6DPW
 
 | | Undecorated GTPgammaS microtubule | | 分子名称: | 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | | 著者 | Zhang, R, Nogales, E. | | 登録日 | 2018-06-09 | | 公開日 | 2018-07-04 | | 最終更新日 | 2024-03-13 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | Separating the effects of nucleotide and EB binding on microtubule structure.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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4BQ0
 | | Pseudomonas aeruginosa beta-alanine:pyruvate aminotransferase holoenzyme without divalent cations on dimer-dimer interface | | 分子名称: | BETA-ALANINE--PYRUVATE TRANSAMINASE, CHLORIDE ION, PYRIDOXAL-5'-PHOSPHATE | | 著者 | Isupov, M.N, Lebedev, A.A, Westlake, A, Sayer, C, Littlechild, J.A. | | 登録日 | 2013-05-29 | | 公開日 | 2013-06-05 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (1.77 Å) | | 主引用文献 | Space-Group and Origin Ambiguity in Macromolecular Structures with Pseudo-Symmetry and its Treatment with the Program Zanuda.
Acta Crystallogr.,Sect.D, 70, 2014
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6ERK
 | | Crystal structure of diaminopelargonic acid aminotransferase from Psychrobacter cryohalolentis | | 分子名称: | 1,2-ETHANEDIOL, Aminotransferase, GLYCEROL, ... | | 著者 | Boyko, K.M, Nikolaeva, A.Y, Bezsudnova, E.Y, Stekhanova, T.N, Rakitina, T.V, Popov, V.O. | | 登録日 | 2017-10-18 | | 公開日 | 2018-09-26 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Diaminopelargonic acid transaminase from Psychrobacter cryohalolentis is active towards (S)-(-)-1-phenylethylamine, aldehydes and alpha-diketones.
Appl. Microbiol. Biotechnol., 102, 2018
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4Z3P
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4Z3N
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5K53
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8QKR
 | | Plasmodium falciparum reticulocyte-binding protein homologue 5 (PfRH5) bound to R5.251 | | 分子名称: | R5251VHCH, R5251VLCL, Reticulocyte-binding protein-like protein 5 | | 著者 | Wright, N.D, Barrett, J.R, Bradshaw, W.J, Paterson, N.G, MacLean, E.M, Ferreira, L, McHugh, K, Koekemoer, L, Draper, S.J. | | 登録日 | 2023-09-16 | | 公開日 | 2024-07-31 | | 最終更新日 | 2024-09-18 | | 実験手法 | X-RAY DIFFRACTION (3.234 Å) | | 主引用文献 | Analysis of the diverse antigenic landscape of the malaria protein RH5 identifies a potent vaccine-induced human public antibody clonotype.
Cell, 187, 2024
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6FIB
 | | Structure of human 4-1BB ligand | | 分子名称: | Tumor necrosis factor ligand superfamily member 9, Tumor necrosis factor ligand superfamily member 9,4-1BBL -CH/CL fusion, Tumor necrosis factor ligand superfamily member 9,Uncharacterized protein | | 著者 | Joseph, C, Claus, C, Ferrara, C, von Hirschheydt, T, Prince, C, Funk, D, Klein, C, Benz, J. | | 登録日 | 2018-01-17 | | 公開日 | 2019-03-13 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Tumor-targeted 4-1BB agonists for combination with T cell bispecific antibodies as off-the-shelf therapy.
Sci Transl Med, 11, 2019
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5E4T
 | | Acetylcholinesterase Methylene Blue with PEG | | 分子名称: | 1,2-ETHANEDIOL, 3,7-BIS(DIMETHYLAMINO)PHENOTHIAZIN-5-IUM, Acetylcholinesterase, ... | | 著者 | Dym, O. | | 登録日 | 2015-10-07 | | 公開日 | 2016-03-30 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.43 Å) | | 主引用文献 | The impact of crystallization conditions on structure-based drug design: A case study on the methylene blue/acetylcholinesterase complex.
Protein Sci., 25, 2016
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8QEZ
 | | Crystal structure of the AMPA receptor GluA2-L504Y-N775S ligand binding domain in complex with L-glutamate and positive allosteric modulator BPAM395 at 1.55A resolution | | 分子名称: | 6-chloranyl-4-cyclopropyl-2,3-dihydrothieno[3,2-e][1,2,4]thiadiazine 1,1-dioxide, ACETATE ION, CACODYLATE ION, ... | | 著者 | Dorosz, J, Laulumaa, S, Frydenvang, K, Kastrup, J.S. | | 登録日 | 2023-09-01 | | 公開日 | 2023-12-27 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | | 主引用文献 | Exploring thienothiadiazine dioxides as isosteric analogues of benzo- and pyridothiadiazine dioxides in the search of new AMPA and kainate receptor positive allosteric modulators.
Eur.J.Med.Chem., 264, 2023
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5TBY
 | | HUMAN BETA CARDIAC HEAVY MEROMYOSIN INTERACTING-HEADS MOTIF OBTAINED BY HOMOLOGY MODELING (USING SWISS-MODEL) OF HUMAN SEQUENCE FROM APHONOPELMA HOMOLOGY MODEL (PDB-3JBH), RIGIDLY FITTED TO HUMAN BETA-CARDIAC NEGATIVELY STAINED THICK FILAMENT 3D-RECONSTRUCTION (EMD-2240) | | 分子名称: | Myosin light chain 3, Myosin regulatory light chain 2, ventricular/cardiac muscle isoform, ... | | 著者 | ALAMO, L, WARE, J.S, PINTO, A, GILLILAN, R.E, SEIDMAN, J.G, SEIDMAN, C.E, PADRON, R. | | 登録日 | 2016-09-13 | | 公開日 | 2017-06-07 | | 最終更新日 | 2020-01-08 | | 実験手法 | ELECTRON MICROSCOPY (20 Å) | | 主引用文献 | Effects of myosin variants on interacting-heads motif explain distinct hypertrophic and dilated cardiomyopathy phenotypes.
Elife, 6, 2017
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5DLP
 | | Acetylcholinesterase Methylene Blue no PEG | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 3,7-BIS(DIMETHYLAMINO)PHENOTHIAZIN-5-IUM, Acetylcholinesterase, ... | | 著者 | Dym, O. | | 登録日 | 2015-09-07 | | 公開日 | 2016-03-30 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | The impact of crystallization conditions on structure-based drug design: A case study on the methylene blue/acetylcholinesterase complex.
Protein Sci., 25, 2016
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6SGO
 | | NMR structure of MLP124017 | | 分子名称: | Secreted protein | | 著者 | Barthe, P, de Guillen, K, Padilla, A, Hecker, A. | | 登録日 | 2019-08-05 | | 公開日 | 2019-12-18 | | 最終更新日 | 2024-06-19 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structural genomics applied to the rust fungus Melampsora larici-populina reveals two candidate effector proteins adopting cystine knot and NTF2-like protein folds.
Sci Rep, 9, 2019
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2M36
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6O9U
 | | KirBac3.1 at a resolution of 2 Angstroms | | 分子名称: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 3,3',3''-phosphoryltripropanoic acid, BARIUM ION, ... | | 著者 | Gulbis, J.M, Clarke, O.B. | | 登録日 | 2019-03-15 | | 公開日 | 2020-05-27 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | A constricted opening in Kir channels does not impede potassium conduction.
Nat Commun, 11, 2020
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6O9T
 | | KirBac3.1 mutant at a resolution of 4.1 Angstroms | | 分子名称: | 2,3,5,6-tetramethyl-1H,7H-pyrazolo[1,2-a]pyrazole-1,7-dione, Inward rectifier potassium channel Kirbac3.1, POTASSIUM ION | | 著者 | Gulbis, J.M, Black, K.A, Miller, D.M. | | 登録日 | 2019-03-15 | | 公開日 | 2020-05-27 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (4.01 Å) | | 主引用文献 | A constricted opening in Kir channels does not impede potassium conduction.
Nat Commun, 11, 2020
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6WU5
 | | Human Calcium and Integrin Binding Protein 3 | | 分子名称: | CALCIUM ION, CHLORIDE ION, Calcium and integrin-binding family member 3, ... | | 著者 | Dionne, G, Shapiro, L. | | 登録日 | 2020-05-04 | | 公開日 | 2021-06-23 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.88 Å) | | 主引用文献 | CIB2 and CIB3 are auxiliary subunits of the mechanotransduction channel of hair cells.
Neuron, 109, 2021
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6X1O
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5O60
 | | Structure of the 50S large ribosomal subunit from Mycobacterium smegmatis | | 分子名称: | 23S rRNA, 50S ribosomal protein L10, 50S ribosomal protein L11, ... | | 著者 | Hentschel, J, Burnside, C, Mignot, I, Leibundgut, M, Boehringer, D, Ban, N. | | 登録日 | 2017-06-02 | | 公開日 | 2017-07-12 | | 最終更新日 | 2024-05-15 | | 実験手法 | ELECTRON MICROSCOPY (3.18 Å) | | 主引用文献 | The Complete Structure of the Mycobacterium smegmatis 70S Ribosome.
Cell Rep, 20, 2017
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6V83
 | | Crystal structure of CTX-M-14 E166A/P167S/D240G beta-lactamase in complex with ceftazidime-1 | | 分子名称: | ACYLATED CEFTAZIDIME, Beta-lactamase | | 著者 | Brown, C.A, Hu, L, Sankaran, B, Prasad, B.V.V, Palzkill, T.G. | | 登録日 | 2019-12-10 | | 公開日 | 2020-04-22 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Antagonism between substitutions in beta-lactamase explains a path not taken in the evolution of bacterial drug resistance.
J.Biol.Chem., 295, 2020
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6V5E
 | | Crystal structure of CTX-M-14 P167S/D240G beta-lactamase | | 分子名称: | Beta-lactamase | | 著者 | Brown, C.A, Hu, L, Sankaran, B, Prasad, B.V.V, Palzkill, T.G. | | 登録日 | 2019-12-04 | | 公開日 | 2020-04-22 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Antagonism between substitutions in beta-lactamase explains a path not taken in the evolution of bacterial drug resistance.
J.Biol.Chem., 295, 2020
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6X6U
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6V7T
 | | Crystal structure of CTX-M-14 E166A/D240G beta-lactamase in complex with ceftazidime | | 分子名称: | ACYLATED CEFTAZIDIME, Beta-lactamase | | 著者 | Brown, C.A, Hu, L, Sankaran, B, Prasad, B.V.V, Palzkill, T.G. | | 登録日 | 2019-12-09 | | 公開日 | 2020-04-22 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.34 Å) | | 主引用文献 | Antagonism between substitutions in beta-lactamase explains a path not taken in the evolution of bacterial drug resistance.
J.Biol.Chem., 295, 2020
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6V6G
 | | Crystal structure of CTX-M-14 E166A/P167S/D240G beta-lactamase | | 分子名称: | Beta-lactamase, DI(HYDROXYETHYL)ETHER, SODIUM ION | | 著者 | Brown, C.A, Hu, L, Sankaran, B, Prasad, B.V.V, Palzkill, T.G. | | 登録日 | 2019-12-05 | | 公開日 | 2020-04-22 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Antagonism between substitutions in beta-lactamase explains a path not taken in the evolution of bacterial drug resistance.
J.Biol.Chem., 295, 2020
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6V6P
 | | Crystal structure of CTX-M-14 E166A/D240G beta-lactamase | | 分子名称: | Beta-lactamase, DI(HYDROXYETHYL)ETHER, SULFATE ION | | 著者 | Brown, C.A, Hu, L, Sankaran, B, Prasad, B.V.V, Palzkill, T.G. | | 登録日 | 2019-12-05 | | 公開日 | 2020-04-22 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | | 主引用文献 | Antagonism between substitutions in beta-lactamase explains a path not taken in the evolution of bacterial drug resistance.
J.Biol.Chem., 295, 2020
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