PDB: 5653 件ウェブページステータス検索Chemie searchBIRD

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3DBP	Crystal Structure of Human Orotidine 5'-Monophosphate Decarboxylase Complexed with 6-NH2-UMP 分子名称: 6-AMINOURIDINE 5'-MONOPHOSPHATE, Orotidine 5'-phosphate decarboxylase, SULFATE ION 著者 Liu, Y, To, T, Bello, A.M, Kotra, L.P, Pai, E.F. 登録日 2008-06-02 公開日 2009-06-23 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Crystal Structure of Human Orotidine 5'-Monophosphate Decarboxylase Complexed with 6-NH2-UMP To be Published
4YCJ	Structure of Acetobacter aceti PurE Y154F 分子名称: 1,2-ETHANEDIOL, N5-carboxyaminoimidazole ribonucleotide mutase, SULFATE ION 著者 Kappock, T.J, Sullivan, K.L. 登録日 2015-02-20 公開日 2016-02-24 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.845 Å) 主引用文献 Structure of a single tryptophan mutant of Acetobacter aceti PurE To Be Published
4RV4	2.65 Angstrom Resolution Crystal Structure of an orotate phosphoribosyltransferase from Bacillus anthracis str. 'Ames Ancestor' in complex with 5-phospho-alpha-D-ribosyl diphosphate (PRPP) 分子名称: 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose, DI(HYDROXYETHYL)ETHER, Orotate phosphoribosyltransferase 著者 Halavaty, A.S, Minasov, G, Shuvalova, L, Winsor, J, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID) 登録日 2014-11-24 公開日 2014-12-17 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.65 Å) 主引用文献 2.65 Angstrom resolution crystal structure of an orotate phosphoribosyltransferase from Bacillus anthracis str. 'Ames Ancestor' in complex with 5-phospho-alpha-D-ribosyl diphosphate (PRPP) To be Published
4U72	Crystal structure of 4-phenylimidazole bound form of human indoleamine 2,3-dioxygenase (A260G mutant) 分子名称: 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, 4-PHENYL-1H-IMIDAZOLE, Indoleamine 2,3-dioxygenase 1, ... 著者 Sugimoto, H, Horitani, M, Kometani, E, Shiro, Y. 登録日 2014-07-30 公開日 2015-09-02 最終更新日 2020-01-29 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Conformation and Mobility of Active Site Loop is Critical for Substrate Binding and Inhibition in Human Indoleamine 2,3-Dioxygenase to be published
4ZC8	Structure of Acetobacter aceti PurE-S57T 分子名称: 1,2-ETHANEDIOL, ACETATE ION, N5-carboxyaminoimidazole ribonucleotide mutase, ... 著者 Kappock, T.J, Sullivan, K.L. 登録日 2015-04-15 公開日 2016-04-27 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.754 Å) 主引用文献 Mutation of the conserved serine in two PurE classes To Be Published
3GZ3	Leishmania major Dihydroorotate Dehydrogenase in complex with orotate 分子名称: Dihydroorotate dehydrogenase, putative, FLAVIN MONONUCLEOTIDE, ... 著者 Cordeiro, A.T, Feliciano, P.R, Nonato, M.C. 登録日 2009-04-06 公開日 2010-04-28 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Leismania major dihydroorotate in complex with orotate To be Published
4S1N	The crystal structure of phosphoribosylglycinamide formyltransferase from Streptococcus pneumoniae TIGR4 分子名称: CHLORIDE ION, Phosphoribosylglycinamide formyltransferase 著者 Tan, K, Zhou, M, Kwon, K, Anderson, W.F, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) 登録日 2015-01-14 公開日 2015-01-28 最終更新日 2017-11-22 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 The crystal structure of phosphoribosylglycinamide formyltransferase from Streptococcus pneumoniae TIGR4 To be Published
3GZH	Crystal structure of phosphate-bound adenylosuccinate lyase from E. coli 分子名称: Adenylosuccinate lyase, PHOSPHATE ION, SODIUM ION 著者 Kozlov, G, Gehring, K, Montreal-Kingston Bacterial Structural Genomics Initiative (BSGI) 登録日 2009-04-07 公開日 2009-08-25 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 The structure of phosphate-bound Escherichia coli adenylosuccinate lyase identifies His171 as a catalytic acid. Acta Crystallogr.,Sect.F, 65, 2009
3E2P	Catalytic subunit of M. Jannaschii aspartate transcarbamoylase in an orthorhombic crystal form 分子名称: Aspartate carbamoyltransferase, SULFATE ION 著者 Vitali, J, Colaneri, M.J. 登録日 2008-08-06 公開日 2009-03-10 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Structure of the catalytic trimer of Methanococcus jannaschii aspartate transcarbamoylase in an orthorhombic crystal form. Acta Crystallogr.,Sect.F, 64, 2008
4U74	Crystal structure of 4-phenylimidazole bound form of human indoleamine 2,3-dioxygenase (G262A mutant) 分子名称: 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, 4-PHENYL-1H-IMIDAZOLE, Indoleamine 2,3-dioxygenase 1, ... 著者 Sugimoto, H, Horitani, M, Kometani, E, Shiro, Y. 登録日 2014-07-30 公開日 2015-09-02 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.31 Å) 主引用文献 Conformation and Mobility of Active Site Loop is Critical for Substrate Binding and Inhibition in Human Indoleamine 2,3-Dioxygenase to be published
3EX1	human orotidyl-5'-monophosphate decarboxylase soaked with 6-cyano-UMP, converted to UMP 分子名称: 6-cyanouridine 5'-phosphate, GLYCEROL, Orotidine-5'-phosphate decarboxylase, ... 著者 Heinrich, D, Diederichsen, U, Rudolph, M. 登録日 2008-10-16 公開日 2009-04-07 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Lys314 is a nucleophile in non-classical reactions of orotidine-5'-monophosphate decarboxylase Chemistry, 15, 2009
3EWY	K314A mutant of human orotidyl-5'-monophosphate decarboxylase soaked with OMP, decarboxylated to UMP 分子名称: GLYCEROL, Orotidine-5'-phosphate decarboxylase, URIDINE-5'-MONOPHOSPHATE 著者 Heinrich, D, Diederichsen, U, Rudolph, M. 登録日 2008-10-16 公開日 2009-04-07 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (1.1 Å) 主引用文献 Lys314 is a nucleophile in non-classical reactions of orotidine-5'-monophosphate decarboxylase Chemistry, 15, 2009
4ZK2	Structure of Acetobacter aceti PurE-S57D 分子名称: 1,2-ETHANEDIOL, N5-carboxyaminoimidazole ribonucleotide mutase 著者 Sullivan, K.L, Kappock, T.J. 登録日 2015-04-29 公開日 2016-05-11 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.749 Å) 主引用文献 Serine mutants of Acetobacter aceti PurE To be published
3EX2	human orotidyl-5'-monophosphate decarboxylase in complex with 6-cyano-UMP 分子名称: 6-cyanouridine 5'-phosphate, GLYCEROL, Orotidine-5'-phosphate decarboxylase 著者 Heinrich, D, Diederichsen, U, Rudolph, M. 登録日 2008-10-16 公開日 2009-04-07 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Lys314 is a nucleophile in non-classical reactions of orotidine-5'-monophosphate decarboxylase Chemistry, 15, 2009
3EWW	D312N mutant of human orotidyl-5'-monophosphate decarboxylase in complex with 6-cyano-UMP, covalent adduct 分子名称: 6-[(E)-iminomethyl]uridine 5'-phosphate, GLYCEROL, Orotidine-5'-phosphate decarboxylase 著者 Heinrich, D, Wittmann, J, Diederichsen, U, Rudolph, M. 登録日 2008-10-16 公開日 2009-04-07 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (1.1 Å) 主引用文献 Lys314 is a nucleophile in non-classical reactions of orotidine-5'-monophosphate decarboxylase Chemistry, 15, 2009
3EWZ	human orotidyl-5'-monophosphate decarboxylase in complex with 5-cyano-UMP 分子名称: 5-CYANO-URIDINE-5'-MONOPHOSPHATE, Orotidine-5'-phosphate decarboxylase, SULFATE ION 著者 Heinrich, D, Diederichsen, U, Rudolph, M. 登録日 2008-10-16 公開日 2009-04-07 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Lys314 is a nucleophile in non-classical reactions of orotidine-5'-monophosphate decarboxylase Chemistry, 15, 2009
3F1Q	Human dihydroorotate dehydrogenase in complex with a leflunomide derivative inhibitor 1 分子名称: (2Z)-N-biphenyl-4-yl-2-cyano-3-hydroxybut-2-enamide, ACETIC ACID, Dihydroorotate dehydrogenase, ... 著者 Heikkila, T, Davies, M, McConkey, G.A, Fishwick, C.W.G, Parsons, M.R, Johnson, A.P. 登録日 2008-10-28 公開日 2009-06-09 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structure-based design, synthesis, and characterization of inhibitors of human and Plasmodium falciparum dihydroorotate dehydrogenases J.Med.Chem., 52, 2009
3EX6	D312N mutant of human orotidyl-5'-monophosphate decarboxylase in complex with 6-azido-UMP, covalent adduct 分子名称: CHLORIDE ION, GLYCEROL, Orotidine-5'-phosphate decarboxylase, ... 著者 Heinrich, D, Diederichsen, U, Rudolph, M. 登録日 2008-10-16 公開日 2009-04-07 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (1.3 Å) 主引用文献 Lys314 is a nucleophile in non-classical reactions of orotidine-5'-monophosphate decarboxylase Chemistry, 15, 2009
3FJL	Human dihydroorotate dehydrogenase in complex with a leflunomide derivative inhibitor 3 分子名称: (2Z)-2-cyano-N-(3'-ethoxybiphenyl-4-yl)-3-hydroxybut-2-enamide, ACETIC ACID, Dihydroorotate dehydrogenase, ... 著者 Heikkila, T. 登録日 2008-12-14 公開日 2009-06-09 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structure-based design, synthesis, and characterization of inhibitors of human and Plasmodium falciparum dihydroorotate dehydrogenases J.Med.Chem., 52, 2009
3GYE	Didydroorotate dehydrogenase from Leishmania major 分子名称: Dihydroorotate dehydrogenase, putative, FLAVIN MONONUCLEOTIDE, ... 著者 Cordeiro, A.T, Feliciano, P.R, Nonato, M.C. 登録日 2009-04-03 公開日 2010-04-07 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Crystal Structure of Leishmania major Dihydroorotate dehydrogenase To be Published
6VCU	Homo sapiens FKBP12 protein bound with APX879 in P32 space group 分子名称: ACETATE ION, N'-[(3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-5,19-dihydroxy-3-{(1E)-1-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]prop-1-en-2-yl}-14,16-dimethoxy-4,10,12,18-tetramethyl-1,20,21-trioxo-8-(prop-2-en-1-yl)-1,3,4,5,6,8,11,12,13,14,15,16,17,18,19,20,21,23,24,25,26,26a-docosahydro-7H-15,19-epoxypyrido[2,1-c][1,4]oxazacyclotricosin-7-ylidene]acetohydrazide, Peptidyl-prolyl cis-trans isomerase FKBP1A 著者 Gobeil, S, Spicer, L. 登録日 2019-12-23 公開日 2020-12-16 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.69 Å) 主引用文献 Leveraging Fungal and Human Calcineurin-Inhibitor Structures, Biophysical Data, and Dynamics To Design Selective and Nonimmunosuppressive FK506 Analogs. Mbio, 12, 2021
6V52	IDO1 IN COMPLEX WITH COMPOUND 1 分子名称: 3-chloro-N-{4-[1-(propylcarbamoyl)cyclobutyl]phenyl}benzamide, Indoleamine 2,3-dioxygenase 1 著者 Lesburg, C.A, Koenig, K.V, Augustin, M.A. 登録日 2019-12-03 公開日 2020-04-08 最終更新日 2020-04-29 実験手法 X-RAY DIFFRACTION (1.78 Å) 主引用文献 Strategic Incorporation of Polarity in Heme-Displacing Inhibitors of Indoleamine-2,3-dioxygenase-1 (IDO1). Acs Med.Chem.Lett., 11, 2020
3KIZ	Crystal structure of Putative phosphoribosylformylglycinamidine cyclo-ligase (YP_676759.1) from CYTOPHAGA HUTCHINSONII ATCC 33406 at 1.50 A resolution 分子名称: 1,2-ETHANEDIOL, ACETATE ION, Phosphoribosylformylglycinamidine cyclo-ligase 著者 Joint Center for Structural Genomics (JCSG) 登録日 2009-11-02 公開日 2009-11-17 最終更新日 2023-02-01 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Crystal structure of Putative phosphoribosylformylglycinamidine cyclo-ligase (YP_676759.1) from CYTOPHAGA HUTCHINSONII ATCC 33406 at 1.50 A resolution To be published
6VTY	Crystal structure of Plasmodium falciparum dihydroorotate dehydrogenase bound with Inhibitor DSM483 分子名称: Dihydroorotate dehydrogenase (quinone), mitochondrial, FLAVIN MONONUCLEOTIDE, ... 著者 Deng, X, Phillips, M. 登録日 2020-02-13 公開日 2020-04-22 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.78 Å) 主引用文献 Lead Optimization of a Pyrrole-Based Dihydroorotate Dehydrogenase Inhibitor Series for the Treatment of Malaria. J.Med.Chem., 63, 2020
6VTN	Crystal structure of Plasmodium falciparum dihydroorotate dehydrogenase bound with Inhibitor DSM557 分子名称: Dihydroorotate dehydrogenase (quinone), mitochondrial, FLAVIN MONONUCLEOTIDE, ... 著者 Deng, X, Phillips, M. 登録日 2020-02-13 公開日 2020-04-22 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Lead Optimization of a Pyrrole-Based Dihydroorotate Dehydrogenase Inhibitor Series for the Treatment of Malaria. J.Med.Chem., 63, 2020

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