PDB: 5470 件ウェブページステータス検索Chemie searchBIRD

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2XA6	Structural basis for homodimerization of the Src-associated during mitosis, 68 kD protein (Sam68) Qua1 domain 分子名称: KH DOMAIN-CONTAINING,RNA-BINDING,SIGNAL TRANSDUCTION-ASSOCIATED PROTEIN 1 著者 Meyer, N.H, Tripsianes, K, Vincendeaux, M, Madl, T, Kateb, F, Brack-Werner, R, Sattler, M. 登録日 2010-03-29 公開日 2010-07-07 最終更新日 2024-06-19 実験手法 SOLUTION NMR 主引用文献 Structural basis for homodimerization of the Src-associated during mitosis, 68-kDa protein (Sam68) Qua1 domain. J. Biol. Chem., 285, 2010
2WTW	Aurora-A Inhibitor Structure (2nd crystal form) 分子名称: 4-{[9-CHLORO-7-(2,6-DIFLUOROPHENYL)-5H-PYRIMIDO[5,4-D][2]BENZAZEPIN-2-YL]AMINO}BENZOIC ACID, SERINE/THREONINE-PROTEIN KINASE 6 AURORA/IPL1-RELATED KINASE 1, BREAST TUMOR-AMPLIFIED KINASE, ... 著者 Kosmopoulou, M, Bayliss, R. 登録日 2009-09-24 公開日 2010-01-26 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (3.302 Å) 主引用文献 Crystal Structure of an Aurora-A Mutant that Mimics Aurora-B Bound to Mln8054: Insights Into Selectivity and Drug Design. Biochem.J., 427, 2010
4HXO	Brd4 Bromodomain 1 complex with 3-{[(3-METHYL-1,2-OXAZOL-5-YL)METHYL]SULFANYL}[1,2,4]TRIAZOLO[4,3-A]PYRIDINE inhibitor 分子名称: 3-{[(3-methyl-1,2-oxazol-5-yl)methyl]sulfanyl}[1,2,4]triazolo[4,3-a]pyridine, Bromodomain-containing protein 4 著者 Chen, T.T, Cao, D.Y, Chen, W.Y, Xiong, B, Shen, J.K, Xu, Y.C. 登録日 2012-11-12 公開日 2013-04-03 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.76 Å) 主引用文献 Fragment-Based Drug Discovery of 2-Thiazolidinones as Inhibitors of the Histone Reader BRD4 Bromodomain. J.Med.Chem., 56, 2013
1WM3	Crystal structure of human SUMO-2 protein 分子名称: Ubiquitin-like protein SMT3B 著者 Huang, W.-C, Ko, T.-P, Li, S.S.-L, Wang, A.H.-J. 登録日 2004-07-02 公開日 2004-11-30 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.2 Å) 主引用文献 Crystal structures of the human SUMO-2 protein at 1.6 A and 1.2 A resolution: implication on the functional differences of SUMO proteins Eur.J.Biochem., 271, 2004
1WJV	Solution structure of the N-terminal zinc finger domain of mouse cell growth regulating nucleolar protein LYAR 分子名称: Cell growth regulating nucleolar protein LYAR, ZINC ION 著者 Yoneyama, M, Tochio, N, Koshiba, S, Inoue, M, Kigawa, T, Muto, Y, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2004-05-29 公開日 2004-11-29 最終更新日 2024-05-29 実験手法 SOLUTION NMR 主引用文献 Solution structure of the N-terminal zinc finger domain of mouse cell growth regulating nucleolar protein LYAR To be Published
4HXS	Brd4 Bromodomain 1 complex with N-[3-(2-OXO-2,3-DIHYDRO-1,3-THIAZOL-4-YL)PHENYL]-1-PHENYLMETHANESULFONAMIDE inhibitor 分子名称: Bromodomain-containing protein 4, N-[3-(2-oxo-2,3-dihydro-1,3-thiazol-4-yl)phenyl]-1-phenylmethanesulfonamide 著者 Chen, T.T, Cao, D.Y, Chen, W.Y, Xiong, B, Shen, J.K, Xu, Y.C. 登録日 2012-11-12 公開日 2013-04-03 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.43 Å) 主引用文献 Fragment-Based Drug Discovery of 2-Thiazolidinones as Inhibitors of the Histone Reader BRD4 Bromodomain. J.Med.Chem., 56, 2013
4I9H	Crystal structure of rabbit LDHA in complex with AP28669 分子名称: 1-O-[3-(5-carboxypyridin-2-yl)-5-fluorophenyl]-6-O-[4-({[(5-carboxypyridin-2-yl)sulfanyl]acetyl}amino)-2-chloro-5-methoxyphenyl]-D-mannitol, L-lactate dehydrogenase A chain 著者 Zhou, T, Stephan, Z.G, Kohlmann, A, Li, F, Commodore, L, Greenfield, M.T, Shakespeare, W.C, Zhu, X, Dalgarno, D.C. 登録日 2012-12-05 公開日 2013-01-23 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.17 Å) 主引用文献 Fragment growing and linking lead to novel nanomolar lactate dehydrogenase inhibitors. J.Med.Chem., 56, 2013
4I8X	Crystal structure of rabbit LDHA in complex with AP27460 分子名称: 6-phenylpyridine-3-carboxylic acid, L-lactate dehydrogenase A chain 著者 Zhou, T, Stephan, Z.G, Kohlmann, A, Li, F, Commodore, L, Greenfield, M.T, Zhu, X, Dalgarno, D.C. 登録日 2012-12-04 公開日 2013-01-23 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.23 Å) 主引用文献 Fragment growing and linking lead to novel nanomolar lactate dehydrogenase inhibitors. J.Med.Chem., 56, 2013
4HXM	Brd4 Bromodomain 1 complex with N-{3-(2-OXO-2,3-DIHYDRO-1,3-THIAZOL-4-YL)-5-[(THIOPHEN-2-YLSULFONYL)AMINO]PHENYL}BUTANAMIDE inhibitor 分子名称: Bromodomain-containing protein 4, N-{3-(2-oxo-2,3-dihydro-1,3-thiazol-4-yl)-5-[(thiophen-2-ylsulfonyl)amino]phenyl}butanamide 著者 Chen, T.T, Cao, D.Y, Chen, W.Y, Xiong, B, Shen, J.K, Xu, Y.C. 登録日 2012-11-12 公開日 2013-04-03 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Fragment-Based Drug Discovery of 2-Thiazolidinones as Inhibitors of the Histone Reader BRD4 Bromodomain. J.Med.Chem., 56, 2013
4I9N	Crystal structure of rabbit LDHA in complex with AP28161 and AP28122 分子名称: 6-({2-[(5-chloro-4-{[(2S)-2,3-dihydroxypropyl]oxy}-2-methoxyphenyl)amino]-2-oxoethyl}sulfanyl)pyridine-3-carboxylic acid, 6-[3-(carboxymethoxy)-5-fluorophenyl]pyridine-3-carboxylic acid, L-lactate dehydrogenase A chain 著者 Zhou, T, Kohlmann, A, Stephan, Z.G, Li, F, Commodore, L, Greenfield, M.T, Shakespeare, W.C, Zhu, X, Dalgarno, D.C. 登録日 2012-12-05 公開日 2013-01-23 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Fragment growing and linking lead to novel nanomolar lactate dehydrogenase inhibitors. J.Med.Chem., 56, 2013
4HXL	Brd4 Bromodomain 1 complex with 3-CYCLOHEXYL-N-{3-(2-OXO-2,3-DIHYDRO-1,3-THIAZOL-4-YL)-5-[(THIOPHEN-2-YLSULFONYL)AMINO]PHENYL}PROPANAMIDE inhibitor 分子名称: 3-cyclohexyl-N-{3-(2-oxo-2,3-dihydro-1,3-thiazol-4-yl)-5-[(thiophen-2-ylsulfonyl)amino]phenyl}propanamide, Bromodomain-containing protein 4 著者 Chen, T.T, Cao, D.Y, Chen, W.Y, Xiong, B, Shen, J.K, Xu, Y.C. 登録日 2012-11-12 公開日 2013-04-03 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.52 Å) 主引用文献 Fragment-Based Drug Discovery of 2-Thiazolidinones as Inhibitors of the Histone Reader BRD4 Bromodomain. J.Med.Chem., 56, 2013
1WF7	Solution structure of the PDZ domain of Enigma homologue protein 分子名称: Enigma homologue protein 著者 Qin, X, Tochio, N, Kigawa, T, Hayashi, F, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2004-05-26 公開日 2004-11-26 最終更新日 2024-05-29 実験手法 SOLUTION NMR 主引用文献 Solution structure of the PDZ domain of Enigma homologue protein To be published
1X4B	Solution structure of RRM domain in Heterogeneous nuclear ribonucleaoproteins A2/B1 分子名称: Heterogeneous nuclear ribonucleoproteins A2/B1 著者 He, F, Muto, Y, Inoue, M, Kigawa, T, Shirouzu, M, Terada, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2005-05-14 公開日 2005-11-14 最終更新日 2024-05-29 実験手法 SOLUTION NMR 主引用文献 Solution structure of RRM domain in Heterogeneous nuclear ribonucleaoproteins A2/B1 To be Published
4I9U	Crystal structure of rabbit LDHA in complex with a fragment inhibitor AP26256 分子名称: 6-({2-[(5-chloro-2-methoxyphenyl)amino]-2-oxoethyl}sulfanyl)pyridine-3-carboxylic acid, L-lactate dehydrogenase A chain 著者 Zhou, T, Kohlmann, A, Stephan, Z.G, Commodore, L, Greenfield, M.T, Zhu, X, Dalgarno, D.C. 登録日 2012-12-05 公開日 2013-01-23 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Fragment growing and linking lead to novel nanomolar lactate dehydrogenase inhibitors. J.Med.Chem., 56, 2013
1WOK	Crystal structure of catalytic domain of human poly(ADP-ribose) polymerase complexed with a quinoxaline-type inhibitor 分子名称: 3-(4-CHLOROPHENYL)QUINOXALINE-5-CARBOXAMIDE, Poly [ADP-ribose] polymerase-1 著者 Iwashita, A, Hattori, K, Yamamoto, H, Ishida, J, Kido, Y, Kamijo, K, Murano, K, Miyake, H, Kinoshita, T, Warizaya, M, Ohkubo, M, Matsuoka, N, Mutoh, S. 登録日 2004-08-20 公開日 2005-03-15 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Discovery of quinazolinone and quinoxaline derivatives as potent and selective poly(ADP-ribose) polymerase-1/2 inhibitors. Febs Lett., 579, 2005
1WZ7	Crystal structure of enhancer of rudimentary homologue (ERH) 分子名称: Enhancer of rudimentary homolog 著者 Arai, R, Kukimoto-Niino, M, Uda-Tochio, H, Morita, S, Uchikubo-Kamo, T, Kigawa, T, Terada, T, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2005-02-26 公開日 2005-05-03 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Crystal structure of an enhancer of rudimentary homolog (ERH) at 2.1 Angstroms resolution. Protein Sci., 14, 2005
4IJQ	Human hypoxanthine-guanine phosphoribosyltransferase in complex with [(2-((Guanine-9H-yl)methyl)propane-1,3-diyl)bis(oxy)]bis(methylene))diphosphonic acid 分子名称: Hypoxanthine-guanine phosphoribosyltransferase, MAGNESIUM ION, SULFATE ION, ... 著者 Guddat, L.W, Keough, D.T, Hockova, D. 登録日 2012-12-22 公開日 2013-03-27 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2.004 Å) 主引用文献 Acyclic nucleoside phosphonates containing a second phosphonate group are potent inhibitors of 6-oxopurine phosphoribosyltransferases and have antimalarial activity J.Med.Chem., 56, 2013
4IFC	Crystal Structure of ADP-bound Human PRPF4B kinase domain 分子名称: ADENOSINE-5'-DIPHOSPHATE, SULFATE ION, Serine/threonine-protein kinase PRP4 homolog 著者 Mechin, I, Haas, K, Chen, X, Zhang, Y, McLean, L. 登録日 2012-12-14 公開日 2013-08-28 最終更新日 2013-11-06 実験手法 X-RAY DIFFRACTION (2.13 Å) 主引用文献 Evaluation of Cancer Dependence and Druggability of PRP4 Kinase Using Cellular, Biochemical, and Structural Approaches. J.Biol.Chem., 288, 2013
4IFS	Crystal structure of the hSSRP1 Middle domain 分子名称: CHLORIDE ION, FACT complex subunit SSRP1 著者 Zhang, W.J, Zeng, F.X, Shao, C, Liu, Y.W, Niu, L.W, Li, X, Teng, M.K. 登録日 2012-12-15 公開日 2014-01-29 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.93 Å) 主引用文献 Crystal structure of the hSSRP1 Middle domain To be Published
4IJP	Crystal Structure of Human PRPF4B kinase domain in complex with 4-{5-[(2-Chloro-pyridin-4-ylmethyl)-carbamoyl]-thiophen-2-yl}-benzo[b]thiophene-2-carboxylic acid amine 分子名称: 4-(5-{[(2-chloropyridin-4-yl)methyl]carbamoyl}thiophen-2-yl)-1-benzothiophene-2-carboxamide, SULFATE ION, Serine/threonine-protein kinase PRP4 homolog 著者 Mechin, I, Haas, K, Chen, X, Zhang, Y, McLean, L. 登録日 2012-12-22 公開日 2013-08-28 最終更新日 2017-11-15 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Evaluation of Cancer Dependence and Druggability of PRP4 Kinase Using Cellular, Biochemical, and Structural Approaches. J.Biol.Chem., 288, 2013
1X4D	Solution structure of RRM domain in Matrin 3 分子名称: Matrin 3 著者 He, F, Muto, Y, Inoue, M, Kigawa, T, Shirouzu, M, Terada, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2005-05-14 公開日 2005-11-14 最終更新日 2024-05-29 実験手法 SOLUTION NMR 主引用文献 Solution structure of RRM domain in Matrin 3 To be Published
4IOO	Crystal Structure of the first bromodomain of BRD4 in complex with N-methyltrimethylacetamide 分子名称: 1,2-ETHANEDIOL, Bromodomain-containing protein 4, DIMETHYL SULFOXIDE, ... 著者 Lolli, G, Battistutta, R. 登録日 2013-01-08 公開日 2013-10-02 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.25 Å) 主引用文献 Different orientations of low-molecular-weight fragments in the binding pocket of a BRD4 bromodomain. Acta Crystallogr.,Sect.D, 69, 2013
1WJP	Solution structure of zf-C2H2 domains from human Zinc finger protein 295 分子名称: ZINC ION, Zinc finger protein 295 著者 Tomizawa, T, Kigawa, T, Saito, K, Koshiba, S, Inoue, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2004-05-29 公開日 2004-11-29 最終更新日 2024-05-29 実験手法 SOLUTION NMR 主引用文献 Solution structure of zf-C2H2 domains from human Zinc finger protein 295 To be Published
1WWQ	Solution Structure of Mouse ER 分子名称: Enhancer of rudimentary homolog 著者 Li, H, Koshiba, S, Inoue, M, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2005-01-12 公開日 2006-01-03 最終更新日 2024-05-29 実験手法 SOLUTION NMR 主引用文献 Solution structure of the mouse enhancer of rudimentary protein reveals a novel fold J.Biomol.Nmr, 32, 2005
4IGG	Full-length human alpha-catenin crystal structure 分子名称: Catenin alpha-1, PHOSPHATE ION 著者 Izard, T, Rangarajan, E.S. 登録日 2012-12-17 公開日 2012-12-26 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (3.66 Å) 主引用文献 Dimer asymmetry defines alpha-catenin interactions. Nat.Struct.Mol.Biol., 20, 2013

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