5DOY
| Crystal structure of the Thermus thermophilus 70S ribosome in complex with antibiotic Hygromycin A, mRNA and three tRNAs in the A, P and E sites at 2.6A resolution | 分子名称: | 16S Ribosomal RNA, 23S Ribosomal RNA, 30S Ribosomal Protein S10, ... | 著者 | Polikanov, Y.S, Starosta, A.L, Juette, M.F, Altman, R.B, Terry, D.S, Lu, W, Burnett, B.J, Dinos, G, Reynolds, K, Blanchard, S.C, Steitz, T.A, Wilson, D.N. | 登録日 | 2015-09-11 | 公開日 | 2015-12-30 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Distinct tRNA Accommodation Intermediates Observed on the Ribosome with the Antibiotics Hygromycin A and A201A. Mol.Cell, 58, 2015
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1PBG
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3OPQ
| Phosphoribosylaminoimidazole carboxylase with fructose-6-phosphate bound to the central channel of the octameric protein structure. | 分子名称: | CHLORIDE ION, FORMIC ACID, FRUCTOSE -6-PHOSPHATE, ... | 著者 | Filippova, E.V, Wawrzak, Z, Kudritska, M, Edwards, A, Savchenko, A, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID) | 登録日 | 2010-09-01 | 公開日 | 2010-11-17 | 最終更新日 | 2017-11-08 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Phosphoribosylaminoimidazole carboxylase with fructose-6-phosphate bound to the central channel of the octameric protein structure. To be Published
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5DK9
| Crystal Structure of the ER-alpha Ligand-binding Domain in complex with a phenylamino-substituted ethyl triaryl-ethylene derivative 4,4'-{2-[3-(phenylamino)phenyl]but-1-ene-1,1-diyl}diphenol | 分子名称: | 4,4'-{2-[3-(phenylamino)phenyl]but-1-ene-1,1-diyl}diphenol, Estrogen receptor, Nuclear receptor coactivator 2 | 著者 | Nwachukwu, J.C, Srinivasan, S, Zheng, Y, Wang, S, Min, J, Dong, C, Liao, Z, Cavett, V, Nowak, J, Houtman, R, Carlson, K.E, Josan, J.S, Elemento, O, Katzenellenbogen, J.A, Zhou, H.B, Nettles, K.W. | 登録日 | 2015-09-03 | 公開日 | 2016-05-04 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.28 Å) | 主引用文献 | Predictive features of ligand-specific signaling through the estrogen receptor. Mol.Syst.Biol., 12, 2016
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5MU6
| Human N-myristoyltransferase (NMT1) with Myristoyl-CoA and IMP-1088 inhibitor bound | 分子名称: | 1-[5-[3,4-bis(fluoranyl)-2-[2-(1,3,5-trimethylpyrazol-4-yl)ethoxy]phenyl]-1-methyl-indazol-3-yl]-~{N},~{N}-dimethyl-methanamine, GLYCEROL, Glycylpeptide N-tetradecanoyltransferase 1, ... | 著者 | Perez-Dorado, I, Bell, A.S, Tate, E.W. | 登録日 | 2017-01-12 | 公開日 | 2018-02-14 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.88 Å) | 主引用文献 | Fragment-derived inhibitors of human N-myristoyltransferase block capsid assembly and replication of the common cold virus. Nat Chem, 10, 2018
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4A0L
| Structure of DDB1-DDB2-CUL4B-RBX1 bound to a 12 bp abasic site containing DNA-duplex | 分子名称: | 12 BP DNA DUPLEX, 12 BP THF CONTAINING DNA DUPLEX, CULLIN-4B, ... | 著者 | Fischer, E.S, Scrima, A, Gut, H, Thoma, N.H. | 登録日 | 2011-09-09 | 公開日 | 2011-12-14 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (7.4 Å) | 主引用文献 | The Molecular Basis of Crl4(Ddb2/Csa) Ubiquitin Ligase Architecture, Targeting, and Activation. Cell(Cambridge,Mass.), 147, 2011
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2GSJ
| cDNA cloning and 1.75A crystal structure determination of PPL2, a novel chimerolectin from Parkia platycephala seeds exhibiting endochitinolytic activity | 分子名称: | SULFATE ION, protein PPL-2 | 著者 | Cavada, B.S, Moreno, F.B, da Rocha, B.A, de Azevedo Jr, W.F, Castellon, R.E.R, Goersch, G.V, Nagano, C.S, de Souza, E.P, Nascimento, K.S, Radis-Baptista, G, Delatorre, P, Leroy, Y, Toyama, M.H, Pinto, V.P, Sampaio, A.H, Barettino, D, Debray, H, Calvete, J.J, Sanz, L. | 登録日 | 2006-04-26 | 公開日 | 2007-03-13 | 最終更新日 | 2017-10-18 | 実験手法 | X-RAY DIFFRACTION (1.73 Å) | 主引用文献 | cDNA cloning and 1.75 A crystal structure determination of PPL2, an endochitinase and N-acetylglucosamine-binding hemagglutinin from Parkia platycephala seeds Febs J., 273, 2006
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5MUQ
| Crystal structure of DC8E8 Fab at pH 7.0 containing a Zn atom | 分子名称: | IMIDAZOLE, ZINC ION, antibody Fab heavy chain, ... | 著者 | Skrabana, R, Novak, M, Cehlar, O, Kontsekova, E. | 登録日 | 2017-01-13 | 公開日 | 2018-05-02 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.62 Å) | 主引用文献 | Crystal structure of DC8E8 Fab at pH 7.0 containing a Zn atom To be published
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1Y4W
| Crystal structure of exo-inulinase from Aspergillus awamori in spacegroup P21 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, ... | 著者 | Nagem, R.A.P, Rojas, A.L, Golubev, A.M, Korneeva, O.S, Eneyskaya, E.V, Kulminskaya, A.A, Neustroev, K.N, Polikarpov, I. | 登録日 | 2004-12-01 | 公開日 | 2004-12-14 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | Crystal structure of exo-inulinase from Aspergillus awamori: the enzyme fold and structural determinants of substrate recognition J.Mol.Biol., 344, 2004
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4A12
| Structure of the global transcription regulator FapR from Staphylococcus aureus in complex with DNA operator | 分子名称: | FAPR PROMOTER, TRANSCRIPTION FACTOR FAPR | 著者 | Albanesi, D, Guerin, M.E, Buschiazzo, A, de Mendoza, D, Alzari, P.M. | 登録日 | 2011-09-13 | 公開日 | 2012-09-26 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (3.15 Å) | 主引用文献 | Structural Basis for Feed-Forward Transcriptional Regulation of Membrane Lipid Homeostasis in Staphylococcus Aureus. Plos Pathog., 9, 2013
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6AW3
| Crystal structure of the HopQ-CEACAM3 L44Q complex | 分子名称: | Carcinoembryonic antigen-related cell adhesion molecule 3, HopQ | 著者 | Bonsor, D.A, Sundberg, E.J. | 登録日 | 2017-09-05 | 公開日 | 2018-05-16 | 最終更新日 | 2018-07-11 | 実験手法 | X-RAY DIFFRACTION (2.66 Å) | 主引用文献 | TheHelicobacter pyloriadhesin protein HopQ exploits the dimer interface of human CEACAMs to facilitate translocation of the oncoprotein CagA. EMBO J., 37, 2018
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1E49
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6AWC
| Structure of 30S ribosomal subunit and RNA polymerase complex in rotated state | 分子名称: | 16S rRNA, 30S ribosomal protein S1, 30S ribosomal protein S10, ... | 著者 | Demo, G, Rasouly, A, Vasilyev, N, Loveland, A.B, Diaz-Avalos, R, Grigorieff, N, Nudler, E, Korostelev, A.A. | 登録日 | 2017-09-05 | 公開日 | 2017-10-18 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (7.9 Å) | 主引用文献 | Structure of RNA polymerase bound to ribosomal 30S subunit. Elife, 6, 2017
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2PLE
| NUCLEAR MAGNETIC RESONANCE STRUCTURE OF AN SH2 DOMAIN OF PHOSPHOLIPASE C-GAMMA1 COMPLEXED WITH A HIGH AFFINITY BINDING PEPTIDE | 分子名称: | PHOSPHOLIPASE C GAMMA-1, C-TERMINAL SH2 DOMAIN, PHOSPHOPEPTIDE FROM PDGF | 著者 | Pascal, S.M, Singer, A.U, Gish, G, Yamazaki, T, Shoelson, S.E, Pawson, T, Kay, L.E, Forman-Kay, J.D. | 登録日 | 1994-08-19 | 公開日 | 1995-01-26 | 最終更新日 | 2017-11-29 | 実験手法 | SOLUTION NMR | 主引用文献 | Nuclear magnetic resonance structure of an SH2 domain of phospholipase C-gamma 1 complexed with a high affinity binding peptide. Cell(Cambridge,Mass.), 77, 1994
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3OW1
| Crystal structure of D-mannonate dehydratase from Chromohalobacter salexigens complexed with MG | 分子名称: | GLYCEROL, MAGNESIUM ION, Mandelate racemase/muconate lactonizing enzyme, ... | 著者 | Fedorov, A.A, Fedorov, E.V, Wichelecki, D, Gerlt, J.A, Almo, S.C. | 登録日 | 2010-09-17 | 公開日 | 2011-09-28 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.798 Å) | 主引用文献 | CRYSTAL STRUCTURE OF D-MANNONATE DEHYDRATASE FROM CHROMOHALOBACTER SALEXIGENS complexed with MG To be Published
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2PK9
| Structure of the Pho85-Pho80 CDK-cyclin Complex of the Phosphate-responsive Signal Transduction Pathway | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Cyclin-dependent protein kinase PHO85, PHO85 cyclin PHO80 | 著者 | Huang, K, Ferrin-O'Connell, I, Zhang, W, Leonard, G.A, O'Shea, E.K, Quiocho, F.A. | 登録日 | 2007-04-17 | 公開日 | 2007-12-11 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.906 Å) | 主引用文献 | Structure of the Pho85-Pho80 CDK-Cyclin Complex of the Phosphate-Responsive Signal Transduction Pathway Mol.Cell, 28, 2007
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5DR6
| Aurora A Kinase in Complex with AA30 and JNJ-7706621 in Space Group P6122 | 分子名称: | 2-(3-bromophenyl)quinoline-4-carboxylic acid, 4-({5-amino-1-[(2,6-difluorophenyl)carbonyl]-1H-1,2,4-triazol-3-yl}amino)benzenesulfonamide, Aurora kinase A | 著者 | Janecek, M, Rossmann, M, Sharma, P, Emery, A, McKenzie, G.J, Huggins, D.J, Stockwell, S, Stokes, J.A, Almeida, E.G, Hardwick, B, Narvaez, A.J, Hyvonen, M, Spring, D.R, Venkitaraman, A.R. | 登録日 | 2015-09-15 | 公開日 | 2016-07-20 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.534 Å) | 主引用文献 | Allosteric modulation of AURKA kinase activity by a small-molecule inhibitor of its protein-protein interaction with TPX2. Sci Rep, 6, 2016
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7V9L
| Cryo-EM structure of the SV1-Gs complex. | 分子名称: | GHRH receptor splice variant 1,GHRH receptor splice variant 1,GHRH receptor splice variant 1,SV1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Cong, Z.T, Zhou, F.L, Zhang, C, Zou, X.Y, Zhang, H.B, Wang, Y.Z, Zhou, Q.T, Cai, X.Q, Liu, Q.F, Li, J, Shao, L.J, Mao, C.Y, Wang, X, Wu, J.H, Xia, T, Zhao, L.H, Jiang, H.L, Zhang, Y, Xu, H.E, Cheng, X, Yang, D.H, Wang, M.W. | 登録日 | 2021-08-26 | 公開日 | 2022-04-06 | 最終更新日 | 2022-05-04 | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | 主引用文献 | Constitutive signal bias mediated by the human GHRHR splice variant 1. Proc.Natl.Acad.Sci.USA, 118, 2021
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7VBH
| Cryo-EM structure of the GIPR/GLP-1R/GCGR triagonist peptide 20-bound human GLP-1R-Gs complex | 分子名称: | Glucagon-like peptide 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Zhao, F.H, Zhou, Q.T, Cong, Z.T, Hang, K.N, Zou, X.Y, Zhang, C, Chen, Y, Dai, A.T, Liang, A.Y, Ming, Q.Q, Wang, M, Chen, L.N, Xu, P.Y, Chang, R.L, Feng, W.B, Xia, T, Zhang, Y, Wu, B.L, Yang, D.H, Zhao, L.H, Xu, H.E, Wang, M.W. | 登録日 | 2021-08-31 | 公開日 | 2022-04-06 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Structural insights into multiplexed pharmacological actions of tirzepatide and peptide 20 at the GIP, GLP-1 or glucagon receptors. Nat Commun, 13, 2022
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6BFJ
| Caspase-3 Mutant - T245D,S249D | 分子名称: | AZIDE ION, Ac-Asp-Glu-Val-Asp-CMK, Caspase-3 | 著者 | Thomas, M.E, Grinshpon, R, Swartz, P.D, Clark, A.C. | 登録日 | 2017-10-26 | 公開日 | 2018-02-21 | 最終更新日 | 2018-04-25 | 実験手法 | X-RAY DIFFRACTION (1.543 Å) | 主引用文献 | Modifications to a common phosphorylation network provide individualized control in caspases. J. Biol. Chem., 293, 2018
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2PRF
| THREE DIMENSIONAL SOLUTION STRUCTURE OF ACANTHAMOEBA PROFILIN I | 分子名称: | PROFILIN IA | 著者 | Archer, S.J, Vinson, V.K, Pollard, T.D, Lattman, E.E, Torchia, D.A. | 登録日 | 1994-01-12 | 公開日 | 1994-05-31 | 最終更新日 | 2024-05-01 | 実験手法 | SOLUTION NMR | 主引用文献 | Three-dimensional solution structure of Acanthamoeba profilin-I. J.Cell Biol., 122, 1993
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5VAW
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5MZW
| Crystal structure of the decarboxylase AibA/AibB | 分子名称: | GLYCEROL, Glutaconate CoA-transferase family, subunit A, ... | 著者 | Bock, T, Luxenburger, E, Hoffmann, J, Schuetza, V, Feiler, C, Mueller, R, Blankenfeldt, W. | 登録日 | 2017-02-02 | 公開日 | 2017-05-31 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.52 Å) | 主引用文献 | AibA/AibB Induces an Intramolecular Decarboxylation in Isovalerate Biosynthesis by Myxococcus xanthus. Angew. Chem. Int. Ed. Engl., 56, 2017
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1E47
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6AOY
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