PDB: 224004 件ウェブページステータス検索Chemie searchBIRD

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9B0Z	Structure of Optineurin bound to HOIP NZF1 domain and M1-linked diubiquitin, crystal form 2 分子名称: E3 ubiquitin-protein ligase RNF31, Optineurin, Ubiquitin, ... 著者 Michel, M.A, Scutts, S, Komander, D. 登録日 2024-03-12 公開日 2024-07-31 実験手法 X-RAY DIFFRACTION (2.41 Å) 主引用文献 Linkage and substrate specificity conferred by NZF ubiquitin binding domains To Be Published
8WIU	Bromodomain and Extra-terminal Domain (BET) BRD4 分子名称: 7-[5-[1-(cyclopropylmethyl)-3,5-dimethyl-pyrazol-4-yl]pyridin-3-yl]-1~{H}-imidazo[4,5-b]pyridine, Isoform C of Bromodomain-containing protein 4 著者 Cao, D, Zhiyan, D, Xiong, B. 登録日 2023-09-25 公開日 2024-01-03 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Discovery of a brain-permeable bromodomain and extra terminal domain (BET) inhibitor with selectivity for BD1 for the treatment of multiple sclerosis. Eur.J.Med.Chem., 265, 2023
9C5S	Disulfide-linked, antiparallel p53-derived peptide dimer (CV1) 分子名称: Cellular tumor antigen p53, SULFATE ION 著者 Vithanage, N, Kreitler, D.K, DiGiorno, M.C, Victorio, C.G, Sawyer, N, Outlaw, V.K. 登録日 2024-06-06 公開日 2024-06-26 最終更新日 2024-08-07 実験手法 X-RAY DIFFRACTION (1.01 Å) 主引用文献 Structural Characterization of Disulfide-Linked p53-Derived Peptide Dimers. Res Sq, 2024
8Y6F	The crystal structure of MMPs cleavable human heavy chain ferritin 分子名称: CHLORIDE ION, FE (III) ION, Ferritin, ... 著者 Yuan, C, Huang, M. 登録日 2024-02-02 公開日 2024-07-17 実験手法 X-RAY DIFFRACTION (2.01 Å) 主引用文献 Engineered protein cages with enhanced extracellular drug release for elevated antitumor efficacy. Int.J.Biol.Macromol., 267, 2024
8X5Y	CryoEM structure of the histamine H1 receptor-BRIL/Anti BRIL Fab complex with astemizole 分子名称: 1-[(4-fluorophenyl)methyl]-N-{1-[2-(4-methoxyphenyl)ethyl]piperidin-4-yl}-1H-benzimidazol-2-amine, Histamine H1 receptor,Soluble cytochrome b562 著者 Wang, D.D, Guo, Q, Tao, Y.Y. 登録日 2023-11-20 公開日 2024-01-17 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Molecular mechanism of antihistamines recognition and regulation of the histamine H 1 receptor. Nat Commun, 15, 2024
9B20	Crystal structure of ADP-ribose diphosphatase from Klebsiella pneumoniae (AMP bound) 分子名称: ADENOSINE MONOPHOSPHATE, ADP-ribose pyrophosphatase, MAGNESIUM ION 著者 Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2024-03-14 公開日 2024-03-27 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Crystal structure of ADP-ribose diphosphatase from Klebsiella pneumoniae (AMP bound) To be published
8VEC	Deep Mutational Scanning of SARS-CoV-2 PLpro 分子名称: Papain-like protease nsp3, ZINC ION 著者 Wu, X, Nguyen, J.V, Call, M.E, Call, M.J. 登録日 2023-12-18 公開日 2024-03-20 最終更新日 2024-08-07 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Mutational profiling of SARS-CoV-2 papain-like protease reveals requirements for function, structure, and drug escape. Nat Commun, 15, 2024
8XHK	Crystal structure of alpha-Oxoamine Synthase Alb29 with PLP cofactor 分子名称: (5-HYDROXY-4,6-DIMETHYLPYRIDIN-3-YL)METHYL DIHYDROGEN PHOSPHATE, Aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme, PYRIDOXAL-5'-PHOSPHATE 著者 Xu, M.J, Zhang, D.K. 登録日 2023-12-18 公開日 2024-05-01 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (2.79 Å) 主引用文献 Structural and mechanistic investigations on CC bond forming alpha-oxoamine synthase allowing L-glutamate as substrate. Int.J.Biol.Macromol., 268, 2024
9ASZ	Crystal structure of SARS-CoV-2 3CL protease in complex with a phenylethyl 2-pyrrolidone inhibitor 分子名称: (1S,2S)-1-hydroxy-2-{[N-({[(2S)-5-oxo-1-(2-phenylethyl)pyrrolidin-2-yl]methoxy}carbonyl)-L-leucyl]amino}-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonic acid, 3C-like proteinase nsp5 著者 Lovell, S, Cooper, A, Battaile, K.P, Dampalla, C.S, Groutas, W.C. 登録日 2024-02-26 公開日 2024-07-10 最終更新日 2024-08-07 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Structure-Guided Design of Potent Coronavirus Inhibitors with a 2-Pyrrolidone Scaffold: Biochemical, Crystallographic, and Virological Studies. J.Med.Chem., 67, 2024
8XT1	Cryo-EM structure of the human 39S mitoribosome with 5uM Tigecycline 分子名称: 16s rRNA, 39S ribosomal protein L22, mitochondrial, ... 著者 Li, X, Wang, M, Cheng, J. 登録日 2024-01-10 公開日 2024-07-10 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Structural basis for differential inhibition of eukaryotic ribosomes by tigecycline. Nat Commun, 15, 2024
8W8T	Crystal structure of human CLEC12A CRD 分子名称: C-type lectin domain family 12 member A, SULFATE ION 著者 Mori, S, Nagae, M, Yamasaki, S. 登録日 2023-09-04 公開日 2024-03-06 最終更新日 2024-05-15 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Crystal structure of the complex of CLEC12A and an antibody that interferes with binding of diverse ligands. Int.Immunol., 36, 2024
9C0C	E.coli GroEL apoenzyme 分子名称: 60 kDa chaperonin 著者 Watson, E.R, Lander, G.C. 登録日 2024-05-25 公開日 2024-08-07 最終更新日 2024-08-14 実験手法 ELECTRON MICROSCOPY (3.41 Å) 主引用文献 Bis-sulfonamido-2-phenylbenzoxazoles Validate the GroES/EL Chaperone System as a Viable Antibiotic Target. J.Am.Chem.Soc., 146, 2024
8WOO	Structure of the wild-type Arabidopsis ABCB19 in the brassinolide and AMP-PNP bound state 分子名称: ABC transporter B family member 19, Brassinolide, MAGNESIUM ION, ... 著者 Ying, W, Wei, H, Liu, X, Sun, L. 登録日 2023-10-07 公開日 2024-03-13 最終更新日 2024-04-03 実験手法 ELECTRON MICROSCOPY (3.9 Å) 主引用文献 Structure and function of the Arabidopsis ABC transporter ABCB19 in brassinosteroid export. Science, 383, 2024
8XIF	The crystal structure of the AEP domain of VACV D5 分子名称: MAGNESIUM ION, PYROPHOSPHATE, Uncoating factor OPG117 著者 Gan, J, Zhang, W. 登録日 2023-12-19 公開日 2024-05-01 最終更新日 2024-07-10 実験手法 X-RAY DIFFRACTION (1.39 Å) 主引用文献 Structural and functional insights into the helicase protein E5 of Mpox virus. Cell Discov, 10, 2024
8VSA	Endogenous trans-translation complex with tmRNA*SmpB in the P site and alanyl-tRNA in the A site of E. coli 70S ribosome 分子名称: 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... 著者 Teran, D, Zhang, Y, Korostelev, A.A. 登録日 2024-01-23 公開日 2024-05-01 実験手法 ELECTRON MICROSCOPY (3.7 Å) 主引用文献 Endogenous trans-translation structure visualizes the decoding of the first tmRNA alanine codon. Front Microbiol, 15, 2024
8XIM	PROTEIN ENGINEERING OF XYLOSE (GLUCOSE) ISOMERASE FROM ACTINOPLANES MISSOURIENSIS. 1. CRYSTALLOGRAPHY AND SITE-DIRECTED MUTAGENESIS OF METAL BINDING SITES 分子名称: D-XYLOSE ISOMERASE, D-xylose, MAGNESIUM ION 著者 Janin, J. 登録日 1992-04-01 公開日 1993-07-15 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Protein engineering of xylose (glucose) isomerase from Actinoplanes missouriensis. 1. Crystallography and site-directed mutagenesis of metal binding sites. Biochemistry, 31, 1992
9EWM	Mpro from SARS-CoV-2 with R4Q R298Q double mutations 分子名称: Non-structural protein 11 著者 Plewka, J, Lis, K, Chykunova, Y, Czarna, A, Kantyka, T, Pyrc, K. 登録日 2024-04-04 公開日 2024-04-24 実験手法 X-RAY DIFFRACTION (2.63 Å) 主引用文献 SARS-CoV-2 M pro oligomerization as a potential target for therapy. Int.J.Biol.Macromol., 267, 2024
8XDO	O-methyltransferase from Lycoris longituba complexed with Mg and SAH 分子名称: GLYCEROL, MAGNESIUM ION, S-ADENOSYL-L-HOMOCYSTEINE, ... 著者 Saw, Y.Y.H, Nakashima, Y, Morita, H. 登録日 2023-12-11 公開日 2024-08-07 実験手法 X-RAY DIFFRACTION (1.37 Å) 主引用文献 Structure-Based Catalytic Mechanism of Amaryllidaceae O-Methyltransferases Acs Catalysis, 2024
8XPT	The Crystal Structure of EHMT1 from Biortus. 分子名称: Histone-lysine N-methyltransferase EHMT1, S-ADENOSYL-L-HOMOCYSTEINE, SULFATE ION, ... 著者 Wang, F, Cheng, W, Yuan, Z, Lin, D, Bao, C. 登録日 2024-01-04 公開日 2024-01-24 実験手法 X-RAY DIFFRACTION (3.35 Å) 主引用文献 The Crystal Structure of EHMT1 from Biortus. To Be Published
9EOW	The 5-terminal stem-loop RNA element of SARS-CoV-2 features highly dynamic structural elements that are sensitive to differences in cellular pH 分子名称: RNA (29-MER) 著者 Wacker, A, Schwalbe, H. 登録日 2024-03-15 公開日 2024-06-19 最終更新日 2024-07-31 実験手法 SOLUTION NMR 主引用文献 The 5'-terminal stem-loop RNA element of SARS-CoV-2 features highly dynamic structural elements that are sensitive to differences in cellular pH. Nucleic Acids Res., 52, 2024
8VK4	Structure of mouse RyR1 in complex with S100A1 (high-Ca2+/CFF/ATP dataset) 分子名称: 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ADENOSINE-5'-TRIPHOSPHATE, CAFFEINE, ... 著者 Weninger, G, Marks, A.R. 登録日 2024-01-08 公開日 2024-02-07 最終更新日 2024-07-10 実験手法 ELECTRON MICROSCOPY (3.56 Å) 主引用文献 Structural insights into the regulation of RyR1 by S100A1. Proc.Natl.Acad.Sci.USA, 121, 2024
9EQF	Crystal structure of the L-arginine hydroxylase VioC MeHis316, bound to Fe(II), L-arginine, and succinate 分子名称: 1,2-ETHANEDIOL, ARGININE, Alpha-ketoglutarate-dependent L-arginine hydroxylase, ... 著者 Hardy, F.J. 登録日 2024-03-21 公開日 2024-07-31 最終更新日 2024-08-21 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Probing Ferryl Reactivity in a Nonheme Iron Oxygenase Using an Expanded Genetic Code. Acs Catalysis, 14, 2024
8XVC	CryoEM structure of ADP-DNA-MuB conformation1 分子名称: ADENOSINE-5'-DIPHOSPHATE, ATP-dependent target DNA activator B 著者 Zhao, X, Zhang, K, Li, S. 登録日 2024-01-14 公開日 2024-08-14 実験手法 ELECTRON MICROSCOPY (4.32 Å) 主引用文献 Elucidating the Architectural dynamics of MuB filaments in bacteriophage Mu DNA transposition. Nat Commun, 15, 2024
9FX6	Crystal structure of Cryo2RT SARS-CoV-2 main protease at 100K 分子名称: 3C-like proteinase nsp5, DIMETHYL SULFOXIDE, MAGNESIUM ION, ... 著者 Huang, C.Y, Aumonier, S, Mac Sweeney, A, Olieric, V, Wang, M. 登録日 2024-07-01 公開日 2024-07-31 最終更新日 2024-08-14 実験手法 X-RAY DIFFRACTION (2.227 Å) 主引用文献 Cryo2RT: a high-throughput method for room-temperature macromolecular crystallography from cryo-cooled crystals. Acta Crystallogr D Struct Biol, 80, 2024
8VRM	Crystal structure of the Pcryo_0619 N-acetyltransferase from Psychrobacter cryohalolentis K5 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, 1,2-ETHANEDIOL, Acetyltransferase, ... 著者 Dunsirn, M.M, Bockhaus, N.J, Thoden, J.B, Holden, H.M. 登録日 2024-01-22 公開日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Biochemical Investigation of the Enzymes Required for the Production of 2,3,4-triacetoamido-2,3,4-trideoxy-l-arabinose in Psychrobacter cryohalolentis K5 To Be Published

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