PDB: 5434 件ウェブページステータス検索Chemie searchBIRD

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5IVY	Linked KDM5A Jmj Domain Bound to the Inhibitor N16 [3-(2-(4-chlorophenyl)acetamido)isonicotinic acid] 分子名称: 3-{[(4-chlorophenyl)acetyl]amino}pyridine-4-carboxylic acid, Lysine-specific demethylase 5A, MANGANESE (II) ION 著者 Horton, J.R, Cheng, X. 登録日 2016-03-21 公開日 2016-07-27 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 Structural Basis for KDM5A Histone Lysine Demethylase Inhibition by Diverse Compounds. Cell Chem Biol, 23, 2016
8BWF	PTBP1 RRM1 bound to an allosteric inhibitor 分子名称: AMINO GROUP, GLYCEROL, Ligand, ... 著者 Schmeing, S, Vetter, I, t Hart, P, Gasper, R. 登録日 2022-12-06 公開日 2023-10-11 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Rationally designed stapled peptides allosterically inhibit PTBP1-RNA-binding. Chem Sci, 14, 2023
3HMF	Crystal Structure of the second Bromodomain of Human Poly-bromodomain containing protein 1 (PB1) 分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, Protein polybromo-1, ... 著者 Filippakopoulos, P, Picaud, S, Keates, T, Muniz, J, von Delft, F, Arrowsmith, C.H, Edwards, A, Weigelt, J, Bountra, C, Knapp, S, Structural Genomics Consortium (SGC) 登録日 2009-05-29 公開日 2009-06-23 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.63 Å) 主引用文献 Histone recognition and large-scale structural analysis of the human bromodomain family. Cell(Cambridge,Mass.), 149, 2012
5IW0	Linked KDM5A Jmj Domain Bound to the Inhibitor N19 [2-(5-((4-chloro-2-methylbenzyl)oxy)-1H-pyrazol-1-yl)isonicotinic acid] 分子名称: 1,2-ETHANEDIOL, 2-OXOGLUTARIC ACID, 2-{5-[(4-chloro-2-methylphenyl)methoxy]-1H-pyrazol-1-yl}pyridine-4-carboxylic acid, ... 著者 Horton, J.R, Cheng, X. 登録日 2016-03-21 公開日 2016-07-27 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.63 Å) 主引用文献 Structural Basis for KDM5A Histone Lysine Demethylase Inhibition by Diverse Compounds. Cell Chem Biol, 23, 2016
7ZRY	Structure of the 2a splicing variant of the full-length human LSD1 bound to CoREST (delta305) 分子名称: FLAVIN-ADENINE DINUCLEOTIDE, Isoform of Lysine-specific histone demethylase 1A, REST corepressor 1 著者 Caroli, J, Mattevi, A. 登録日 2022-05-06 公開日 2022-08-03 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Fine-tuned KDM1A alternative splicing regulates human cardiomyogenesis through an enzymatic-independent mechanism. Iscience, 25, 2022
5L4K	The human 26S proteasome lid 分子名称: 26S proteasome complex subunit DSS1, 26S proteasome non-ATPase regulatory subunit 1, 26S proteasome non-ATPase regulatory subunit 11, ... 著者 Schweitzer, A, Aufderheide, A, Rudack, T, Beck, F. 登録日 2016-05-25 公開日 2016-09-07 最終更新日 2024-05-08 実験手法 ELECTRON MICROSCOPY (3.9 Å) 主引用文献 Structure of the human 26S proteasome at a resolution of 3.9 angstrom. Proc.Natl.Acad.Sci.USA, 113, 2016
8A6L	Human 4F2hc-LAT2 heterodimeric amino acid transporter in complex with anticalin D11vs 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 4F2hc cell-surface antigen heavy chain, Anticalin D11vs, ... 著者 Jeckelmann, J.M, Fotiadis, D. 登録日 2022-06-18 公開日 2022-11-09 実験手法 ELECTRON MICROSCOPY (3.18 Å) 主引用文献 Structure of the human heterodimeric transporter 4F2hc-LAT2 in complex with Anticalin, an alternative binding protein for applications in single-particle cryo-EM. Sci Rep, 12, 2022
5L8J	Aurora-A kinase domain in complex with vNAR-D01 S93R 分子名称: 1,2-ETHANEDIOL, ADENOSINE-5'-DIPHOSPHATE, Aurora kinase A, ... 著者 Burgess, S.G, Bayliss, R. 登録日 2016-06-08 公開日 2016-07-20 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.68 Å) 主引用文献 Allosteric inhibition of Aurora-A kinase by a synthetic vNAR domain. Open Biology, 6, 2016
7ZN7	Cryo-EM structure of RCMV-E E27 bound to human DDB1 (deltaBPB) and rat STAT2 CCD 分子名称: B27a, DNA damage-binding protein 1, Signal transducer and activator of transcription, ... 著者 Lauer, S, Spahn, C.M.T, Schwefel, D. 登録日 2022-04-20 公開日 2022-11-09 最終更新日 2023-03-15 実験手法 ELECTRON MICROSCOPY (3.78 Å) 主引用文献 Structural mechanism of CRL4-instructed STAT2 degradation via a novel cytomegaloviral DCAF receptor. Embo J., 42, 2023
5KUS	Human cyclophilin A at 100K, Data set 6 分子名称: Peptidyl-prolyl cis-trans isomerase A 著者 Russi, S, Gonzalez, A, Kenner, L.R, Keedy, D.A, Fraser, J.S, van den Bedem, H. 登録日 2016-07-13 公開日 2016-08-10 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Conformational variation of proteins at room temperature is not dominated by radiation damage. J Synchrotron Radiat, 24, 2017
5KV1	Human cyclophilin A at 278K, Data set 3 分子名称: Peptidyl-prolyl cis-trans isomerase A 著者 Russi, S, Gonzalez, A, Kenner, L.R, Keedy, D.A, Fraser, J.S, van den Bedem, H. 登録日 2016-07-13 公開日 2016-08-10 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Conformational variation of proteins at room temperature is not dominated by radiation damage. J Synchrotron Radiat, 24, 2017
3J5Y	Structure of the mammalian ribosomal pre-termination complex associated with eRF1-eRF3-GDPNP 分子名称: 5'-R(*AP*UP*UP*GP*UP*AP*AP*AP*AP*A)-3', Eukaryotic peptide chain release factor GTP-binding subunit ERF3A, Eukaryotic peptide chain release factor subunit 1, ... 著者 des Georges, A, Hashem, Y, Unbehaun, A, Grassucci, R.A, Taylor, D, Hellen, C.U.T, Pestova, T.V, Frank, J. 登録日 2013-11-21 公開日 2013-12-25 最終更新日 2018-07-18 実験手法 ELECTRON MICROSCOPY (9.7 Å) 主引用文献 Structure of the mammalian ribosomal pre-termination complex associated with eRF1*eRF3*GDPNP. Nucleic Acids Res., 42, 2014
8BGF	NMR solution structure of the N-terminal RRM and flanking linker regions of Polypyrimidine tract binding protein 1 using the CYANA CONSENSUS method. 分子名称: Polypyrimidine tract-binding protein 1 著者 Damberger, F.D, Beusch, I, Allain, F.H.-T. 登録日 2022-10-27 公開日 2023-11-08 実験手法 SOLUTION NMR 主引用文献 N-terminal domain of Polypyrimidine-tract binding protein is a dynamic folding platform for adaptive RNA recognition To Be Published
3L0E	X-ray crystal structure of a Potent Liver X Receptor Modulator 分子名称: N-(2-chloro-6-fluorobenzyl)-1-methyl-N-{[3'-(methylsulfonyl)biphenyl-4-yl]methyl}-1H-imidazole-4-sulfonamide, Nuclear receptor coactivator 2, Oxysterols receptor LXR-beta 著者 Gampe Jr, R.T. 登録日 2009-12-09 公開日 2010-04-07 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Discovery of tertiary sulfonamides as potent liver X receptor antagonists. J.Med.Chem., 53, 2010
3L3L	PARP complexed with A906894 分子名称: 3-oxo-2-piperidin-4-yl-2,3-dihydro-1H-isoindole-4-carboxamide, Poly [ADP-ribose] polymerase 1 著者 Park, C.H. 登録日 2009-12-17 公開日 2010-12-22 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Discovery and SAR of substituted 3-oxoisoindoline-4-carboxamides as potent inhibitors of poly(ADP-ribose) polymerase (PARP) for the treatment of cancer. Bioorg.Med.Chem.Lett., 20, 2010
8BTT	Structure of human RTCB 分子名称: MANGANESE (II) ION, RNA-splicing ligase RtcB homolog 著者 Kopp, J, Gerber, J.L, Peschek, J. 登録日 2022-11-30 公開日 2023-12-13 最終更新日 2024-04-17 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Structural and mechanistic insights into activation of the human RNA ligase RTCB by Archease. Nat Commun, 15, 2024
3KTT	Atomic model of bovine TRiC CCT2(beta) subunit derived from a 4.0 Angstrom cryo-EM map 分子名称: T-complex protein 1 subunit beta 著者 Cong, Y, Baker, M.L, Ludtke, S.J, Frydman, J, Chiu, W. 登録日 2009-11-25 公開日 2010-03-16 最終更新日 2024-02-21 実験手法 ELECTRON MICROSCOPY (4 Å) 主引用文献 4.0-A resolution cryo-EM structure of the mammalian chaperonin TRiC/CCT reveals its unique subunit arrangement. Proc.Natl.Acad.Sci.USA, 107, 2010
7ZNN	Cryo-EM structure of RCMV-E E27 bound to human DDB1 (deltaBPB) and full-length rat STAT2 分子名称: B27a, DNA damage-binding protein 1, Signal transducer and activator of transcription, ... 著者 Lauer, S, Spahn, C.M.T, Schwefel, D. 登録日 2022-04-21 公開日 2022-11-09 最終更新日 2023-03-15 実験手法 ELECTRON MICROSCOPY (4.8 Å) 主引用文献 Structural mechanism of CRL4-instructed STAT2 degradation via a novel cytomegaloviral DCAF receptor. Embo J., 42, 2023
3LBD	LIGAND-BINDING DOMAIN OF THE HUMAN RETINOIC ACID RECEPTOR GAMMA BOUND TO 9-CIS RETINOIC ACID 分子名称: (9cis)-retinoic acid, RETINOIC ACID RECEPTOR GAMMA 著者 Klaholz, B.P, Renaud, J.-P, Mitschler, A, Moras, D, Structural Proteomics in Europe (SPINE) 登録日 1998-02-04 公開日 1999-03-02 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Conformational adaptation of agonists to the human nuclear receptor RAR gamma. Nat.Struct.Biol., 5, 1998
5KPO	Structure of human PARP1 catalytic domain bound to a quinazoline-2,4(1H,3H)-dione inhibitor 分子名称: 1-[[3-(4-ethyl-3-oxidanylidene-piperazin-1-yl)carbonyl-4-fluoranyl-phenyl]methyl]quinazoline-2,4-dione, Poly [ADP-ribose] polymerase 1 著者 Cao, R, Wang, Y.L, Zhou, J, Yao, H.P, Huang, N, Xu, B.L. 登録日 2016-07-05 公開日 2016-12-21 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2.65 Å) 主引用文献 Structure of human PARP1 catalytic domain bound to a quinazoline-2,4(1H,3H)-dione inhibitor To Be Published
5KUN	Human cyclophilin A at 100K, Data set 2 分子名称: Peptidyl-prolyl cis-trans isomerase A 著者 Russi, S, Gonzalez, A, Kenner, L.R, Keedy, D.A, Fraser, J.S, van den Bedem, H. 登録日 2016-07-13 公開日 2016-08-10 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Conformational variation of proteins at room temperature is not dominated by radiation damage. J Synchrotron Radiat, 24, 2017
5KUW	Human cyclophilin A at 100K, Data set 9 分子名称: Peptidyl-prolyl cis-trans isomerase A 著者 Russi, S, Gonzalez, A, Kenner, L.R, Keedy, D.A, Fraser, J.S, van den Bedem, H. 登録日 2016-07-13 公開日 2016-08-10 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Conformational variation of proteins at room temperature is not dominated by radiation damage. J Synchrotron Radiat, 24, 2017
5KV5	Human cyclophilin A at 278K, Data set 7 分子名称: Peptidyl-prolyl cis-trans isomerase A 著者 Russi, S, Gonzalez, A, Kenner, L.R, Keedy, D.A, Fraser, J.S, van den Bedem, H. 登録日 2016-07-13 公開日 2016-08-10 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Conformational variation of proteins at room temperature is not dominated by radiation damage. J Synchrotron Radiat, 24, 2017
3HU2	Structure of p97 N-D1 R86A mutant in complex with ATPgS 分子名称: MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, Transitional endoplasmic reticulum ATPase 著者 Tang, W.-K. 登録日 2009-06-12 公開日 2010-06-16 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.85 Å) 主引用文献 A novel ATP-dependent conformation in p97 N-D1 fragment revealed by crystal structures of disease-related mutants. Embo J., 29, 2010
5KPQ	Structure of human PARP1 catalytic domain bound to a quinazoline-2,4(1H,3H)-dione inhibitor 分子名称: 1-[[4-fluoranyl-3-[(3R)-3-methyl-4-propyl-piperazin-1-yl]carbonyl-phenyl]methyl]quinazoline-2,4-dione, Poly [ADP-ribose] polymerase 1 著者 Cao, R, Wang, Y.L, Zhou, J, Huang, N, Xu, B.L. 登録日 2016-07-05 公開日 2016-12-14 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.55 Å) 主引用文献 Structure of human PARP1 catalytic domain bound to a quinazoline-2,4(1H,3H)-dione inhibitor To Be Published

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