8JNE
| The cryo-EM structure of the decameric RAD51 ring bound to the nucleosome without the linker DNA binding | 分子名称: | DNA (153-MER), DNA (156-MER), DNA repair protein RAD51 homolog 1, ... | 著者 | Shioi, T, Hatazawa, S, Ogasawara, M, Takizawa, Y, Kurumizaka, H. | 登録日 | 2023-06-06 | 公開日 | 2024-03-27 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (4.68 Å) | 主引用文献 | Cryo-EM structures of RAD51 assembled on nucleosomes containing a DSB site. Nature, 628, 2024
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8K7E
| Crystal structure of human lysosomal alpha-galactosidase A in complex with (2R,3R,4S,5R)-2-(aminomethyl)-5-(hydroxymethyl)pyrrolidine-3,4-diol | 分子名称: | (2~{R},3~{R},4~{S},5~{R})-2-(aminomethyl)-5-(hydroxymethyl)pyrrolidine-3,4-diol, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Li, H.Y, Huang, K.F, Ko, T.P, Cheng, W.C. | 登録日 | 2023-07-26 | 公開日 | 2024-04-10 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Mechanistic Insights into Dibasic Iminosugars as pH-Selective Pharmacological Chaperones to Stabilize Human alpha-Galactosidase. Jacs Au, 4, 2024
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8K7L
| Crystal structure of human lysosomal alpha-galactosidase A in complex with (2R,3R,4S,5R)-2-(aminomethyl)-5-(hydroxymethyl)-1-methylpyrrolidine-3,4-diol | 分子名称: | (2~{R},3~{R},4~{S},5~{R})-2-(aminomethyl)-5-(hydroxymethyl)-1-methyl-pyrrolidine-3,4-diol, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Li, H.Y, Huang, K.F, Ko, T.P, Cheng, W.C. | 登録日 | 2023-07-26 | 公開日 | 2024-04-10 | 最終更新日 | 2024-10-09 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Mechanistic Insights into Dibasic Iminosugars as pH-Selective Pharmacological Chaperones to Stabilize Human alpha-Galactosidase. Jacs Au, 4, 2024
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8JNF
| The cryo-EM structure of the RAD51 filament bound to the nucleosome | 分子名称: | DNA (153-MER), DNA (156-MER), DNA repair protein RAD51 homolog 1, ... | 著者 | Shioi, T, Hatazawa, S, Ogasawara, M, Takizawa, Y, Kurumizaka, H. | 登録日 | 2023-06-06 | 公開日 | 2024-03-27 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (6.91 Å) | 主引用文献 | Cryo-EM structures of RAD51 assembled on nucleosomes containing a DSB site. Nature, 628, 2024
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6CM4
| Structure of the D2 Dopamine Receptor Bound to the Atypical Antipsychotic Drug Risperidone | 分子名称: | 3-[2-[4-(6-fluoranyl-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl]-2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one, D(2) dopamine receptor, endolysin chimera, ... | 著者 | Wang, S, Che, T, Levit, A, Shoichet, B.K, Wacker, D, Roth, B.L. | 登録日 | 2018-03-02 | 公開日 | 2018-03-14 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.867 Å) | 主引用文献 | Structure of the D2 dopamine receptor bound to the atypical antipsychotic drug risperidone. Nature, 555, 2018
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8CE1
| Cytochrome c maturation complex CcmABCD | 分子名称: | Cytochrome c biogenesis ATP-binding export protein CcmA, Heme exporter protein B, Heme exporter protein C, ... | 著者 | Ilcu, L, Zhang, L, Einsle, O. | 登録日 | 2023-02-01 | 公開日 | 2023-09-06 | 実験手法 | ELECTRON MICROSCOPY (3.47 Å) | 主引用文献 | Architecture of the Heme-translocating CcmABCD/E complex required for Cytochrome c maturation. Nat Commun, 14, 2023
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8CEA
| Cytochrome c maturation complex CcmABCD, E154Q | 分子名称: | Cytochrome c biogenesis ATP-binding export protein CcmA, Heme exporter protein B, Heme exporter protein C, ... | 著者 | Ilcu, L, Zhang, L, Einsle, O. | 登録日 | 2023-02-01 | 公開日 | 2023-09-06 | 実験手法 | ELECTRON MICROSCOPY (3.94 Å) | 主引用文献 | Architecture of the Heme-translocating CcmABCD/E complex required for Cytochrome c maturation. Nat Commun, 14, 2023
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6VBY
| Cinnamate 4-hydroxylase (C4H1) from Sorghum bicolor | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Cinnamic acid 4-hydroxylase, GLYCEROL, ... | 著者 | Zhang, B, Kang, C, Lewis, K.M. | 登録日 | 2019-12-19 | 公開日 | 2020-05-06 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Structure and Function of the Cytochrome P450 Monooxygenase Cinnamate 4-hydroxylase fromSorghum bicolor. Plant Physiol., 183, 2020
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3B9L
| Human serum albumin complexed with myristate and AZT | 分子名称: | 3'-azido-3'-deoxythymidine, MYRISTIC ACID, Serum albumin | 著者 | Zhu, L, Yang, F, Chen, L, Meehan, E.J, Huang, M. | 登録日 | 2007-11-05 | 公開日 | 2008-05-27 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | A new drug binding subsite on human serum albumin and drug-drug interaction studied by X-ray crystallography J.Struct.Biol., 162, 2008
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8JND
| The cryo-EM structure of the nonameric RAD51 ring bound to the nucleosome with the linker DNA binding | 分子名称: | DNA (153-MER), DNA (156-MER), DNA repair protein RAD51 homolog 1, ... | 著者 | Shioi, T, Hatazawa, S, Ogasawara, M, Takizawa, Y, Kurumizaka, H. | 登録日 | 2023-06-06 | 公開日 | 2024-03-27 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (3.66 Å) | 主引用文献 | Cryo-EM structures of RAD51 assembled on nucleosomes containing a DSB site. Nature, 628, 2024
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6IQU
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6VCN
| Crystal structure of E.coli RppH in complex with ppcpG | 分子名称: | PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER, RNA pyrophosphohydrolase, SULFATE ION | 著者 | Gao, A, Vasilyev, N, Kaushik, A, Duan, W, Serganov, A. | 登録日 | 2019-12-21 | 公開日 | 2020-02-05 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Principles of RNA and nucleotide discrimination by the RNA processing enzyme RppH. Nucleic Acids Res., 48, 2020
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8OF1
| Structure of ALDH5F1 from moss Physcomitrium patens in complex with NAD+ in the contracted conformation | 分子名称: | 1,2-ETHANEDIOL, 3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL, DI(HYDROXYETHYL)ETHER, ... | 著者 | Morera, S, Kopecny, D, Vigouroux, A. | 登録日 | 2023-03-13 | 公開日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (1.81 Å) | 主引用文献 | A study on abiotic stress responses of aldehyde dehydrogenase (ALDH) superfamilies in moss and barley focused on members linked to the GABA shunt pathway To Be Published
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8BRT
| Crystal structure of a variant of penicillin G acylase from Bacillaceae i. s. sp. FJAT-27231 with reduced surface entropy and additionally engineered crystal contact | 分子名称: | (R,R)-2,3-BUTANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CALCIUM ION, ... | 著者 | Wichmann, J, Mayer, J, Mattes, H, Lukat, P, Blankenfeldt, W, Biedendieck, R. | 登録日 | 2022-11-23 | 公開日 | 2023-05-03 | 最終更新日 | 2024-06-19 | 実験手法 | X-RAY DIFFRACTION (1.31 Å) | 主引用文献 | Multistep Engineering of a Penicillin G Acylase for Systematic Improvement of Crystallization Efficiency Cryst.Growth Des., 2023
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8BRJ
| Escherichia coli anaerobic fatty acid beta oxidation trifunctional enzyme (anEcTFE) trimeric complex | 分子名称: | 3-ketoacyl-CoA thiolase FadI, Fatty acid oxidation complex subunit alpha | 著者 | Sah-Teli, S.K, Pinkas, M, Novacek, J, Venkatesan, R. | 登録日 | 2022-11-23 | 公開日 | 2023-05-17 | 最終更新日 | 2024-07-24 | 実験手法 | ELECTRON MICROSCOPY (4.08 Å) | 主引用文献 | Structural basis for different membrane-binding properties of E. coli anaerobic and human mitochondrial beta-oxidation trifunctional enzymes. Structure, 31, 2023
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6V6Y
| Crystal Structure of T. thermophilus methylenetetrahydrofolate dehydrogenase (MTHFD) | 分子名称: | Bifunctional protein FolD, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | 著者 | Maiello, F, Coelho, C, Gallo, G, Sucharski, F, Hardy, L, Wurtele, M. | 登録日 | 2019-12-06 | 公開日 | 2020-05-27 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.15201569 Å) | 主引用文献 | Crystal structure of Thermus thermophilus methylenetetrahydrofolate dehydrogenase and determinants of thermostability. Plos One, 15, 2020
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8BNU
| Escherichia coli anaerobic fatty acid beta oxidation trifunctional enzyme (anEcTFE) tetrameric complex | 分子名称: | 3-ketoacyl-CoA thiolase FadI, Fatty acid oxidation complex subunit alpha | 著者 | Sah-Teli, S.K, Pinkas, M, Novacek, J, Venkatesan, R. | 登録日 | 2022-11-14 | 公開日 | 2023-05-17 | 最終更新日 | 2024-07-24 | 実験手法 | ELECTRON MICROSCOPY (3.55 Å) | 主引用文献 | Structural basis for different membrane-binding properties of E. coli anaerobic and human mitochondrial beta-oxidation trifunctional enzymes. Structure, 31, 2023
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6V7N
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6M7X
| Structure of human CYP11B1 in complex with fadrozole | 分子名称: | 4-[(5S)-5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl]benzonitrile, Cytochrome P450 11B1, mitochondrial, ... | 著者 | Scott, E.E, Brixius-Anderko, S. | 登録日 | 2018-08-21 | 公開日 | 2018-11-21 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.095 Å) | 主引用文献 | Structure of human cortisol-producing cytochrome P450 11B1 bound to the breast cancer drug fadrozole provides insights for drug design. J. Biol. Chem., 294, 2019
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4ZLE
| Cellobionic acid phosphorylase - ligand free structure | 分子名称: | CHLORIDE ION, GLYCEROL, Putative b-glycan phosphorylase, ... | 著者 | Nam, Y.W, Arakawa, T, Fushinobu, S. | 登録日 | 2015-05-01 | 公開日 | 2015-06-10 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Crystal Structure and Substrate Recognition of Cellobionic Acid Phosphorylase, Which Plays a Key Role in Oxidative Cellulose Degradation by Microbes. J.Biol.Chem., 290, 2015
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8K7J
| Crystal structure of human lysosomal alpha-galactosidase A in complex with (2R,3R,4S,5R)-2-((dimethylamino)methyl)-5-(hydroxymethyl)pyrrolidine-3,4-diol | 分子名称: | (2~{R},3~{R},4~{S},5~{R})-2-[(dimethylamino)methyl]-5-(hydroxymethyl)pyrrolidine-3,4-diol, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Li, H.Y, Huang, K.F, Ko, T.P, Cheng, W.C. | 登録日 | 2023-07-26 | 公開日 | 2024-04-10 | 実験手法 | X-RAY DIFFRACTION (2.01 Å) | 主引用文献 | Mechanistic Insights into Dibasic Iminosugars as pH-Selective Pharmacological Chaperones to Stabilize Human alpha-Galactosidase. Jacs Au, 4, 2024
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8K7F
| Crystal structure of human lysosomal alpha-galactosidase A in complex with (2R,3S,4R,5R)-2,5-bis(hydroxymethyl)pyrrolidine-3,4-diol | 分子名称: | (2~{R},3~{R},4~{S},5~{R})-2,5-bis(hydroxymethyl)pyrrolidine-3,4-diol, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Li, H.Y, Huang, K.F, Ko, T.P, Cheng, W.C. | 登録日 | 2023-07-26 | 公開日 | 2024-04-10 | 最終更新日 | 2024-10-16 | 実験手法 | X-RAY DIFFRACTION (1.98 Å) | 主引用文献 | Mechanistic Insights into Dibasic Iminosugars as pH-Selective Pharmacological Chaperones to Stabilize Human alpha-Galactosidase. Jacs Au, 4, 2024
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8BRS
| Crystal structure of a variant of penicillin G acylase from Bacillaceae i. s. sp. FJAT-27231 with reduced surface entropy and additionally engineered crystal contact. | 分子名称: | (R,R)-2,3-BUTANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CALCIUM ION, ... | 著者 | Wichmann, J, Mayer, J, Mattes, H, Lukat, P, Blankenfeldt, W, Biedendieck, R. | 登録日 | 2022-11-23 | 公開日 | 2023-05-03 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | 主引用文献 | Multistep Engineering of a Penicillin G Acylase for Systematic Improvement of Crystallization Efficiency Cryst.Growth Des., 2023
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6COM
| 2.3A crystal structure of E. coli phosphoenolpyruvate carboxykinase mutant Asp269Asn | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, MAGNESIUM ION, ... | 著者 | Sokaribo, A.S, Cotelesage, J.H, Novakovski, B, Goldie, H, Sanders, D. | 登録日 | 2018-03-12 | 公開日 | 2018-04-04 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Kinetic and structural analysis of Escherichia coli phosphoenolpyruvate carboxykinase mutants. Biochim Biophys Acta Gen Subj, 1864, 2020
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8K7G
| Crystal structure of human lysosomal alpha-galactosidase A in complex with (2R,3S,4R,5R)-2,5-bis(hydroxymethyl)pyrrolidine-3,4-diol | 分子名称: | (2~{R},3~{R},4~{S},5~{R})-2,5-bis(hydroxymethyl)pyrrolidine-3,4-diol, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Li, H.Y, Huang, K.F, Ko, T.P, Cheng, W.C. | 登録日 | 2023-07-26 | 公開日 | 2024-04-10 | 最終更新日 | 2024-10-16 | 実験手法 | X-RAY DIFFRACTION (2.32 Å) | 主引用文献 | Mechanistic Insights into Dibasic Iminosugars as pH-Selective Pharmacological Chaperones to Stabilize Human alpha-Galactosidase. Jacs Au, 4, 2024
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