3NKY

Structure of a mutant P44S of Foot-and-mouth disease Virus RNA-dependent RNA polymerase

Summary for 3NKY

Entry DOI	10.2210/pdb3nky/pdb
Related	1U09 1WNE 2E9R 2E9T 2E9Z 2EC0 3NL0
Descriptor	3D polymerase, MAGNESIUM ION (3 entities in total)
Functional Keywords	foot-and-mouth disease virus rna dependent rna polymerase, ribavirin, 3d polymerase picornavirus, transferase
Biological source	Foot-and-mouth disease virus - type C
Cellular location	Picornain 3C: Host cytoplasm (By similarity): Q9QCE4
Total number of polymer chains	1
Total formula weight	53483.18
Authors	Agudo, R.,Ferrer-Orta, C.,Arias, A.,Perez-Luque, R.,Verdaguer, N.,Domingo, E. (deposition date: 2010-06-21, release date: 2011-05-25, Last modification date: 2023-11-01)
Primary citation	Agudo, R.,Ferrer-Orta, C.,Arias, A.,de la Higuera, I.,Perales, C.,Perez-Luque, R.,Verdaguer, N.,Domingo, E. A multi-step process of viral adaptation to a mutagenic nucleoside analogue by modulation of transition types leads to extinction-escape. Plos Pathog., 6:e1001072-e1001072, 2010 Cited by PubMed: 20865120 DOI: 10.1371/journal.ppat.1001072 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.28 Å)

Structure validation