PDB: 48062 件ウェブページステータス検索Chemie searchBIRD

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5IWF	Linked KDM5A Jmj Domain Bound to the Inhibitor 2-(((2-((2-(dimethylamino)ethyl)(ethyl)amino)-2-oxoethyl)amino)methyl)isonicotinamid 分子名称: 2-[[[2-[2-(dimethylamino)ethyl-ethyl-amino]-2-oxidanylidene-ethyl]amino]methyl]pyridine-4-carboxamide, Lysine-specific demethylase 5A,Lysine-specific demethylase 5A, MANGANESE (II) ION 著者 Horton, J.R, Cheng, X. 登録日 2016-03-22 公開日 2016-07-27 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.289 Å) 主引用文献 Structural Basis for KDM5A Histone Lysine Demethylase Inhibition by Diverse Compounds. Cell Chem Biol, 23, 2016
5IXU	Crystal structure of an uncharacterized NIPSNAP domain protein from Burkholderia xenovorans 分子名称: SULFATE ION, Uncharacterized protein 著者 Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2016-03-23 公開日 2016-03-30 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Crystal structure of an uncharacterized protein from Burkholderia xenovorans to be published
5J7F	Structure of MDM2 with low molecular weight inhibitor with aliphatic linker. 分子名称: 4-({6-[(6-chloro-3-{1-[(4-chlorophenyl)methyl]-4-(4-fluorophenyl)-1H-imidazol-5-yl}-1H-indole-2-carbonyl)oxy]hexyl}amino)-4-oxobutanoic acid, E3 ubiquitin-protein ligase Mdm2 著者 Twarda-Clapa, A, Kubica, K, Guzik, K, Dubin, G, Holak, T.A. 登録日 2016-04-06 公開日 2017-05-17 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 1,4,5-Trisubstituted Imidazole-Based p53-MDM2/MDMX Antagonists with Aliphatic Linkers for Conjugation with Biological Carriers. J. Med. Chem., 60, 2017
5J5Q	AMP-PNP-stabilized ATPase domain of topoisomerase IV from Streptococcus pneumoniae, complex type II 分子名称: DNA (5'-D(*GP*CP*AP*TP*AP*TP*AP*TP*AP*TP*AP*TP*GP*C)-3'), DNA topoisomerase 4 subunit B, MAGNESIUM ION, ... 著者 Laponogov, I, Pan, X.-S, Skamrova, G, Umrekar, T, Fisher, L.M, Sanderson, M.R. 登録日 2016-04-03 公開日 2017-07-26 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.83 Å) 主引用文献 Trapping of the transport-segment DNA by the ATPase domains of a type II topoisomerase. Nat Commun, 9, 2018
5J67	Structure of Astrotactin-2, a conserved vertebrate-specific and perforin-like membrane protein involved in neuronal development 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Astrotactin-2, D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE, ... 著者 Ni, T, Harlos, K, Gilbert, R.J.C. 登録日 2016-04-04 公開日 2016-05-25 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (3.16 Å) 主引用文献 Structure of astrotactin-2: a conserved vertebrate-specific and perforin-like membrane protein involved in neuronal development. Open Biology, 6, 2016
5J93	Five minutes iron loaded Rana Catesbeiana H' ferritin variant E57A/E136A/D140A 分子名称: CHLORIDE ION, FE (II) ION, Ferritin, ... 著者 Pozzi, C, Di Pisa, F, Mangani, S, Bernacchioni, C, Turano, P. 登録日 2016-04-08 公開日 2016-10-05 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.1 Å) 主引用文献 Ferroxidase Activity in Eukaryotic Ferritin is Controlled by Accessory-Iron-Binding Sites in the Catalytic Cavity. Chemistry, 22, 2016
5J9M	tRNA guanine Transglycosylase (TGT) in co-crystallized complex with 2-(methylamino)-1H-benzo[d]imidazole-5-carboxamide 分子名称: 1,2-ETHANEDIOL, 2-(methylamino)-1H-benzimidazole-5-carboxamide, CHLORIDE ION, ... 著者 Ehrmann, F.R, Heine, A, Klebe, G. 登録日 2016-04-10 公開日 2017-05-24 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.33 Å) 主引用文献 Benzimidazole-based Inhibitors as a Novel Scaffold to Inhibit Z.mobilis TGT and Study Protein Flexibility and the Contributions of Active Site Residues to Binding Affinity of lin-Benzopurines. To be Published
5IV4	Crystal structure of the human soluble adenylyl cyclase in complex with the allosteric inhibitor LRE1 分子名称: 1,2-ETHANEDIOL, 6-chloro-N~4~-cyclopropyl-N~4~-[(thiophen-2-yl)methyl]pyrimidine-2,4-diamine, ACETATE ION, ... 著者 Kleinboelting, S, Steegborn, C. 登録日 2016-03-18 公開日 2016-08-17 最終更新日 2022-11-30 実験手法 X-RAY DIFFRACTION (1.79 Å) 主引用文献 Discovery of LRE1 as a specific and allosteric inhibitor of soluble adenylyl cyclase. Nat.Chem.Biol., 12, 2016
5IVF	Linked KDM5A Jmj Domain Bound to the Inhibitor N10 8-(1-methyl-1H-imidazol-4-yl)-2-(4,4,4-trifluorobutoxy)pyrido[3,4-d]pyrimidin-4-ol 分子名称: 8-(1-methyl-1H-imidazol-4-yl)-2-(4,4,4-trifluorobutoxy)pyrido[3,4-d]pyrimidin-4-ol, Lysine-specific demethylase 5A, MANGANESE (II) ION 著者 Horton, J.R, Cheng, X. 登録日 2016-03-20 公開日 2016-07-27 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.683 Å) 主引用文献 Structural Basis for KDM5A Histone Lysine Demethylase Inhibition by Diverse Compounds. Cell Chem Biol, 23, 2016
5IVN	BC2 nanobody in complex with the BC2 peptide tag 分子名称: BC2-nanobody, Cadherin derived peptide 著者 Braun, M.B, Stehle, T. 登録日 2016-03-21 公開日 2016-04-06 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1 Å) 主引用文献 Peptides in headlock - a novel high-affinity and versatile peptide-binding nanobody for proteomics and microscopy. Sci Rep, 6, 2016
5IVX	Crystal Structure of B4.2.3 T-Cell Receptor and H2-Dd P18-I10 Complex 分子名称: 1,2-ETHANEDIOL, Beta-2-microglobulin, H-2 class I histocompatibility antigen, ... 著者 Natarajan, K, Jiang, J, Margulies, D. 登録日 2016-03-21 公開日 2017-03-29 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 An allosteric site in the T-cell receptor C beta domain plays a critical signalling role. Nat Commun, 8, 2017
5IZJ	Complex of PKA with the bisubstrate protein kinase inhibitor ARC-1411 分子名称: 4-(piperazin-1-yl)-7H-pyrrolo[2,3-d]pyrimidine, 47P-AZ1-DAR-DAR, 47P-AZ1-DAR-DAR-DAR, ... 著者 Pflug, A, Enkvist, E, Uri, A, Engh, R.A. 登録日 2016-03-25 公開日 2016-07-20 最終更新日 2019-06-19 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Bifunctional Ligands for Inhibition of Tight-Binding Protein-Protein Interactions. Bioconjug.Chem., 27, 2016
5IUD	Human DNA polymerase alpha in binary complex with a DNA:DNA template-primer 分子名称: DNA polymerase alpha catalytic subunit, DNA primer, DNA template 著者 Coloma, J, Aggarwal, A.K. 登録日 2016-03-17 公開日 2016-04-13 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (3.3 Å) 主引用文献 Human DNA polymerase alpha in binary complex with a DNA:DNA template-primer. Sci Rep, 6, 2016
5IVV	Linked KDM5A Jmj Domain Bound to the Inhibitor N12 [3-((1-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)amino)isonicotinic acid] 分子名称: 3-[(1-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)amino]pyridine-4-carboxylic acid, Lysine-specific demethylase 5A, MANGANESE (II) ION 著者 Horton, J.R, Cheng, X. 登録日 2016-03-21 公開日 2016-07-27 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.848 Å) 主引用文献 Structural Basis for KDM5A Histone Lysine Demethylase Inhibition by Diverse Compounds. Cell Chem Biol, 23, 2016
5J05	DIY G-Quadruplexes: Solution structure of d(GGGTTTGGGTTTTGGGAGGG) in sodium 分子名称: DNA (5'-D(*GP*GP*GP*TP*TP*TP*GP*GP*GP*TP*TP*TP*TP*GP*GP*GP*AP*GP*GP*G)-3') 著者 Dvorkin, S.A, Karsisiotis, A.I, Webba da Silva, M. 登録日 2016-03-27 公開日 2017-04-05 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 Encoding canonical DNA quadruplex structure. Sci Adv, 4, 2018
5J5Y	Translation initiation factor 4E in complex with m2(7,2'O)GppCCl2ppG mRNA 5' cap analog 分子名称: 2-amino-9-{5-O-[(R)-{[(S)-{dichloro[(R)-hydroxy(phosphonooxy)phosphoryl]methyl}(hydroxy)phosphoryl]oxy}(hydroxy)phosphoryl]-2-O-methyl-beta-D-ribofuranosyl}-7-methyl-9H-purin-7-ium-6-olate, Eukaryotic translation initiation factor 4E, GLYCEROL 著者 Warminski, M, Nowak, E, Rydzik, A.M, Kowalska, J, Jemielity, J, Nowotny, M. 登録日 2016-04-04 公開日 2017-05-10 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 mRNA cap analogues substituted in the tetraphosphate chain with CX2: identification of O-to-CCl2 as the first bridging modification that confers resistance to decapping without impairing translation. Nucleic Acids Res., 45, 2017
5J72	Cwp6 from Clostridium difficile 分子名称: CALCIUM ION, CHLORIDE ION, CITRIC ACID, ... 著者 Renko, M, Usenik, A, Turk, D. 登録日 2016-04-05 公開日 2017-02-08 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 The CWB2 Cell Wall-Anchoring Module Is Revealed by the Crystal Structures of the Clostridium difficile Cell Wall Proteins Cwp8 and Cwp6. Structure, 25, 2017
5J6D	Discovery of acyl guanidine tryptophan hydroxylase-1 inhibitors 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 4-[(N-{[2-(3-methoxyphenoxy)-6-(piperidin-1-yl)phenyl]methyl}carbamimidoyl)carbamoyl]-L-phenylalanine, FE (III) ION, ... 著者 Stein, A.J, Goldberg, D.R, De Lombaert, S. 登録日 2016-04-04 公開日 2016-05-25 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Discovery of acyl guanidine tryptophan hydroxylase-1 inhibitors. Bioorg.Med.Chem.Lett., 26, 2016
5J70	The Chd1 DNA-binding domain in complex with 17mer DNA duplex 分子名称: Chromo domain-containing protein 1, DNA (5'-D(*CP*GP*CP*TP*GP*GP*AP*AP*AP*TP*TP*TP*CP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*GP*AP*AP*AP*TP*TP*TP*CP*CP*AP*GP*CP*G)-3') 著者 Bowman, G.D, Jenkins, K.R, Hauk, G. 登録日 2016-04-05 公開日 2017-06-21 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.956 Å) 主引用文献 Chd1 domains communicate across the DNA gyres of the nucleosome To Be Published
5JCO	Structure and dynamics of single-isoform recombinant neuronal human tubulin 分子名称: GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER, ... 著者 Vemu, A, Atherton, J, Spector, J.O, Szyk, A, Moores, C.A, Roll-Mecak, A. 登録日 2016-04-15 公開日 2016-05-04 最終更新日 2024-03-06 実験手法 ELECTRON MICROSCOPY (4 Å) 主引用文献 Structure and Dynamics of Single-isoform Recombinant Neuronal Human Tubulin. J.Biol.Chem., 291, 2016
5JHQ	ARCs 1-3 of human Tankyrase-1 bound to a peptide derived from IRAP 分子名称: Peptide derived from insulin-responsive aminopeptidase (IRAP), Tankyrase-1 著者 Eisemann, T, Pascal, J.M. 登録日 2016-04-21 公開日 2016-09-21 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Tankyrase-1 Ankyrin Repeats Form an Adaptable Binding Platform for Targets of ADP-Ribose Modification. Structure, 24, 2016
5JJK	Rho transcription termination factor bound to rA7 and 6 ADP-BeF3 molecules 分子名称: ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, MAGNESIUM ION, ... 著者 Thomsen, N.D, Lawson, M.R, Witkowsky, L.B, Qu, S, Berger, J.M. 登録日 2016-04-24 公開日 2016-11-16 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (3.15 Å) 主引用文献 Molecular mechanisms of substrate-controlled ring dynamics and substepping in a nucleic acid-dependent hexameric motor. Proc. Natl. Acad. Sci. U.S.A., 113, 2016
5IV3	Crystal structure of human soluble adenylyl cyclase in complex with alpha,beta-methyleneadenosine-5'-triphosphate and the allosteric inhibitor LRE1 分子名称: 1,2-ETHANEDIOL, 6-chloro-N~4~-cyclopropyl-N~4~-[(thiophen-2-yl)methyl]pyrimidine-2,4-diamine, ACETATE ION, ... 著者 Kleinboelting, S, Steegborn, C. 登録日 2016-03-18 公開日 2016-08-17 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.86 Å) 主引用文献 Discovery of LRE1 as a specific and allosteric inhibitor of soluble adenylyl cyclase. Nat.Chem.Biol., 12, 2016
5IWU	Macrolide 2'-phosphotransferase type II complexed with erythromycin 分子名称: ACETATE ION, CALCIUM ION, ERYTHROMYCIN A, ... 著者 Berghuis, A.M, Fong, D.H. 登録日 2016-03-22 公開日 2017-04-26 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.3 Å) 主引用文献 Structural Basis for Kinase-Mediated Macrolide Antibiotic Resistance. Structure, 25, 2017
5IZN	The crystal structure of 50S ribosomal protein L25 from Vibrio vulnificus CMCP6 分子名称: 50S ribosomal protein L25, PHOSPHATE ION 著者 Tan, K, Zhou, M, Kwon, K, Anderson, W.F, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) 登録日 2016-03-25 公開日 2016-04-06 最終更新日 2024-10-09 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 The crystal structure of 50S ribosomal protein L25 from Vibrio vulnificus CMCP6 To Be Published

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