8ZQ3
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8WJN
| Cryo-EM structure of 6-subunit Smc5/6 head region | 分子名称: | Non-structural maintenance of chromosome element 3, Non-structural maintenance of chromosomes element 1, Non-structural maintenance of chromosomes element 4, ... | 著者 | Li, Q, Zhang, J, Zhang, X, Cheng, T, Wang, Z, Jin, D, Chen, Z, Wang, L. | 登録日 | 2023-09-26 | 公開日 | 2024-06-26 | 最終更新日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (5.58 Å) | 主引用文献 | Cryo-EM structures of Smc5/6 in multiple states reveal its assembly and functional mechanisms. Nat.Struct.Mol.Biol., 2024
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8VOH
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8P9J
| Crystal structure of the first bromodomain of human BRD4 in complex with the dual BET/HDAC inhibitor NB500 | 分子名称: | 1,2-ETHANEDIOL, Bromodomain-containing protein 4, ~{N}-(2-aminophenyl)-5-(6-methyl-7-oxidanylidene-1~{H}-pyrrolo[2,3-c]pyridin-4-yl)pyridine-2-carboxamide | 著者 | Balourdas, D.I, Bauer, N, Knapp, S, Joerger, A.C, Structural Genomics Consortium (SGC) | 登録日 | 2023-06-06 | 公開日 | 2023-07-05 | 最終更新日 | 2024-06-26 | 実験手法 | X-RAY DIFFRACTION (1.42 Å) | 主引用文献 | Development of Potent Dual BET/HDAC Inhibitors via Pharmacophore Merging and Structure-Guided Optimization. Acs Chem.Biol., 19, 2024
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8VOV
| Structure of VCP in complex with an ATPase activator and ADP (D2 domains only, hexameric form) | 分子名称: | (3R)-N-[2-(ethylsulfanyl)phenyl]-3-(1-oxo-1,3-dihydro-2H-isoindol-2-yl)butanamide, ADENOSINE-5'-DIPHOSPHATE, Transitional endoplasmic reticulum ATPase | 著者 | Jones, N.H, Urnivicius, L, Kapoor, T.M. | 登録日 | 2024-01-16 | 公開日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Allosteric activation of VCP, an AAA unfoldase, by small molecule mimicry. Proc.Natl.Acad.Sci.USA, 121, 2024
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9F4H
| UP1 in complex with Z106579662 | 分子名称: | Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed, [4-(propan-2-yl)piperazin-1-yl](thiophen-2-yl)methanone | 著者 | Dunnett, L, Prischi, F. | 登録日 | 2024-04-27 | 公開日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Enhanced identification of small molecules binding to hnRNP A1 via in silico hotspot and cryptic pockets mapping coupled with X-Ray fragment screening To Be Published
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8Y91
| Structure of NET-nomifensine in outward-open state | 分子名称: | (4S)-2-methyl-4-phenyl-3,4-dihydro-1H-isoquinolin-8-amine, CHLORIDE ION, SODIUM ION, ... | 著者 | Zhang, H, Xu, E.H, Jiang, Y. | 登録日 | 2024-02-06 | 公開日 | 2024-05-29 | 最終更新日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (3.13 Å) | 主引用文献 | Dimerization and antidepressant recognition at noradrenaline transporter. Nature, 630, 2024
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8VVA
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8WCO
| (S)-citramalyl-CoA lyase | 分子名称: | ACETYL COENZYME *A, Probable acyl-CoA lyase beta chain | 著者 | Huang, Q, Bao, R. | 登録日 | 2023-09-13 | 公開日 | 2024-05-15 | 最終更新日 | 2024-07-24 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Structural and functional characterization of itaconyl-CoA hydratase and citramalyl-CoA lyase involved in itaconate metabolism of Pseudomonas aeruginosa. Structure, 32, 2024
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9EOF
| Structure of the human INTS5/8/10/15 subcomplex | 分子名称: | Integrator complex subunit 10, Integrator complex subunit 15, Integrator complex subunit 5, ... | 著者 | Razew, M, Galej, W.P. | 登録日 | 2024-03-14 | 公開日 | 2024-06-12 | 最終更新日 | 2024-07-24 | 実験手法 | ELECTRON MICROSCOPY (7.7 Å) | 主引用文献 | Structural basis of the Integrator complex assembly and association with transcription factors. Mol.Cell, 84, 2024
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8XZD
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9F50
| UP1 in complex with Z906021418 | 分子名称: | 5-chloro-2-(propan-2-yl)pyrimidine-4-carboxamide, Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed | 著者 | Dunnett, L, Prischi, F. | 登録日 | 2024-04-28 | 公開日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Enhanced identification of small molecules binding to hnRNP A1 via in silico hotspot and cryptic pockets mapping coupled with X-Ray fragment screening To Be Published
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8OVH
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8ORN
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9FII
| Crystal Structure of oxidized NuoEF variant E222K(NuoF) from Aquifex aeolicus | 分子名称: | CHLORIDE ION, FE2/S2 (INORGANIC) CLUSTER, FLAVIN MONONUCLEOTIDE, ... | 著者 | Wohlwend, D, Friedrich, T, Goeppert-Asadollahpour, S. | 登録日 | 2024-05-29 | 公開日 | 2024-07-17 | 最終更新日 | 2024-08-14 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structural robustness of the NADH binding site in NADH:ubiquinone oxidoreductase (complex I). Biochim Biophys Acta Bioenerg, 1865, 2024
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8YAX
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9F4T
| UP1 in complex with EN300-805013 | 分子名称: | Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed, N-(4-methoxyphenyl)glycinamide | 著者 | Dunnett, L, Prischi, F. | 登録日 | 2024-04-28 | 公開日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.42 Å) | 主引用文献 | Enhanced identification of small molecules binding to hnRNP A1 via in silico hotspot and cryptic pockets mapping coupled with X-Ray fragment screening To Be Published
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8YF0
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8P3A
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8YXR
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9F5K
| UP1 in complex with Z33546965 | 分子名称: | Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed, ~{N}-(2-azanyl-2-oxidanylidene-ethyl)-4-methoxy-benzamide | 著者 | Dunnett, L, Prischi, F. | 登録日 | 2024-04-29 | 公開日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Enhanced identification of small molecules binding to hnRNP A1 via in silico hotspot and cryptic pockets mapping coupled with X-Ray fragment screening To Be Published
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9ATN
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9IJP
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8WB6
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9F4S
| UP1 in complex with Z56880342 | 分子名称: | Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed, N-ethyl-N'-(5-methyl-1,2-oxazol-3-yl)urea | 著者 | Dunnett, L, Prischi, F. | 登録日 | 2024-04-28 | 公開日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Enhanced identification of small molecules binding to hnRNP A1 via in silico hotspot and cryptic pockets mapping coupled with X-Ray fragment screening To Be Published
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