PDB: 47065 件ウェブページステータス検索Chemie searchBIRD

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6AV0	Structure of human neuronal nitric oxide synthase R354A/G357D mutant heme domain in complex with 3-(2-(6-Amino-4-methylpyridin-2-yl)ethyl)-5-(3-(methylamino)propyl)benzonitrile 分子名称: 3-[2-(6-amino-4-methylpyridin-2-yl)ethyl]-5-[3-(methylamino)propyl]benzonitrile, 5,6,7,8-TETRAHYDROBIOPTERIN, Nitric oxide synthase, ... 著者 LI, H, Poulos, T.L. 登録日 2017-09-01 公開日 2018-07-11 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.996 Å) 主引用文献 Improvement of Cell Permeability of Human Neuronal Nitric Oxide Synthase Inhibitors Using Potent and Selective 2-Aminopyridine-Based Scaffolds with a Fluorobenzene Linker. J. Med. Chem., 60, 2017
4Y1T	Structural basis for Ca2+-mediated interaction of the perforin C2 domain with lipid membranes 分子名称: CALCIUM ION, Perforin-1 著者 Conroy, P.J, Yagi, H, Whisstock, J.C, Norton, R.S. 登録日 2015-02-09 公開日 2015-09-02 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.666 Å) 主引用文献 Structural Basis for Ca2+-mediated Interaction of the Perforin C2 Domain with Lipid Membranes. J.Biol.Chem., 290, 2015
2N82	solution structure of the complex of microRNA 20b pre-element with Rbfox RRM 分子名称: RNA (5'-R(*GP*GP*UP*AP*GP*UP*UP*UP*UP*GP*GP*CP*AP*UP*GP*AP*CP*UP*CP*UP*AP*CP*C)-3'), RNA binding protein fox-1 homolog 1 著者 Yang, F, Chen, Y, Varani, G. 登録日 2015-09-30 公開日 2016-04-13 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 Rbfox proteins regulate microRNA biogenesis by sequence-specific binding to their precursors and target downstream Dicer. Nucleic Acids Res., 44, 2016
6AV1	Structure of human neuronal nitric oxide synthase R354A/G357D mutant heme domain in complex with 6-(3-(3-(Dimethylamino)propyl)-5-fluorophenethyl)-4-methylpyridin-2-amine 分子名称: 5,6,7,8-TETRAHYDROBIOPTERIN, 6-(2-{3-[3-(dimethylamino)propyl]-5-fluorophenyl}ethyl)-4-methylpyridin-2-amine, Nitric oxide synthase, ... 著者 Li, H, Poulos, T.L. 登録日 2017-09-01 公開日 2018-07-11 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.45 Å) 主引用文献 Improvement of Cell Permeability of Human Neuronal Nitric Oxide Synthase Inhibitors Using Potent and Selective 2-Aminopyridine-Based Scaffolds with a Fluorobenzene Linker. J. Med. Chem., 60, 2017
4Y2T	Structure of soluble epoxide hydrolase in complex with 3-[4-(benzyloxy)phenyl]propan-1-ol 分子名称: 3-[4-(benzyloxy)phenyl]propan-1-ol, Bifunctional epoxide hydrolase 2, MAGNESIUM ION 著者 Amano, Y, Yamaguchi, T. 登録日 2015-02-10 公開日 2015-05-06 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Identification of N-ethylmethylamine as a novel scaffold for inhibitors of soluble epoxide hydrolase by crystallographic fragment screening Bioorg.Med.Chem., 23, 2015
5U36	Crystal Structure Of A Mutant M. Jannashii Tyrosyl-tRNA Synthetase 分子名称: Tyrosine--tRNA ligase 著者 Luo, X, Fu, G, Zhu, X, Wilson, I.A, Wang, F. 登録日 2016-12-01 公開日 2017-06-07 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (3.03 Å) 主引用文献 Genetically encoding phosphotyrosine and its nonhydrolyzable analog in bacteria. Nat. Chem. Biol., 13, 2017
6AXF	Structure of RasGRP2 in complex with Rap1B 分子名称: RAS guanyl-releasing protein 2, Ras-related protein Rap-1b 著者 Kondo, Y, Iwig, J.S, Kuriyan, J. 登録日 2017-09-06 公開日 2017-10-11 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 A histidine pH sensor regulates activation of the Ras-specific guanine nucleotide exchange factor RasGRP1. Elife, 6, 2017
4XQF	Tailspike protein mutant E372Q (delta D470/N471) of E. coli bacteriophage HK620 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, FORMIC ACID, SODIUM ION, ... 著者 Gohlke, U, Broeker, N.K, Heinemann, U, Seckler, R, Barbirz, S. 登録日 2015-01-19 公開日 2016-01-27 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Enthalpic cost of water removal from a hydrophobic glucose binding cavity on HK620 tailspike protein. to be published
2NOW	An unusual twin-His arrangement in the pore of ammonia channels is essential for substrate conductance 分子名称: ACETATE ION, Ammonia channel, GLYCEROL, ... 著者 Lupo, D, Winkler, F.K. 登録日 2006-10-26 公開日 2006-11-14 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 An unusual twin-his arrangement in the pore of ammonia channels is essential for substrate conductance J.Biol.Chem., 281, 2006
4XT9	RORgamma (263-509) complexed with GSK2435341A and SRC2 分子名称: LYS-ILE-LEU-HIS-ARG-LEU-LEU-GLN, N-[4-(2,5-dichlorophenyl)-5-phenyl-1,3-thiazol-2-yl]-2-[4-(ethylsulfonyl)phenyl]acetamide, Nuclear receptor ROR-gamma, ... 著者 Wang, Y, Ma, Y. 登録日 2015-01-23 公開日 2015-08-12 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Discovery of N-(4-aryl-5-aryloxy-thiazol-2-yl)-amides as potent ROR gamma t inverse agonists Bioorg.Med.Chem., 23, 2015
2NOX	Crystal structure of tryptophan 2,3-dioxygenase from Ralstonia metallidurans 分子名称: PROTOPORPHYRIN IX CONTAINING FE, Tryptophan 2,3-dioxygenase 著者 Zhang, Y, Kang, S.A, Mukherjee, T, Bale, S, Crane, B.R, Begley, T.P, Ealick, S.E. 登録日 2006-10-26 公開日 2006-12-19 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Crystal structure and mechanism of tryptophan 2,3-dioxygenase, a heme enzyme involved in tryptophan catabolism and in quinolinate biosynthesis. Biochemistry, 46, 2007
6AN2	STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE (RT) TERNARY COMPLEX WITH A DOUBLE STRANDED DNA AND AN INCOMING D4TTP AT PH 7.5 分子名称: 2',3'-DEHYDRO-2',3'-DEOXY-THYMIDINE 5'-TRIPHOSPHATE, DNA PRIMER (5'- D(*AP*CP*AP*GP*TP*CP*CP*CP*TP*GP*TP*TP*CP*GP*GP*GP*CP*GP*CP*CP*GP)-3'), DNA TEMPLATE (5'- D(*AP*TP*GP*AP*AP*CP*GP*GP*CP*GP*CP*CP*CP*GP*AP*AP*CP*AP*GP*GP*GP*AP*CP*TP*GP*TP*G)-3'), ... 著者 Martinez, S.E, Das, K, Arnold, E. 登録日 2017-08-11 公開日 2018-08-15 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Structure of HIV-1 reverse transcriptase/d4TTP complex: Novel DNA cross-linking site and pH-dependent conformational changes. Protein Sci., 28, 2019
5UBV	ATPase domain of i-AAA protease from Myceliophthora thermophila 分子名称: ADENOSINE-5'-DIPHOSPHATE, ATPase domain of i-AAA protease, CITRIC ACID, ... 著者 Shi, H, Glynn, S.E. 登録日 2016-12-21 公開日 2017-12-27 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.45 Å) 主引用文献 Structure of the ATPase domain of i-AAA protease from Myceliophthora thermophila To Be Published
2NAC	HIGH RESOLUTION STRUCTURES OF HOLO AND APO FORMATE DEHYDROGENASE 分子名称: NAD-DEPENDENT FORMATE DEHYDROGENASE, SULFATE ION 著者 Lamzin, V.S, Dauter, Z, Popov, V.O, Harutyunyan, E.H, Wilson, K.S. 登録日 1994-07-06 公開日 1995-01-26 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 High resolution structures of holo and apo formate dehydrogenase. J.Mol.Biol., 236, 1994
2NMR	An unusual twin-His arrangement in the pore of ammonia channels is essential for substrate conductance 分子名称: ACETATE ION, Ammonia channel, GLYCEROL, ... 著者 Lupo, D, Winkler, F.K. 登録日 2006-10-23 公開日 2006-11-14 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 An unusual twin-his arrangement in the pore of ammonia channels is essential for substrate conductance J.Biol.Chem., 281, 2006
5UF1	Crystal Structure of Variable Lymphocyte Receptor (VLR) O13 in complex with H-trisaccharide 分子名称: CHLORIDE ION, O13, alpha-L-fucopyranose-(1-2)-beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose 著者 Gunn, R.J, Collins, B.C, McKitrick, T.R, Cummings, R.D, Cooper, M.D, Herrin, B.R, Wilson, I.A. 登録日 2017-01-03 公開日 2017-10-18 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.03 Å) 主引用文献 Structural Insights into VLR Fine Specificity for Blood Group Carbohydrates. Structure, 25, 2017
4XY7	Crystal structure of the complex of ribosome inactivating protein from Momordica balsamina with N-acetylglucosamine at 2.5 A resolution 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, Ribosome inactivating protein 著者 Yamini, S, Pandey, S, Kaur, P, Sharma, S, Singh, T.P. 登録日 2015-02-02 公開日 2015-09-23 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Crystal structure of the complex of ribosome inactivating protein from Momordica balsamina with N- acetylglucosamine at 2.5 A resolution To Be Published
2N98	Solution structure of acyl carrier protein LipD from Actinoplanes friuliensis 分子名称: Acyl carrier protein 著者 Paul, S, Ishida, H, Liu, Z, Nguyen, L.T, Vogel, H.J. 登録日 2015-11-10 公開日 2016-11-16 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 Structural and dynamic characterization of a freestanding acyl carrier protein involved in the biosynthesis of cyclic lipopeptide antibiotics. Protein Sci., 26, 2017
5TPU	x-ray structure of the WlaRB TDP-quinovose 3,4-ketoisomerase from campylobacter jejuni 分子名称: CHLORIDE ION, Putative uncharacterized protein, THYMIDINE-5'-DIPHOSPHATE 著者 Holden, H.M, Thoden, J.B, Li, J.Z, Riegert, A.S, Goneau, M.-F, Cunningham, A.M, Vinogradov, E, Schoenhofen, I.C, Gilbert, M. 登録日 2016-10-21 公開日 2017-02-01 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Characterization of the dTDP-Fuc3N and dTDP-Qui3N biosynthetic pathways in Campylobacter jejuni 81116. Glycobiology, 27, 2017
4Y11	Trypsin in complex with with BPTI mutant (2S)-2-amino-4,4,4-trifluorobutanoic acid 分子名称: CALCIUM ION, Cationic trypsin, GLYCEROL, ... 著者 Loll, B, Ye, S, Berger, A.A, Muelow, U, Alings, C, Wahl, M.C, Koksch, B. 登録日 2015-02-06 公開日 2015-06-24 最終更新日 2018-04-18 実験手法 X-RAY DIFFRACTION (1.3 Å) 主引用文献 Fluorine teams up with water to restore inhibitor activity to mutant BPTI. Chem Sci, 6, 2015
6ASF	NMR and Restrained Molecular Dynamics Determination of the Structure of an Aza-Benzimidazole Derivative Complex with the DNA Minor Groove of an -AAGATA- Sequence 分子名称: DNA (5'-D(*CP*CP*AP*AP*GP*AP*TP*AP*G)-3'), DNA (5'-D(*CP*TP*AP*TP*CP*TP*TP*GP*G)-3') 著者 Harika, N.K, Germann, M.W, Boykin, D.W. 登録日 2017-08-24 公開日 2018-01-31 最終更新日 2024-05-01 実験手法 SOLUTION NMR 主引用文献 First Structure of a Designed Minor Groove Binding Heterocyclic Cation that Specifically Recognizes Mixed DNA Base Pair Sequences. Chemistry, 23, 2017
4XXJ	Crystal Structure of Escherichia coli-Expressed Halobacterium salinarum Bacteriorhodopsin in the Trimeric Form 分子名称: Bacteriorhodopsin, EICOSANE, [(Z)-octadec-9-enyl] (2R)-2,3-bis(oxidanyl)propanoate 著者 Bratanov, D, Balandin, T, Round, E, Gushchin, I, Gordeliy, V. 登録日 2015-01-30 公開日 2015-07-01 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 An Approach to Heterologous Expression of Membrane Proteins. The Case of Bacteriorhodopsin. Plos One, 10, 2015
2NNC	Structure of the sulfur carrier protein SoxY from Chlorobium limicola f thiosulfatophilum 分子名称: CHLORIDE ION, NITROGEN MOLECULE, PHOSPHATE ION, ... 著者 Stout, J, Van Driessche, G, Savvides, S.N, Van Beeumen, J. 登録日 2006-10-24 公開日 2007-03-13 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.14 Å) 主引用文献 X-ray crystallographic analysis of the sulfur carrier protein SoxY from Chlorobium limicola f. thiosulfatophilum reveals a tetrameric structure. Protein Sci., 16, 2007
6AYF	TRPML3/ML-SA1 complex at pH 7.4 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Mucolipin-3 著者 Zhou, X, Li, M, Su, D, Jia, Q, Li, H, Li, X, Yang, J. 登録日 2017-09-08 公開日 2017-11-08 最終更新日 2024-03-13 実験手法 ELECTRON MICROSCOPY (3.62 Å) 主引用文献 Cryo-EM structures of the human endolysosomal TRPML3 channel in three distinct states. Nat. Struct. Mol. Biol., 24, 2017
5UG2	CcP gateless cavity 分子名称: 6-fluoro-2-methylimidazo[1,2-a]pyridin-3-amine, PROTOPORPHYRIN IX CONTAINING FE, Peroxidase 著者 Stein, R.M, Fischer, M, Shoichet, B.K. 登録日 2017-01-06 公開日 2017-02-01 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (1.34 Å) 主引用文献 Testing inhomogeneous solvation theory in structure-based ligand discovery. Proc. Natl. Acad. Sci. U.S.A., 114, 2017

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