7NN5
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7N9W
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2J15
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![BU of 2j15 by Molmil](/molmil-images/mine/2j15) | Cyclic MrIA: An exceptionally stable and potent cyclic conotoxin with a novel topological fold that targets the norepinephrine transporter. | 分子名称: | MAI126P | 著者 | Lovelace, E.S, Armishaw, C.J, Colgrave, M.L, Walstrom, M.E, Alewood, P.F, Daly, N.L, Craik, D.J. | 登録日 | 2006-08-09 | 公開日 | 2006-11-01 | 最終更新日 | 2018-05-09 | 実験手法 | SOLUTION NMR | 主引用文献 | Cyclic MrIA: a stable and potent cyclic conotoxin with a novel topological fold that targets the norepinephrine transporter. J. Med. Chem., 49, 2006
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4M54
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![BU of 4m54 by Molmil](/molmil-images/mine/4m54) | The structure of the staphyloferrin B precursor biosynthetic enzyme SbnB bound to N-(1-amino-1-carboxyl-2-ethyl)-glutamic acid and NADH | 分子名称: | 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, CHLORIDE ION, N-[(2S)-2-amino-2-carboxyethyl]-L-glutamic acid, ... | 著者 | Kobylarz, M.J, Murphy, M.E.P. | 登録日 | 2013-08-07 | 公開日 | 2014-07-09 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.36 Å) | 主引用文献 | Synthesis of L-2,3-diaminopropionic acid, a siderophore and antibiotic precursor. Chem.Biol., 21, 2014
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5AO5
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![BU of 5ao5 by Molmil](/molmil-images/mine/5ao5) | Endo180 D1-4, monoclinic form | 分子名称: | C-TYPE MANNOSE RECEPTOR 2, SODIUM ION, SULFATE ION | 著者 | Paracuellos, P, Briggs, D.C, Carafoli, F, Loncar, T, Hohenester, E. | 登録日 | 2015-09-09 | 公開日 | 2015-10-28 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.48 Å) | 主引用文献 | Insights Into Collagen Uptake by C-Type Mannose Receptors from the Crystal Structure of Endo180 Domains 1-4. Structure, 23, 2015
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4Q24
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![BU of 4q24 by Molmil](/molmil-images/mine/4q24) | Crystal structure of Cyclo(L-leucyl-L-phenylalanyl) synthase | 分子名称: | Cyclo(L-leucyl-L-phenylalanyl) synthase, PHENYLMETHYL N-[(2S)-4-CHLORO-3-OXO-1-PHENYL-BUTAN-2-YL]CARBAMATE | 著者 | Moutiez, M, Schmitt, E, Seguin, J, Thai, R, Favry, E, Mechulam, Y, Gondry, M. | 登録日 | 2014-04-07 | 公開日 | 2014-10-08 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Unravelling the mechanism of non-ribosomal peptide synthesis by cyclodipeptide synthases. Nat Commun, 5, 2014
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2BVP
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![BU of 2bvp by Molmil](/molmil-images/mine/2bvp) | Structures of Three HIV-1 HLA-B5703-Peptide Complexes and Identification of Related HLAs Potentially Associated with Long-Term Non-Progression | 分子名称: | BETA-2-MICROGLOBULIN, HIV-P24, HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, ... | 著者 | Stewart-Jones, G.B, Gillespie, G, Overton, I.M, Kaul, R, Roche, P, Mcmichael, A.J, Rowland-Jones, S, Jones, E.Y. | 登録日 | 2005-07-01 | 公開日 | 2005-09-07 | 最終更新日 | 2019-10-09 | 実験手法 | X-RAY DIFFRACTION (1.35 Å) | 主引用文献 | Structures of three HIV-1 HLA-B*5703-peptide complexes and identification of related HLAs potentially associated with long-term nonprogression. J Immunol., 175, 2005
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2BVX
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![BU of 2bvx by Molmil](/molmil-images/mine/2bvx) | Design and Discovery of Novel, Potent Thrombin Inhibitors with a Solubilizing Cationic P1-P2-Linker | 分子名称: | ALPHA THROMBIN, HIRUDIN VARIANT-2, N-(5-CHLORO-BENZO[B]THIOPHEN-3-YLMETHYL)-2-[6-CHLORO-OXO-3-(2-PYRIDIN-2-YL-ETHYLAMINO)-2H-PYRAZIN-1-YL]-ACETAMIDE | 著者 | Bulat, S, Bosio, S, Grabowski, E, Papadopoulos, M.A, Cerezo-Galvez, S, Rosenbaum, C, Matassa, V.G, Ott, I, Metz, G, Schamberger, J, Sekul, R, Feurer, A. | 登録日 | 2005-07-04 | 公開日 | 2006-10-25 | 最終更新日 | 2016-12-21 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Design and Discovery of Novel, Potent Pyrazinone-Based Thrombin Inhibitors with a Solubilizing P1-P2-Linker Lett.Drug Des.Discovery, 3, 2006
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2MK0
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![BU of 2mk0 by Molmil](/molmil-images/mine/2mk0) | Structure of the PSCD4-domain of the cell wall protein pleuralin-1 from the diatom Cylindrotheca fusiformis | 分子名称: | HEP200 protein | 著者 | De Sanctis, S, Wenzler, M, Kroeger, N, Malloni, W.M, Sumper, M, Deutzmann, R, Zadravec, P, Brunner, E, Kremer, W, Kalbitzer, S.H.R. | 登録日 | 2014-01-22 | 公開日 | 2015-02-25 | 最終更新日 | 2023-06-14 | 実験手法 | SOLUTION NMR | 主引用文献 | PSCD Domains of Pleuralin-1 from the Diatom Cylindrotheca fusiformis: NMR Structures and Interactions with Other Biosilica-Associated Proteins. Structure, 24, 2016
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6GUF
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![BU of 6guf by Molmil](/molmil-images/mine/6guf) | CDK2/CyclinA in complex with CGP74514A | 分子名称: | Cyclin-A2, Cyclin-dependent kinase 2, N2-[(1R,2S)-2-AMINOCYCLOHEXYL]-N6-(3-CHLOROPHENYL)-9-ETHYL-9H-PURINE-2,6-DIAMINE | 著者 | Wood, D.J, Korolchuk, S, Tatum, N.J, Wang, L.Z, Endicott, J.A, Noble, M.E.M, Martin, M.P. | 登録日 | 2018-06-19 | 公開日 | 2018-12-05 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | 主引用文献 | Differences in the Conformational Energy Landscape of CDK1 and CDK2 Suggest a Mechanism for Achieving Selective CDK Inhibition. Cell Chem Biol, 26, 2019
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2C3F
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![BU of 2c3f by Molmil](/molmil-images/mine/2c3f) | The structure of a group A streptococcal phage-encoded tail-fibre showing hyaluronan lyase activity. | 分子名称: | HYALURONIDASE, PHAGE ASSOCIATED, SODIUM ION | 著者 | Taylor, E.J, Smith, N.L, Linsay, A.-M, Charnock, S.J, Turkenburg, J.P, Dodson, E.J, Davies, G.J, Black, G.W. | 登録日 | 2005-10-06 | 公開日 | 2005-11-29 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.81 Å) | 主引用文献 | Structure of a Group a Streptococcal Phage-Encoded Virulence Factor Reveals Catalytically Active Triple-Stranded Beta-Helix Proc.Natl.Acad.Sci.USA, 102, 2005
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2MN0
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1F2B
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![BU of 1f2b by Molmil](/molmil-images/mine/1f2b) | CRYSTAL STRUCTURE ANALYSIS OF CRUZAIN BOUND TO VINYL SULFONE DERIVED INHIBITOR (III) | 分子名称: | 3-[N-[BENZYLOXYCARBONYL]-PHENYLALANINYL-AMINO]-5-PHENYL-PENTANE-1-SULFONIC ACID 4-NITRO-PHENYL ESTER, CRUZAIN | 著者 | Brinen, L.S, Hansell, E, Roush, W.R, McKerrow, J.H, Fletterick, R.J. | 登録日 | 2000-05-23 | 公開日 | 2000-07-26 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | A target within the target: probing cruzain's P1' site to define structural determinants for the Chagas' disease protease. Structure Fold.Des., 8, 2000
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5BV7
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![BU of 5bv7 by Molmil](/molmil-images/mine/5bv7) | Crystal structure of human LCAT (L4F, N5D) in complex with Fab of an agonistic antibody | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 27C3 heavy chain, 27C3 light chain, ... | 著者 | Piper, D.E, Romanow, W.G, Thibault, S.T, Walker, N.P.C. | 登録日 | 2015-06-04 | 公開日 | 2015-12-16 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | 主引用文献 | Agonistic Human Antibodies Binding to Lecithin-Cholesterol Acyltransferase Modulate High Density Lipoprotein Metabolism. J.Biol.Chem., 291, 2016
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4Q2L
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1F2C
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![BU of 1f2c by Molmil](/molmil-images/mine/1f2c) | CRYSTAL STRUCTURE ANALYSIS OF CRYZAIN BOUND TO VINYL SULFONE DERIVED INHIBITOR (IV) | 分子名称: | 3-[[N-[4-METHYL-PIPERAZINYL]CARBONYL]-PHENYLALANINYL-AMINO]-5-PHENYL-PENTANE-1-SULFONIC ACID BENZYLOXY-AMIDE, CRUZAIN | 著者 | Brinen, L.S, Hansell, E, Roush, W.R, McKerrow, J.H, Fletterick, R.J. | 登録日 | 2000-05-23 | 公開日 | 2000-07-26 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | A target within the target: probing cruzain's P1' site to define structural determinants for the Chagas' disease protease. Structure Fold.Des., 8, 2000
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2IHD
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![BU of 2ihd by Molmil](/molmil-images/mine/2ihd) | Crystal structure of Human Regulator of G-protein signaling 8, RGS8 | 分子名称: | CHLORIDE ION, Regulator of G-protein signaling 8 | 著者 | Turnbull, A.P, Papagrigoriou, E, Ugochukwu, E, Salah, E, Gileadi, C, Burgess, N, Bhatia, C, Gileadi, O, Bray, J, Elkins, J, von Delft, F, Weigelt, J, Edwards, A, Arrowsmith, C, Sundstrom, M, Doyle, D.A, Structural Genomics Consortium (SGC) | 登録日 | 2006-09-26 | 公開日 | 2006-11-21 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Structural diversity in the RGS domain and its interaction with heterotrimeric G protein alpha-subunits. Proc.Natl.Acad.Sci.Usa, 105, 2008
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6EJ9
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5NJH
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![BU of 5njh by Molmil](/molmil-images/mine/5njh) | Triazolopyrimidines stabilize microtubules by binding to the vinca inhibitor site of tubulin | 分子名称: | 5-chloranyl-7-[(1~{R},5~{S})-3-methoxy-8-azabicyclo[3.2.1]octan-8-yl]-6-[2,4,6-tris(fluoranyl)phenyl]-[1,2,4]triazolo[1,5-a]pyrimidine, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ... | 著者 | Sharma, A, Calvo, G.S, Prota, A.E, Diaz, J.F, Steinmetz, M.O. | 登録日 | 2017-03-28 | 公開日 | 2017-06-21 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.394 Å) | 主引用文献 | Triazolopyrimidines Are Microtubule-Stabilizing Agents that Bind the Vinca Inhibitor Site of Tubulin. Cell Chem Biol, 24, 2017
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3ADZ
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![BU of 3adz by Molmil](/molmil-images/mine/3adz) | Crystal structure of the C(30) carotenoid dehydrosqualene synthase from Staphylococcus aureus complexed with intermediate PSPP | 分子名称: | Dehydrosqualene synthase, MAGNESIUM ION, {(1R,2R,3R)-2-[(3E)-4,8-dimethylnona-3,7-dien-1-yl]-2-methyl-3-[(1E,5E)-2,6,10-trimethylundeca-1,5,9-trien-1-yl]cyclopropyl}methyl trihydrogen diphosphate | 著者 | Liu, C.I, Jeng, W.Y, Wang, A.H.J, Oldfield, E. | 登録日 | 2010-01-31 | 公開日 | 2010-11-24 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (1.89 Å) | 主引用文献 | Mechanism of action and inhibition of dehydrosqualene synthase. Proc.Natl.Acad.Sci.USA, 107, 2010
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7NE8
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![BU of 7ne8 by Molmil](/molmil-images/mine/7ne8) | Tick salivary protein BSAP1 | 分子名称: | tick salivary protein BSAP1 | 著者 | Denisov, S.S, Ippel, J.H, Castoldi, E, Hackeng, T.M, Dijkgraaf, I. | 登録日 | 2021-02-03 | 公開日 | 2021-06-16 | 最終更新日 | 2023-06-14 | 実験手法 | SOLUTION NMR | 主引用文献 | Molecular basis of anticoagulant and anticomplement activity of the tick salivary protein Salp14 and its homologs. J.Biol.Chem., 297, 2021
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3IMW
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![BU of 3imw by Molmil](/molmil-images/mine/3imw) | Transthyretin in complex with (E)-2,6-dibromo-4-(2,6-dimethoxystyryl)aniline | 分子名称: | 2,6-dibromo-4-[(E)-2-(2,6-dimethoxyphenyl)ethenyl]aniline, Transthyretin | 著者 | Connelly, S, Wilson, I.A. | 登録日 | 2009-08-11 | 公開日 | 2010-01-12 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.31 Å) | 主引用文献 | A substructure combination strategy to create potent and selective transthyretin kinetic stabilizers that prevent amyloidogenesis and cytotoxicity. J.Am.Chem.Soc., 132, 2010
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2M2D
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![BU of 2m2d by Molmil](/molmil-images/mine/2m2d) | Human programmed cell death 1 receptor | 分子名称: | Programmed cell death protein 1 | 著者 | Veverka, V, Cheng, X, Waters, L.C, Muskett, F.W, Morgan, S, Lesley, A, Griffiths, M, Stubberfield, C, Griffin, R, Henry, A.J, Robinson, M.K, Jansson, A, Ladbury, J.E, Ikemizu, S, Davis, S.J, Carr, M.D. | 登録日 | 2012-12-18 | 公開日 | 2013-02-27 | 最終更新日 | 2013-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Structure and interactions of the human programmed cell death 1 receptor. J.Biol.Chem., 288, 2013
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1JR3
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![BU of 1jr3 by Molmil](/molmil-images/mine/1jr3) | Crystal Structure of the Processivity Clamp Loader Gamma Complex of E. coli DNA Polymerase III | 分子名称: | DNA polymerase III subunit gamma, DNA polymerase III, delta subunit, ... | 著者 | Jeruzalmi, D, O'Donnell, M, Kuriyan, J. | 登録日 | 2001-08-10 | 公開日 | 2001-09-26 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Crystal structure of the processivity clamp loader gamma (gamma) complex of E. coli DNA polymerase III. Cell(Cambridge,Mass.), 106, 2001
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6H5C
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![BU of 6h5c by Molmil](/molmil-images/mine/6h5c) | Crystal structure of DHQ1 from Salmonella typhi covalently modified by ligand 1 | 分子名称: | (1~{S},3~{R},4~{S},5~{R})-3-methyl-3,4,5-tris(hydroxyl)cyclohexane-1-carboxylic Acid, 3-dehydroquinate dehydratase | 著者 | Sanz-Gaitero, M, Maneiro, M, Lence, E, Otero, J.M, Thompson, P, Hawkins, A.R, Gonzalez-Bello, C, van Raaij, M.J. | 登録日 | 2018-07-24 | 公開日 | 2019-07-24 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.14 Å) | 主引用文献 | Hydroxylammonium Derivatives for Selective Active-site Lysine Modification in the Anti-virulence Bacterial Target DHQ1 Enzyme. Org Chem Front, 9, 2019
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