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7FZO

Crystal Structure of human FABP4 in complex with 4-oxo-3-(2-phenylethyl)-10-oxa-3-azatricyclo[5.2.1.01,5]dec-8-ene-6-carboxylic acid, i.e. SMILES [C@H]12[C@@]3(O[C@H]([C@H]2C(=O)O)C=C3)CN(C1=O)CCc1ccccc1 with IC50=3.5 microM

Summary for 7FZO
Entry DOI10.2210/pdb7fzo/pdb
Group depositionTo be published (G_1002264)
DescriptorFatty acid-binding protein, adipocyte, (3aR,6S,7R,7aS)-1-oxo-2-(2-phenylethyl)-1,2,3,6,7,7a-hexahydro-3a,6-epoxyisoindole-7-carboxylic acid, FORMIC ACID, ... (4 entities in total)
Functional Keywordslipid binding protein, fatty acid binding protein, cytoplasm, lipid-binding, transport, protein binding
Biological sourceHomo sapiens (human)
Total number of polymer chains1
Total formula weight15367.52
Authors
Ehler, A.,Benz, J.,Obst, U.,Brunner, M.,Rudolph, M.G. (deposition date: 2023-04-27, release date: 2023-06-14, Last modification date: 2024-11-20)
Primary citationObst, U.,Magnone, C.,Kuhn, B.,Rudolph, M.G.
Crystal Structure of a human FABP4 complex
To be published,
Experimental method
X-RAY DIFFRACTION (0.99 Å)
Structure validation

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PDB entries from 2024-11-20

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