5UN1
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![BU of 5un1 by Molmil](/molmil-images/mine/5un1) | Crystal structure of GluN1/GluN2B delta-ATD NMDA receptor | 分子名称: | (5S,10R)-5-methyl-10,11-dihydro-5H-5,10-epiminodibenzo[a,d][7]annulene, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Song, X, Gouaux, E. | 登録日 | 2017-01-30 | 公開日 | 2018-02-07 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (3.6 Å) | 主引用文献 | Mechanism of NMDA receptor channel block by MK-801 and memantine. Nature, 556, 2018
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5UM0
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5UOT
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5UNJ
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![BU of 5unj by Molmil](/molmil-images/mine/5unj) | Structure of Human Liver Receptor Homolog 1 in complex with PGC1a and RJW100 | 分子名称: | (1R,3aR,6aR)-5-hexyl-4-phenyl-3a-(1-phenylethenyl)-1,2,3,3a,6,6a-hexahydropentalen-1-ol, Nuclear receptor subfamily 5 group A member 2, Peroxisome proliferator-activated gamma coactivator 1-alpha | 著者 | Mays, S.G, Ortlund, E.A. | 登録日 | 2017-01-31 | 公開日 | 2017-04-19 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.959 Å) | 主引用文献 | Structure and Dynamics of the Liver Receptor Homolog 1-PGC1 alpha Complex. Mol. Pharmacol., 92, 2017
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2NSA
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4YLB
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5UO5
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![BU of 5uo5 by Molmil](/molmil-images/mine/5uo5) | Structure of human neuronal nitric oxide synthase heme domain in complex with (RS)-3-[(2-amino-4-methylquinolin-7-yl)methoxy]-5-(2-(methylamino)propyl)benzonitrile | 分子名称: | 3-[(2-amino-4-methylquinolin-7-yl)methoxy]-5-[(2R)-2-(methylamino)propyl]benzonitrile, 3-[(2-amino-4-methylquinolin-7-yl)methoxy]-5-[(2S)-2-(methylamino)propyl]benzonitrile, 5,6,7,8-TETRAHYDROBIOPTERIN, ... | 著者 | Li, H, Poulos, T.L. | 登録日 | 2017-01-31 | 公開日 | 2017-05-03 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Nitrile in the Hole: Discovery of a Small Auxiliary Pocket in Neuronal Nitric Oxide Synthase Leading to the Development of Potent and Selective 2-Aminoquinoline Inhibitors. J. Med. Chem., 60, 2017
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5UTJ
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![BU of 5utj by Molmil](/molmil-images/mine/5utj) | Crystal Structure of TGT in complex with 2,6-dioxy-8-azapurine, 2,6-dioxy-8-azapurine, 2,6-dioxy-8-azapurine | 分子名称: | 8-AZAXANTHINE, DI(HYDROXYETHYL)ETHER, DIMETHYL SULFOXIDE, ... | 著者 | Hassaan, E, Heine, A, Klebe, G. | 登録日 | 2017-02-15 | 公開日 | 2018-03-07 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.549 Å) | 主引用文献 | Fragments as Novel Starting Points for tRNA-Guanine Transglycosylase Inhibitors Found by Alternative Screening Strategies. Chemmedchem, 15, 2020
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4YAB
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![BU of 4yab by Molmil](/molmil-images/mine/4yab) | Crystal structure of TRIM24 PHD-bromodomain complexed with 1-methyl-5-(2-methyl-1 3-thiazol-4-yl)-2 3-dihydro-1H-indol-2-one (1) | 分子名称: | 1-methyl-5-(2-methyl-1,3-thiazol-4-yl)-1,3-dihydro-2H-indol-2-one, SULFATE ION, Transcription intermediary factor 1-alpha, ... | 著者 | Poncet-Montange, G, Palmer, W, Jones, P. | 登録日 | 2015-02-17 | 公開日 | 2015-06-24 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Structure-Guided Design of IACS-9571, a Selective High-Affinity Dual TRIM24-BRPF1 Bromodomain Inhibitor. J.Med.Chem., 59, 2016
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6B8F
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![BU of 6b8f by Molmil](/molmil-images/mine/6b8f) | Contracted Human Heavy-Chain Ferritin Crystal-Hydrogel Hybrid | 分子名称: | CALCIUM ION, FE (III) ION, Ferritin heavy chain | 著者 | Zhang, L, Bailey, J.B, Subramanian, R, Tezcan, F.A. | 登録日 | 2017-10-07 | 公開日 | 2018-05-02 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (1.06 Å) | 主引用文献 | Hyperexpandable, self-healing macromolecular crystals with integrated polymer networks. Nature, 557, 2018
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4YR8
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![BU of 4yr8 by Molmil](/molmil-images/mine/4yr8) | Crystal structure of JNK in complex with a regulator protein | 分子名称: | CHLORIDE ION, Dual specificity protein phosphatase 16, Mitogen-activated protein kinase 8 | 著者 | Liu, X, Wang, J, Wu, J.W, Wang, Z.X. | 登録日 | 2015-03-14 | 公開日 | 2016-03-16 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | A conserved motif in JNK/p38-specific MAPK phosphatases as a determinant for JNK1 recognition and inactivation. Nat Commun, 7, 2016
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4YAD
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![BU of 4yad by Molmil](/molmil-images/mine/4yad) | Crystal structure of TRIM24 PHD-bromodomain complexed with 2,4-dimethoxy-N-(1-methyl-2-oxo-1,2,3,4-tetrahydroquinolin-6-yl)benzene-1-sulfonamide (3b) | 分子名称: | 2,4-dimethoxy-N-(1-methyl-2-oxo-1,2,3,4-tetrahydroquinolin-6-yl)benzenesulfonamide, CHLORIDE ION, GLYCEROL, ... | 著者 | Poncet-Montange, G, Palmer, W, Jones, P. | 登録日 | 2015-02-17 | 公開日 | 2015-06-24 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.73 Å) | 主引用文献 | Structure-Guided Design of IACS-9571, a Selective High-Affinity Dual TRIM24-BRPF1 Bromodomain Inhibitor. J.Med.Chem., 59, 2016
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5SXM
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2NV5
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![BU of 2nv5 by Molmil](/molmil-images/mine/2nv5) | Crystal structure of a C-terminal phosphatase domain of Rattus norvegicus ortholog of human protein tyrosine phosphatase, receptor type, D (PTPRD) | 分子名称: | PTPRD, PHOSPHATASE | 著者 | Bonanno, J.B, Gilmore, J, Bain, K.T, Iizuka, M, Xu, W, Wasserman, S, Smith, D, Sauder, J.M, Burley, S.K, Almo, S.C, New York SGX Research Center for Structural Genomics (NYSGXRC) | 登録日 | 2006-11-10 | 公開日 | 2006-11-21 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structural genomics of protein phosphatases. J.STRUCT.FUNCT.GENOM., 8, 2007
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5SYR
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![BU of 5syr by Molmil](/molmil-images/mine/5syr) | Crystal Structure of ATPase delta1-79 Spa47 R350A | 分子名称: | Probable ATP synthase SpaL/MxiB, SULFATE ION | 著者 | Morales, Y, Johnson, S.J, Burgess, J.L, Burgess, R.A, Dickenson, N.E. | 登録日 | 2016-08-11 | 公開日 | 2016-11-02 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Structural and Biochemical Characterization of Spa47 Provides Mechanistic Insight into Type III Secretion System ATPase Activation and Shigella Virulence Regulation. J. Biol. Chem., 291, 2016
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6BAH
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![BU of 6bah by Molmil](/molmil-images/mine/6bah) | Trastuzumab Fab v3 with 5-diphenyl meditope variant | 分子名称: | Immunoglobulin G binding protein A, Protein L, Trastuzumab Fab heavy chain,IGH@ protein, ... | 著者 | Bzymek, K.P, King, J.D, Williams, J.C. | 登録日 | 2017-10-12 | 公開日 | 2018-09-05 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Template-Catalyzed, Disulfide Conjugation of Monoclonal Antibodies Using a Natural Amino Acid Tag. Bioconjug. Chem., 29, 2018
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6ANQ
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![BU of 6anq by Molmil](/molmil-images/mine/6anq) | STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE (RT) TERNARY COMPLEX WITH A DOUBLE STRANDED DNA AND AN INCOMING D4TTP AT PH 8.5 | 分子名称: | 2',3'-DEHYDRO-2',3'-DEOXY-THYMIDINE 5'-TRIPHOSPHATE, DNA PRIMER (5'- D(*AP*CP*AP*GP*TP*CP*CP*CP*TP*GP*TP*TP*CP*GP*GP*GP*CP*GP*CP*CP*GP)-3'), DNA TEMPLATE (5'- D(*AP*TP*GP*AP*AP*CP*GP*GP*CP*GP*CP*CP*CP*GP*AP*AP*CP*AP*GP*GP*GP*AP*CP*TP*GP*TP*G)-3'), ... | 著者 | Martinez, S.E, Das, K, Arnold, E. | 登録日 | 2017-08-14 | 公開日 | 2018-08-15 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.586 Å) | 主引用文献 | Structure of HIV-1 reverse transcriptase/d4TTP complex: Novel DNA cross-linking site and pH-dependent conformational changes. Protein Sci., 28, 2019
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2NU9
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6BB2
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![BU of 6bb2 by Molmil](/molmil-images/mine/6bb2) | Lactate Dehydrogenase in complex with inhibitor (S)-5-((2-chlorophenyl)thio)-6'-(4-fluorophenoxy)-4-hydroxy-2-(thiophen-3-yl)-2,3-dihydro-[2,2'-bipyridin]-6(1H)-one | 分子名称: | (2S)-5-[(2-chlorophenyl)sulfanyl]-6'-(4-fluorophenoxy)-4-hydroxy-2-(thiophen-3-yl)-2,3-dihydro[2,2'-bipyridin]-6(1H)-one, L-lactate dehydrogenase A chain, LACTIC ACID, ... | 著者 | Ultsch, M, Eigenbrot, C. | 登録日 | 2017-10-16 | 公開日 | 2018-10-24 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.47 Å) | 主引用文献 | Structure-guided optimization and in vivo activities of hydroxylactone and hydroxylactam Inhibitors of Human Lactate Dehydrogenase To Be Published
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6AP8
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2NVJ
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![BU of 2nvj by Molmil](/molmil-images/mine/2nvj) | NMR structures of transmembrane segment from subunit a from the yeast proton V-ATPase | 分子名称: | 25mer peptide from Vacuolar ATP synthase subunit a, vacuolar isoform | 著者 | Hemminga, M.A, van Mierlo, C.P, Wechselberger, R, de Jong, E.R, Duarte, A.M. | 登録日 | 2006-11-13 | 公開日 | 2007-10-02 | 最終更新日 | 2023-12-27 | 実験手法 | SOLUTION NMR | 主引用文献 | Segment TM7 from the cytoplasmic hemi-channel from V(O)-H(+)-V-ATPase includes a flexible region that has a potential role in proton translocation Biochim.Biophys.Acta, 1768, 2007
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6AST
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![BU of 6ast by Molmil](/molmil-images/mine/6ast) | NMR and Restrained Molecular Dynamics Determination of the Structure of an Aza-Benzimidazole Derivative Complex with the DNA Minor Groove of an -AAGATA Sequence | 分子名称: | DNA (5'-D(*CP*CP*AP*AP*GP*AP*TP*AP*G)-3'), DNA (5'-D(*CP*TP*AP*TP*CP*TP*TP*GP*G)-3'), amino(4-{[(2-{4-[amino(iminio)methyl]phenyl}-3H-imidazo[4,5-b]pyridin-5-yl)oxy]methyl}phenyl)methaniminium | 著者 | Harika, N.K, Germann, M.W, Wilson, W.D. | 登録日 | 2017-08-25 | 公開日 | 2018-01-31 | 最終更新日 | 2024-05-01 | 実験手法 | SOLUTION NMR | 主引用文献 | First Structure of a Designed Minor Groove Binding Heterocyclic Cation that Specifically Recognizes Mixed DNA Base Pair Sequences. Chemistry, 23, 2017
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5TA1
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![BU of 5ta1 by Molmil](/molmil-images/mine/5ta1) | Crystal structure of BuGH86wt | 分子名称: | 1,2-ETHANEDIOL, CALCIUM ION, GLYCEROL, ... | 著者 | Pluvinage, B, Boraston, A.B. | 登録日 | 2016-09-09 | 公開日 | 2017-09-13 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Molecular basis of an agarose metabolic pathway acquired by a human intestinal symbiont. Nat Commun, 9, 2018
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5SV1
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![BU of 5sv1 by Molmil](/molmil-images/mine/5sv1) | Structure of the ExbB/ExbD complex from E. coli at pH 4.5 | 分子名称: | Biopolymer transport protein ExbB, Biopolymer transport protein ExbD, MERCURY (II) ION | 著者 | Celia, H, Botos, I, Lloubes, R, Buchanan, S.K, Noinaj, N. | 登録日 | 2016-08-04 | 公開日 | 2016-09-28 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | 主引用文献 | Structural insight into the role of the Ton complex in energy transduction. Nature, 538, 2016
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2NYL
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![BU of 2nyl by Molmil](/molmil-images/mine/2nyl) | Crystal structure of Protein Phosphatase 2A (PP2A) holoenzyme with the catalytic subunit carboxyl terminus truncated | 分子名称: | MANGANESE (II) ION, Protein phosphatase 2, regulatory subunit A (PR 65), ... | 著者 | Xing, Y, Xu, Y, Chen, Y, Chao, Y, Lin, Z, Shi, Y. | 登録日 | 2006-11-20 | 公開日 | 2006-12-12 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (3.8 Å) | 主引用文献 | Structure of the Protein Phosphatase 2A Holoenzyme. Cell(Cambridge,Mass.), 127, 2006
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