PDB: 35712 件ウェブページステータス検索Chemie searchBIRD

---

5JAD	Compound binding to Human Lipoprotein-Associated Phospholipase A2 (Lp-PLA2)discovered through fragment screening 分子名称: CHLORIDE ION, DIMETHYL SULFOXIDE, MAGNESIUM ION, ... 著者 Day, P.J, Woolford, A.J.-A. 登録日 2016-04-12 公開日 2016-05-25 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Exploitation of a Novel Binding Pocket in Human Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) Discovered through X-ray Fragment Screening. J.Med.Chem., 59, 2016
4YZP	Crystal structure of a tri-modular GH5 (subfamily 4) endo-beta-1, 4-glucanase from Bacillus licheniformis 分子名称: Cellulose hydrolase 著者 Liberato, M.V, Popov, A, Polikarpov, I. 登録日 2015-03-25 公開日 2016-09-07 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Molecular characterization of a family 5 glycoside hydrolase suggests an induced-fit enzymatic mechanism. Sci Rep, 6, 2016
5JAH	Exploitation of a Novel Binding Pocket in Human Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) Discovered Through X-Ray Fragment Screening 分子名称: 1,5,5-trimethylimidazolidine-2,4-dione, CHLORIDE ION, Platelet-activating factor acetylhydrolase 著者 Day, P.J. 登録日 2016-04-12 公開日 2016-05-25 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.06 Å) 主引用文献 Exploitation of a Novel Binding Pocket in Human Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) Discovered through X-ray Fragment Screening. J.Med.Chem., 59, 2016
7DWC	Bacteroides thetaiotaomicron VPI5482 BTAxe1 分子名称: Xylanase 著者 Wang, L.Y, Wang, Y.L, Xin, F.J, Sun, L.C. 登録日 2021-01-17 公開日 2022-01-19 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.804 Å) 主引用文献 Rational Design for Broadened Substrate Specificity and Enhanced Activity of a Novel Acetyl Xylan Esterase from Bacteroides thetaiotaomicron. J.Agric.Food Chem., 69, 2021
4Z26	Mimivirus R135 (residues 51-702) 分子名称: FLAVIN-ADENINE DINUCLEOTIDE, Putative GMC-type oxidoreductase R135 著者 Klose, T, Rossmann, M.G. 登録日 2015-03-28 公開日 2015-05-13 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.915 Å) 主引用文献 A Mimivirus Enzyme that Participates in Viral Entry. Structure, 23, 2015
1HEP	STRUCTURAL AND THERMODYNAMIC ANALYSIS OF COMPENSATING MUTATIONS WITHIN THE CORE OF CHICKEN EGG WHITE LYSOZYME 分子名称: HEN EGG WHITE LYSOZYME 著者 Wilson, K.P, Malcolm, B.A, Matthews, B.W. 登録日 1992-01-10 公開日 1993-10-31 最終更新日 2021-06-30 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structural and thermodynamic analysis of compensating mutations within the core of chicken egg white lysozyme. J.Biol.Chem., 267, 1992
4N8Z	In situ lysozyme crystallized on a MiTeGen micromesh with benzamidine ligand 分子名称: BENZAMIDINE, CHLORIDE ION, Lysozyme C, ... 著者 Yin, X, Scalia, A, Leroy, L, Cuttitta, C.M, Polizzo, G.M, Ericson, D.L, Roessler, C.G, Campos, O, Agarwal, R, Allaire, M, Orville, A.M, Jackimowicz, R, Ma, M.Y, Sweet, R.M, Soares, A.S. 登録日 2013-10-18 公開日 2013-10-30 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.2 Å) 主引用文献 Hitting the target: fragment screening with acoustic in situ co-crystallization of proteins plus fragment libraries on pin-mounted data-collection micromeshes. Acta Crystallogr.,Sect.D, 70, 2014
1GYD	Structure of Cellvibrio cellulosa alpha-L-arabinanase 分子名称: ARABINAN ENDO-1,5-ALPHA-L-ARABINOSIDASE A 著者 Nurizzo, D, Turkenburg, J.P, Charnock, S.J, Roberts, S.M, Dodson, E.J, McKie, V.A, Taylor, E.J, Gilbert, H.J, Davies, G.J. 登録日 2002-04-23 公開日 2002-08-23 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Cellvibrio japonicus alpha-L-arabinanase 43A has a novel five-blade beta-propeller fold. Nat. Struct. Biol., 9, 2002
1GYP	CRYSTAL STRUCTURE OF GLYCOSOMAL GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE FROM LEISHMANIA MEXICANA: IMPLICATIONS FOR STRUCTURE-BASED DRUG DESIGN AND A NEW POSITION FOR THE INORGANIC PHOSPHATE BINDING SITE 分子名称: GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, PHOSPHATE ION 著者 Kim, H, Feil, I.K, Verlinde, C.L.M.J, Petra, P.H, Hol, W.G.J. 登録日 1995-08-01 公開日 1995-12-07 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Crystal structure of glycosomal glyceraldehyde-3-phosphate dehydrogenase from Leishmania mexicana: implications for structure-based drug design and a new position for the inorganic phosphate binding site. Biochemistry, 34, 1995
3NKD	Structure of CRISP-associated protein Cas1 from Escherichia coli str. K-12 分子名称: CRISPR-associated protein Cas1 著者 Nocek, B, Skarina, T, Beloglazova, N, Savchenko, A, Joachimiak, A, Yakunin, A. 登録日 2010-06-18 公開日 2010-08-25 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 A dual function of the CRISPR-Cas system in bacterial antivirus immunity and DNA repair. Mol.Microbiol., 79, 2011
1GOW	BETA-GLYCOSIDASE FROM SULFOLOBUS SOLFATARICUS 分子名称: BETA-GLYCOSIDASE 著者 Pearl, L.H, Aguilar, C.F, Sanderson, I. 登録日 1996-09-19 公開日 1997-08-20 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Crystal structure of the beta-glycosidase from the hyperthermophilic archeon Sulfolobus solfataricus: resilience as a key factor in thermostability. J.Mol.Biol., 271, 1997
3NKN	Crystal structure of mouse autotaxin in complex with 14:0-LPA 分子名称: (2R)-2-hydroxy-3-(phosphonooxy)propyl tetradecanoate, 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Nishimasu, H, Ishitani, R, Mihara, E, Takagi, J, Aoki, J, Nureki, O. 登録日 2010-06-20 公開日 2011-01-19 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Crystal structure of autotaxin and insight into GPCR activation by lipid mediators Nat.Struct.Mol.Biol., 18, 2011
1GRB	SUBSTRATE BINDING AND CATALYSIS BY GLUTATHIONE REDUCTASE AS DERIVED FROM REFINED ENZYME: SUBSTRATE CRYSTAL STRUCTURES AT 2 ANGSTROMS RESOLUTION 分子名称: FLAVIN-ADENINE DINUCLEOTIDE, GLUTATHIONE REDUCTASE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... 著者 Karplus, P.A, Schulz, G.E. 登録日 1992-12-15 公開日 1994-01-31 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Substrate binding and catalysis by glutathione reductase as derived from refined enzyme: substrate crystal structures at 2 A resolution. J.Mol.Biol., 210, 1989
1U2Y	In situ extension as an approach for identifying novel alpha-amylase inhibitors, structure containing D-gluconhydroximo-1,5-lactam 分子名称: (2S,3S,4R,5R)-6-(HYDROXYAMINO)-2-(HYDROXYMETHYL)-2,3,4,5-TETRAHYDROPYRIDINE-3,4,5-TRIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-amylase, ... 著者 Numao, S, Li, C, Damager, I, Wrodnigg, T.M, Begum, A, Overall, C.M, Brayer, G.D, Withers, S.G. 登録日 2004-07-20 公開日 2004-09-07 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 In Situ Extension as an Approach for Identifying Novel alpha-Amylase Inhibitors. J.Biol.Chem., 279, 2004
5R87	PanDDA analysis group deposition INTERLEUKIN-1 BETA -- Fragment Z44592329 in complex with INTERLEUKIN-1 BETA 分子名称: Interleukin-1 beta, N-phenyl-N'-pyridin-3-ylurea, SULFATE ION 著者 De Nicola, G.F, Nichols, C.E. 登録日 2020-03-03 公開日 2020-04-22 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (1.47 Å) 主引用文献 Mining the PDB for Tractable Cases Where X-ray Crystallography Combined with Fragment Screens Can Be Used to Systematically Design Protein-Protein Inhibitors: Two Test Cases Illustrated by IL1 beta-IL1R and p38 alpha-TAB1 Complexes. J.Med.Chem., 63, 2020
3N0U	Crystal structure of Tm1821, the 8-oxoguanine DNA glycosylase of Thermotoga maritima 分子名称: Probable N-glycosylase/DNA lyase, SODIUM ION 著者 Cooper, D.R, Roy, A, Derewenda, Z.S, Integrated Center for Structure and Function Innovation (ISFI) 登録日 2010-05-14 公開日 2011-04-06 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Crystal structure of Tm1821, the 8-oxoguanine DNA glycosylase of Thermotoga maritima To be Published
3MZS	Crystal Structure of Cytochrome P450 CYP11A1 in complex with 22-hydroxy-cholesterol 分子名称: (3alpha,8alpha,22R)-cholest-5-ene-3,22-diol, Cholesterol side-chain cleavage enzyme, ISOPROPYL ALCOHOL, ... 著者 Stout, C.D, Annalora, A, Mast, N, Pikuleva, I. 登録日 2010-05-12 公開日 2010-12-15 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structural Basis for Three-step Sequential Catalysis by the Cholesterol Side Chain Cleavage Enzyme CYP11A1. J.Biol.Chem., 286, 2011
5R8L	PanDDA analysis group deposition INTERLEUKIN-1 BETA -- Fragment Z1891773393 in complex with INTERLEUKIN-1 BETA 分子名称: Interleukin-1 beta, N-{4-[(1S)-1-aminoethyl]phenyl}cyclopropanecarboxamide, SULFATE ION 著者 De Nicola, G.F, Nichols, C.E. 登録日 2020-03-03 公開日 2020-04-22 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (1.56 Å) 主引用文献 Mining the PDB for Tractable Cases Where X-ray Crystallography Combined with Fragment Screens Can Be Used to Systematically Design Protein-Protein Inhibitors: Two Test Cases Illustrated by IL1 beta-IL1R and p38 alpha-TAB1 Complexes. J.Med.Chem., 63, 2020
1HD7	A Second Divalent Metal Ion in the Active Site of a New Crystal Form of Human Apurinic/Apyridinimic Endonuclease, Ape1, and its Implications for the Catalytic Mechanism 分子名称: DNA-(APURINIC OR APYRIMIDINIC SITE) LYASE, LEAD (II) ION 著者 Beernink, P.T, Segelke, B.W, Rupp, B. 登録日 2000-11-09 公開日 2001-02-16 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Two Divalent Metal Ions in the Active Site of a New Crystal Form of Human Apurinic/Apyrimidinic Endonuclease, Ape1: Implications for the Catalytic Mechanism J.Mol.Biol., 307, 2001
5JFG	Structure of humanised RadA-mutant humRadA22F in complex with peptide FHTA 分子名称: CALCIUM ION, DIMETHYL SULFOXIDE, DNA repair and recombination protein RadA, ... 著者 Fischer, G, Marsh, M, Moschetti, T, Sharpe, T, Scott, D, Morgan, M, Ng, H, Skidmore, J, Venkitaraman, A, Abell, C, Blundell, T.L, Hyvonen, M. 登録日 2016-04-19 公開日 2016-10-26 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (1.77 Å) 主引用文献 Humanisation of RadA from Pyrococcus furiosus To Be Published
1GT8	DIHYDROPYRIMIDINE DEHYDROGENASE (DPD) FROM PIG, TERNARY COMPLEX WITH NADPH AND URACIL-4-ACETIC ACID 分子名称: DIHYDROPYRIMIDINE DEHYDROGENASE, FLAVIN MONONUCLEOTIDE, FLAVIN-ADENINE DINUCLEOTIDE, ... 著者 Dobritzsch, D, Ricagno, S, Schneider, G, Schnackerz, K.D, Lindqvist, Y. 登録日 2002-01-14 公開日 2002-04-11 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (3.3 Å) 主引用文献 Crystal structure of the productive ternary complex of dihydropyrimidine dehydrogenase with NADPH and 5-iodouracil. Implications for mechanism of inhibition and electron transfer. J. Biol. Chem., 277, 2002
3N1X	X-ray Crystal Structure of Toluene/o-Xylene Monooxygenase Hydroxylase T201C Mutant 分子名称: 1,2-ETHANEDIOL, FE (III) ION, HYDROXIDE ION, ... 著者 Sazinsky, M.H, McCormick, M.S, Lippard, S.J. 登録日 2010-05-17 公開日 2010-10-13 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Active Site Threonine Facilitates Proton Transfer during Dioxygen Activation at the Diiron Center of Toluene/o-Xylene Monooxygenase Hydroxylase. J.Am.Chem.Soc., 132, 2010
5R93	PanDDA analysis group deposition Form1 MAP kinase p38-alpha -- Fragment KCL077 in complex with MAP kinase p38-alpha 分子名称: CHLORIDE ION, DIMETHYL SULFOXIDE, MAGNESIUM ION, ... 著者 De Nicola, G.F, Nichols, C.E. 登録日 2020-03-04 公開日 2020-07-22 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (1.489 Å) 主引用文献 Mining the PDB for Tractable Cases Where X-ray Crystallography Combined with Fragment Screens Can Be Used to Systematically Design Protein-Protein Inhibitors: Two Test Cases Illustrated by IL1 beta-IL1R and p38 alpha-TAB1 Complexes. J.Med.Chem., 63, 2020
1GTE	DIHYDROPYRIMIDINE DEHYDROGENASE (DPD) FROM PIG, BINARY COMPLEX WITH 5-IODOURACIL 分子名称: 5-IODOURACIL, DIHYDROPYRIMIDINE DEHYDROGENASE, FLAVIN MONONUCLEOTIDE, ... 著者 Dobritzsch, D, Ricagno, S, Schneider, G, Schnackerz, K.D, Lindqvist, Y. 登録日 2002-01-15 公開日 2002-04-11 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Crystal structure of the productive ternary complex of dihydropyrimidine dehydrogenase with NADPH and 5-iodouracil. Implications for mechanism of inhibition and electron transfer. J. Biol. Chem., 277, 2002
4MOR	Pyranose 2-oxidase H450G/V546C double mutant with 3-fluorinated galactose 分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 3-deoxy-3-fluoro-beta-D-galactopyranose, DIHYDROFLAVINE-ADENINE DINUCLEOTIDE, ... 著者 Tan, T.C, Spadiut, O, Gandini, R, Haltrich, D, Divne, C. 登録日 2013-09-12 公開日 2014-02-05 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Structural Basis for Binding of Fluorinated Glucose and Galactose to Trametes multicolor Pyranose 2-Oxidase Variants with Improved Galactose Conversion. Plos One, 9, 2014

<939940941942943944945946947948949950951952953954>