PDB: 37722 件ウェブページステータス検索Chemie searchBIRD

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6CRB	Ternary complex crystal structure of DNA polymerase Beta with a dideoxy terminated primer with CF2, beta, gamma dATP analogue 分子名称: 9-{2-deoxy-5-O-[(S)-{[(S)-[difluoro(phosphono)methyl](hydroxy)phosphoryl]oxy}(hydroxy)phosphoryl]-alpha-D-erythro-pentofuranosyl}-9H-purin-6-amine, DNA polymerase beta, Downstream Primer Strand, ... 著者 Batra, V.K, Wilson, S.H. 登録日 2018-03-16 公開日 2018-07-18 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.151 Å) 主引用文献 Mapping Functional Substrate-Enzyme Interactions in the pol beta Active Site through Chemical Biology: Structural Responses to Acidity Modification of Incoming dNTPs. Biochemistry, 57, 2018
1ZSA	CARBONIC ANHYDRASE II MUTANT E117Q, APO FORM 分子名称: CARBONIC ANHYDRASE II 著者 Lesburg, C.A, Christianson, D.W. 登録日 1996-01-09 公開日 1996-07-11 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Reversal of the hydrogen bond to zinc ligand histidine-119 dramatically diminishes catalysis and enhances metal equilibration kinetics in carbonic anhydrase II. Biochemistry, 35, 1996
7WIN	Crystal structure of BAZ2B TAM domain 分子名称: Bromodomain adjacent to zinc finger domain protein 2B 著者 Feng, Y.Y, Liu, K, Min, J.R. 登録日 2022-01-04 公開日 2022-02-02 最終更新日 2024-10-23 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Crystal structure of the BAZ2B TAM domain. Heliyon, 8, 2022
1ZSB	CARBONIC ANHYDRASE II MUTANT E117Q, TRANSITION STATE ANALOGUE ACETAZOLAMIDE 分子名称: 5-ACETAMIDO-1,3,4-THIADIAZOLE-2-SULFONAMIDE, CARBONIC ANHYDRASE II, ZINC ION 著者 Lesburg, C.A, Christianson, D.W. 登録日 1996-01-09 公開日 1996-07-11 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Reversal of the hydrogen bond to zinc ligand histidine-119 dramatically diminishes catalysis and enhances metal equilibration kinetics in carbonic anhydrase II. Biochemistry, 35, 1996
6M04	Structure of the human homo-hexameric LRRC8D channel at 4.36 Angstroms 分子名称: Volume-regulated anion channel subunit LRRC8D 著者 Nakamura, R, Kasuya, G, Yokoyama, T, Shirouzu, M, Ishitani, R, Nureki, O. 登録日 2020-02-20 公開日 2020-06-17 最終更新日 2024-10-09 実験手法 ELECTRON MICROSCOPY (4.36 Å) 主引用文献 Cryo-EM structure of the volume-regulated anion channel LRRC8D isoform identifies features important for substrate permeation. Commun Biol, 3, 2020
1ZSC	CARBONIC ANHYDRASE II MUTANT E117Q, HOLO FORM 分子名称: CARBONIC ANHYDRASE II, ZINC ION 著者 Lesburg, C.A, Christianson, D.W. 登録日 1996-01-09 公開日 1996-07-11 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Reversal of the hydrogen bond to zinc ligand histidine-119 dramatically diminishes catalysis and enhances metal equilibration kinetics in carbonic anhydrase II. Biochemistry, 35, 1996
1ZWC	STRUCTURE OF BOVINE PARATHYROID HORMONE FRAGMENT 1-37, NMR, 10 STRUCTURES 分子名称: PARATHYROID HORMONE 著者 Roesch, P, Marx, U.C. 登録日 1996-06-17 公開日 1997-03-12 最終更新日 2024-05-22 実験手法 SOLUTION NMR 主引用文献 Solution structures of human parathyroid hormone fragments hPTH(1-34) and hPTH(1-39) and bovine parathyroid hormone fragment bPTH(1-37). Biochem.Biophys.Res.Commun., 267, 2000
1ZWG	SUCCINYL HUMAN PARATHYROID HORMONE 4-37, NMR, 10 STRUCTURES 分子名称: PARATHYROID HORMONE 著者 Roesch, P, Marx, U.C. 登録日 1996-06-17 公開日 1997-06-16 最終更新日 2022-03-02 実験手法 SOLUTION NMR 主引用文献 Strukturen Verschiedener Parathormonfragmente in Loesung, 1996
6LUU	apo- Carbonic Anhydrase II pH 7.8 0 atm CO2 分子名称: Carbonic anhydrase 2, GLYCEROL 著者 Kim, C.U, Kim, J.K. 登録日 2020-02-02 公開日 2020-08-19 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.2 Å) 主引用文献 Elucidating the role of metal ions in carbonic anhydrase catalysis. Nat Commun, 11, 2020
1ZWA	STRUCTURE OF HUMAN PARATHYROID HORMONE FRAGMENT 1-34, NMR, 10 STRUCTURES 分子名称: PARATHYROID HORMONE 著者 Roesch, P, Marx, U.C. 登録日 1996-06-17 公開日 1997-03-12 最終更新日 2024-05-22 実験手法 SOLUTION NMR 主引用文献 Solution structures of human parathyroid hormone fragments hPTH(1-34) and hPTH(1-39) and bovine parathyroid hormone fragment bPTH(1-37). Biochem.Biophys.Res.Commun., 267, 2000
1ZWB	STRUCTURE OF HUMAN PARATHYROID HORMONE FRAGMENT 2-37, NMR, 10 STRUCTURES 分子名称: PARATHYROID HORMONE 著者 Roesch, P, Marx, U.C. 登録日 1996-06-17 公開日 1997-03-12 最終更新日 2024-05-22 実験手法 SOLUTION NMR 主引用文献 Structure-activity relation of NH2-terminal human parathyroid hormone fragments. J.Biol.Chem., 273, 1998
3GDH	Methyltransferase domain of human Trimethylguanosine Synthase 1 (TGS1) bound to m7GTP and adenosyl-homocysteine (active form) 分子名称: 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE, R-1,2-PROPANEDIOL, S-1,2-PROPANEDIOL, ... 著者 Monecke, T, Dickmanns, A, Ficner, R. 登録日 2009-02-24 公開日 2009-06-23 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural basis for m7G-cap hypermethylation of small nuclear, small nucleolar and telomerase RNA by the dimethyltransferase TGS1. Nucleic Acids Res., 37, 2009
1ZWE	STRUCTURE OF HUMAN PARATHYROID HORMONE FRAGMENT 4-37, NMR, 10 STRUCTURES 分子名称: PARATHYROID HORMONE 著者 Roesch, P, Marx, U.C. 登録日 1996-06-17 公開日 1997-03-12 最終更新日 2024-05-22 実験手法 SOLUTION NMR 主引用文献 Structure-activity relation of NH2-terminal human parathyroid hormone fragments. J.Biol.Chem., 273, 1998
2F3J	The solution structure of the REF2-I mRNA export factor (residues 1-155). 分子名称: RNA and export factor binding protein 2 著者 Golovanov, A.P, Hautbergue, G.M, Wilson, S.A, Lian, L.Y. 登録日 2005-11-21 公開日 2006-10-31 最終更新日 2024-05-29 実験手法 SOLUTION NMR 主引用文献 The solution structure of REF2-I reveals interdomain interactions and regions involved in binding mRNA export factors and RNA. Rna, 12, 2006
3OWP	Human cAMP-dependent protein kinase in complex with an inhibitor 分子名称: (2S)-2-amino-N'-[(1E)-(3-bromo-4-hydroxyphenyl)methylidene]-2-phenylethanehydrazide, cAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase inhibitor alpha 著者 Koester, H, Heine, A, Klebe, G. 登録日 2010-09-20 公開日 2011-09-21 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (1.88 Å) 主引用文献 fragment based drug design on PKA To be Published
6CJV	Carbonic anhydrase IX-mimic in complex with sucralose 分子名称: 4-chloro-4-deoxy-alpha-D-galactopyranose-(1-2)-1,6-dichloro-1,6-dideoxy-beta-D-fructofuranose, Carbonic anhydrase 2, ZINC ION 著者 Lomelino, C.L, Murray, A.B, McKenna, R. 登録日 2018-02-26 公開日 2018-08-08 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.547 Å) 主引用文献 Sweet Binders: Carbonic Anhydrase IX in Complex with Sucralose. ACS Med Chem Lett, 9, 2018
2ACS	AN ANION BINDING SITE IN HUMAN ALDOSE REDUCTASE: MECHANISTIC IMPLICATIONS FOR THE BINDING OF CITRATE, CACODYLATE, AND GLUCOSE-6-PHOSPHATE 分子名称: ALDOSE REDUCTASE, CITRIC ACID, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE 著者 Harrison, D.H, Bohren, K.M, Gabbay, K.H, Petsko, G.A, Ringe, D. 登録日 1994-04-15 公開日 1994-07-31 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (1.76 Å) 主引用文献 An anion binding site in human aldose reductase: mechanistic implications for the binding of citrate, cacodylate, and glucose 6-phosphate. Biochemistry, 33, 1994
6NHK	Mortalin nucleotide binding domain in the ADP-bound state 分子名称: ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, MAGNESIUM ION, ... 著者 Page, R.C, Moseng, M.A, Nix, J.C. 登録日 2018-12-23 公開日 2019-04-17 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.777 Å) 主引用文献 Biophysical Consequences of EVEN-PLUS Syndrome Mutations for the Function of Mortalin. J.Phys.Chem.B, 123, 2019
4M2V	Genetically engineered Carbonic Anhydrase IX in complex with Brinzolamide 分子名称: (+)-4-ETHYLAMINO-3,4-DIHYDRO-2-(METHOXY)PROPYL-2H-THIENO[3,2-E]-1,2-THIAZINE-6-SULFONAMIDE-1,1-DIOXIDE, Carbonic anhydrase 2, ZINC ION 著者 Pinard, M.P, Boone, C.D, Rife, B.D, Supuran, C.T, Mckenna, R. 登録日 2013-08-05 公開日 2013-11-06 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.718 Å) 主引用文献 Structural study of interaction between brinzolamide and dorzolamide inhibition of human carbonic anhydrases. Bioorg.Med.Chem., 21, 2013
2ACR	AN ANION BINDING SITE IN HUMAN ALDOSE REDUCTASE: MECHANISTIC IMPLICATIONS FOR THE BINDING OF CITRATE, CACODYLATE, AND GLUCOSE-6-PHOSPHATE 分子名称: ALDOSE REDUCTASE, CACODYLATE ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE 著者 Harrison, D.H, Bohren, K.M, Gabbay, K.H, Petsko, G.A, Ringe, D. 登録日 1994-04-15 公開日 1994-07-31 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (1.76 Å) 主引用文献 An anion binding site in human aldose reductase: mechanistic implications for the binding of citrate, cacodylate, and glucose 6-phosphate. Biochemistry, 33, 1994
6CM9	Structure of the cargo bound AP-1:Arf1:tetherin-Nef closed trimer monomeric subunit 分子名称: ADP-ribosylation factor 1, AP-1 complex subunit beta-1, AP-1 complex subunit gamma-1, ... 著者 Morris, K.L, Buffalo, C.Z, Ren, X, Hurley, J.H. 登録日 2018-03-03 公開日 2018-08-08 最終更新日 2024-03-13 実験手法 ELECTRON MICROSCOPY (3.73 Å) 主引用文献 HIV-1 Nefs Are Cargo-Sensitive AP-1 Trimerization Switches in Tetherin Downregulation. Cell, 174, 2018
2AGT	Aldose Reductase Mutant Leu 300 Pro complexed with Fidarestat 分子名称: (2S,4S)-2-AMINOFORMYL-6-FLUORO-SPIRO[CHROMAN-4,4'-IMIDAZOLIDINE]-2',5'-DIONE, Aldose reductase, CHLORIDE ION, ... 著者 Petrova, T, Steuber, H, Hazemann, I, Cousido-Siah, A, Mitschler, A, Chung, R, Oka, M, Klebe, G, El-Kabbani, O, Joachimiak, A, Podjarny, A. 登録日 2005-07-27 公開日 2005-09-20 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (1 Å) 主引用文献 Factorizing Selectivity Determinants of Inhibitor Binding toward Aldose and Aldehyde Reductases: Structural and Thermodynamic Properties of the Aldose Reductase Mutant Leu300Pro-Fidarestat Complex J.Med.Chem., 48, 2005
6NQ2	Cryo-EM structure of human TPC2 channel in the ligand-bound closed state 分子名称: (2R)-3-{[(S)-hydroxy{[(1S,2R,3R,4S,5S,6R)-2,4,6-trihydroxy-3,5-bis(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}propane-1,2-diyl dioctanoate, Two pore calcium channel protein 2 著者 She, J, Zeng, W, Guo, J, Chen, Q, Bai, X, Jiang, Y. 登録日 2019-01-18 公開日 2019-03-27 最終更新日 2019-11-20 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 Structural mechanisms of phospholipid activation of the human TPC2 channel. Elife, 8, 2019
6NKV	Ternary complex crystal structure of DNA polymerase Beta with "hot-spot sequence" with beta-gamma CHF analogue of dGTP 分子名称: 2'-DEOXY-5'-O-[(R)-{[(R)-[(R)-FLUORO(PHOSPHONO)METHYL](HYDROXY)PHOSPHORYL]OXY}(HYDROXY)PHOSPHORYL]GUANOSINE, CHLORIDE ION, DNA (5'-D(*CP*CP*GP*AP*AP*CP*AP*AP*GP*CP*AP*TP*CP*AP*GP*C)-3'), ... 著者 Batra, V.K, Wilson, S.H. 登録日 2019-01-07 公開日 2020-01-08 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Revealing an Internal Stabilization Deficiency in the DNA Polymerase beta K289M Cancer Variant through the Combined Use of Chemical Biology and X-ray Crystallography. Biochemistry, 59, 2020
2WUL	CRYSTAL STRUCTURE OF THE HUMAN GLUTAREDOXIN 5 WITH BOUND GLUTATHIONE IN AN FES CLUSTER 分子名称: CHLORIDE ION, DI(HYDROXYETHYL)ETHER, FE2/S2 (INORGANIC) CLUSTER, ... 著者 Roos, A.K, Johansson, C, Guo, K, Yue, W.W, Pike, A.C.W, Cooper, C.D.O, Pilka, E.S, Kavanagh, K.L, Chaikuad, A, von Delft, F, Arrowsmith, C.H, Weigelt, J, Edwards, A, Bountra, C, Oppermann, U. 登録日 2009-10-06 公開日 2009-10-20 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 The Crystal Structure of Human Glrx5: Iron Sulphur Cluster Coordination, Tetrameric Assembly and Monomer Activity. Biochem.J., 433, 2011

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