4WJ0
| Structure of PH1245, a cas1 from Pyrococcus horikoshii | 分子名称: | CHLORIDE ION, CRISPR-associated endonuclease Cas1 | 著者 | Petit, P, Brown, G, Savchenko, A, Yakunin, A.F. | 登録日 | 2014-09-29 | 公開日 | 2014-10-15 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | 主引用文献 | Structure of PH1245, a cas1 from Pyrococcus horikoshii To Be Published
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8R8M
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4RJ3
| CDK2 with EGFR inhibitor compound 8 | 分子名称: | 1-cyclopentyl-N-[2-(4-methoxypiperidin-1-yl)pyrimidin-4-yl]-1H-pyrrolo[3,2-c]pyridin-6-amine, ACETATE ION, Cyclin-dependent kinase 2 | 著者 | Eigenbrot, C, Yin, J. | 登録日 | 2014-10-08 | 公開日 | 2014-11-26 | 最終更新日 | 2015-01-14 | 実験手法 | X-RAY DIFFRACTION (1.63 Å) | 主引用文献 | Discovery of Selective and Noncovalent Diaminopyrimidine-Based Inhibitors of Epidermal Growth Factor Receptor Containing the T790M Resistance Mutation. J.Med.Chem., 57, 2014
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7N2V
| Elongating 70S ribosome complex in a spectinomycin-stalled intermediate state of translocation bound to EF-G in an active, GTP conformation (INT1) | 分子名称: | 1,4-DIAMINOBUTANE, 16S rRNA, 23S rRNA, ... | 著者 | Rundlet, E.J, Holm, M, Schacherl, M, Natchiar, K.S, Altman, R.B, Spahn, C.M.T, Myasnikov, A.G, Blanchard, S.C. | 登録日 | 2021-05-29 | 公開日 | 2021-07-14 | 最終更新日 | 2021-08-11 | 実験手法 | ELECTRON MICROSCOPY (2.54 Å) | 主引用文献 | Structural basis of early translocation events on the ribosome. Nature, 595, 2021
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8SYL
| Cryo-EM structure of the Escherichia coli 70S ribosome in complex with amikacin, mRNA, and A-, P-, and E-site tRNAs | 分子名称: | (2S)-N-[(1R,2S,3S,4R,5S)-4-[(2R,3R,4S,5S,6R)-6-(aminomethyl)-3,4,5-tris(oxidanyl)oxan-2-yl]oxy-5-azanyl-2-[(2S,3R,4S,5S ,6R)-4-azanyl-6-(hydroxymethyl)-3,5-bis(oxidanyl)oxan-2-yl]oxy-3-oxidanyl-cyclohexyl]-4-azanyl-2-oxidanyl-butanamide, 16S Ribosomal RNA, 23S Ribosomal RNA, ... | 著者 | Seely, S.M, Gagnon, M.G. | 登録日 | 2023-05-25 | 公開日 | 2023-08-09 | 最終更新日 | 2023-11-15 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Molecular basis of the pleiotropic effects by the antibiotic amikacin on the ribosome. Nat Commun, 14, 2023
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7NBU
| Structure of the HigB1 toxin mutant K95A from Mycobacterium tuberculosis (Rv1955) and its target, the cspA mRNA, on the E. coli Ribosome. | 分子名称: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | 著者 | Giudice, E, Mansour, M, Chat, S, D'Urso, G, Gillet, R, Genevaux, P. | 登録日 | 2021-01-27 | 公開日 | 2022-03-02 | 最終更新日 | 2024-04-24 | 実験手法 | ELECTRON MICROSCOPY (3.11 Å) | 主引用文献 | Substrate recognition and cryo-EM structure of the ribosome-bound TAC toxin of Mycobacterium tuberculosis. Nat Commun, 13, 2022
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2VUK
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8EQV
| Cryo-EM structure of PRC2 in complex with the long isoform of AEBP2 | 分子名称: | Histone-binding protein RBBP4, Histone-lysine N-methyltransferase EZH2, Polycomb protein EED, ... | 著者 | Boudes, M, Zhang, Q, Flanigan, S.F, Davidovich, C. | 登録日 | 2022-10-09 | 公開日 | 2024-07-31 | 実験手法 | ELECTRON MICROSCOPY (3.64 Å) | 主引用文献 | To be updated To Be Published
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8XXN
| Cryo-EM structure of the human 43S ribosome with PDCD4 | 分子名称: | 18S rRNA, 40S ribosomal protein S10, 40S ribosomal protein S11, ... | 著者 | Ye, X, Huang, Z, Li, Y, Wang, M, Cheng, J. | 登録日 | 2024-01-18 | 公開日 | 2024-05-01 | 最終更新日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Human tumor suppressor PDCD4 directly interacts with ribosomes to repress translation. Cell Res., 34, 2024
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8XXL
| Cryo-EM structure of the human 40S ribosome with PDCD4 | 分子名称: | 18S rRNA, 40S ribosomal protein S10, 40S ribosomal protein S11, ... | 著者 | Ye, X, Huang, Z, Li, Y, Wang, M, Cheng, J. | 登録日 | 2024-01-18 | 公開日 | 2024-05-01 | 最終更新日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Human tumor suppressor PDCD4 directly interacts with ribosomes to repress translation. Cell Res., 34, 2024
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8XXM
| Cryo-EM structure of the human 40S ribosome with PDCD4 and eIF3G | 分子名称: | 18S rRNA, 40S ribosomal protein S10, 40S ribosomal protein S11, ... | 著者 | Ye, X, Huang, Z, Li, Y, Wang, M, Cheng, J. | 登録日 | 2024-01-18 | 公開日 | 2024-05-01 | 最終更新日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Human tumor suppressor PDCD4 directly interacts with ribosomes to repress translation. Cell Res., 34, 2024
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8QOA
| Structure of SecM-stalled Escherichia coli 70S ribosome | 分子名称: | 16S rRNA, 23S rRNA, 30S ribosomal protein S16, ... | 著者 | Gersteuer, F, Morici, M, Wilson, D.N. | 登録日 | 2023-09-28 | 公開日 | 2024-03-20 | 最終更新日 | 2024-04-24 | 実験手法 | ELECTRON MICROSCOPY (2 Å) | 主引用文献 | The SecM arrest peptide traps a pre-peptide bond formation state of the ribosome. Nat Commun, 15, 2024
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7UXC
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7UXH
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8FKU
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8FKT
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7N30
| Elongating 70S ribosome complex in a hybrid-H2* pre-translocation (PRE-H2*) conformation | 分子名称: | 1,4-DIAMINOBUTANE, 16S rRNA, 23S rRNA, ... | 著者 | Rundlet, E.J, Holm, M, Schacherl, M, Natchiar, K.S, Altman, R.B, Spahn, C.M.T, Myasnikov, A.G, Blanchard, S.C. | 登録日 | 2021-05-30 | 公開日 | 2021-07-14 | 最終更新日 | 2021-08-11 | 実験手法 | ELECTRON MICROSCOPY (2.66 Å) | 主引用文献 | Structural basis of early translocation events on the ribosome. Nature, 595, 2021
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7N2C
| Elongating 70S ribosome complex in a fusidic acid-stalled intermediate state of translocation bound to EF-G(GDP) (INT2) | 分子名称: | 1,4-DIAMINOBUTANE, 16S rRNA, 23S rRNA, ... | 著者 | Rundlet, E.J, Holm, M, Schacherl, M, Natchiar, K.S, Altman, R.B, Spahn, C.M.T, Myasnikov, A.G, Blanchard, S.C. | 登録日 | 2021-05-28 | 公開日 | 2021-07-14 | 最終更新日 | 2021-08-11 | 実験手法 | ELECTRON MICROSCOPY (2.72 Å) | 主引用文献 | Structural basis of early translocation events on the ribosome. Nature, 595, 2021
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7N31
| Elongating 70S ribosome complex in a post-translocation (POST) conformation | 分子名称: | 1,4-DIAMINOBUTANE, 16S rRNA, 23S rRNA, ... | 著者 | Rundlet, E.J, Holm, M, Schacherl, M, Natchiar, K.S, Altman, R.B, Spahn, C.M.T, Myasnikov, A.G, Blanchard, S.C. | 登録日 | 2021-05-31 | 公開日 | 2021-07-14 | 最終更新日 | 2021-08-11 | 実験手法 | ELECTRON MICROSCOPY (2.69 Å) | 主引用文献 | Structural basis of early translocation events on the ribosome. Nature, 595, 2021
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7N2U
| Elongating 70S ribosome complex in a hybrid-H1 pre-translocation (PRE-H1) conformation | 分子名称: | 1,4-DIAMINOBUTANE, 16S rRNA, 23S rRNA, ... | 著者 | Rundlet, E.J, Holm, M, Schacherl, M, Natchiar, K.S, Altman, R.B, Spahn, C.M.T, Myasnikov, A.G, Blanchard, S.C. | 登録日 | 2021-05-29 | 公開日 | 2021-07-14 | 最終更新日 | 2021-08-11 | 実験手法 | ELECTRON MICROSCOPY (2.53 Å) | 主引用文献 | Structural basis of early translocation events on the ribosome. Nature, 595, 2021
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7N1P
| Elongating 70S ribosome complex in a classical pre-translocation (PRE-C) conformation | 分子名称: | 1,4-DIAMINOBUTANE, 16S rRNA, 23S rRNA, ... | 著者 | Rundlet, E.J, Holm, M, Schacherl, M, Natchiar, S.K, Altman, R.B, Spahn, C.M.T, Myasnikov, A.G, Blanchard, S.C. | 登録日 | 2021-05-28 | 公開日 | 2021-07-14 | 最終更新日 | 2021-08-11 | 実験手法 | ELECTRON MICROSCOPY (2.33 Å) | 主引用文献 | Structural basis of early translocation events on the ribosome. Nature, 595, 2021
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4JYK
| Structure of E. coli Transcriptional Regulator RutR with bound uracil | 分子名称: | HTH-type transcriptional regulator RutR, SULFATE ION, URACIL | 著者 | Cooper, D.R, Knapik, A.A, Petkowski, J.J, Porebski, P.J, Osinski, T, Almo, S.C, Minor, W, New York Structural Genomics Research Consortium (NYSGRC) | 登録日 | 2013-03-29 | 公開日 | 2013-08-14 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Structure of E. coli Transcriptional Regulator RutR with bound uracil To be Published
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3F8M
| Crystal Structure of PhnF from Mycobacterium smegmatis | 分子名称: | GLYCEROL, GntR-family protein transcriptional regulator | 著者 | Busby, J.N, Gebhard, S, Cook, G.M, Lott, S.J, Baker, E.N, Money, V.A. | 登録日 | 2008-11-12 | 公開日 | 2009-11-17 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Crystal structure of PhnF, a GntR-family transcription regulator in Mycobacterium smegmatis To be Published
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1JFS
| PURINE REPRESSOR MUTANT-HYPOXANTHINE-PURF OPERATOR COMPLEX | 分子名称: | 5'-D(*TP*AP*CP*GP*CP*AP*AP*AP*CP*GP*TP*TP*TP*GP*CP*GP*T)-3', HYPOXANTHINE, PURINE NUCLEOTIDE SYNTHESIS REPRESSOR | 著者 | Huffman, J.L, Lu, F, Zalkin, H, Brennan, R.G. | 登録日 | 2001-06-21 | 公開日 | 2002-02-08 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Role of residue 147 in the gene regulatory function of the Escherichia coli purine repressor. Biochemistry, 41, 2002
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3BP3
| Crystal structure of EIIB | 分子名称: | Glucose-specific phosphotransferase enzyme IIB component, SULFATE ION | 著者 | Cha, S.S, Jung, H.I, An, Y.J. | 登録日 | 2007-12-18 | 公開日 | 2008-11-04 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Analyses of Mlc-IIBGlc interaction and a plausible molecular mechanism of Mlc inactivation by membrane sequestration. Proc.Natl.Acad.Sci.Usa, 105, 2008
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