PDB: 242842 件ウェブページステータス検索Chemie searchBIRD

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9JKD	Crystal structure of Aspergillus fumigatus polymycovirus 1 ploymerase elongation complex 分子名称: GLYCEROL, RNA (30-MER), RNA (5'-R(P*GP*GP*AP*UP*AP*UP*AP*AP*U)-3'), ... 著者 Jia, H, Gong, P. 登録日 2024-09-15 公開日 2025-03-26 最終更新日 2025-04-30 実験手法 X-RAY DIFFRACTION (2.34 Å) 主引用文献 An evolutionarily unique viral RdRP suggests a common dual-function feature of the priming element. Sci Adv, 11, 2025
6J5L	Crystal structure of Trk-A in complex with the Pan-Trk Kinase Inhibitor, compound 10e 分子名称: High affinity nerve growth factor receptor, N-{2-[({3-[6-(piperazin-1-yl)pyridin-3-yl]-1H-indazol-5-yl}amino)methyl]phenyl}methanesulfonamide 著者 Kensuke, A, Kazutaka, I. 登録日 2019-01-11 公開日 2019-07-17 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 The discovery of novel 3-aryl-indazole derivatives as peripherally restricted pan-Trk inhibitors for the treatment of pain. Bioorg.Med.Chem.Lett., 29, 2019
8BI5	Crystal structure of human Choline Kinase A in complex with UNC0737 分子名称: 1,2-ETHANEDIOL, 2-cyclohexyl-6-methoxy-~{N}-methyl-~{N}-(1-propan-2-ylpiperidin-4-yl)-7-(3-pyrrolidin-1-ylpropoxy)quinazolin-4-amine, CHLORIDE ION, ... 著者 Diaz-Saez, L, Ward, J, Kennedy, E, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Huber, K, Structural Genomics Consortium (SGC) 登録日 2022-11-01 公開日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Crystal structure of human Choline Kinase A in complex with UNC0737 To Be Published
8BI6	Crystal structure of human Choline Kinase A in complex with UNC0638 分子名称: 1,2-ETHANEDIOL, 2-cyclohexyl-6-methoxy-N-[1-(1-methylethyl)piperidin-4-yl]-7-(3-pyrrolidin-1-ylpropoxy)quinazolin-4-amine, CHLORIDE ION, ... 著者 Diaz-Saez, L, Ward, J, Kennedy, E, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Huber, K, Structural Genomics Consortium (SGC) 登録日 2022-11-01 公開日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Crystal structure of human Choline Kinase A in complex with UNC0638 To Be Published
4Z4J	Crystal Structure of cellobiose 2-epimerase from Caldicellulosiruptor saccharolyticus DSM 8903 分子名称: 1,2-ETHANEDIOL, Cellobiose 2-epimerase, ISOPROPYL ALCOHOL 著者 Shen, Q.Y, Zhang, Y.Z. 登録日 2015-04-02 公開日 2016-04-13 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (1.542 Å) 主引用文献 Crystal Structure of cellobiose 2-epimerase from Caldicellulosiruptor saccharolyticus DSM 8903 to be published
6G22	Crystal structure of human mitochondrial 5'(3')-deoxyribonucleotidase in complex with the inhibitor PB-PEU 分子名称: 1-{2-deoxy-3,5-O-[phenyl(phosphono)methylidene]-beta-D-threo-pentofuranosyl}-5-[(E)-2-phosphonoethenyl]pyrimidine-2,4(1H,3H)-dione, 5'(3')-deoxyribonucleotidase, mitochondrial, ... 著者 Pachl, P, Rezacova, P, Brynda, J. 登録日 2018-03-22 公開日 2018-07-11 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Structure-based optimization of bisphosphonate nucleoside inhibitors of human 5'(3')-deoxyribonucleotidases Eur.J.Org.Chem., 2018
6U6O	Crystal structure of a vaccine-elicited anti-HIV-1 rhesus macaque antibody DH846 分子名称: DH846 Fab heavy chain, DH846 Fab light chain 著者 Chen, W.-H, Choe, M, Saunders, K.O, Joyce, M.G. 登録日 2019-08-30 公開日 2021-03-24 最終更新日 2024-10-09 実験手法 X-RAY DIFFRACTION (2.806 Å) 主引用文献 Structural and genetic convergence of HIV-1 neutralizing antibodies in vaccinated non-human primates. Plos Pathog., 17, 2021
7RY7	Structure of Plasmepsin X (PM10, PMX) from Plasmodium falciparum 3D7 分子名称: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, Plasmepsin X 著者 Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2021-08-24 公開日 2022-02-02 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structures of plasmepsin X from Plasmodium falciparum reveal a novel inactivation mechanism of the zymogen and molecular basis for binding of inhibitors in mature enzyme. Protein Sci., 31, 2022
8VPR	Crystal structure of mouse Importin alpha in complex with Dengue 1 NS5 central NLS peptide 分子名称: Importin subunit alpha-1, RNA-directed RNA polymerase NS5 central NLS peptide 著者 Cheng, C.X, Swarbrick, C.M.D, Forwood, J.K. 登録日 2024-01-16 公開日 2024-08-21 最終更新日 2024-12-25 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Serotype-Specific Regulation of Dengue Virus NS5 Protein Subcellular Localization. Acs Infect Dis., 10, 2024
6G26	The crystal structure of the Burkholderia pseudomallei HicAB complex 分子名称: 1,2-ETHANEDIOL, HicA, HicB, ... 著者 Winter, A.J, Isupov, M.N, Williams, C, Crump, M.P. 登録日 2018-03-22 公開日 2018-10-31 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.49 Å) 主引用文献 The molecular basis of protein toxin HicA-dependent binding of the protein antitoxin HicB to DNA. J. Biol. Chem., 293, 2018
5NW9	Crystal structure of the complex of Tdp1 with duplex DNA 分子名称: DNA (5'-D(P*TP*GP*CP*GP*CP*AP*GP*TP*A)-3'), Tyrosyl-DNA phosphodiesterase 1 著者 Richardson, J.M, Ruksenaite, E, Morris, E.R. 登録日 2017-05-05 公開日 2018-01-10 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.04 Å) 主引用文献 Structural basis for DNA 3'-end processing by human tyrosyl-DNA phosphodiesterase 1. Nat Commun, 9, 2018
8PKL	Escherichia coli paused disome complex (leading 70S non-rotated closed PRE state) 分子名称: 1,4-DIAMINOBUTANE, 16S ribosomal RNA, 23S ribosomal RNA, ... 著者 Fluegel, T, Schacherl, M. 登録日 2023-06-26 公開日 2024-03-06 最終更新日 2025-03-12 実験手法 ELECTRON MICROSCOPY (3.09 Å) 主引用文献 Transient disome complex formation in native polysomes during ongoing protein synthesis captured by cryo-EM. Nat Commun, 15, 2024
7RXV	Human Methionine Adenosyltransferase 2A bound to Methylthioadenosine, Malonate (MLA) and MgF3 分子名称: 5'-DEOXY-5'-METHYLTHIOADENOSINE, ALANINE, GLYCEROL, ... 著者 Fedorov, E, Niland, C.N, Schramm, V.L, Ghosh, A. 登録日 2021-08-23 公開日 2021-11-03 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.07 Å) 主引用文献 Mechanism of Triphosphate Hydrolysis by Human MAT2A at 1.07 angstrom Resolution. J.Am.Chem.Soc., 143, 2021
9G1T	Human LTC4 synthase in complex with compound 5 分子名称: 1-(4-chloranyl-3-fluoranyl-phenyl)-9-[(~{E})-3-phenylprop-2-enoyl]-1,9-diazaspiro[5.5]undecan-2-one, Leukotriene C4 synthase, PALMITIC ACID, ... 著者 Srinivas, H. 登録日 2024-07-10 公開日 2025-02-26 最終更新日 2025-03-05 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Discovery of GJG057, a Potent and Highly Selective Inhibitor of Leukotriene C4 Synthase. J.Med.Chem., 68, 2025
9CBH	Crystal Structure of Danio rerio Histone Deacetylase 10 in Complex with p-Aminomethyl Phenylthioketone 分子名称: 1-[4-(aminomethyl)phenyl]-2-sulfanylethan-1-one, PHOSPHATE ION, POTASSIUM ION, ... 著者 Goulart Stollmaier, J, Christianson, D.W. 登録日 2024-06-19 公開日 2024-09-11 最終更新日 2024-10-30 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Design, Synthesis, and Structural Evaluation of Acetylated Phenylthioketone Inhibitors of HDAC10. Acs Med.Chem.Lett., 15, 2024
9BS3	Wild type DNA Ligase 1 with 5'-rG:C 分子名称: ADENOSINE MONOPHOSPHATE, DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*TP*G)-3'), DNA (5'-D(P*GP*TP*CP*CP*GP*AP*CP*CP*AP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), ... 著者 KanalElamparithi, B, Caglayan, M. 登録日 2024-05-12 公開日 2024-09-25 最終更新日 2024-11-20 実験手法 X-RAY DIFFRACTION (2.69 Å) 主引用文献 Structures of LIG1 uncover the mechanism of sugar discrimination against 5'-RNA-DNA junctions during ribonucleotide excision repair. J.Biol.Chem., 300, 2024
5JZJ	Crystal structure of DCLK1-KD in complex with AMPPN 分子名称: AMP PHOSPHORAMIDATE, MAGNESIUM ION, SULFATE ION, ... 著者 Patel, O, Lucet, I. 登録日 2016-05-17 公開日 2016-08-24 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.71 Å) 主引用文献 Biochemical and Structural Insights into Doublecortin-like Kinase Domain 1. Structure, 24, 2016
9G14	Human LTC4 synthase in complex with compound 2 分子名称: 1-(phenylmethyl)-9-quinoxalin-2-yl-1,9-diazaspiro[5.5]undecan-2-one, DODECYL-BETA-D-MALTOSIDE, GLUTATHIONE, ... 著者 Srinivas, H. 登録日 2024-07-09 公開日 2025-02-26 最終更新日 2025-03-05 実験手法 X-RAY DIFFRACTION (2.24 Å) 主引用文献 Discovery of GJG057, a Potent and Highly Selective Inhibitor of Leukotriene C4 Synthase. J.Med.Chem., 68, 2025
8APH	rotational state 2c of the Trypanosoma brucei mitochondrial ATP synthase dimer 分子名称: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, 2-{[(4-O-alpha-D-glucopyranosyl-alpha-D-glucopyranosyl)oxy]methyl}-4-{[(3beta,9beta,14beta,17beta,25R)-spirost-5-en-3-yl]oxy}butyl 4-O-alpha-D-glucopyranosyl-alpha-D-glucopyranoside, ... 著者 Muehleip, A, Gahura, O, Zikova, A, Amunts, A. 登録日 2022-08-09 公開日 2022-10-26 実験手法 ELECTRON MICROSCOPY (3.8 Å) 主引用文献 An ancestral interaction module promotes oligomerization in divergent mitochondrial ATP synthases. Nat Commun, 13, 2022
6X9I	Human DNMT1(729-1600) Bound to Zebularine-Containing 12mer dsDNA 分子名称: 1,2-ETHANEDIOL, DNA (5'-D(*GP*AP*GP*GP*CP*(5CM)P*GP*CP*CP*TP*GP*C)-3'), DNA (5'-D(*GP*CP*AP*GP*G)-R(P*(PYO))-D(P*GP*GP*CP*CP*TP*C)-3'), ... 著者 Pathuri, S, Horton, J.R, Cheng, X. 登録日 2020-06-02 公開日 2021-07-07 最終更新日 2024-12-25 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Discovery of a first-in-class reversible DNMT1-selective inhibitor with improved tolerability and efficacy in acute myeloid leukemia. Nat Cancer, 2, 2021
8APJ	rotational state 2d of Trypanosoma brucei mitochondrial ATP synthase 分子名称: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, 2-{[(4-O-alpha-D-glucopyranosyl-alpha-D-glucopyranosyl)oxy]methyl}-4-{[(3beta,9beta,14beta,17beta,25R)-spirost-5-en-3-yl]oxy}butyl 4-O-alpha-D-glucopyranosyl-alpha-D-glucopyranoside, ... 著者 Muehleip, A, Gahura, O, Zikova, A, Amunts, A. 登録日 2022-08-09 公開日 2022-10-26 実験手法 ELECTRON MICROSCOPY (3.8 Å) 主引用文献 An ancestral interaction module promotes oligomerization in divergent mitochondrial ATP synthases. Nat Commun, 13, 2022
8APG	rotational state 2b of the Trypanosoma brucei mitochondrial ATP synthase dimer 分子名称: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, 2-{[(4-O-alpha-D-glucopyranosyl-alpha-D-glucopyranosyl)oxy]methyl}-4-{[(3beta,9beta,14beta,17beta,25R)-spirost-5-en-3-yl]oxy}butyl 4-O-alpha-D-glucopyranosyl-alpha-D-glucopyranoside, ... 著者 Muehleip, A, Gahura, O, Zikova, A, Amunts, A. 登録日 2022-08-09 公開日 2022-10-26 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 An ancestral interaction module promotes oligomerization in divergent mitochondrial ATP synthases. Nat Commun, 13, 2022
5IS8	Crystal structure of mouse CARM1 in complex with inhibitor SA0271 分子名称: 1,2-ETHANEDIOL, 5'-{[(3S)-3-amino-3-carboxypropyl](2-chloroethyl)amino}-5'-deoxyadenosine, Histone-arginine methyltransferase CARM1, ... 著者 Cura, V, Marechal, N, Mailliot, J, Troffer-Charlier, N, Hassenboehler, P, Wurtz, J.M, Bonnefond, L, Cavarelli, J. 登録日 2016-03-15 公開日 2017-03-15 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.709 Å) 主引用文献 Crystal structure of mouse CARM1 in complex with inhibitor SA0271 To Be Published
8APA	rotational state 1a of the Trypanosoma brucei mitochondrial ATP synthase dimer 分子名称: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, 2-{[(4-O-alpha-D-glucopyranosyl-alpha-D-glucopyranosyl)oxy]methyl}-4-{[(3beta,9beta,14beta,17beta,25R)-spirost-5-en-3-yl]oxy}butyl 4-O-alpha-D-glucopyranosyl-alpha-D-glucopyranoside, ... 著者 Muehleip, A, Gahura, O, Zikova, A, Amunts, A. 登録日 2022-08-09 公開日 2022-10-26 実験手法 ELECTRON MICROSCOPY (3.7 Å) 主引用文献 An ancestral interaction module promotes oligomerization in divergent mitochondrial ATP synthases. Nat Commun, 13, 2022
8APE	rotational state 1e of the Trypanosoma brucei mitochondrial ATP synthase dimer 分子名称: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, 2-{[(4-O-alpha-D-glucopyranosyl-alpha-D-glucopyranosyl)oxy]methyl}-4-{[(3beta,9beta,14beta,17beta,25R)-spirost-5-en-3-yl]oxy}butyl 4-O-alpha-D-glucopyranosyl-alpha-D-glucopyranoside, ... 著者 Muehleip, A, Gahura, O, Zikova, A, Amunts, A. 登録日 2022-08-09 公開日 2022-10-26 実験手法 ELECTRON MICROSCOPY (3.7 Å) 主引用文献 An ancestral interaction module promotes oligomerization in divergent mitochondrial ATP synthases. Nat Commun, 13, 2022

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