7OHW
 
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7OHV
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7OHS
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7OHR
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7OHP
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7NAD
 | | State E2 nucleolar 60S ribosomal biogenesis intermediate - Spb4 local refinement model | | 分子名称: | 25S rRNA, 5.8S rRNA, 60S ribosomal protein L17-A, ... | | 著者 | Cruz, V.E, Sekulski, K, Peddada, N, Erzberger, J.P. | | 登録日 | 2021-06-21 | | 公開日 | 2022-11-09 | | 最終更新日 | 2024-06-05 | | 実験手法 | ELECTRON MICROSCOPY (3.04 Å) | | 主引用文献 | Sequence-specific remodeling of a topologically complex RNP substrate by Spb4.
Nat.Struct.Mol.Biol., 29, 2022
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7NAC
 | | State E2 nucleolar 60S ribosomal biogenesis intermediate - Composite model | | 分子名称: | 25S rRNA, 25S rRNA (cytosine(2870)-C(5))-methyltransferase, 27S pre-rRNA (guanosine(2922)-2'-O)-methyltransferase, ... | | 著者 | Cruz, V.E, Sekulski, K, Peddada, N, Erzberger, J.P. | | 登録日 | 2021-06-21 | | 公開日 | 2022-11-09 | | 最終更新日 | 2024-06-05 | | 実験手法 | ELECTRON MICROSCOPY (3.04 Å) | | 主引用文献 | Sequence-specific remodeling of a topologically complex RNP substrate by Spb4.
Nat.Struct.Mol.Biol., 29, 2022
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7MQJ
 | | Dhr1 Helicase Core | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Probable ATP-dependent RNA helicase DHR1 | | 著者 | Miller, L, Chaker-Margot, M, Klinge, S. | | 登録日 | 2021-05-05 | | 公開日 | 2021-09-22 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.23 Å) | | 主引用文献 | Nucleolar maturation of the human small subunit processome.
Science, 373, 2021
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7MQA
 | | Cryo-EM structure of the human SSU processome, state post-A1 | | 分子名称: | 18S rRNA, 40S ribosomal protein S11, 40S ribosomal protein S12, ... | | 著者 | Vanden Broeck, A, Singh, S, Klinge, S. | | 登録日 | 2021-05-05 | | 公開日 | 2021-09-22 | | 最終更新日 | 2021-09-29 | | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | | 主引用文献 | Nucleolar maturation of the human small subunit processome.
Science, 373, 2021
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7LUV
 | | Cryo-EM structure of the yeast THO-Sub2 complex | | 分子名称: | ATP-dependent RNA helicase SUB2, THO complex subunit 2, THO complex subunit HPR1, ... | | 著者 | Xie, Y, Ren, Y. | | 登録日 | 2021-02-23 | | 公開日 | 2021-04-14 | | 最終更新日 | 2024-03-06 | | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | | 主引用文献 | Cryo-EM structure of the yeast TREX complex and coordination with the SR-like protein Gbp2.
Elife, 10, 2021
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7LIU
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7JL3
 | | Cryo-EM structure of RIG-I:dsRNA filament in complex with RIPLET PrySpry domain (trimer) | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Antiviral innate immune response receptor RIG-I, E3 ubiquitin-protein ligase RNF135, ... | | 著者 | Kato, K, Ahmad, S, Hur, S. | | 登録日 | 2020-07-29 | | 公開日 | 2020-12-09 | | 最終更新日 | 2024-03-06 | | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | | 主引用文献 | Structural analysis of RIG-I-like receptors reveals ancient rules of engagement between diverse RNA helicases and TRIM ubiquitin ligases.
Mol.Cell, 81, 2021
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7JL1
 | | Cryo-EM structure of RIG-I:dsRNA in complex with RIPLET PrySpry domain (monomer) | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Antiviral innate immune response receptor RIG-I, E3 ubiquitin-protein ligase RNF135, ... | | 著者 | Kato, K, Ahmad, S, Hur, S. | | 登録日 | 2020-07-29 | | 公開日 | 2020-12-09 | | 最終更新日 | 2024-03-06 | | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | | 主引用文献 | Structural analysis of RIG-I-like receptors reveals ancient rules of engagement between diverse RNA helicases and TRIM ubiquitin ligases.
Mol.Cell, 81, 2021
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7GQU
 | | Crystal Structure of Werner helicase fragment 517-945 in covalent complex with N-[(E,1S)-1-cyclopropyl-3-methylsulfonylprop-2-enyl]-2-(1,1-difluoroethyl)-4-phenoxypyrimidine-5-carboxamide | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN, GLYCEROL, ... | | 著者 | Classen, M, Benz, J, Brugger, D, Tagliente, O, Rudolph, M.G. | | 登録日 | 2023-10-19 | | 公開日 | 2024-05-01 | | 最終更新日 | 2024-05-29 | | 実験手法 | X-RAY DIFFRACTION (1.54 Å) | | 主引用文献 | Chemoproteomic discovery of a covalent allosteric inhibitor of WRN helicase.
Nature, 629, 2024
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7GQT
 | | Crystal Structure of Werner helicase fragment 517-945 in complex with ATP | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN, MAGNESIUM ION, ... | | 著者 | Classen, M, Benz, J, Brugger, D, Rudolph, M.G. | | 登録日 | 2023-10-19 | | 公開日 | 2024-05-01 | | 最終更新日 | 2024-05-29 | | 実験手法 | X-RAY DIFFRACTION (2.21 Å) | | 主引用文献 | Chemoproteomic discovery of a covalent allosteric inhibitor of WRN helicase.
Nature, 629, 2024
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7GQS
 | | Crystal Structure of Werner helicase fragment 517-945 in complex with ADP | | 分子名称: | 1,2-ETHANEDIOL, ADENOSINE-5'-DIPHOSPHATE, Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN, ... | | 著者 | Classen, M, Benz, J, Brugger, D, Rudolph, M.G. | | 登録日 | 2023-10-19 | | 公開日 | 2024-05-01 | | 最終更新日 | 2024-05-29 | | 実験手法 | X-RAY DIFFRACTION (1.57 Å) | | 主引用文献 | Chemoproteomic discovery of a covalent allosteric inhibitor of WRN helicase.
Nature, 629, 2024
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7FSF
 | | CRYSTAL STRUCTURE OF T. MARITIMA REVERSE GYRASE ACTIVE SITE VARIANT Y851F | | 分子名称: | Reverse gyrase, ZINC ION | | 著者 | Rasche, R, Kummel, D, Rudolph, M.G, Klostermeier, D. | | 登録日 | 2023-01-04 | | 公開日 | 2023-05-10 | | 最終更新日 | 2024-05-22 | | 実験手法 | X-RAY DIFFRACTION (2.77 Å) | | 主引用文献 | Structure of reverse gyrase with a minimal latch that supports ATP-dependent positive supercoiling without specific interactions with the topoisomerase domain.
Acta Crystallogr D Struct Biol, 79, 2023
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7FSE
 | | Crystal Structure of T. maritima reverse gyrase with a minimal latch | | 分子名称: | CHLORIDE ION, DODECAETHYLENE GLYCOL, Reverse gyrase, ... | | 著者 | Rasche, R, Kummel, D, Rudolph, M.G, Klostermeier, D. | | 登録日 | 2023-01-04 | | 公開日 | 2023-05-10 | | 最終更新日 | 2024-05-22 | | 実験手法 | X-RAY DIFFRACTION (2.89 Å) | | 主引用文献 | Structure of reverse gyrase with a minimal latch that supports ATP-dependent positive supercoiling without specific interactions with the topoisomerase domain.
Acta Crystallogr D Struct Biol, 79, 2023
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7EVO
 | | The cryo-EM structure of the human 17S U2 snRNP | | 分子名称: | HIV Tat-specific factor 1, PHD finger-like domain-containing protein 5A, RNA helicase, ... | | 著者 | Zhang, X, Zhan, X, Shi, Y. | | 登録日 | 2021-05-21 | | 公開日 | 2022-08-03 | | 最終更新日 | 2024-05-22 | | 実験手法 | ELECTRON MICROSCOPY (2.5 Å) | | 主引用文献 | Structural insights into branch site proofreading by human spliceosome.
Nat.Struct.Mol.Biol., 2024
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7EVN
 | | The cryo-EM structure of the DDX42-SF3b complex | | 分子名称: | ATP-dependent RNA helicase DDX42, PHD finger-like domain-containing protein 5A, Splicing factor 3B subunit 1, ... | | 著者 | Zhang, X, Zhan, X, Shi, Y. | | 登録日 | 2021-05-21 | | 公開日 | 2022-08-03 | | 最終更新日 | 2024-01-17 | | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | | 主引用文献 | Structural insights into branch site proofreading by human spliceosome
Nat.Struct.Mol.Biol., 2024
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7DVQ
 | | Cryo-EM Structure of the Activated Human Minor Spliceosome (minor Bact Complex) | | 分子名称: | 116 kDa U5 small nuclear ribonucleoprotein component, 5'-O-[(S)-hydroxy{[(R)-hydroxy{[(S)-hydroxy(methoxy)phosphoryl]oxy}phosphoryl]oxy}phosphoryl]guanosine, Armadillo repeat-containing protein 7, ... | | 著者 | Bai, R, Wan, R, Wang, L, Xu, K, Zhang, Q, Lei, J, Shi, Y. | | 登録日 | 2021-01-14 | | 公開日 | 2021-03-31 | | 実験手法 | ELECTRON MICROSCOPY (2.89 Å) | | 主引用文献 | Structure of the activated human minor spliceosome.
Science, 371, 2021
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7DTK
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7DDX
 | | Crystal structure of KANK1 S1179F mutant in complex wtih eIF4A1 | | 分子名称: | Eukaryotic initiation factor 4A-I, GLYCEROL, KN motif and ankyrin repeat domains 1, ... | | 著者 | Pan, W, Xu, Y, Wei, Z. | | 登録日 | 2020-10-30 | | 公開日 | 2021-09-08 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Nephrotic-syndrome-associated mutation of KANK2 induces pathologic binding competition with physiological interactor KIF21A.
J.Biol.Chem., 297, 2021
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7DD3
 | | Cryo-EM structure of the pre-mRNA-loaded DEAH-box ATPase/helicase Prp2 in complex with Spp2 | | 分子名称: | PRP2 isoform 1, Pre-mRNA-splicing factor SPP2, pre-mRNA | | 著者 | Bai, R, Wan, R, Yan, C, Qi, J, Zhang, P, Lei, J, Shi, Y. | | 登録日 | 2020-10-27 | | 公開日 | 2021-01-06 | | 最終更新日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Mechanism of spliceosome remodeling by the ATPase/helicase Prp2 and its coactivator Spp2.
Science, 371, 2021
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7DCR
 | | cryo-EM structure of the DEAH-box helicase Prp2 in complex with its coactivator Spp2 | | 分子名称: | PRP2 isoform 1, Pre-mRNA-splicing factor SPP2 | | 著者 | Bai, R, Wan, R, Yan, C, Jia, Q, Zhang, P, Lei, J, Shi, Y. | | 登録日 | 2020-10-26 | | 公開日 | 2021-01-06 | | 最終更新日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (3.15 Å) | | 主引用文献 | Mechanism of spliceosome remodeling by the ATPase/helicase Prp2 and its coactivator Spp2.
Science, 371, 2021
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