Crystal structure of a ternary complex of human symplekin NTD, human Ssu72 and a RNA poymerase II CTD peptide phosphorylated at SER-7

Summary for 4H3H

Related3O2Q 4H3K
DescriptorSymplekin, RNA polymerase II subunit A C-terminal domain phosphatase SSU72, Pol II CTD peptide, ... (5 entities in total)
Functional Keywordsheat repeat, phosphatase, rna polymerase ii, hydrolase
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm, cytoskeleton Q92797
Nucleus Q9NP77
Total number of polymer chains5
Total molecular weight130005.5
Xiang, K.,Tong, L. (deposition date: 2012-09-13, release date: 2012-10-31, Last modification date: 2017-11-15)
Primary citation
Xiang, K.,Manley, J.L.,Tong, L.
An unexpected binding mode for a Pol II CTD peptide phosphorylated at Ser7 in the active site of the CTD phosphatase Ssu72.
Genes Dev., 26:2265-2270, 2012
PubMed: 23070812 (PDB entries with the same primary citation)
DOI: 10.1101/gad.198853.112
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.2238 0.1% 5.7% 2.0%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
PDB entries from 2020-10-21