7ZRY

Structure of the 2a splicing variant of the full-length human LSD1 bound to CoREST (delta305)

Summary for 7ZRY

• Entry DOI: 10.2210/pdb7zry/pdb
• Descriptor: Isoform of Lysine-specific histone demethylase 1A, REST corepressor 1, FLAVIN-ADENINE DINUCLEOTIDE (3 entities in total)
• Functional Keywords: demethylase, histone, splicing, epigenetics, flavoprotein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 115850.57

Authors

Caroli, J.,Mattevi, A. (deposition date: 2022-05-06, release date: 2022-08-03, Last modification date: 2024-01-31)

• Primary citation: Astro, V.,Ramirez-Calderon, G.,Pennucci, R.,Caroli, J.,Saera-Vila, A.,Cardona-Londono, K.,Forastieri, C.,Fiacco, E.,Maksoud, F.,Alowaysi, M.,Sogne, E.,Falqui, A.,Gonzalez, F.,Montserrat, N.,Battaglioli, E.,Mattevi, A.,Adamo, A.; Fine-tuned KDM1A alternative splicing regulates human cardiomyogenesis through an enzymatic-independent mechanism.; Iscience, 25:104665-104665, 2022; PubMed: 35856020; DOI: 10.1016/j.isci.2022.104665

Experimental method

X-RAY DIFFRACTION (2.7 Å)