6AN2

STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE (RT) TERNARY COMPLEX WITH A DOUBLE STRANDED DNA AND AN INCOMING D4TTP AT PH 7.5

Summary for 6AN2

• Entry DOI: 10.2210/pdb6an2/pdb
• Descriptor: HIV-1 REVERSE TRANSCRIPTASE P66 SUBUNIT, HIV-1 REVERSE TRANSCRIPTASE P51 SUBUNIT, DNA TEMPLATE (5'- D(*AP*TP*GP*AP*AP*CP*GP*GP*CP*GP*CP*CP*CP*GP*AP*AP*CP*AP*GP*GP*GP*AP*CP*TP*GP*TP*G)-3'), ... (8 entities in total)
• Functional Keywords: rt, dna, crosslink, n site complex, pyrophosphorolysis, p51, p66, transferase-dna complex, d4t (stavudine), transferase/dna
• Biological source: Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1); More
• Total number of polymer chains: 8
• Total formula weight: 263801.88

Authors

Martinez, S.E.,Das, K.,Arnold, E. (deposition date: 2017-08-11, release date: 2018-08-15, Last modification date: 2023-10-04)

• Primary citation: Martinez, S.E.,Bauman, J.D.,Das, K.,Arnold, E.; Structure of HIV-1 reverse transcriptase/d4TTP complex: Novel DNA cross-linking site and pH-dependent conformational changes.; Protein Sci., 28:587-597, 2019; PubMed: 30499174; DOI: 10.1002/pro.3559

Experimental method

X-RAY DIFFRACTION (2.7 Å)