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7RY7

Structure of Plasmepsin X (PM10, PMX) from Plasmodium falciparum 3D7

Replaces:  6ORS
Summary for 7RY7
Entry DOI10.2210/pdb7ry7/pdb
DescriptorPlasmepsin X, 2-acetamido-2-deoxy-beta-D-glucopyranose, 1,2-ETHANEDIOL, ... (4 entities in total)
Functional Keywordsssgcid, plasmepsin x, plasmodium falciparum, pm10, pmx, structural genomics, seattle structural genomics center for infectious disease, hydrolase
Biological sourcePlasmodium falciparum (isolate 3D7)
Total number of polymer chains1
Total formula weight53364.27
Authors
Seattle Structural Genomics Center for Infectious Disease (SSGCID) (deposition date: 2021-08-24, release date: 2022-02-02, Last modification date: 2023-10-18)
Primary citationKesari, P.,Deshmukh, A.,Pahelkar, N.,Suryawanshi, A.B.,Rathore, I.,Mishra, V.,Dupuis, J.H.,Xiao, H.,Gustchina, A.,Abendroth, J.,Labaied, M.,Yada, R.Y.,Wlodawer, A.,Edwards, T.E.,Lorimer, D.D.,Bhaumik, P.
Structures of plasmepsin X from Plasmodium falciparum reveal a novel inactivation mechanism of the zymogen and molecular basis for binding of inhibitors in mature enzyme.
Protein Sci., 31:882-899, 2022
Cited by
PubMed: 35048450
DOI: 10.1002/pro.4279
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.1 Å)
Structure validation

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