8Q71
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![BU of 8q71 by Molmil](/molmil-images/mine/8q71) | Crystal structure of SARS-CoV-2 main protease (MPro) in complex with the inhibitor GC-67 | 分子名称: | (2~{S})-1-(3,4-dichlorophenyl)-4-(4-methoxypyridin-3-yl)carbonyl-~{N}-(thiophen-2-ylmethyl)piperazine-2-carboxamide, 3C-like proteinase nsp5 | 著者 | Strater, N, Muller, C.E, Sylvester, K, Weisse, R.H, Useini, A, Gao, S, Song, L, Liu, Z, Zhan, P. | 登録日 | 2023-08-15 | 公開日 | 2023-12-06 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.322 Å) | 主引用文献 | Design, Synthesis, and Biological Evaluation of Trisubstituted Piperazine Derivatives as Noncovalent Severe Acute Respiratory Syndrome Coronavirus 2 Main Protease Inhibitors with Improved Antiviral Activity and Favorable Druggability. J.Med.Chem., 66, 2023
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8Q3Y
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1BJR
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![BU of 1bjr by Molmil](/molmil-images/mine/1bjr) | COMPLEX FORMED BETWEEN PROTEOLYTICALLY GENERATED LACTOFERRIN FRAGMENT AND PROTEINASE K | 分子名称: | CALCIUM ION, LACTOFERRIN, PROTEINASE K | 著者 | Singh, T.P, Sharma, S, Karthikeyan, S, Betzel, C, Bhatia, K.L. | 登録日 | 1998-06-27 | 公開日 | 1998-11-04 | 最終更新日 | 2023-08-02 | 実験手法 | X-RAY DIFFRACTION (2.44 Å) | 主引用文献 | Crystal structure of a complex formed between proteolytically-generated lactoferrin fragment and proteinase K. Proteins, 33, 1998
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8Q85
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1BM3
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![BU of 1bm3 by Molmil](/molmil-images/mine/1bm3) | IMMUNOGLOBULIN OPG2 FAB-PEPTIDE COMPLEX | 分子名称: | IMMUNOGLOBULIN OPG2 FAB, CONSTANT DOMAIN, VARIABLE DOMAIN | 著者 | Kodandapani, R, Veerapandian, L, Ni, C.Z, Chiou, C.-K, Whital, R, Kunicki, T.J, Ely, K.R. | 登録日 | 1999-04-15 | 公開日 | 1999-04-20 | 最終更新日 | 2023-08-09 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Conformational change in an anti-integrin antibody: structure of OPG2 Fab bound to a beta 3 peptide. Biochem.Biophys.Res.Commun., 251, 1998
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8PFH
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![BU of 8pfh by Molmil](/molmil-images/mine/8pfh) | Crystal structure of the yeast septin complex Shs1-Cdc12-Cdc3-Cdc10 | 分子名称: | CDC10 isoform 1, CDC12 isoform 1, Cell division control protein 3, ... | 著者 | Grupp, B, Denkhaus, L, Gerhardt, S, Gronemeyer, T. | 登録日 | 2023-06-16 | 公開日 | 2023-12-06 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (3.24 Å) | 主引用文献 | The structure of a tetrameric septin complex reveals a hydrophobic element essential for NC-interface integrity. Commun Biol, 7, 2024
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8Q77
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![BU of 8q77 by Molmil](/molmil-images/mine/8q77) | STRUCTURE OF PROTEIN KINASE CK2 CATALYTIC SUBUNIT (ISOFORM CK2ALPHA'; CSNK2A2 GENE PRODUCT) IN COMPLEX WITH THE BISUBSTRATE INHIBITOR ARC-780 | 分子名称: | (2~{S})-2-[[(2~{S})-2-[[(2~{S})-2-[12-[[4-[[5-(4-carboxyphenyl)-1,3-thiazol-2-yl]amino]-4-oxidanylidene-butanoyl]-(2-hydroxy-2-oxoethyl)amino]dodecanoylamino]-4-oxidanyl-4-oxidanylidene-butanoyl]amino]-4-oxidanyl-4-oxidanylidene-butanoyl]amino]butanedioic acid, 1,2-ETHANEDIOL, CHLORIDE ION, ... | 著者 | Werner, C, Lindenblatt, D, Niefind, K. | 登録日 | 2023-08-15 | 公開日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (1.255 Å) | 主引用文献 | Discovery and Exploration of Protein Kinase CK2 Binding Sites Using CK2alpha Cys336Ser as an Exquisite Crystallographic Tool Kinases Phosphatases, 2023
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1BSS
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![BU of 1bss by Molmil](/molmil-images/mine/1bss) | ECORV-T93A/DNA/CA2+ | 分子名称: | 5'-D(*AP*AP*AP*GP*AP*TP*AP*TP*CP*TP*T)-3', CALCIUM ION, ECORV ENDONUCLEASE | 著者 | Perona, J.J, Horton, N.C. | 登録日 | 1998-08-30 | 公開日 | 1998-09-02 | 最終更新日 | 2023-08-02 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | Metal ion-mediated substrate-assisted catalysis in type II restriction endonucleases Proc.Natl.Acad.Sci.USA, 95, 1998
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8Q84
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![BU of 8q84 by Molmil](/molmil-images/mine/8q84) | |
1BUA
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8Q9S
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![BU of 8q9s by Molmil](/molmil-images/mine/8q9s) | STRUCTURE OF PROTEIN KINASE CK2 CATALYTIC SUBUNIT (ISOFORM CK2ALPHA'; CSNK2A2 GENE PRODUCT) IN COMPLEX WITH THE INHIBITOR SGC-CK2-1 | 分子名称: | 1,2-ETHANEDIOL, Casein kinase II subunit alpha', ~{N}-[5-[[3-cyano-7-(cyclopropylamino)-3~{H}-pyrazolo[1,5-a]pyrimidin-5-yl]amino]-2-methyl-phenyl]propanamide | 著者 | Werner, C, Lindenblatt, D, Niefind, K. | 登録日 | 2023-08-21 | 公開日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (1.352 Å) | 主引用文献 | Discovery and Exploration of Protein Kinase CK2 Binding Sites Using CK2alpha Cys336Ser as an Exquisite Crystallographic Tool Kinases Phosphatases, 2023
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8PZ3
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8PUY
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![BU of 8puy by Molmil](/molmil-images/mine/8puy) | TEAD2 with a covalent inhibitor | 分子名称: | MYRISTIC ACID, Transcriptional enhancer factor TEF-4, ~{N}-[3-[(3-pentoxyphenyl)amino]phenyl]propanamide | 著者 | Guichou, J.F, Gelin, M, Allemand, F. | 登録日 | 2023-07-17 | 公開日 | 2023-12-13 | 最終更新日 | 2024-01-03 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Development of HC-258, a Covalent Acrylamide TEAD Inhibitor That Reduces Gene Expression and Cell Migration. Acs Med.Chem.Lett., 14, 2023
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8Q6M
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![BU of 8q6m by Molmil](/molmil-images/mine/8q6m) | Human SOD1 low dose data collecton | 分子名称: | ACETATE ION, COPPER (II) ION, SULFATE ION, ... | 著者 | Antonyuk, S.V, Hossain, A, Agar, J.N, Hasnain, S.S. | 登録日 | 2023-08-14 | 公開日 | 2023-12-13 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.77 Å) | 主引用文献 | Evaluating protein cross-linking as a therapeutic strategy to stabilize SOD1 variants in a mouse model of familial ALS. Plos Biol., 22, 2024
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8Q6F
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8Q7I
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8PHB
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![BU of 8phb by Molmil](/molmil-images/mine/8phb) | Crystal structure of apo Cami1 | 分子名称: | CRISPR-associated protein, APE2256 family | 著者 | Tamulaitiene, G, Tamulaitis, G, Mogila, I, Keda, K. | 登録日 | 2023-06-19 | 公開日 | 2023-12-13 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Ribosomal stalk-captured CARF-RelE ribonuclease inhibits translation following CRISPR signaling. Science, 382, 2023
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6Y0J
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7QNC
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![BU of 7qnc by Molmil](/molmil-images/mine/7qnc) | Cryo-EM structure of human full-length extrasynaptic alpha4beta3delta GABA(A)R in complex with THIP (gaboxadol), histamine and nanobody Nb25 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 4,5,6,7-tetrahydro-[1,2]oxazolo[5,4-c]pyridin-3-one, ... | 著者 | Sente, A, Desai, R, Naydenova, K, Malinauskas, T, Jounaidi, Y, Miehling, J, Zhou, X, Masiulis, S, Hardwick, S.W, Chirgadze, D.Y, Miller, K.W, Aricescu, A.R. | 登録日 | 2021-12-20 | 公開日 | 2022-04-13 | 最終更新日 | 2022-04-20 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Differential assembly diversifies GABA A receptor structures and signalling. Nature, 604, 2022
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8Q6S
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![BU of 8q6s by Molmil](/molmil-images/mine/8q6s) | A carbohydrate esterase family 15 (CE15) glucuronoyl esterase from Phocaeicola vulgatus ATCC 8482 | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, DI(HYDROXYETHYL)ETHER, Putative acetyl xylan esterase, ... | 著者 | Mazurkewich, S, Seveso, A, Banerjee, S, Lo Leggio, L, Larsbrink, J. | 登録日 | 2023-08-14 | 公開日 | 2023-12-13 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.99 Å) | 主引用文献 | Polysaccharide utilization loci from Bacteroidota encode CE15 enzymes with possible roles in cleaving pectin-lignin bonds. Appl.Environ.Microbiol., 90, 2024
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8Q6G
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![BU of 8q6g by Molmil](/molmil-images/mine/8q6g) | HUMAN PI4KIIIB IN COMPLEX WITH COVALENTLY BOUND INHIBITOR (COMPOUND 8) | 分子名称: | 1,2-ETHANEDIOL, 3-(3,4-dimethoxyphenyl)-7-[(4-fluorosulfonyloxyphenyl)methylamino]-2,5-dimethyl-pyrazolo[1,5-a]pyrimidine, MAGNESIUM ION, ... | 著者 | Somers, D.O. | 登録日 | 2023-08-11 | 公開日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.541 Å) | 主引用文献 | Covalent targeting of non-cysteine residues in PI4KIII beta. Rsc Chem Biol, 4, 2023
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7QN5
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![BU of 7qn5 by Molmil](/molmil-images/mine/7qn5) | Cryo-EM structure of human full-length extrasynaptic alpha4beta3delta GABA(A)R in complex with nanobody Nb25 | 分子名称: | 1,2-DIPALMITOYL-SN-GLYCERO-3-PHOSPHATE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Sente, A, Desai, R, Naydenova, K, Malinauskas, T, Jounaidi, Y, Miehling, J, Zhou, X, Masiulis, S, Hardwick, S.W, Chirgadze, D.Y, Miller, K.W, Aricescu, A.R. | 登録日 | 2021-12-20 | 公開日 | 2022-04-13 | 最終更新日 | 2022-05-04 | 実験手法 | ELECTRON MICROSCOPY (2.5 Å) | 主引用文献 | Differential assembly diversifies GABA A receptor structures and signalling. Nature, 604, 2022
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8PUX
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![BU of 8pux by Molmil](/molmil-images/mine/8pux) | TEAD2 with a covalent inhibitor | 分子名称: | MYRISTIC ACID, Transcriptional enhancer factor TEF-4, ~{N}-[2-[(3-pentoxyphenyl)amino]phenyl]propanamide | 著者 | Guichou, J.F, Gelin, M, Allemand, F. | 登録日 | 2023-07-17 | 公開日 | 2023-12-13 | 最終更新日 | 2024-01-03 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Development of HC-258, a Covalent Acrylamide TEAD Inhibitor That Reduces Gene Expression and Cell Migration. Acs Med.Chem.Lett., 14, 2023
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8Q6H
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7QN7
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![BU of 7qn7 by Molmil](/molmil-images/mine/7qn7) | Cryo-EM structure of human full-length extrasynaptic alpha4beta3delta GABA(A)R in complex with GABA, histamine and nanobody Nb25 | 分子名称: | 1,2-DIPALMITOYL-SN-GLYCERO-3-PHOSPHATE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Sente, A, Desai, R, Naydenova, K, Malinauskas, T, Jounaidi, Y, Miehling, J, Zhou, X, Masiulis, S, Hardwick, S.W, Chirgadze, D.Y, Miller, K.W, Aricescu, A.R. | 登録日 | 2021-12-20 | 公開日 | 2022-04-13 | 最終更新日 | 2023-11-15 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Differential assembly diversifies GABA A receptor structures and signalling. Nature, 604, 2022
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