PDB: 230764 件ウェブページステータス検索Chemie searchBIRD

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4C4I	Structure-based design of orally bioavailable pyrrolopyridine inhibitors of the mitotic kinase MPS1 分子名称: 2-(2-(2-(2-(2-(2-ETHOXYETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHANOL, DUAL SPECIFICITY PROTEIN KINASE TTK, tert-butyl 6-{[2-chloro-4-(dimethylcarbamoyl)phenyl]amino}-2-(1,3-oxazol-5-yl)-1H-pyrrolo[3,2-c]pyridine-1-carboxylate 著者 Naud, S, Westwood, I.M, Faisal, A, Sheldrake, P, Bavetsias, V, Atrash, B, Liu, M, Hayes, A, Schmitt, J, Wood, A, Choi, V, Boxall, K, Mak, G, Gurden, M, Valenti, M, de Haven Brandon, A, Henley, A, Baker, R, McAndrew, C, Matijssen, B, Burke, R, Eccles, S.A, Raynaud, F.I, Linardopoulos, S, van Montfort, R, Blagg, J. 登録日 2013-09-05 公開日 2013-12-04 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.65 Å) 主引用文献 Structure-Based Design of Orally Bioavailable 1H-Pyrrolo[3, 2-C]Pyridine Inhibitors of the Mitotic Kinase Monopolar Spindle 1 (Mps1). J.Med.Chem., 56, 2013
1JDR	Crystal Structure of a Proximal Domain Potassium Binding Variant of Cytochrome c Peroxidase 分子名称: Cytochrome c Peroxidase, POTASSIUM ION, PROTOPORPHYRIN IX CONTAINING FE 著者 Bonagura, C.A, Sundaramoorthy, M, Bhaskar, B, Poulos, T.L. 登録日 2001-06-14 公開日 2001-06-27 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 The effects of an engineered cation site on the structure, activity, and EPR properties of cytochrome c peroxidase. Biochemistry, 38, 1999
1MK8	Crystal Structure of a Mutant Cytochrome c Peroxidase showing a Novel Trp-Tyr Covalent Cross-link 分子名称: Cytochrome c Peroxidase, PROTOPORPHYRIN IX CONTAINING FE 著者 Bhaskar, B, Immoos, C.E, Shimizu, H, Farmer, P.J, Poulos, T.L. 登録日 2002-08-28 公開日 2003-04-08 最終更新日 2024-11-20 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 A Novel Heme and Peroxide-Dependent Tryptophan-Tyrosine Cross-Link in a Mutant of Cytochrome c Peroxidase J.Mol.Biol., 328, 2003
1MKQ	Crystal Structure of the Mutant Variant of Cytochrome c Peroxidase in the 'Open' Uncross-linked form 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, Cytochrome c Peroxidase, PROTOPORPHYRIN IX CONTAINING FE 著者 Bhaskar, B, Immoos, C.E, Shimizu, H, Farmer, P.J, Poulos, T.L. 登録日 2002-08-29 公開日 2003-04-08 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (1.64 Å) 主引用文献 A Novel Heme and Peroxide-Dependent Tryptophan-Tyrosine Cross-Link in a Mutant of Cytochrome c Peroxidase J.Mol.Biol., 328, 2003
3KQH	Three Conformational Snapshots of the Hepatitis C Virus NS3 Helicase Reveal a Ratchet Translocation Mechanism 分子名称: 5'-D(*AP*AP*AP*AP*AP*A)-3', Serine protease/NTPase/helicase NS3 著者 Gu, M, Rice, C.M. 登録日 2009-11-17 公開日 2010-01-26 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Three conformational snapshots of the hepatitis C virus NS3 helicase reveal a ratchet translocation mechanism. Proc.Natl.Acad.Sci.USA, 107, 2010
3KQL	Three Conformational Snapshots of the Hepatitis C Virus NS3 Helicase Reveal a Ratchet Translocation Mechanism 分子名称: 5'-D(*TP*TP*TP*TP*TP*T)-3', ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... 著者 Gu, M, Rice, C.M. 登録日 2009-11-17 公開日 2010-01-26 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Three conformational snapshots of the hepatitis C virus NS3 helicase reveal a ratchet translocation mechanism. Proc.Natl.Acad.Sci.USA, 107, 2010
3DTU	Catalytic core subunits (I and II) of cytochrome c oxidase from Rhodobacter sphaeroides complexed with deoxycholic acid 分子名称: (3ALPHA,5BETA,12ALPHA)-3,12-DIHYDROXYCHOLAN-24-OIC ACID, CADMIUM ION, CALCIUM ION, ... 著者 Qin, L, Mills, D.A, Buhrow, L, Hiser, C, Ferguson-Miller, S. 登録日 2008-07-15 公開日 2008-09-16 最終更新日 2024-10-09 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 A conserved steroid binding site in cytochrome C oxidase. Biochemistry, 47, 2008
4QO5	Hypothetical multiheme protein 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, HEME C, ... 著者 Rajendran, C. 登録日 2014-06-19 公開日 2015-12-23 最終更新日 2024-11-27 実験手法 X-RAY DIFFRACTION (1.697 Å) 主引用文献 In meso crystal structure of a novel membrane-associated octaheme cytochrome c from the Crenarchaeon Ignicoccus hospitalis. Febs J., 283, 2016
4RA5	Human Protein Kinase C THETA IN COMPLEX WITH LIGAND COMPOUND 11a (6-[(1,3-Dimethyl-azetidin-3-yl)-methyl-amino]-4(R)-methyl-7-phenyl-2,10-dihydro-9-oxa-1,2,4a-triaza-phenanthren-3-one) 分子名称: (1R)-9-[(1,3-dimethylazetidin-3-yl)(methyl)amino]-1-methyl-8-phenyl-3,5-dihydro[1,2,4]triazino[3,4-c][1,4]benzoxazin-2(1H)-one, 1,2-ETHANEDIOL, HUMAN PROTEIN KINASE C THETA, ... 著者 Argiriadi, M.A, George, D.M. 登録日 2014-09-09 公開日 2014-10-08 最終更新日 2024-11-06 実験手法 X-RAY DIFFRACTION (2.61 Å) 主引用文献 Optimized Protein Kinase C theta (PKC theta ) Inhibitors Reveal Only Modest Anti-inflammatory Efficacy in a Rodent Model of Arthritis. J.Med.Chem., 58, 2015
5YRY	Crystal structure of C-terminal redox domain of APR1 from Arabidopsis thaliana 分子名称: 5'-adenylylsulfate reductase 1, chloroplastic 著者 Hsu, C.H. 登録日 2017-11-11 公開日 2018-11-14 最終更新日 2024-03-27 実験手法 X-RAY DIFFRACTION (2.698 Å) 主引用文献 C-terminal Redox Domain ofArabidopsisAPR1 is a Non-Canonical Thioredoxin Domain with Glutaredoxin Function. Antioxidants (Basel), 8, 2019
1ML2	Crystal Structure of a Mutant Variant of Cytochrome c Peroxidase with Zn(II)-(20-oxo-Protoporphyrin IX) 分子名称: 20-OXO-PROTOPORPHYRIN IX CONTAINING ZN(II), Cytochrome c Peroxidase 著者 Bhaskar, B, Immoos, C.E, Shimizu, H, Farmer, P.J, Poulos, T.L. 登録日 2002-08-29 公開日 2003-04-08 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 A Novel Heme and Peroxide-Dependent Tryptophan-Tyrosine Cross-Link in a Mutant of Cytochrome c Peroxidase J.Mol.Biol., 328, 2003
1LM2	NMR structural characterization of the reduction of chromium(VI) to chromium(III) by cytochrome c7 分子名称: CHROMIUM ION, HEME C, cytochrome c7 著者 Assfalg, M, Bertini, I, Bruschi, M, Michel, C, Turano, P. 登録日 2002-04-30 公開日 2002-07-31 最終更新日 2024-10-30 実験手法 SOLUTION NMR 主引用文献 The metal reductase activity of some multiheme cytochromes c: NMR structural characterization of the reduction of chromium(VI) to chromium(III) by cytochrome c(7). Proc.Natl.Acad.Sci.USA, 99, 2002
3BIZ	Wee1 kinase complex with inhibitor PD331618 分子名称: 4-(2-chlorophenyl)-8-[3-(dimethylamino)propoxy]-9-hydroxy-6-methylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione, CHLORIDE ION, Wee1-like protein kinase 著者 Squire, C.J, Dickson, J.M, Ivanovic, I, Baker, E.N. 登録日 2007-12-02 公開日 2007-12-25 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Synthesis and structure-activity relationships of soluble 8-substituted 4-(2-chlorophenyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3(2H,6H)-diones as inhibitors of the Wee1 and Chk1 checkpoint kinases. Bioorg.Med.Chem.Lett., 18, 2008
3M97	Structure of the soluble domain of cytochrome c552 with its flexible linker segment from Paracoccus denitrificans 分子名称: Cytochrome c-552, HEME C, ZINC ION 著者 Rajendran, C, Ermler, U, Ludwig, B, Michel, H. 登録日 2010-03-20 公開日 2010-07-21 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.332 Å) 主引用文献 Structure at 1.5 A resolution of cytochrome c(552) with its flexible linker segment, a membrane-anchored protein from Paracoccus denitrificans. Acta Crystallogr.,Sect.D, 66, 2010
4JIK	X-RAY Crystal structure of compound 22a (R)-2-(4-chlorophenyl)-8-(piperidin-3-ylamino)imidazo[1,2-c]pyrimidine-5-carboxamide bound to human chk1 kinase domain 分子名称: 2-(4-chlorophenyl)-8-[(3S)-piperidin-3-ylamino]imidazo[1,2-c]pyrimidine-5-carboxamide, Serine/threonine-protein kinase Chk1 著者 Fischmann, T.O. 登録日 2013-03-06 公開日 2013-04-17 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Potency switch between CHK1 and MK2: discovery of imidazo[1,2-a]pyrazine- and imidazo[1,2-c]pyrimidine-based kinase inhibitors. Bioorg.Med.Chem.Lett., 23, 2013
3FYI	Catalytic core subunits (I and II) of cytochrome C oxidase from Rhodobacter sphaeroides in the reduced state bound with cyanide 分子名称: CADMIUM ION, CALCIUM ION, COPPER (I) ION, ... 著者 Qin, L, Mills, D.A, Proshlyakov, D.A, Hiser, C, Ferguson-Miller, S. 登録日 2009-01-22 公開日 2009-06-16 最終更新日 2024-11-06 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Redox dependent conformational changes in cytochrome c oxidase suggest a gating mechanism for proton uptake. Biochemistry, 48, 2009
5O10	Y48H mutant of human cytochrome c 分子名称: Cytochrome c, HEME C 著者 Moreno-Chicano, T, Deacon, O.M, Hough, M.A, Worrall, J.A.R. 登録日 2017-05-17 公開日 2018-03-28 最終更新日 2024-10-23 実験手法 X-RAY DIFFRACTION (1.36 Å) 主引用文献 Heightened Dynamics of the Oxidized Y48H Variant of Human Cytochrome c Increases Its Peroxidatic Activity. Biochemistry, 56, 2017
4RA4	Crystal Structure of Human Protein Kinase C Alpha in Complex with Compound 28 ((R)-6-((3S,4S)-1,3-Dimethyl-piperidin-4-yl)-7-(2-fluoro-phenyl)-4-methyl-2,10-dihydro-9-oxa-1,2,4a-triaza-phenanthren-3-one) 分子名称: (1R)-9-[(3S,4S)-1,3-dimethylpiperidin-4-yl]-8-(2-fluorophenyl)-1-methyl-3,5-dihydro[1,2,4]triazino[3,4-c][1,4]benzoxazin-2(1H)-one, Protein kinase C 著者 Argiriadi, M.A, George, D.M. 登録日 2014-09-09 公開日 2014-10-08 最終更新日 2024-11-20 実験手法 X-RAY DIFFRACTION (2.63 Å) 主引用文献 Optimized Protein Kinase C theta (PKC theta ) Inhibitors Reveal Only Modest Anti-inflammatory Efficacy in a Rodent Model of Arthritis. J.Med.Chem., 58, 2015
1S05	NMR-validated structural model for oxidized R.palustris cytochrome c556 分子名称: Cytochrome c-556, HEME C 著者 Bertini, I, Faraone-Mennella, J, Gray, H.B, Luchinat, C, Parigi, G, Winkler, J.R. 登録日 2003-12-30 公開日 2004-01-20 最終更新日 2024-10-09 実験手法 SOLUTION NMR 主引用文献 NMR-validated structural model for oxidized Rhodopseudomonas palustris cytochrome c(556). J.Biol.Inorg.Chem., 9, 2004
2NRR	Crystal structure of the C-terminal RNAseH endonuclase domain of UvrC 分子名称: UvrABC system protein C 著者 Karakas, E, Truglio, J.J, Kisker, C. 登録日 2006-11-02 公開日 2007-02-06 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (1.2 Å) 主引用文献 Structure of the C-terminal half of UvrC reveals an RNase H endonuclease domain with an Argonaute-like catalytic triad. Embo J., 26, 2007
2NRX	Crystal structure of the C-terminal half of UvrC, in the presence of sulfate molecules 分子名称: GLYCEROL, SULFATE ION, UvrABC system protein C 著者 Karakas, E, Truglio, J.J, Kisker, C. 登録日 2006-11-02 公開日 2007-02-06 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structure of the C-terminal half of UvrC reveals an RNase H endonuclease domain with an Argonaute-like catalytic triad. Embo J., 26, 2007
6CI0	Catalytic core subunits (I and II) of cytochrome C oxidase from Rhodobacter sphaeroides with E101A (II) mutation 分子名称: (2S,3R)-heptane-1,2,3-triol, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CADMIUM ION, ... 著者 Liu, J, Hiser, C, Ferguson-Miller, S. 登録日 2018-02-23 公開日 2018-04-25 最終更新日 2024-10-09 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 The K-path entrance in cytochrome c oxidase is defined by mutation of E101 and controlled by an adjacent ligand binding domain. Biochim. Biophys. Acta, 1859, 2018
1GX7	Best model of the electron transfer complex between cytochrome c3 and [Fe]-hydrogenase 分子名称: 1,3-PROPANEDITHIOL, CARBON MONOXIDE, CYANIDE ION, ... 著者 Elantak, L, Morelli, X, Bornet, O, Hatchikian, C, Czjzek, M, Dolla, A, Guerlesquin, F. 登録日 2002-03-28 公開日 2003-07-31 最終更新日 2024-11-06 実験手法 SOLUTION NMR, THEORETICAL MODEL 主引用文献 The Cytochrome C(3)-[Fe]-Hydrogenase Electron-Transfer Complex: Structural Model by NMR Restrained Docking FEBS Lett., 548, 2003
7CRG	Beta-strand-mediated dimeric formation of the extended Ig-like domains of human lamin A/C 分子名称: Prelamin-A/C 著者 Ahn, J, Ha, N.C. 登録日 2020-08-13 公開日 2021-08-25 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Beta-strand-mediated dimeric formation of the Ig-like domains of human lamin A/C and B1. Biochem.Biophys.Res.Commun., 550, 2021
1N64	Crystal structure analysis of the immunodominant antigenic site on Hepatitis C virus protein bound to mAb 19D9D6 分子名称: Fab 19D9D6 heavy chain, Fab 19D9D6 light chain, Genome polyprotein Capsid protein C 著者 Menez, R, Bossus, M, Muller, B, Sibai, G, Dalbon, P, Ducancel, F, Jolivet-Reynaud, C, Stura, E. 登録日 2002-11-08 公開日 2003-02-25 最終更新日 2024-11-13 実験手法 X-RAY DIFFRACTION (2.34 Å) 主引用文献 Crystal structure of a hydrophobic immunodominant antigenic site on hepatitis C virus core protein complexed to monoclonal antibody 19D9D6. J.Immunol., 170, 2003

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