9B0Z
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8WIU
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![BU of 8wiu by Molmil](/molmil-images/mine/8wiu) | Bromodomain and Extra-terminal Domain (BET) BRD4 | 分子名称: | 7-[5-[1-(cyclopropylmethyl)-3,5-dimethyl-pyrazol-4-yl]pyridin-3-yl]-1~{H}-imidazo[4,5-b]pyridine, Isoform C of Bromodomain-containing protein 4 | 著者 | Cao, D, Zhiyan, D, Xiong, B. | 登録日 | 2023-09-25 | 公開日 | 2024-01-03 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Discovery of a brain-permeable bromodomain and extra terminal domain (BET) inhibitor with selectivity for BD1 for the treatment of multiple sclerosis. Eur.J.Med.Chem., 265, 2023
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9C5S
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![BU of 9c5s by Molmil](/molmil-images/mine/9c5s) | Disulfide-linked, antiparallel p53-derived peptide dimer (CV1) | 分子名称: | Cellular tumor antigen p53, SULFATE ION | 著者 | Vithanage, N, Kreitler, D.K, DiGiorno, M.C, Victorio, C.G, Sawyer, N, Outlaw, V.K. | 登録日 | 2024-06-06 | 公開日 | 2024-06-26 | 最終更新日 | 2024-08-07 | 実験手法 | X-RAY DIFFRACTION (1.01 Å) | 主引用文献 | Structural Characterization of Disulfide-Linked p53-Derived Peptide Dimers. Res Sq, 2024
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8Y6F
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8X5Y
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9B20
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8VEC
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![BU of 8vec by Molmil](/molmil-images/mine/8vec) | Deep Mutational Scanning of SARS-CoV-2 PLpro | 分子名称: | Papain-like protease nsp3, ZINC ION | 著者 | Wu, X, Nguyen, J.V, Call, M.E, Call, M.J. | 登録日 | 2023-12-18 | 公開日 | 2024-03-20 | 最終更新日 | 2024-08-07 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Mutational profiling of SARS-CoV-2 papain-like protease reveals requirements for function, structure, and drug escape. Nat Commun, 15, 2024
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8XHK
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![BU of 8xhk by Molmil](/molmil-images/mine/8xhk) | Crystal structure of alpha-Oxoamine Synthase Alb29 with PLP cofactor | 分子名称: | (5-HYDROXY-4,6-DIMETHYLPYRIDIN-3-YL)METHYL DIHYDROGEN PHOSPHATE, Aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme, PYRIDOXAL-5'-PHOSPHATE | 著者 | Xu, M.J, Zhang, D.K. | 登録日 | 2023-12-18 | 公開日 | 2024-05-01 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (2.79 Å) | 主引用文献 | Structural and mechanistic investigations on CC bond forming alpha-oxoamine synthase allowing L-glutamate as substrate. Int.J.Biol.Macromol., 268, 2024
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9ASZ
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![BU of 9asz by Molmil](/molmil-images/mine/9asz) | Crystal structure of SARS-CoV-2 3CL protease in complex with a phenylethyl 2-pyrrolidone inhibitor | 分子名称: | (1S,2S)-1-hydroxy-2-{[N-({[(2S)-5-oxo-1-(2-phenylethyl)pyrrolidin-2-yl]methoxy}carbonyl)-L-leucyl]amino}-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonic acid, 3C-like proteinase nsp5 | 著者 | Lovell, S, Cooper, A, Battaile, K.P, Dampalla, C.S, Groutas, W.C. | 登録日 | 2024-02-26 | 公開日 | 2024-07-10 | 最終更新日 | 2024-08-07 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Structure-Guided Design of Potent Coronavirus Inhibitors with a 2-Pyrrolidone Scaffold: Biochemical, Crystallographic, and Virological Studies. J.Med.Chem., 67, 2024
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8XT1
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![BU of 8xt1 by Molmil](/molmil-images/mine/8xt1) | Cryo-EM structure of the human 39S mitoribosome with 5uM Tigecycline | 分子名称: | 16s rRNA, 39S ribosomal protein L22, mitochondrial, ... | 著者 | Li, X, Wang, M, Cheng, J. | 登録日 | 2024-01-10 | 公開日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Structural basis for differential inhibition of eukaryotic ribosomes by tigecycline. Nat Commun, 15, 2024
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8W8T
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![BU of 8w8t by Molmil](/molmil-images/mine/8w8t) | Crystal structure of human CLEC12A CRD | 分子名称: | C-type lectin domain family 12 member A, SULFATE ION | 著者 | Mori, S, Nagae, M, Yamasaki, S. | 登録日 | 2023-09-04 | 公開日 | 2024-03-06 | 最終更新日 | 2024-05-15 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Crystal structure of the complex of CLEC12A and an antibody that interferes with binding of diverse ligands. Int.Immunol., 36, 2024
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9C0C
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![BU of 9c0c by Molmil](/molmil-images/mine/9c0c) | E.coli GroEL apoenzyme | 分子名称: | 60 kDa chaperonin | 著者 | Watson, E.R, Lander, G.C. | 登録日 | 2024-05-25 | 公開日 | 2024-08-07 | 最終更新日 | 2024-08-14 | 実験手法 | ELECTRON MICROSCOPY (3.41 Å) | 主引用文献 | Bis-sulfonamido-2-phenylbenzoxazoles Validate the GroES/EL Chaperone System as a Viable Antibiotic Target. J.Am.Chem.Soc., 146, 2024
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8WOO
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![BU of 8woo by Molmil](/molmil-images/mine/8woo) | Structure of the wild-type Arabidopsis ABCB19 in the brassinolide and AMP-PNP bound state | 分子名称: | ABC transporter B family member 19, Brassinolide, MAGNESIUM ION, ... | 著者 | Ying, W, Wei, H, Liu, X, Sun, L. | 登録日 | 2023-10-07 | 公開日 | 2024-03-13 | 最終更新日 | 2024-04-03 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Structure and function of the Arabidopsis ABC transporter ABCB19 in brassinosteroid export. Science, 383, 2024
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8XIF
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8VSA
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![BU of 8vsa by Molmil](/molmil-images/mine/8vsa) | Endogenous trans-translation complex with tmRNA*SmpB in the P site and alanyl-tRNA in the A site of E. coli 70S ribosome | 分子名称: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | 著者 | Teran, D, Zhang, Y, Korostelev, A.A. | 登録日 | 2024-01-23 | 公開日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Endogenous trans-translation structure visualizes the decoding of the first tmRNA alanine codon. Front Microbiol, 15, 2024
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8XIM
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9EWM
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![BU of 9ewm by Molmil](/molmil-images/mine/9ewm) | Mpro from SARS-CoV-2 with R4Q R298Q double mutations | 分子名称: | Non-structural protein 11 | 著者 | Plewka, J, Lis, K, Chykunova, Y, Czarna, A, Kantyka, T, Pyrc, K. | 登録日 | 2024-04-04 | 公開日 | 2024-04-24 | 実験手法 | X-RAY DIFFRACTION (2.63 Å) | 主引用文献 | SARS-CoV-2 M pro oligomerization as a potential target for therapy. Int.J.Biol.Macromol., 267, 2024
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8XDO
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8XPT
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![BU of 8xpt by Molmil](/molmil-images/mine/8xpt) | The Crystal Structure of EHMT1 from Biortus. | 分子名称: | Histone-lysine N-methyltransferase EHMT1, S-ADENOSYL-L-HOMOCYSTEINE, SULFATE ION, ... | 著者 | Wang, F, Cheng, W, Yuan, Z, Lin, D, Bao, C. | 登録日 | 2024-01-04 | 公開日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (3.35 Å) | 主引用文献 | The Crystal Structure of EHMT1 from Biortus. To Be Published
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9EOW
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8VK4
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9EQF
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![BU of 9eqf by Molmil](/molmil-images/mine/9eqf) | Crystal structure of the L-arginine hydroxylase VioC MeHis316, bound to Fe(II), L-arginine, and succinate | 分子名称: | 1,2-ETHANEDIOL, ARGININE, Alpha-ketoglutarate-dependent L-arginine hydroxylase, ... | 著者 | Hardy, F.J. | 登録日 | 2024-03-21 | 公開日 | 2024-07-31 | 最終更新日 | 2024-08-21 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Probing Ferryl Reactivity in a Nonheme Iron Oxygenase Using an Expanded Genetic Code. Acs Catalysis, 14, 2024
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8XVC
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9FX6
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![BU of 9fx6 by Molmil](/molmil-images/mine/9fx6) | Crystal structure of Cryo2RT SARS-CoV-2 main protease at 100K | 分子名称: | 3C-like proteinase nsp5, DIMETHYL SULFOXIDE, MAGNESIUM ION, ... | 著者 | Huang, C.Y, Aumonier, S, Mac Sweeney, A, Olieric, V, Wang, M. | 登録日 | 2024-07-01 | 公開日 | 2024-07-31 | 最終更新日 | 2024-08-14 | 実験手法 | X-RAY DIFFRACTION (2.227 Å) | 主引用文献 | Cryo2RT: a high-throughput method for room-temperature macromolecular crystallography from cryo-cooled crystals. Acta Crystallogr D Struct Biol, 80, 2024
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8VRM
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![BU of 8vrm by Molmil](/molmil-images/mine/8vrm) | Crystal structure of the Pcryo_0619 N-acetyltransferase from Psychrobacter cryohalolentis K5 | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, 1,2-ETHANEDIOL, Acetyltransferase, ... | 著者 | Dunsirn, M.M, Bockhaus, N.J, Thoden, J.B, Holden, H.M. | 登録日 | 2024-01-22 | 公開日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Biochemical Investigation of the Enzymes Required for the Production of 2,3,4-triacetoamido-2,3,4-trideoxy-l-arabinose in Psychrobacter cryohalolentis K5 To Be Published
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