PDB: 243083 件ウェブページステータス検索Chemie searchBIRD

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5GYK	Crystal Structure of Mdm12-deletion mutant 分子名称: 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, Mitochondrial distribution and morphology protein 12 著者 Jeong, H, Park, J, Lee, C. 登録日 2016-09-22 公開日 2016-11-16 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (3.596 Å) 主引用文献 Crystal structure of Mdm12 reveals the architecture and dynamic organization of the ERMES complex EMBO Rep., 17, 2016
7QU7	ATAD2 in complex with FragLite16 分子名称: 1,2-ETHANEDIOL, 4-bromanyl-1,8-naphthyridine, ATPase family AAA domain-containing protein 2, ... 著者 Turberville, S, Martin, M.P, Hope, I, Noble, M.E.M. 登録日 2022-01-17 公開日 2022-11-23 最終更新日 2024-11-13 実験手法 X-RAY DIFFRACTION (2.13 Å) 主引用文献 Mapping Ligand Interactions of Bromodomains BRD4 and ATAD2 with FragLites and PepLites─Halogenated Probes of Druglike and Peptide-like Molecular Interactions. J.Med.Chem., 65, 2022
7PEB	cryo-EM structure of DEPTOR bound to human mTOR complex 1, focussed on one protomer 分子名称: DEP domain-containing mTOR-interacting protein, INOSITOL HEXAKISPHOSPHATE, Regulatory-associated protein of mTOR, ... 著者 Waelchli, M, Maier, T. 登録日 2021-08-09 公開日 2021-09-08 最終更新日 2024-07-17 実験手法 ELECTRON MICROSCOPY (3.67 Å) 主引用文献 Regulation of human mTOR complexes by DEPTOR. Elife, 10, 2021
7PEA	cryo-EM structure of DEPTOR bound to human mTOR complex 1, overall refinement 分子名称: DEP domain-containing mTOR-interacting protein, INOSITOL HEXAKISPHOSPHATE, Regulatory-associated protein of mTOR, ... 著者 Waelchli, M, Maier, T. 登録日 2021-08-09 公開日 2021-09-08 最終更新日 2024-07-17 実験手法 ELECTRON MICROSCOPY (4.07 Å) 主引用文献 Regulation of human mTOR complexes by DEPTOR. Elife, 10, 2021
7PEC	cryo-EM structure of DEPTOR bound to human mTOR complex 1, DEPt-bound subset local refinement 分子名称: DEP domain-containing mTOR-interacting protein, INOSITOL HEXAKISPHOSPHATE, Regulatory-associated protein of mTOR, ... 著者 Waelchli, M, Maier, T. 登録日 2021-08-09 公開日 2021-09-08 最終更新日 2024-07-17 実験手法 ELECTRON MICROSCOPY (4.24 Å) 主引用文献 Regulation of human mTOR complexes by DEPTOR. Elife, 10, 2021
6YGA	Crystal structure of the apo NatC complex 分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... 著者 Grunwald, S, Hopf, L, Bock-Bierbaum, T, Lally, C.C, Spahn, C.M.T, Daumke, O. 登録日 2020-03-27 公開日 2020-10-28 最終更新日 2024-11-20 実験手法 X-RAY DIFFRACTION (2.397 Å) 主引用文献 Divergent architecture of the heterotrimeric NatC complex explains N-terminal acetylation of cognate substrates. Nat Commun, 11, 2020
4WMW	The structure of MBP-MCL1 bound to ligand 5 at 1.9A 分子名称: 1,2-ETHANEDIOL, 2-hydroxy-5-(methylsulfanyl)benzoic acid, FORMIC ACID, ... 著者 Clifton, M.C, Dranow, D.M. 登録日 2014-10-09 公開日 2015-05-06 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 A Maltose-Binding Protein Fusion Construct Yields a Robust Crystallography Platform for MCL1. Plos One, 10, 2015
6HCN	Adenovirus Type 5 Fiber Knob protein at 1.49A resolution 分子名称: 1,2-ETHANEDIOL, Fiber protein, MAGNESIUM ION 著者 Rizkallah, P.J, Parker, A.L, Baker, A.T. 登録日 2018-08-15 公開日 2019-02-13 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.49 Å) 主引用文献 Diversity within the adenovirus fiber knob hypervariable loops influences primary receptor interactions. Nat Commun, 10, 2019
8RHQ	Crystal structure of HLA-A*11:01 in complex with SVLNDIFSRL, an 10-mer epitope from SARS-CoV-2 Spike (S975-984) 分子名称: 1,2-ETHANEDIOL, Beta-2-microglobulin, CHLORIDE ION, ... 著者 Ahn, Y.M, Maddumage, J.C, Szeto, C, Gras, S. 登録日 2023-12-16 公開日 2024-05-15 最終更新日 2024-11-20 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 The impact of SARS-CoV-2 spike mutation on peptide presentation is HLA allomorph-specific. Curr Res Struct Biol, 7, 2024
6W5L	2.1 A resolution structure of Norovirus 3CL protease in complex with inhibitor 7g 分子名称: (2~{S})-~{N}-[(1~{R})-1-[bis($l^{1}-oxidanyl)-methoxy-$l^{5}-sulfanyl]-1-oxidanyl-3-[(3~{R})-2-oxidanylidenepyrrolidin-3-yl]propan-2-yl]-2-[[[2-(3-chlorophenyl)-2-methyl-propoxy]-oxidanylidene-methyl]amino]-4-methyl-pentanamide, 3C-LIKE PROTEASE 著者 Lovell, S, Kashipathy, M.M, Battaile, K.P, Rathnayake, A.D, Kim, Y, Chang, K.O, Groutas, W.C. 登録日 2020-03-13 公開日 2020-09-30 最終更新日 2024-10-23 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structure-Guided Optimization of Dipeptidyl Inhibitors of Norovirus 3CL Protease. J.Med.Chem., 63, 2020
6PYU	Human PI3Kdelta in complex with Compound 4-2 ((3S)-1'-(cyclopropanecarbonyl)-5-(quinoxalin-6-yl)spiro[indole-3,2'-pyrrolidin]-2(1H)-one) 分子名称: (3S)-1'-(cyclopropanecarbonyl)-5-(quinoxalin-6-yl)spiro[indole-3,2'-pyrrolidin]-2(1H)-one, Phosphatidylinositol 3-kinase regulatory subunit alpha, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform 著者 Lesburg, C.A, Augustin, M.A. 登録日 2019-07-30 公開日 2019-08-28 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.54 Å) 主引用文献 Design of selective PI3K delta inhibitors using an iterative scaffold-hopping workflow. Bioorg.Med.Chem.Lett., 29, 2019
5MZ8	Crystal structure of aldehyde dehydrogenase 21 (ALDH21) from Physcomitrella patens in complex with the reaction product succinate 分子名称: 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... 著者 Kopecny, D, Vigouroux, A, Briozzo, P, Morera, S. 登録日 2017-01-31 公開日 2017-08-09 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 The ALDH21 gene found in lower plants and some vascular plants codes for a NADP(+) -dependent succinic semialdehyde dehydrogenase. Plant J., 92, 2017
6VW9	C-terminal regulatory domain of the chloride transporter KCC-1 from C. elegans, proteolyzed during crystallization 分子名称: 3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL, GLYCEROL, K+/Cl-Cotransporter 著者 Zimanyi, C.M, Cheung, J. 登録日 2020-02-19 公開日 2020-07-15 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structure of the Regulatory Cytosolic Domain of a Eukaryotic Potassium-Chloride Cotransporter. Structure, 28, 2020
4WMS	STRUCTURE OF APO MBP-MCL1 AT 1.9A 分子名称: 1,2-ETHANEDIOL, FORMIC ACID, MAGNESIUM ION, ... 著者 Clifton, M.C, Dranow, D.M. 登録日 2014-10-09 公開日 2015-05-06 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 A Maltose-Binding Protein Fusion Construct Yields a Robust Crystallography Platform for MCL1. Plos One, 10, 2015
8RPH	JanthE from Janthinobacterium sp. HH01,ketobutyryl-ThDP 分子名称: (2~{S})-2-[3-[(4-azanyl-2-methyl-pyrimidin-5-yl)methyl]-4-methyl-5-[2-[oxidanyl(phosphonooxy)phosphoryl]oxyethyl]-1,3-thiazol-2-yl]-2-oxidanyl-butanoic acid, FLAVIN-ADENINE DINUCLEOTIDE, MAGNESIUM ION, ... 著者 Lanza, L, Leogrande, C, Rabe von Pappenheim, F, Tittmann, K, Mueller, M. 登録日 2024-01-16 公開日 2024-06-12 最終更新日 2024-08-21 実験手法 X-RAY DIFFRACTION (2.96 Å) 主引用文献 Identification and Characterization of Thiamine Diphosphate-Dependent Lyases with an Unusual CDG Motif. Angew.Chem.Int.Ed.Engl., 63, 2024
8RCP	Structure of Human Serum Albumin in complex with Myristic Acid 分子名称: 1,2-ETHANEDIOL, MYRISTIC ACID, Serum albumin 著者 Pomyalov, S, Sidorenko, V.S, Grollman, A.P, Shoham, G. 登録日 2023-12-06 公開日 2024-06-26 最終更新日 2024-11-20 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structural and mechanistic insights into the transport of aristolochic acids and their active metabolites by human serum albumin. J.Biol.Chem., 300, 2024
6HOY	Human Sirt6 in complex with ADP-ribose and the inhibitor trichostatin A 分子名称: 1,2-ETHANEDIOL, NAD-dependent protein deacetylase sirtuin-6, SULFATE ION, ... 著者 You, W, Steegborn, C. 登録日 2018-09-18 公開日 2018-11-14 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Structural Basis of Sirtuin 6 Inhibition by the Hydroxamate Trichostatin A: Implications for Protein Deacylase Drug Development. J.Med.Chem., 61, 2018
4WX2	Crystal structure of Tryptophan Synthase from Salmonella typhimurium in complex with two F6F molecules in the alpha-site and one F6F molecule in the beta-site 分子名称: 1,2-ETHANEDIOL, 2-{[4-(TRIFLUOROMETHOXY)BENZOYL]AMINO}ETHYL DIHYDROGEN PHOSPHATE, DI(HYDROXYETHYL)ETHER, ... 著者 Hilario, E, Caulkins, B.G, Young, R.P, Niks, D, Dunn, M.F, Mueller, L.J, Fan, L. 登録日 2014-11-13 公開日 2015-11-18 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Visualizing the tunnel in tryptophan synthase with crystallography: Insights into a selective filter for accommodating indole and rejecting water. Biochim.Biophys.Acta, 1864, 2016
6HLY	Structure in P212121 form of the PBP AgtB in complex with agropinic acid from A.tumefacien R10 分子名称: 1,2-ETHANEDIOL, Agropine permease, agropinic acid 著者 Morera, S, Marty, L, Vigouroux, A. 登録日 2018-09-11 公開日 2018-12-26 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Structural basis for two efficient modes of agropinic acid opine import into the bacterial pathogenAgrobacterium tumefaciens. Biochem. J., 476, 2019
9BP2	The death domain (DD) of the human mucosa associated lymphoid tissue lymphoma translocation protein 1 (MALT1) 分子名称: Mucosa-associated lymphoid tissue lymphoma translocation protein 1 著者 Chen, C.-L, Tesmer, J.J.G. 登録日 2024-05-06 公開日 2025-05-14 実験手法 X-RAY DIFFRACTION (2.01 Å) 主引用文献 The death domain (DD) of the human mucosa associated lymphoid tissue lymphoma translocation protein 1 (MALT1) To Be Published
8VSM	Ternary structure of 14-3-3 sigma, ARAF phosphopeptide (pS214) and compound 78 (1124378) 分子名称: 1-[8-(4-bromophenyl)sulfonyl-5-oxa-2,8-diazaspiro[3.5]nonan-2-yl]-2-chloranyl-ethanone, 14-3-3 protein sigma, CHLORIDE ION, ... 著者 Vickery, H.R, Virta, J.M, Pennings, M, Konstantinidou, M, van den Oetelaar, M, Neitz, R.J, Ottmann, C, Brunsveld, L, Arkin, M.R. 登録日 2024-01-24 公開日 2025-03-19 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Ternary structure of 14-3-3 sigma, ARAF phosphopeptide (pS214) and compound 78 (1124378) To Be Published
6HNJ	The ligand-bound, open structure of CD0873, a substrate binding protein with adhesive properties from Clostridium difficile. 分子名称: 1,2-ETHANEDIOL, ABC-type transport system, sugar-family extracellular solute-binding protein, ... 著者 Bradshaw, W.J, Kovacs-Simon, A, Harmer, N.J, Michell, S.L, Acharya, K.R. 登録日 2018-09-15 公開日 2019-08-28 最終更新日 2024-05-15 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Molecular features of lipoprotein CD0873: A potential vaccine against the human pathogenClostridioides difficile. J.Biol.Chem., 294, 2019
4X6M	FACTOR XIA IN COMPLEX WITH THE INHIBITOR 1-{(1S)-1-[4-(3-amino-1H-indazol-6-yl)-5-chloro-1H-imidazol-2-yl]-2-phenylethyl}-3-[2-(aminomethyl)-5-chlorobenzyl]urea 分子名称: 1,2-ETHANEDIOL, 1-{(1S)-1-[4-(3-amino-1H-indazol-6-yl)-5-chloro-1H-imidazol-2-yl]-2-phenylethyl}-3-[2-(aminomethyl)-5-chlorobenzyl]urea, Coagulation factor XI, ... 著者 Wei, A. 登録日 2014-12-08 公開日 2015-02-18 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structure-based design of inhibitors of coagulation factor XIa with novel P1 moieties. Bioorg.Med.Chem.Lett., 25, 2015
4WJ1	Crystal structure of EspB from the ESX-1 type VII secretion system 分子名称: Antigen MTB48, Mycobacterial protein 著者 Solomonson, M, Strynadka, N.C.J. 登録日 2014-09-29 公開日 2015-02-25 最終更新日 2024-10-30 実験手法 X-RAY DIFFRACTION (2.415 Å) 主引用文献 Structure of EspB from the ESX-1 type VII secretion system and insights into its export mechanism. Structure, 23, 2015
7P1A	Carbonic Anhydrase VII Sultam Based Inhibitors 分子名称: 4-[2-[4-[(4-methylphenyl)methyl]-1,1-bis(oxidanylidene)-1,2,4-thiadiazinan-2-yl]ethyl]benzenesulfonamide, Carbonic anhydrase 7, GLYCEROL, ... 著者 D'Ambrosio, K, De Simone, G. 登録日 2021-07-01 公開日 2021-11-17 最終更新日 2024-11-13 実験手法 X-RAY DIFFRACTION (1.58 Å) 主引用文献 Sultam based Carbonic Anhydrase VII inhibitors for the management of neuropathic pain. Eur.J.Med.Chem., 227, 2021

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