PDB: 5515 件ウェブページステータス検索Chemie searchBIRD

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5F72	De novo design and crystallographic validation of antibodies targeting a pre-selected epitope 分子名称: Kelch-like ECH-associated protein 1, Single chain Fv from a Fab 著者 Liu, X, Taylor, R.D, Griffin, L, Coker, S, Adams, R, Ceska, T, Shi, J, Lawson, A.D.G, Baker, T. 登録日 2015-12-07 公開日 2016-12-14 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 De novo design and crystallographic validation of antibodies targeting a pre-selected epitope To Be Published
6XWI	Solution NMR structure of the S0_2.126 designed protein 分子名称: S0_2.126 著者 Abriata, L.A. 登録日 2020-01-23 公開日 2020-04-15 最終更新日 2023-06-14 実験手法 SOLUTION NMR 主引用文献 De novo protein design enables the precise induction of RSV-neutralizing antibodies. Science, 368, 2020
6XXV	Crystal Structure of a computationally designed Immunogen S2_1.2 in complex with its elicited antibody C57 分子名称: Antibody C57, Heavy Chain, Light Chain, ... 著者 Yang, C, Sesterhenn, F, Correia, B.E, Pojer, F. 登録日 2020-01-28 公開日 2020-04-22 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.20116425 Å) 主引用文献 De novo protein design enables the precise induction of RSV-neutralizing antibodies. Science, 368, 2020
6S3D	Structure of D25 Fab in complex with scaffold S0_2.126 分子名称: Heavy Chain, Light Chain, S0_2.126 著者 Cramer, J.T, Krey, T. 登録日 2019-06-25 公開日 2020-04-22 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 De novo protein design enables the precise induction of RSV-neutralizing antibodies. Science, 368, 2020
8GL3	De novo design of monomeric helical bundles for pH-controlled membrane lysis 分子名称: pRLB-519 著者 Goldbach, N, Bera, A.K, Baker, D, Kang, A. 登録日 2023-03-20 公開日 2023-09-06 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 De novo design of monomeric helical bundles for pH-controlled membrane lysis. Protein Sci., 32, 2023
5J0I	De novo design of protein homo-oligomers with modular hydrogen bond network-mediated specificity 分子名称: Designed protein 2L6HC3_12 著者 Sankaran, B, Zwart, P.H, Pereira, J.H, Baker, D, Boyken, S, Chen, Z, Groves, B, Langan, R.A, Oberdorfer, G, Ford, A, Gilmore, J, Xu, C, DiMaio, F, Seelig, G. 登録日 2016-03-28 公開日 2016-05-25 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.202 Å) 主引用文献 De novo design of protein homo-oligomers with modular hydrogen-bond network-mediated specificity. Science, 352, 2016
5J0J	De novo design of protein homo-oligomers with modular hydrogen bond network-mediated specificity 分子名称: designed protein 2L6HC3_6 著者 Sankaran, B, Zwart, P.H, Pereira, J.H, Baker, D, Boyken, S, Chen, Z, Groves, B, Langan, R.A, Oberdorfer, G, Ford, A, Gilmore, J, Xu, C, DiMaio, F, Seelig, G. 登録日 2016-03-28 公開日 2016-05-25 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.256 Å) 主引用文献 De novo design of protein homo-oligomers with modular hydrogen-bond network-mediated specificity. Science, 352, 2016
5J73	De novo design of protein homo-oligomers with modular hydrogen bond network-mediated specificity 分子名称: protein design 2L4HC2_9 著者 Sankaran, B, Zwart, P.H, Pereira, J.H, Baker, D, Boyken, S, Chen, Z, Groves, B, Langan, R.A, Oberdorfer, G, Ford, A, Gilmore, J, Xu, C, DiMaio, F, Seelig, G. 登録日 2016-04-05 公開日 2016-05-25 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.56 Å) 主引用文献 De novo design of protein homo-oligomers with modular hydrogen-bond network-mediated specificity. Science, 352, 2016
5IZS	De novo design of protein homo-oligomers with modular hydrogen bond network-mediated specificity 分子名称: Designed protein 5L6HC3_1 著者 Sankaran, B, Zwart, P.H, Pereira, J.H, Baker, D, Boyken, S, Chen, Z, Oberdorfer, G. 登録日 2016-03-25 公開日 2016-05-25 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.36 Å) 主引用文献 De novo design of protein homo-oligomers with modular hydrogen-bond network-mediated specificity. Science, 352, 2016
5J0K	De novo design of protein homo-oligomers with modular hydrogen bond network-mediated specificity 分子名称: designed protein 2L4HC2_23 著者 Sankaran, B, Zwart, P.H, Pereira, J.H, Baker, D, Boyken, S, Chen, Z, Groves, B, Langan, R.A, Oberdorfer, G, Ford, A, Gilmore, J, Xu, C, DiMaio, F, Seelig, G. 登録日 2016-03-28 公開日 2016-05-25 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (1.54 Å) 主引用文献 De novo design of protein homo-oligomers with modular hydrogen-bond network-mediated specificity. Science, 352, 2016
5J0H	De novo design of protein homo-oligomers with modular hydrogen bond network-mediated specificity 分子名称: Design construct 2L6HC3_13 著者 Sankaran, B, Zwart, P.H, Pereira, J.H, Baker, D, Boyken, S, Chen, Z, Groves, B, Langan, R.A, Oberdorfer, G, Ford, A, Gilmore, J, Xu, C, DiMaio, F, Seelig, G. 登録日 2016-03-28 公開日 2016-05-25 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (1.64 Å) 主引用文献 De novo design of protein homo-oligomers with modular hydrogen-bond network-mediated specificity. Science, 352, 2016
5J10	De novo design of protein homo-oligomers with modular hydrogen bond network-mediated specificity 分子名称: peptide design 2L4HC2_24 著者 Sankaran, B, Zwart, P.H, Pereira, J.H, Baker, D, Boyken, S, Chen, Z, Groves, B, Langan, R.A, Oberdorfer, G, Ford, A, Gilmore, J, Xu, C, DiMaio, F, Seelig, G. 登録日 2016-03-28 公開日 2016-05-25 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.02 Å) 主引用文献 De novo design of protein homo-oligomers with modular hydrogen-bond network-mediated specificity. Science, 352, 2016
5J2L	De novo design of protein homo-oligomers with modular hydrogen bond network-mediated specificity 分子名称: protein design 2L4HC2_11 著者 Sankaran, B, Zwart, P.H, Pereira, J.H, Baker, D, Boyken, S, Chen, Z, Groves, B, Langan, R.A, Oberdorfer, G, Ford, A, Gilmore, J, Xu, C, DiMaio, F, Seelig, G. 登録日 2016-03-29 公開日 2016-05-25 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (1.96 Å) 主引用文献 De novo design of protein homo-oligomers with modular hydrogen-bond network-mediated specificity. Science, 352, 2016
5J0L	De novo design of protein homo-oligomers with modular hydrogen bond network-mediated specificity 分子名称: designed protein 3L6HC2_2 著者 Sankaran, B, Zwart, P.H, Pereira, J.H, Baker, D, Boyken, S, Chen, Z, Groves, B, Langan, R.A, Oberdorfer, G, Ford, A, Gilmore, J, Xu, C, DiMaio, F, Seelig, G. 登録日 2016-03-28 公開日 2016-07-06 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.63 Å) 主引用文献 De novo design of protein homo-oligomers with modular hydrogen-bond network-mediated specificity. Science, 352, 2016
8ETQ	Designed pentafoil knot protein folded into a trefoil knot 分子名称: k-cTRP5 著者 Doyle, L.A, Kibler, R.D, Bradley, P, Stoddard, B.L. 登録日 2022-10-17 公開日 2023-10-25 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.42 Å) 主引用文献 De novo design of knotted tandem repeat proteins. Nat Commun, 14, 2023
8FLX	De novo designed homotrimer; the fusion product of BGL17 and DHR59 分子名称: LK031 著者 Kibler, R.D, Kennedy, M.A, Stoddard, B.L, Lee, S. 登録日 2022-12-22 公開日 2023-06-28 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (4.5 Å) 主引用文献 De novo designed homotrimer; the fusion product of BGL17 and DHR59 To Be Published
7SQ5	Designed trefoil knot protein, variant 3 分子名称: Designed trefoil knot protein, variant 3, SODIUM ION 著者 Takushi, B, Doyle, L, Stoddard, B.L, Bradley, P. 登録日 2021-11-04 公開日 2022-11-09 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.205 Å) 主引用文献 De novo design of knotted tandem repeat proteins. Nat Commun, 14, 2023
6CZG	Structure of a redesigned beta barrel, b11L5F_LGL 分子名称: b11L5F_LGL 著者 Doyle, L.A, Stoddard, B.L. 登録日 2018-04-09 公開日 2018-09-19 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 De novo design of a fluorescence-activating beta-barrel. Nature, 561, 2018
6CZJ	Structure of a redesigned beta barrel, b10 分子名称: SULFATE ION, b10 著者 Doyle, L.A, Stoddard, B.L. 登録日 2018-04-09 公開日 2018-09-19 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 De novo design of a fluorescence-activating beta-barrel. Nature, 561, 2018
3ZFS	Cryo-EM structure of the F420-reducing NiFe-hydrogenase from a methanogenic archaeon with bound substrate 分子名称: CARBONMONOXIDE-(DICYANO) IRON, COENZYME F420, F420-REDUCING HYDROGENASE, ... 著者 Mills, D.J, Vitt, S, Strauss, M, Shima, S, Vonck, J. 登録日 2012-12-12 公開日 2013-03-06 最終更新日 2024-05-08 実験手法 ELECTRON MICROSCOPY (4 Å) 主引用文献 De Novo Modeling of the F420-Reducing [Nife]-Hydrogenase from a Methanogenic Archaeon by Cryo-Electron Microscopy Elife, 2, 2013
4IH5	Hepatitis C Virus polymerase NS5B (BK) with fragment-based compounds 分子名称: 4-(2-phenylhydrazinyl)-1H-pyrazolo[3,4-d]pyrimidine, RNA-directed RNA polymerase 著者 Harris, S.F, Ghate, M. 登録日 2012-12-18 公開日 2013-07-03 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 De novo fragment design: a medicinal chemistry approach to fragment-based lead generation. J.Med.Chem., 56, 2013
4IH6	Hepatitis C Virus polymerase NS5B (BK) with fragment-based compounds 分子名称: (5S)-3-(4-tert-butylbenzyl)-5-(propan-2-yl)imidazolidine-2,4-dione, RNA-directed RNA polymerase 著者 Harris, S.F, Wong, A. 登録日 2012-12-18 公開日 2013-07-03 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 De novo fragment design: a medicinal chemistry approach to fragment-based lead generation. J.Med.Chem., 56, 2013
4IH7	Hepatitis C Virus polymerase NS5B (BK) with fragment-based compounds 分子名称: 3-(3-tert-butylphenyl)pyridin-2(1H)-one, RNA-directed RNA polymerase, ZINC ION 著者 Harris, S.F, Wong, A. 登録日 2012-12-18 公開日 2013-07-03 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 De novo fragment design: a medicinal chemistry approach to fragment-based lead generation. J.Med.Chem., 56, 2013
1Y4C	Designed Helical Protein fusion MBP 分子名称: Maltose binding protein fused with designed helical protein, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose 著者 LaPorte, S.L, Forsyth, C.M, Cunningham, B.C, Miercke, L.J, Akhavan, D, Stroud, R.M. 登録日 2004-11-30 公開日 2005-02-15 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 De novo design of an IL-4 antagonist and its structure at 1.9 A. Proc.Natl.Acad.Sci.Usa, 102, 2005
8YE0	Crystal structure of KgpF prenyltransferase 分子名称: 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, LynF/TruF/PatF family peptide O-prenyltransferase, MAGNESIUM ION, ... 著者 Hamada, K, Inoue, S, Goto, Y, Suga, H, Ogata, K, Sengoku, T. 登録日 2024-02-21 公開日 2024-06-19 実験手法 X-RAY DIFFRACTION (1.94 Å) 主引用文献 De Novo Discovery of Pseudo-Natural Prenylated Macrocyclic Peptide Ligands. Angew.Chem.Int.Ed.Engl., 2024

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