4H3H
Crystal structure of a ternary complex of human symplekin NTD, human Ssu72 and a RNA poymerase II CTD peptide phosphorylated at SER-7
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, D) | Symplekin | polymer | 351 | 39647.0 | 2 | UniProt (Q92797) Pfam (PF11935) | Homo sapiens (human) | |
| 2 | B, D (B, E) | RNA polymerase II subunit A C-terminal domain phosphatase SSU72 | polymer | 214 | 24758.8 | 2 | UniProt (Q9NP77) Pfam (PF04722) | Homo sapiens (human) | CTD phosphatase SSU72 |
| 3 | E (F) | Pol II CTD peptide | polymer | 10 | 1099.0 | 1 | |||
| 4 | F (B) | PHOSPHATE ION | non-polymer | 95.0 | 1 | Chemie (PO4) | |||
| 5 | G, H, I, J (A, B, D, E) | water | water | 18.0 | 63 | Chemie (HOH) |
Sequence modifications
A, D: 30 - 360 (UniProt: Q92797)
B, E: 1 - 194 (UniProt: Q9NP77)
| PDB | External Database | Details |
|---|---|---|
| Met 10 | - | expression tag |
| Gly 11 | - | expression tag |
| Ser 12 | - | expression tag |
| Ser 13 | - | expression tag |
| His 14 | - | expression tag |
| His 15 | - | expression tag |
| His 16 | - | expression tag |
| His 17 | - | expression tag |
| His 18 | - | expression tag |
| His 19 | - | expression tag |
| Ser 20 | - | expression tag |
| Ser 21 | - | expression tag |
| Gly 22 | - | expression tag |
| Leu 23 | - | expression tag |
| Val 24 | - | expression tag |
| Pro 25 | - | expression tag |
| Arg 26 | - | expression tag |
| Gly 27 | - | expression tag |
| Ser 28 | - | expression tag |
| His 29 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Met -19 | - | expression tag |
| Gly -18 | - | expression tag |
| Ser -17 | - | expression tag |
| Ser -16 | - | expression tag |
| His -15 | - | expression tag |
| His -14 | - | expression tag |
| His -13 | - | expression tag |
| His -12 | - | expression tag |
| His -11 | - | expression tag |
| His -10 | - | expression tag |
| Ser -9 | - | expression tag |
| Ser -8 | - | expression tag |
| Gly -7 | - | expression tag |
| Leu -6 | - | expression tag |
| Val -5 | - | expression tag |
| Pro -4 | - | expression tag |
| Arg -3 | - | expression tag |
| Gly -2 | - | expression tag |
| Ser -1 | - | expression tag |
| His 0 | - | expression tag |
| Ser 12 | Cys 12 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 129910.5 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 95.0 | |
| All* | Total formula weight | 130005.5 |
