PDB: 299 件ウェブページステータス検索Chemie searchBIRD

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2FN7	Crystal structure of the lactate dehydrogenase from cryptosporidium parvum complexed with substrate (lactic acid) and cofactor (b-nicotinamide adenine dinucleotide) 分子名称: GLYCEROL, LACTIC ACID, Lactate Dehydrogenase, ... 著者 Senkovich, O.A, Chattopadhyay, D. 登録日 2006-01-10 公開日 2007-01-23 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structure of cryptosporidium parvum lactate dehydrogenase in complex with substrates and cofactors To be Published
6BB1	Lactate Dehydrogenase in complex with inhibitor (R)-5-((2-chlorophenyl)thio)-6'-(4-fluorophenoxy)-4-hydroxy-2-(thiophen-3-yl)-2,3-dihydro-[2,2'-bipyridin]-6(1H)-one 分子名称: (2R)-5-[(2-chlorophenyl)sulfanyl]-6'-(4-fluorophenoxy)-4-hydroxy-2-(thiophen-3-yl)-2,3-dihydro[2,2'-bipyridin]-6(1H)-one, L-lactate dehydrogenase A chain, LACTIC ACID, ... 著者 Ultsch, M, Eigenbrot, C. 登録日 2017-10-16 公開日 2018-10-24 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structure-guided optimization and in vivo activities of hydroxylactone and hydroxylactam Inhibitors of Human Lactate Dehydrogenase To Be Published
1OC4	Lactate dehydrogenase from Plasmodium berghei 分子名称: GLYCEROL, L-LACTATE DEHYDROGENASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... 著者 Winter, V.J, Brady, R.L. 登録日 2003-02-05 公開日 2003-09-18 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Crystal Structure of Plasmodium Berghei Lactate Dehydrogenase Indicates the Unique Structural Differences of These Enzymes are Shared Across the Plasmodium Genus Mol.Biochem.Parasitol., 131, 2003
6JML	Re-refined structure of R-state L-lactate dehydrogenase fromLactobacillus casei 分子名称: L-lactate dehydrogenase, SULFATE ION 著者 Arai, K, Miyanaga, A, Uchikoba, H, Fushinobu, S, Taguchi, H. 登録日 2019-03-12 公開日 2020-05-06 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Crystal structure of penta mutant of L-lactate dehydrogenase from Lactobacillus casei To Be Published
1V6A	Crystal Structure of L-lactate dehydrogenase from Cyprinus carpio 分子名称: L-lactate dehydrogenase A chain, alpha-D-glucopyranose-(1-1)-alpha-D-glucopyranose 著者 Watanabe, K, Motoshima, H. 登録日 2003-11-28 公開日 2005-02-15 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Crystal Structure of L-lactate dehydrogenase from Cyprinus carpio To be Published
3CZM	T. Gondii bradyzoite-specific LDH (LDH2) in complex with NAD and OXQ 分子名称: 4-HYDROXY-1,2,5-OXADIAZOLE-3-CARBOXYLIC ACID, L-lactate dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE 著者 Wilson, D.K, Susko, M.S. 登録日 2008-04-29 公開日 2009-06-02 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 T. Gondii bradyzoite-specific LDH (LDH2) in complex with NAD and OXQ To be Published
2E37	Structure of TT0471 protein from Thermus thermophilus 分子名称: L-lactate dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, SULFATE ION 著者 Lokanath, N.K, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2006-11-21 公開日 2007-11-27 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structure of TT0471 protein from Thermus thermophilus To be Published
1I10	HUMAN MUSCLE L-LACTATE DEHYDROGENASE M CHAIN, TERNARY COMPLEX WITH NADH AND OXAMATE 分子名称: 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, ACETATE ION, L-LACTATE DEHYDROGENASE M CHAIN, ... 著者 Read, J.A, Winter, V.J, Eszes, C.M, Sessions, R.B, Brady, R.L. 登録日 2001-01-30 公開日 2001-03-28 最終更新日 2023-08-09 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structural basis for altered activity of M- and H-isozyme forms of human lactate dehydrogenase. Proteins, 43, 2001
6IHD	Crystal structure of Malate dehydrogenase from Metallosphaera sedula 分子名称: 2-ETHOXYETHANOL, Malate dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE 著者 Lee, D, Kim, K.J. 登録日 2018-09-29 公開日 2019-02-06 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Crystal structure and biochemical characterization of malate dehydrogenase from Metallosphaera sedula Biochem. Biophys. Res. Commun., 509, 2019
1EZ4	CRYSTAL STRUCTURE OF NON-ALLOSTERIC L-LACTATE DEHYDROGENASE FROM LACTOBACILLUS PENTOSUS AT 2.3 ANGSTROM RESOLUTION 分子名称: LACTATE DEHYDROGENASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE 著者 Uchikoba, H, Fushinobu, S, Wakagi, T, Konno, M, Taguchi, H, Matsuzawa, H. 登録日 2000-05-10 公開日 2001-12-28 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Crystal structure of non-allosteric L-lactate dehydrogenase from Lactobacillus pentosus at 2.3 A resolution: specific interactions at subunit interfaces. Proteins, 46, 2002
8FW6	Human Lactate Dehydrogenase A in Complex with Inhibitor CHK-336 分子名称: (2P)-2-{5-(cyclopropylmethyl)-3-(4-fluorophenyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]-1H-pyrazol-1-yl}-1,3-thiazole-4-carboxylic acid, 1,2-ETHANEDIOL, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, ... 著者 Lowther, W.T, Gumpena, R. 登録日 2023-01-20 公開日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.34 Å) 主引用文献 Human Lactate Dehydrogenase A in complex with inhibitor CHK-336 To Be Published
2V65	Apo LDH from the psychrophile C. gunnari 分子名称: L-LACTATE DEHYDROGENASE A CHAIN 著者 Coquelle, N, Madern, D, Vellieux, F. 登録日 2007-07-13 公開日 2007-09-25 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Activity, Stability and Structural Studies of Lactate Dehydrogenases Adapted to Extreme Thermal Environments. J.Mol.Biol., 374, 2007
4I9N	Crystal structure of rabbit LDHA in complex with AP28161 and AP28122 分子名称: 6-({2-[(5-chloro-4-{[(2S)-2,3-dihydroxypropyl]oxy}-2-methoxyphenyl)amino]-2-oxoethyl}sulfanyl)pyridine-3-carboxylic acid, 6-[3-(carboxymethoxy)-5-fluorophenyl]pyridine-3-carboxylic acid, L-lactate dehydrogenase A chain 著者 Zhou, T, Kohlmann, A, Stephan, Z.G, Li, F, Commodore, L, Greenfield, M.T, Shakespeare, W.C, Zhu, X, Dalgarno, D.C. 登録日 2012-12-05 公開日 2013-01-23 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Fragment growing and linking lead to novel nanomolar lactate dehydrogenase inhibitors. J.Med.Chem., 56, 2013
4AJE	rat LDHA in complex with 2-(4-bromophenoxy)propanedioic acid 分子名称: 2-(4-BROMANYLPHENOXY)PROPANEDIOIC ACID, GLYCEROL, L-LACTATE DEHYDROGENASE A CHAIN, ... 著者 Tucker, J.A, Brassington, C, Hassall, G, Vogtherr, M, Ward, R, Tart, J, Davies, G, Pearson, S. 登録日 2012-02-16 公開日 2012-03-21 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 The Design and Synthesis of Novel Lactate Dehydrogenase a Inhibitors by Fragment-Based Lead Generation J.Med.Chem., 55, 2012
4KDF	Crystal Structure of Thermus thermophilus Malate Dehydrogenase in Complex with NAD 分子名称: Malate dehydrogenase, SULFATE ION 著者 Hsu, C.-H, Hong, C.-H, Chang, Y.-Y. 登録日 2013-04-25 公開日 2014-02-05 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.356 Å) 主引用文献 Crystal structures and molecular dynamics simulations of thermophilic malate dehydrogenase reveal critical loop motion for co-substrate binding. Plos One, 8, 2013
3PQD	Crystal structure of L-lactate dehydrogenase from Bacillus subtilis complexed with FBP and NAD+ 分子名称: 1,6-di-O-phosphono-beta-D-fructofuranose, L-lactate dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE 著者 Zhang, Y, Garavito, R.M. 登録日 2010-11-26 公開日 2012-01-18 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.376 Å) 主引用文献 Crystal structure of L-lactate dehydrogenase from Bacillus subtilis complexed with FBP and NAD+ To be Published
3H3F	Rabbit muscle L-lactate dehydrogenase in complex with NADH and oxamate 分子名称: 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, ACETATE ION, L-lactate dehydrogenase A chain, ... 著者 Bujacz, A, Bujacz, G, Swiderek, K, Paneth, P. 登録日 2009-04-16 公開日 2009-09-15 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.38 Å) 主引用文献 Modeling of isotope effects on binding oxamate to lactic dehydrogenase J.Phys.Chem.B, 113, 2009
4AJP	Human LDHA in complex with 2-((4-(4-((3-((2-methyl-1,3-benzothiazol- 6yl)amino)-3-oxo-propyl)amino)-4-oxo-butyl)phenyl)methyl)propanedioic acid 分子名称: GLYCEROL, L-LACTATE DEHYDROGENASE A CHAIN, SULFATE ION, ... 著者 Tucker, J.A, Brassington, C, Caputo, A, Ward, R, Pearson, S, Watson, M, Tart, J, Davies, G. 登録日 2012-02-16 公開日 2012-03-21 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.38 Å) 主引用文献 The Design and Synthesis of Novel Lactate Dehydrogenase a Inhibitors by Fragment-Based Lead Generation J.Med.Chem., 55, 2012
5ZJD	Lactate dehydrogenase with NADH and MLA 分子名称: 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, L-lactate dehydrogenase A chain, MALONATE ION 著者 Han, C.W, Jang, S.B. 登録日 2018-03-20 公開日 2019-07-24 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.394 Å) 主引用文献 Machilin A Inhibits Tumor Growth and Macrophage M2 Polarization Through the Reduction of Lactic Acid. Cancers (Basel), 11, 2019
4OJN	Crystal structure of human muscle L-lactate dehydrogenase 分子名称: GLYCEROL, L-lactate dehydrogenase A chain, PENTAETHYLENE GLYCOL 著者 Kolappan, S, Craig, L. 登録日 2014-01-21 公開日 2014-12-03 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structures of lactate dehydrogenase A (LDHA) in apo, ternary and inhibitor-bound forms. Acta Crystallogr.,Sect.D, 71, 2015
6BB3	Lactate Dehydrogenase in complex with inhibitor 3-((2-chlorophenyl)thio)-6-(6-((4-fluorophenyl)amino)pyridin-2-yl)-4-hydroxy-6-(thiophen-3-yl)-5,6-dihydro-2H-pyran-2-one 分子名称: (6R)-3-[(2-chlorophenyl)sulfanyl]-6-{6-[(4-fluorophenyl)amino]pyridin-2-yl}-4-hydroxy-6-(thiophen-3-yl)-5,6-dihydro-2H-pyran-2-one, L-lactate dehydrogenase A chain, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... 著者 Chen, Z, Eigenbrot, C. 登録日 2017-10-16 公開日 2018-10-24 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structure-guided optimization and in vivo activities of hydroxylactone and hydroxylactam Inhibitors of Human Lactate Dehydrogenase To Be Published
7MDH	STRUCTURAL BASIS FOR LIGHT ACITVATION OF A CHLOROPLAST ENZYME. THE STRUCTURE OF SORGHUM NADP-MALATE DEHYDROGENASE IN ITS OXIDIZED FORM 分子名称: PROTEIN (MALATE DEHYDROGENASE), ZINC ION 著者 Johansson, K, Ramaswamy, S, Saarinen, M, Lemaire-Chamley, M, Issakidis-Bourguet, E, Miginiac-Maslow, M, Eklund, H. 登録日 1999-02-16 公開日 1999-06-04 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structural basis for light activation of a chloroplast enzyme: the structure of sorghum NADP-malate dehydrogenase in its oxidized form. Biochemistry, 38, 1999
4WLV	Crystal structure of NAD bound MDH2 分子名称: Malate dehydrogenase, mitochondrial, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... 著者 Eo, Y.M, Han, B.G, Ahn, H.C. 登録日 2014-10-08 公開日 2015-11-25 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Crystal structure of NAD bound MDH2 To Be Published
6BAG	Lactate Dehydrogenase in complex with inhibitor (R)-5-((2-chlorophenyl)thio)-6'-((4-fluorophenyl)amino)-4-hydroxy-2-(thiophen-3-yl)-2,3-dihydro-[2,2'-bipyridin]-6(1H)-one 分子名称: (2R)-5-[(2-chlorophenyl)sulfanyl]-6'-[(4-fluorophenyl)amino]-4-hydroxy-2-(thiophen-3-yl)-2,3-dihydro[2,2'-bipyridin]-6(1H)-one, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, L-lactate dehydrogenase A chain, ... 著者 Ultsch, M, Eigenbrot, C. 登録日 2017-10-12 公開日 2018-10-17 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structure-guided optimization and in vivo activities of hydroxylactone and hydroxylactam Inhibitors of Human Lactate Dehydrogenase To Be Published
5NFR	Crystal structure of malate dehydrogenase from Plasmodium falciparum (PfMDH) 分子名称: CITRIC ACID, Malate dehydrogenase 著者 Lunev, S, Romero, A.R, Batista, F.A, Wrenger, C, Groves, M.R. 登録日 2017-03-15 公開日 2018-01-31 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Oligomeric interfaces as a tool in drug discovery: Specific interference with activity of malate dehydrogenase of Plasmodium falciparum in vitro. PLoS ONE, 13, 2018

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