specify the acetylation of the newly synthesized H3/H4 heterodimer by the Hat1p/Hat2p complex Genes Dev., 28, 2014
6A17	Crystal structure of CYP90B1 in complex with brassinazole 分子名称: (2R,3S)-4-(4-chlorophenyl)-2-phenyl-3-(1H-1,2,4-triazol-1-yl)butan-2-ol, CHLORIDE ION, Cytochrome P450 90B1, ... 著者 Fujiyama, K, Hino, T, Kanadani, M, Mizutani, M, Nagano, S. 登録日 2018-06-06 公開日 2019-06-12 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.301 Å) 主引用文献 Structural insights into a key step of brassinosteroid biosynthesis and its inhibition. Nat.Plants, 5, 2019
4POM	Crystal structures of thioredoxin with mesna at 1.85A resolution 分子名称: 1-THIOETHANESULFONIC ACID, Thioredoxin 著者 Sridhar, V, Chie-Leon, B, Badger, J, Nienaber, V.L, Hausheer, F.H. 登録日 2014-02-26 公開日 2014-10-29 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 BNP7787 Forms Novel Covalent Adducts on Human Thioredoxin and Modulates Thioredoxin Activity J Pharmacol Clin Toxicol, 2, 2014
6A1T	Charcot-Leyden crystal protein/Galectin-10 variant E33A with lactose 分子名称: Galectin-10, beta-D-galactopyranose-(1-4)-beta-D-glucopyranose 著者 Su, J. 登録日 2018-06-08 公開日 2018-12-26 最終更新日 2024-03-27 実験手法 X-RAY DIFFRACTION (1.97 Å) 主引用文献 Identification of key amino acid residues determining ligand binding specificity, homodimerization and cellular distribution of human galectin-10 Glycobiology, 29, 2019
4PUW	Human Aldose Reductase complexed with a ligand with an IDD structure (2-[5-fluoro-2-(prop-2-ynylcarbamoyl)phenoxy]acetic acid) at 1.12 A 分子名称: Aldose reductase, CITRIC ACID, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... 著者 Rechlin, C, Heine, A, Klebe, G. 登録日 2014-03-14 公開日 2015-04-08 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.12 Å) 主引用文献 Aldose Reductase: How expensive is the opening of the specificity pocket? IDD ligands under investigation To be Published
4PH5	Structure of human DNA polymerase beta complexed with a nicked DNA containing a AC at N-1 position and GC at N position 分子名称: DNA (5'-D(*CP*CP*GP*AP*CP*GP*AP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*CP*C)-3'), DNA (5'-D(P*GP*TP*CP*GP*G)-3'), ... 著者 Koag, M.C, Lee, S. 登録日 2014-05-04 公開日 2015-05-06 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.55 Å) 主引用文献 The spontaneous base substitution mechanisms of human DNA polymerase beta To Be Published
4PHD	Structure of human DNA polymerase beta complexed with A in the template base paired with incoming non-hydrolyzable CTP and MANGANESE 分子名称: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]cytidine, DNA (5'-D(*CP*CP*GP*AP*CP*AP*TP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*A)-3'), ... 著者 Koag, M.C, Lee, S. 登録日 2014-05-06 公開日 2014-09-24 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.21 Å) 主引用文献 The spontaneous replication error and the mismatch discrimination mechanisms of human DNA polymerase beta. Nucleic Acids Res., 42, 2015
5XRG	Galectin-10/Charcot-Leyden crystal protein crystal structure 分子名称: GLYCEROL, Galectin-10 著者 Su, J. 登録日 2017-06-08 公開日 2018-01-24 最終更新日 2024-03-27 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Galectin-10: a new structural type of prototype galectin dimer and effects on saccharide ligand binding. Glycobiology, 28, 2018
4PQ7	The crystal structure of the human carbonic anhydrase ii in complex with a sulfamide inhibitor 分子名称: 1-but-2-ynoxy-4-[(sulfamoylamino)methyl]benzene, Carbonic anhydrase 2, GLYCEROL, ... 著者 Alterio, V, De Simone, G. 登録日 2014-02-28 公開日 2014-10-08 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Hydrophobic substituents of the phenylmethylsulfamide moiety can be used for the development of new selective carbonic anhydrase inhibitors. Biomed Res Int, 2014, 2014
5XRK	Galectin-10/Charcot-Leyden crystal protein variant C57A crystal structure 分子名称: GLYCEROL, Galectin-10 著者 Su, J. 登録日 2017-06-08 公開日 2018-01-24 最終更新日 2024-03-27 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Galectin-10: a new structural type of prototype galectin dimer and effects on saccharide ligand binding. Glycobiology, 28, 2018

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