PDB: 13252 件ウェブページステータス検索Chemie searchBIRD

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3KMQ	G62S mutant of foot-and-mouth disease virus RNA-polymerase in complex with a template- primer RNA, tetragonal structure 分子名称: 3D polymerase, RNA (5'-R(*GP*GP*CP*CP*C)-3'), RNA (5'-R(P*GP*GP*GP*CP*C)-3') 著者 Ferrer-Orta, C, Verdaguer, N, Perez-Luque, R. 登録日 2009-11-11 公開日 2010-07-07 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.11 Å) 主引用文献 Structure of foot-and-mouth disease virus mutant polymerases with reduced sensitivity to ribavirin J.Virol., 84, 2010
5UHD	Crystal structure of Mycobacterium tuberculosis transcription initiation complex containing 4nt RNA in complex with Rifampin 分子名称: DNA (5'-D(*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*CP*GP*AP*GP*G)-3'), DNA (5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*G)-3'), DNA-directed RNA polymerase subunit alpha, ... 著者 Lin, W, Das, K, Feng, Y, Ebright, R.H. 登録日 2017-01-11 公開日 2017-04-12 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (4.01 Å) 主引用文献 Structural Basis of Mycobacterium tuberculosis Transcription and Transcription Inhibition. Mol. Cell, 66, 2017
5UH5	Crystal structure of Mycobacterium tuberculosis transcription initiation complex containing 3 nt of RNA 分子名称: DNA (5'-D(*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*CP*CP*AP*GP*G)-3'), DNA (5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*G)-3'), DNA-directed RNA polymerase subunit alpha, ... 著者 Lin, W, Das, K, Feng, Y, Ebright, R.H. 登録日 2017-01-10 公開日 2017-04-12 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (3.746 Å) 主引用文献 Structural Basis of Mycobacterium tuberculosis Transcription and Transcription Inhibition. Mol. Cell, 66, 2017
3IVK	Crystal Structure of the Catalytic Core of an RNA Polymerase Ribozyme Complexed with an Antigen Binding Antibody Fragment 分子名称: CADMIUM ION, CHLORIDE ION, Fab heavy chain, ... 著者 Koldobskaya, Y, Duguid, E.M, Shechner, D.M, Koide, S, Kossiakoff, A.A, Bartel, D.P, Piccirilli, J.A. 登録日 2009-09-01 公開日 2010-03-02 最終更新日 2017-11-01 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Crystal structure of the catalytic core of an RNA-polymerase ribozyme. Science, 326, 2009
8A8F	Crystal structure of Glc7 phosphatase in complex with the regulatory region of Ref2 分子名称: MANGANESE (II) ION, PHOSPHATE ION, RNA end formation protein 2, ... 著者 Carminati, M, Manav, C.M, Bellini, D, Passmore, L.A. 登録日 2022-06-22 公開日 2023-11-29 最終更新日 2024-06-12 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 A direct interaction between CPF and RNA Pol II links RNA 3' end processing to transcription. Mol.Cell, 83, 2023
3KLV	M296I G62S mutant of foot-and-mouth disease virus RNA-polymerase in complex with a template- primer RNA 分子名称: 3D polymerase, MAGNESIUM ION, RNA (5'-R(*AP*UP*GP*GP*GP*CP*C)-3'), ... 著者 Ferrer-Orta, C, Sierra, M, Agudo, R, Perez-Luque, R, Arias, A, Verdaguer, N. 登録日 2009-11-09 公開日 2010-07-07 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Structure of foot-and-mouth disease virus mutant polymerases with reduced sensitivity to ribavirin J.Virol., 84, 2010
2FVC	Crystal structure of NS5B BK strain (delta 24) in complex with a 3-(1,1-Dioxo-2H-(1,2,4)-benzothiadiazin-3-yl)-4-hydroxy-2(1H)-quinolinone 分子名称: 3-(1,1-dioxido-4H-1,2,4-benzothiadiazin-3-yl)-4-hydroxy-1-(3-methylbutyl)quinolin-2(1H)-one, polyprotein 著者 Concha, N.O, Wonacott, A, Singh, O. 登録日 2006-01-30 公開日 2007-01-16 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 3-(1,1-dioxo-2H-(1,2,4)-benzothiadiazin-3-yl)-4-hydroxy-2(1H)-quinolinones, potent inhibitors of hepatitis C virus RNA-dependent RNA polymerase. J.Med.Chem., 49, 2006
8CWT	Complex structure of WhiB3 and the SigmaAr4-RNAP Beta flap tip chimera in space group P43212 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, IRON/SULFUR CLUSTER, NICKEL (II) ION, ... 著者 Wan, T, Zhang, L. 登録日 2022-05-19 公開日 2023-05-17 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (1.35 Å) 主引用文献 Structural basis of DNA binding by the WhiB-like transcription factor WhiB3 in Mycobacterium tuberculosis. J.Biol.Chem., 299, 2023
3C66	Yeast poly(A) polymerase in complex with Fip1 residues 80-105 分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, GLYCEROL, Poly(A) polymerase, ... 著者 Bohm, A, Meinke, G. 登録日 2008-02-02 公開日 2008-05-20 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Structure of yeast poly(A) polymerase in complex with a peptide from Fip1, an intrinsically disordered protein. Biochemistry, 47, 2008
8P7D	CryoEM structure of METTL6 tRNA SerRS complex in a 1:1:2 stoichiometry 分子名称: MAGNESIUM ION, S-ADENOSYL-L-HOMOCYSTEINE, Serine tRNA, ... 著者 Throll, P, Dolce, L.G, Kowalinski, E. 登録日 2023-05-30 公開日 2024-06-12 最終更新日 2024-07-10 実験手法 ELECTRON MICROSCOPY (4.2 Å) 主引用文献 Structural basis of tRNA recognition by the m 3 C RNA methyltransferase METTL6 in complex with SerRS seryl-tRNA synthetase. Nat.Struct.Mol.Biol., 2024
8P7B	CryoEM structure of METTL6 tRNA SerRS complex in a 1:2:2 stoichiometry 分子名称: MAGNESIUM ION, S-ADENOSYL-L-HOMOCYSTEINE, Serine tRNA, ... 著者 Throll, P, Dolce, L.G, Kowalinski, E. 登録日 2023-05-30 公開日 2024-06-12 最終更新日 2024-07-10 実験手法 ELECTRON MICROSCOPY (2.42 Å) 主引用文献 Structural basis of tRNA recognition by the m 3 C RNA methyltransferase METTL6 in complex with SerRS seryl-tRNA synthetase. Nat.Struct.Mol.Biol., 2024
8P7C	CryoEM structure of METTL6 tRNA SerRS complex in a 2:2:2 stoichiometry 分子名称: MAGNESIUM ION, S-ADENOSYL-L-HOMOCYSTEINE, Serine tRNA, ... 著者 Throll, P, Dolce, L.G, Kowalinski, E. 登録日 2023-05-30 公開日 2024-06-12 最終更新日 2024-07-10 実験手法 ELECTRON MICROSCOPY (3.7 Å) 主引用文献 Structural basis of tRNA recognition by the m 3 C RNA methyltransferase METTL6 in complex with SerRS seryl-tRNA synthetase. Nat.Struct.Mol.Biol., 2024
4H3H	Crystal structure of a ternary complex of human symplekin NTD, human Ssu72 and a RNA poymerase II CTD peptide phosphorylated at SER-7 分子名称: PHOSPHATE ION, Pol II CTD peptide, RNA polymerase II subunit A C-terminal domain phosphatase SSU72, ... 著者 Xiang, K, Tong, L. 登録日 2012-09-13 公開日 2012-10-31 最終更新日 2017-11-15 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 An unexpected binding mode for a Pol II CTD peptide phosphorylated at Ser7 in the active site of the CTD phosphatase Ssu72. Genes Dev., 26, 2012
3NKY	Structure of a mutant P44S of Foot-and-mouth disease Virus RNA-dependent RNA polymerase 分子名称: 3D polymerase, MAGNESIUM ION 著者 Agudo, R, Ferrer-Orta, C, Arias, A, Perez-Luque, R, Verdaguer, N, Domingo, E. 登録日 2010-06-21 公開日 2011-05-25 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.28 Å) 主引用文献 A multi-step process of viral adaptation to a mutagenic nucleoside analogue by modulation of transition types leads to extinction-escape. Plos Pathog., 6, 2010
4WSE	Crystal structure of the Mimivirus polyadenylate synthase 分子名称: Putative poly(A) polymerase catalytic subunit 著者 Priet, S, Lartigue, A, Claverie, J.M, Abergel, C. 登録日 2014-10-27 公開日 2015-04-01 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.84 Å) 主引用文献 mRNA maturation in giant viruses: variation on a theme. Nucleic Acids Res., 43, 2015
5TRK	CRYSTAL STRUCTURE OF THE HEPATITIS C VIRUS NS5B RNA- DEPENDENT RNA POLYMERASE IN COMPLEX WITH N-{3-[(benzenecarbonyl)amino]-4-[(4-chlorophenyl)methoxy]benzene-1-carbonyl}glycine 分子名称: (2E)-3-(4-{[(1-{[(13-cyclohexyl-6-oxo-6,7-dihydro-5H-indolo[1,2-d][1,4]benzodiazepin-10-yl)carbonyl]amino}cyclopentyl)carbonyl]amino}phenyl)prop-2-enoic acid, Genome polyprotein, N-{3-[(benzenecarbonyl)amino]-4-[(4-chlorophenyl)methoxy]benzene-1-carbonyl}glycine, ... 著者 Sheriff, S. 登録日 2016-10-26 公開日 2016-11-30 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.06 Å) 主引用文献 Discovery and initial optimization of alkoxyanthranilic acid derivatives as inhibitors of HCV NS5B polymerase. Bioorg. Med. Chem. Lett., 27, 2017
8CWR	Complex structure of WhiB3 and the SigmaAr4-RNAP Beta flap tip chimera in space group R3 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, IRON/SULFUR CLUSTER, NICKEL (II) ION, ... 著者 Wan, T, Zhang, L. 登録日 2022-05-19 公開日 2023-05-17 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Structural basis of DNA binding by the WhiB-like transcription factor WhiB3 in Mycobacterium tuberculosis. J.Biol.Chem., 299, 2023
4LCK	Co-crystal structure of a T-box riboswitch stem I domain in complex with its cognate tRNA 分子名称: MAGNESIUM ION, Ribosomal protein YbxF, STRONTIUM ION, ... 著者 Zhang, J, Ferre-D'Amare, A.R. 登録日 2013-06-21 公開日 2013-07-31 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Co-crystal structure of a T-box riboswitch stem I domain in complex with its cognate tRNA. Nature, 500, 2013
8G9F	Complete auto-inhibitory complex of Xenopus laevis DNA polymerase alpha-primase 分子名称: DNA polymerase alpha catalytic subunit, DNA polymerase alpha subunit B, DNA primase, ... 著者 Mullins, E.A, Chazin, W.J, Eichman, B.F. 登録日 2023-02-21 公開日 2023-04-12 最終更新日 2024-05-29 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 A mechanistic model of primer synthesis from catalytic structures of DNA polymerase alpha-primase. Nat.Struct.Mol.Biol., 31, 2024
5FJ7	Structure of the P2 polymerase inside in vitro assembled bacteriophage phi6 polymerase complex, with P1 included 分子名称: MAJOR INNER PROTEIN P1, MANGANESE (II) ION, RNA-DIRECTED RNA POLYMERASE 著者 Ilca, S, Kotecha, A, Sun, X, Poranen, M.P, Stuart, D.I, Huiskonen, J.T. 登録日 2015-10-06 公開日 2015-11-04 最終更新日 2024-05-08 実験手法 ELECTRON MICROSCOPY (7.9 Å) 主引用文献 Localized Reconstruction of Subunits from Electron Cryomicroscopy Images of Macromolecular Complexes. Nat.Commun., 6, 2015
5FJ6	Structure of the P2 polymerase inside in vitro assembled bacteriophage phi6 polymerase complex 分子名称: MANGANESE (II) ION, RNA-DIRECTED RNA POLYMERASE 著者 Ilca, S, Kotecha, A, Sun, X, Poranen, M.P, Stuart, D.I, Huiskonen, J.T. 登録日 2015-10-06 公開日 2015-11-04 最終更新日 2024-05-08 実験手法 ELECTRON MICROSCOPY (7.9 Å) 主引用文献 Localized Reconstruction of Subunits from Electron Cryomicroscopy Images of Macromolecular Complexes. Nat.Commun., 6, 2015
5JJR	Dengue 3 NS5 protein with compound 29 分子名称: 1,2-ETHANEDIOL, 5-[5-(3-hydroxyprop-1-yn-1-yl)thiophen-2-yl]-4-methoxy-2-methyl-N-[(quinolin-8-yl)sulfonyl]benzamide, DI(HYDROXYETHYL)ETHER, ... 著者 Lescar, J, El Sahili, A. 登録日 2016-04-25 公開日 2016-07-06 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.99 Å) 主引用文献 Potent Allosteric Dengue Virus NS5 Polymerase Inhibitors: Mechanism of Action and Resistance Profiling Plos Pathog., 12, 2016
5JJS	Dengue 3 NS5 protein with compound 27 分子名称: 1,2-ETHANEDIOL, 5-[5-(3-hydroxyprop-1-yn-1-yl)thiophen-2-yl]-2,4-dimethoxy-N-{[(1R,3R)-3-methoxycyclohexyl]sulfonyl}benzamide, DI(HYDROXYETHYL)ETHER, ... 著者 Lescar, J, El Sahili, A. 登録日 2016-04-25 公開日 2016-07-06 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Potent Allosteric Dengue Virus NS5 Polymerase Inhibitors: Mechanism of Action and Resistance Profiling Plos Pathog., 12, 2016
8P1M	Structure of hantaan orthohantavirus (HTNV) polymerase bound to 5'vRNA and NTP Mg 分子名称: ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, RNA (5'-R(P*AP*GP*UP*AP*G)-3'), ... 著者 Keown, J.R, Carrique, L, Grimes, J.M. 登録日 2023-05-12 公開日 2024-05-22 実験手法 ELECTRON MICROSCOPY (3.23 Å) 主引用文献 Structure of hantaan orthohantavirus (HTNV) polymerase bound to 5'vRNA and NTP Mg To Be Published
7L7B	Clostridioides difficile RNAP with fidaxomicin 分子名称: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... 著者 Boyaci, H, Campbell, E.A, Darst, S.A, Chen, J. 登録日 2020-12-28 公開日 2022-02-02 最終更新日 2024-05-29 実験手法 ELECTRON MICROSCOPY (3.26 Å) 主引用文献 Basis of narrow-spectrum activity of fidaxomicin on Clostridioides difficile. Nature, 604, 2022

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