PDB: 38176 件ウェブページステータス検索Chemie searchBIRD

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3LWT	Crystal structure of the Yeast Sac1: Implications for its phosphoinositide phosphatase function 分子名称: Phosphoinositide phosphatase SAC1 著者 Mao, Y, Manford, A, Xia, T, Saxena, A.K, Stefan, C, Hu, F, Emr, S.D. 登録日 2010-02-24 公開日 2010-05-05 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.956 Å) 主引用文献 Crystal structure of the yeast Sac1: implications for its phosphoinositide phosphatase function. Embo J., 29, 2010
3VXG	Crystal structure of conjugated polyketone reductase C2 from Candida Parapsilosis 分子名称: Conjugated polyketone reductase C2 著者 Qin, H.-M, Yamamura, A, Miyakawa, T, Maruoka, S, Ohtsuka, J, Nagata, K, Kataoka, M, Shimizu, S, Tanokura, M. 登録日 2012-09-13 公開日 2013-08-07 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Structure of conjugated polyketone reductase from Candida parapsilosis IFO 0708 reveals conformational changes for substrate recognition upon NADPH binding Appl.Microbiol.Biotechnol., 98, 2014
7MZ4	Structure of human DNA polymerase beta complexed with 3-deaza-3-methyladenine (3dMeA) in the template base paired with incoming dTTP 分子名称: 5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]thymidine, DNA (5'-D(*CP*CP*GP*AP*CP*(DZM)P*TP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*A)-3'), ... 著者 Koag, M.-C, Lee, S. 登録日 2021-05-24 公開日 2022-06-01 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.076 Å) 主引用文献 Structure of human DNA polymerase beta complexed with 3-deaza-3-methyladenine (3dMeA) in the template base paired with incoming dTTP To Be Published
2FNM	Activation of human carbonic anhdyrase II by exogenous proton donors 分子名称: ZINC ION, carbonic anhydrase 2 著者 Bhatt, D, Fisher, S.Z, Tu, C, McKenna, R, Silverman, D.N. 登録日 2006-01-11 公開日 2006-11-28 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Location of binding sites in small molecule rescue of human carbonic anhydrase II. Biophys.J., 92, 2007
7MZ8	Structure of human DNA polymerase beta complexed with 3-deaza-3-methyladenine (3dMeA) at N-1 of the template base paired with incoming dTTP 分子名称: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]cytidine, DNA (5'-D(*CP*CP*GP*AP*CP*GP*(DZM)P*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*T)-3'), ... 著者 Koag, M.-C, Lee, S. 登録日 2021-05-24 公開日 2022-06-01 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Structure Of Human Dna Polymerase Beta Complexed With 8Oa As The Template Base In A 1-Nucleotide Gapped Dna To Be Published
4DSS	Crystal structure of peroxiredoxin Ahp1 from Saccharomyces cerevisiae in complex with thioredoxin Trx2 分子名称: Peroxiredoxin type-2, Thioredoxin-2 著者 Lian, F.M, Yu, J, Ma, X.X, Yu, X.J, Chen, Y, Zhou, C.Z. 登録日 2012-02-19 公開日 2012-04-11 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structural Snapshots of Yeast Alkyl Hydroperoxide Reductase Ahp1 Peroxiredoxin Reveal a Novel Two-cysteine Mechanism of Electron Transfer to Eliminate Reactive Oxygen Species. J.Biol.Chem., 287, 2012
4KUV	Crystal structure of human carbonic anhydrase II in complex with the 5-(3-(4-chlorophenylsulfonyl)ureido)pyridine-2-sulfonamide inhibitor 分子名称: 5-({[(4-chlorophenyl)sulfonyl]carbamoyl}amino)pyridine-2-sulfonamide, BETA-MERCAPTOETHANOL, Carbonic anhydrase 2, ... 著者 Ferraroni, M. 登録日 2013-05-22 公開日 2014-06-25 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.35 Å) 主引用文献 New classes of carbonic anhydrase inhibitors to be published
6YGF	NADase from Aspergillus fumigatus with trapped reaction products 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, AfNADase, ... 著者 Stromland, O, Ziegler, M, Kallio, J.P. 登録日 2020-03-27 公開日 2020-12-23 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Discovery of fungal surface NADases predominantly present in pathogenic species. Nat Commun, 12, 2021
7MZ3	Structure of human DNA polymerase beta complexed with 3-deaza-3-methyladenine (3dMeA) as the template base in a 1-nucleotide gapped DNA 分子名称: DNA (5'-D(*CP*CP*GP*AP*CP*(DZM)P*TP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*A)-3'), DNA (5'-D(P*GP*TP*CP*GP*G)-3'), ... 著者 Koag, M.-C, Lee, S. 登録日 2021-05-24 公開日 2022-06-01 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.418 Å) 主引用文献 Structure of human DNA polymerase beta complexed with 3-deaza-3-methyladenine (3dMeA) as the template base in a 1-nucleotide gapped DNA To Be Published
5E9W	Crystal structure of mRNA cap guanine-N7 methyltransferase obtained by limited proteolysis 分子名称: S-ADENOSYL-L-HOMOCYSTEINE, mRNA cap guanine-N7 methyltransferase 著者 Petit, P, Cowling, V.H. 登録日 2015-10-15 公開日 2016-07-13 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.283 Å) 主引用文献 Molecular basis of RNA guanine-7 methyltransferase (RNMT) activation by RAM. Nucleic Acids Res., 44, 2016
8C0Q	Crystal structure of human carbonic anhydrase II in complex with a coumarin derivative. 分子名称: (4-methyl-2-oxidanylidene-chromen-7-yl)methanesulfonamide, Carbonic anhydrase 2, ZINC ION 著者 Alterio, V, De Simone, G, Esposito, D. 登録日 2022-12-19 公開日 2023-03-08 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (1.67 Å) 主引用文献 A Combined in Silico and Structural Study Opens New Perspectives on Aliphatic Sulfonamides, a Still Poorly Investigated Class of CA Inhibitors. Biology (Basel), 12, 2023
8CEB	Type2 alpha-synuclein filament assembled in vitro by wild-type and mutant (7 residues insertion) protein 分子名称: Alpha-synuclein 著者 Yang, Y, Garringer, J.H, Shi, Y, Lovestam, S, Sew, P.C, Zhang, X.J, Kotecha, A, Bacioglu, M, Koto, A, Takao, M, Spillantini, G.M, Ghetti, B, Vidal, R, Murzin, G.A, Scheres, H.W.S, Goedert, M. 登録日 2023-02-01 公開日 2023-03-08 最終更新日 2024-07-24 実験手法 ELECTRON MICROSCOPY (2.8 Å) 主引用文献 New SNCA mutation and structures of alpha-synuclein filaments from juvenile-onset synucleinopathy. Acta Neuropathol, 145, 2023
5DUC	Crystal structure of M. tuberculosis EchA6 bound to ligand GSK951A 分子名称: (5R,7S)-N-(1,3-benzodioxol-5-ylmethyl)-5-(4-ethylphenyl)-7-(trifluoromethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide, Probable enoyl-CoA hydratase echA6 著者 Cox, J.A.G, Besra, G.S, Futterer, K. 登録日 2015-09-18 公開日 2016-01-20 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.704 Å) 主引用文献 THPP target assignment reveals EchA6 as an essential fatty acid shuttle in mycobacteria. Nat Microbiol, 1, 2016
6VQ7	Mammalian V-ATPase from rat brain - composite model of rotational state 2 bound to ADP and SidK (built from focused refinement models) 分子名称: ADENOSINE-5'-DIPHOSPHATE, ATPase H+-transporting V1 subunit A, ATPase H+-transporting V1 subunit D, ... 著者 Abbas, Y.M, Rubinstein, J.L. 登録日 2020-02-04 公開日 2020-03-18 最終更新日 2024-03-06 実験手法 ELECTRON MICROSCOPY (4 Å) 主引用文献 Structure of V-ATPase from the mammalian brain. Science, 367, 2020
2G0N	The Crystal Structure of the Human RAC3 in complex with GDP and Chloride 分子名称: CHLORIDE ION, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... 著者 Ugochukwu, E, Yang, X, Zao, Y, Elkins, J, Gileadi, C, Burgess, N, Colebrook, S, Gileadi, O, Fedorov, O, Bunkoczi, G, Sundstrom, M, Arrowsmith, C, Weigelt, J, Edwards, A, von Delft, F, Doyle, D, Structural Genomics Consortium (SGC) 登録日 2006-02-13 公開日 2006-05-30 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 The Crystal Structure of the Human RAC3 in complex with GDP and Chloride To be Published
6SAC	N-terminal expression tag remainder of human Carbonic Anhydrase II covalently modified by fragment 分子名称: (4-CARBOXYPHENYL)(CHLORO)MERCURY, 1-(1,3-dimethyl-1H-pyrazol-5-yl)methanamine, Carbonic anhydrase 2, ... 著者 Gloeckner, S, Heine, A, Klebe, G. 登録日 2019-07-16 公開日 2020-04-15 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.02 Å) 主引用文献 A Proof-of-Concept Fragment Screening of a Hit-Validated 96-Compounds Library against Human Carbonic Anhydrase II. Biomolecules, 10, 2020
6SB0	cryo-EM structure of mTORC1 bound to PRAS40-fused active RagA/C GTPases 分子名称: GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, Proline-rich AKT1 substrate 1, ... 著者 Anandapadamanaban, M, Berndt, A, Masson, G.R, Perisic, O, Williams, R.L. 登録日 2019-07-18 公開日 2019-10-16 最終更新日 2024-05-22 実験手法 ELECTRON MICROSCOPY (5.5 Å) 主引用文献 Architecture of human Rag GTPase heterodimers and their complex with mTORC1. Science, 366, 2019
8CPM	Human apoferritin after 405 nm laser exposure 分子名称: Ferritin heavy chain, N-terminally processed, MAGNESIUM ION, ... 著者 Last, M.G.F, Noteborn, W.E.M, Sharp, T.H. 登録日 2023-03-03 公開日 2023-03-15 最終更新日 2023-11-22 実験手法 ELECTRON MICROSCOPY (1.81 Å) 主引用文献 Super-resolution fluorescence imaging of cryosamples does not limit achievable resolution in cryoEM. J.Struct.Biol., 215, 2023
8C0R	Crystal structure of human carbonic anhydrase II in complex with a coumarin derivative. 分子名称: Carbonic anhydrase 2, ZINC ION, bis(fluoranyl)-(4-methyl-2-oxidanylidene-chromen-7-yl)methanesulfonamide 著者 Alterio, V, De Simone, G, Esposito, D. 登録日 2022-12-19 公開日 2023-03-08 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (1.56 Å) 主引用文献 A Combined in Silico and Structural Study Opens New Perspectives on Aliphatic Sulfonamides, a Still Poorly Investigated Class of CA Inhibitors. Biology (Basel), 12, 2023
3DVD	X-ray crystal structure of mutant N62D of human Carbonic Anhydrase II 分子名称: Carbonic anhydrase 2, ZINC ION 著者 Avvaru, B.S. 登録日 2008-07-18 公開日 2008-11-11 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Role of hydrophilic residues in proton transfer during catalysis by human carbonic anhydrase II. Biochemistry, 47, 2008
6YKO	Neisseria gonorrhoeae Leucyl-tRNA Synthetase in Complex with Compound 11a 分子名称: 1,2-ETHANEDIOL, Leucine--tRNA ligase, MAGNESIUM ION, ... 著者 Pang, L, Strelkov, S.V, Weeks, S.D. 登録日 2020-04-06 公開日 2020-12-02 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.21 Å) 主引用文献 Synthesis and structure-activity studies of novel anhydrohexitol-based Leucyl-tRNA synthetase inhibitors. Eur.J.Med.Chem., 211, 2021
4F5N	Open ternary complex of R283K DNA polymerase beta with a metal free dCTP analog 分子名称: 2'-deoxy-5'-O-[(S)-{difluoro[(S)-hydroxy(phosphonooxy)phosphoryl]methyl}(hydroxy)phosphoryl]cytidine, DNA (5'-D(*CP*CP*GP*AP*CP*GP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*C)-3'), ... 著者 Freudenthal, B.D, Beard, W.A, Wilson, S.H. 登録日 2012-05-13 公開日 2012-12-12 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structures of dNTP Intermediate States during DNA Polymerase Active Site Assembly. Structure, 20, 2012
4F9O	Crystal Structure of recombinant human Hexokinase type I with 2-deoxy-Glucose 6-Phosphate 分子名称: 2-deoxy-6-O-phosphono-beta-D-glucopyranose, CITRIC ACID, Hexokinase-1, ... 著者 Shen, L, Honzatko, R.B. 登録日 2012-05-19 公開日 2013-06-12 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.65 Å) 主引用文献 Inhibitor Sites of Unequal Affinity Linked by Binding Synergism in Mutant Forms of Recombinant Human Hexokinase Type-I to be published
4F5R	Open and closed ternary complex of R283K DNA polymerase beta with a dCTP analog in the same asymmetric unit 分子名称: 2'-deoxy-5'-O-[(S)-{difluoro[(S)-hydroxy(phosphonooxy)phosphoryl]methyl}(hydroxy)phosphoryl]cytidine, DNA (5'-D(*CP*CP*GP*AP*CP*GP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*C)-3'), ... 著者 Freudenthal, B.D, Beard, W.A, Wilson, S.H. 登録日 2012-05-13 公開日 2012-12-12 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Structures of dNTP Intermediate States during DNA Polymerase Active Site Assembly. Structure, 20, 2012
2FNK	Activation of Human Carbonic Anhydrase II by exogenous proton donors 分子名称: Carbonic anhydrase 2, ZINC ION 著者 Bhatt, D, Fisher, S.Z, Tu, C, McKenna, R, Silverman, D.N. 登録日 2006-01-11 公開日 2006-11-28 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Location of binding sites in small molecule rescue of human carbonic anhydrase II. Biophys.J., 92, 2007

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