8C0R
Crystal structure of human carbonic anhydrase II in complex with a coumarin derivative.
Summary for 8C0R
| Entry DOI | 10.2210/pdb8c0r/pdb |
| Descriptor | Carbonic anhydrase 2, ZINC ION, bis(fluoranyl)-(4-methyl-2-oxidanylidene-chromen-7-yl)methanesulfonamide, ... (4 entities in total) |
| Functional Keywords | difluoromethanesulfonamide, protein-inhibitor complex, carbonic anhydrase ii, coumarin, lyase |
| Biological source | Homo sapiens (human) |
| Total number of polymer chains | 1 |
| Total formula weight | 29643.73 |
| Authors | Alterio, V.,De Simone, G.,Esposito, D. (deposition date: 2022-12-19, release date: 2023-03-08, Last modification date: 2024-02-14) |
| Primary citation | Langella, E.,Esposito, D.,Monti, S.M.,Supuran, C.T.,De Simone, G.,Alterio, V. A Combined in Silico and Structural Study Opens New Perspectives on Aliphatic Sulfonamides, a Still Poorly Investigated Class of CA Inhibitors. Biology (Basel), 12:-, 2023 Cited by PubMed: 36829558DOI: 10.3390/biology12020281 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.56 Å) |
Structure validation
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