9BOO
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![BU of 9boo by Molmil](/molmil-images/mine/9boo) | Crystal structure of MERS-CoV Nsp5 in complex with PF-07817883 | 分子名称: | 3C-like proteinase nsp5, N-(methoxycarbonyl)-3-methyl-L-valyl-(4R)-N-{(1Z,2S)-1-imino-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-4-(trifluoromethyl)-L-prolinamide | 著者 | Chen, P, Arutyunova, E, Lemieux, M.J. | 登録日 | 2024-05-05 | 公開日 | 2024-08-07 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | A Structural Comparison of Oral SARS-CoV-2 Drug Candidate Ibuzatrelvir Complexed with the Main Protease (Mpro) of SARS-CoV-2 and MERS-CoV Jacs Au, 2024
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8WY1
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![BU of 8wy1 by Molmil](/molmil-images/mine/8wy1) | The structure of cyclization domain in cyclic beta-1,2-glucan synthase from Thermoanaerobacter italicus | 分子名称: | Glycosyltransferase 36 | 著者 | Tanaka, N, Saito, R, Kobayashi, K, Nakai, H, Kamo, S, Kuramochi, K, Taguchi, H, Nakajima, M, Masaike, T. | 登録日 | 2023-10-30 | 公開日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (3.9 Å) | 主引用文献 | Functional and structural analysis of a cyclization domain in a cyclic beta-1,2-glucan synthase. Appl.Microbiol.Biotechnol., 108, 2024
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9G2W
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8X3H
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8X3E
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![BU of 8x3e by Molmil](/molmil-images/mine/8x3e) | CYP725A4-Taxa-4,11-diene complex | 分子名称: | (1~{R},3~{R},8~{R})-4,8,12,15,15-pentamethyltricyclo[9.3.1.0^{3,8}]pentadeca-4,11-diene, PROTOPORPHYRIN IX CONTAINING FE, Taxadiene 5-alpha hydroxylase | 著者 | Chang, Z, Wang, Q. | 登録日 | 2023-11-13 | 公開日 | 2024-08-14 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Unraveling the Catalytic Mechanism of Taxadiene-5alpha-hydroxylase from Crystallography and Computational Analyses. Acs Catalysis, 14, 2024
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8XDV
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8YVP
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![BU of 8yvp by Molmil](/molmil-images/mine/8yvp) | canine immunoproteasome 20S subunit in complex with compound 1 | 分子名称: | Proteasome subunit alpha type-1, Proteasome subunit alpha type-2, Proteasome subunit alpha type-3, ... | 著者 | Kashima, A, Arai, Y. | 登録日 | 2024-03-29 | 公開日 | 2024-07-31 | 実験手法 | ELECTRON MICROSCOPY (2.5 Å) | 主引用文献 | Optimization of alpha-amido boronic acids via cryo-electron microscopy analysis: Discovery of a novel highly selective immunoproteasome subunit LMP7 ( beta 5i)/LMP2 ( beta 1i) dual inhibitor. Bioorg.Med.Chem., 109, 2024
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9EYU
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![BU of 9eyu by Molmil](/molmil-images/mine/9eyu) | Human PRMT5 in complex with AZ compound 1 | 分子名称: | (1~{S})-2-[(2-carbamimidamido-1,3-thiazol-5-yl)methyl]-~{N}-[(4-fluorophenyl)methyl]-3-oxidanylidene-1~{H}-isoindole-1-carboxamide, 5'-DEOXY-5'-METHYLTHIOADENOSINE, Methylosome protein WDR77, ... | 著者 | Debreczeni, J. | 登録日 | 2024-04-09 | 公開日 | 2024-08-14 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | Discovery and In Vivo Efficacy of AZ-PRMT5i-1, a Novel PRMT5 Inhibitor with High MTA Cooperativity. J.Med.Chem., 2024
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8X2I
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9CYS
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![BU of 9cys by Molmil](/molmil-images/mine/9cys) | Toxin/immunity complex for a T6SS lipase effector from E. cloacae | 分子名称: | Ankyrin repeat domain-containing protein, CITRIC ACID, GLYCEROL, ... | 著者 | Cuthbert, B.J, Jensen, S.J, Goulding, C.W, Hayes, C.S. | 登録日 | 2024-08-02 | 公開日 | 2024-08-14 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Advanced glycation end-product (AGE) crosslinking activates a type 6 secretion system phospholipase effector protein Nature Communications, 2024
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8WZF
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![BU of 8wzf by Molmil](/molmil-images/mine/8wzf) | Dark state SFX structure of hen egg white lysozyme microcrystals immobilized with a Mn carbonyl complex at RT. | 分子名称: | CHLORIDE ION, Lysozyme C, SODIUM ION, ... | 著者 | Maity, B, Shoji, M, Luo, F, Nakane, T, Abe, S, Owada, S, Kang, J, Tono, K, Tanaka, R, Thuc, T.T, Kojima, M, Hishikawa, Y, Tanaka, J, Tian, J, Noya, H, Nakasuji, Y, Asanuma, A, Yao, X, Iwata, S, Shigeta, Y, Nango, E, Ueno, T. | 登録日 | 2023-11-01 | 公開日 | 2024-07-31 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Real-time observation of a metal complex-driven reaction intermediate using a porous protein crystal and serial femtosecond crystallography. Nat Commun, 15, 2024
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8VR3
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![BU of 8vr3 by Molmil](/molmil-images/mine/8vr3) | crystal structure of the Pcryo_0618 aminotransferase from Psychrobacter cryohalolentis K5 in the presence of its internal aldimine | 分子名称: | 1,2-ETHANEDIOL, 2,2'-(1,4-diazepane-1,4-diyl)di(ethane-1-sulfonic acid), CHLORIDE ION, ... | 著者 | Bockhaus, N.J, Thoden, J.B, Holden, H.M. | 登録日 | 2024-01-20 | 公開日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Biochemical Investigation of the Enzymes Required for the Production of 2,3,4-triacetoamido-2,3,4-trideoxy-l-arabinose in Psychrobacter cryohalolentis K5 To Be Published
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8WFL
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9COZ
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8Y2T
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![BU of 8y2t by Molmil](/molmil-images/mine/8y2t) | Crystal structure of 3C protease from coxsackievirus B3 | 分子名称: | Protease 3C | 著者 | Jiang, H.H, Zou, X.F, Zhang, J, Li, J. | 登録日 | 2024-01-27 | 公開日 | 2024-08-14 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Crystal structures of the 3C proteases from Coxsackievirus B3 and B4. Acta Crystallogr.,Sect.F, 80, 2024
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8XJ6
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![BU of 8xj6 by Molmil](/molmil-images/mine/8xj6) | The Cryo-EM structure of MPXV E5 apo conformation | 分子名称: | AMP PHOSPHORAMIDATE, Monkeypox virus E5, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | 著者 | Zhang, W, Liu, Y, Gao, H, Gan, J. | 登録日 | 2023-12-20 | 公開日 | 2024-05-01 | 最終更新日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (3.32 Å) | 主引用文献 | Structural and functional insights into the helicase protein E5 of Mpox virus. Cell Discov, 10, 2024
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8X2H
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9CX6
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9CII
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![BU of 9cii by Molmil](/molmil-images/mine/9cii) | Crystal structure of Staphylococcal nuclease variant Delta+PHS V23D/L36R at cryogenic temperature | 分子名称: | CALCIUM ION, THYMIDINE-3',5'-DIPHOSPHATE, Thermonuclease | 著者 | Zhang, Y, Schlessman, J.L, Robinson, A.C, Garcia-Moreno E, B. | 登録日 | 2024-07-03 | 公開日 | 2024-08-07 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Crystal structure of Staphylococcal nuclease variant Delta+PHS V23D/L36R at cryogenic temperature To Be Published
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8WU8
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![BU of 8wu8 by Molmil](/molmil-images/mine/8wu8) | Crystal structure of the human RAD9-RAD1(F64A/M256A/F266A)-HUS1-RHINO(88-99) complex | 分子名称: | Cell cycle checkpoint control protein RAD9A, Cell cycle checkpoint protein RAD1, Checkpoint protein HUS1, ... | 著者 | Hara, K, Nagata, K, Iida, N, Hashimoto, H. | 登録日 | 2023-10-20 | 公開日 | 2024-02-14 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (2.81 Å) | 主引用文献 | Structural basis for intra- and intermolecular interactions on RAD9 subunit of 9-1-1 checkpoint clamp implies functional 9-1-1 regulation by RHINO. J.Biol.Chem., 300, 2024
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9EPX
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![BU of 9epx by Molmil](/molmil-images/mine/9epx) | Crystal structure of human Casein Kinase II subunit alpha (CK2a1) in complex with allosteric ligand FGC3331 | 分子名称: | 1,2-ETHANEDIOL, 7-[(2-chloranyl-1,3-benzothiazol-6-yl)sulfonyl]-~{N}-[(3-chloranyl-4-phenyl-phenyl)methyl]-7-azaspiro[3.5]nonan-2-amine, Casein kinase II subunit alpha, ... | 著者 | Kraemer, A, Greco, F, Knapp, S, Structural Genomics Consortium (SGC) | 登録日 | 2024-03-20 | 公開日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Crystal structure of human Casein Kinase II subunit alpha (CK2a1) in complex with allosteric ligand FGC3331 To Be Published
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9EMV
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![BU of 9emv by Molmil](/molmil-images/mine/9emv) | SARS-CoV-2 nsp10-16 methyltransferase in complex with Sangivamycin and m7GpppA (Cap0-analog)/m7GpppAm (Cap1-analog) | 分子名称: | 1,2-ETHANEDIOL, 2'-O-methyltransferase nsp16, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... | 著者 | Kremling, V, Sprenger, J, Oberthuer, D, Scheer, T.E.S. | 登録日 | 2024-03-11 | 公開日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.34 Å) | 主引用文献 | SARS-CoV-2 methyltransferase nsp10-16 in complex with natural and drug-like purine analogs for guiding structure-based drug development To Be Published
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9BPF
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9F44
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8XE2
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![BU of 8xe2 by Molmil](/molmil-images/mine/8xe2) | O-methyltransferase from Lycoris longituba D230A variant complexed with Mg, SAH, and 3,4-dihydroxybenzaldehyde | 分子名称: | GLYCEROL, MAGNESIUM ION, Protocatechuic aldehyde, ... | 著者 | Saw, Y.Y.H, Nakashima, Y, Morita, H. | 登録日 | 2023-12-11 | 公開日 | 2024-08-07 | 実験手法 | X-RAY DIFFRACTION (2.43 Å) | 主引用文献 | Structure-Based Catalytic Mechanism of Amaryllidaceae O-Methyltransferases Acs Catalysis, 2024
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