6M7X
Structure of human CYP11B1 in complex with fadrozole
Summary for 6M7X
| Entry DOI | 10.2210/pdb6m7x/pdb |
| Descriptor | Cytochrome P450 11B1, mitochondrial, 4-[(5S)-5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl]benzonitrile, PROTOPORPHYRIN IX CONTAINING FE, ... (4 entities in total) |
| Functional Keywords | cytochrome p450, cyp11b1, s-fadrozole, cortisol, oxidoreductase |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 2 |
| Total formula weight | 113032.20 |
| Authors | Scott, E.E.,Brixius-Anderko, S. (deposition date: 2018-08-21, release date: 2018-11-21, Last modification date: 2023-10-11) |
| Primary citation | Brixius-Anderko, S.,Scott, E.E. Structure of human cortisol-producing cytochrome P450 11B1 bound to the breast cancer drug fadrozole provides insights for drug design. J. Biol. Chem., 294:453-460, 2019 Cited by PubMed: 30425102DOI: 10.1074/jbc.RA118.006214 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.095 Å) |
Structure validation
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